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Volumn 107, Issue 29, 2010, Pages 12747-12754

B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression

Author keywords

B cell receptor; Follicular lymphoma; Phospho flow cytometry; Signaling profile

Indexed keywords

CD40 ANTIGEN; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 7; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; PREDNISONE; VINCRISTINE;

EID: 77955643156     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002057107     Document Type: Article
Times cited : (133)

References (51)
  • 2
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, et al. (2008) Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell 14: 335-343.
    • (2008) Cancer Cell , vol.14 , pp. 335-343
    • Kotecha, N.1
  • 3
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: Mirage or reality? Nat Med 15:1010-1012.
    • (2009) Nat Med , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 5
    • 0021703548 scopus 로고
    • The natural history of initially untreated low-grade non-Hodgkin's lymphomas
    • Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin's lymphomas. N Engl J Med 311:1471-1475.
    • (1984) N Engl J Med , vol.311 , pp. 1471-1475
    • Horning, S.J.1    Rosenberg, S.A.2
  • 6
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 0141680424 scopus 로고    scopus 로고
    • Cell signaling and cancer
    • Martin GS (2003) Cell signaling and cancer. Cancer Cell 4:167-174.
    • (2003) Cancer Cell , vol.4 , pp. 167-174
    • Martin, G.S.1
  • 8
    • 8644252736 scopus 로고    scopus 로고
    • Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    • Dave SS, et al. (2004) Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 351:2159-2169.
    • (2004) N Engl J Med , vol.351 , pp. 2159-2169
    • Dave, S.S.1
  • 9
    • 33846974737 scopus 로고    scopus 로고
    • Gene-expression and immunohistochemical study of specific Tcell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma
    • Glas AM, et al. (2007) Gene-expression and immunohistochemical study of specific Tcell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma. J Clin Oncol 25:390-398.
    • (2007) J Clin Oncol , vol.25 , pp. 390-398
    • Glas, A.M.1
  • 10
    • 0036884819 scopus 로고    scopus 로고
    • Regulation of B-cell fate by antigen-receptor signals
    • DOI 10.1038/nri955
    • Niiro H, Clark EA (2002) Regulation of B-cell fate by antigen-receptor signals. Nat Rev Immunol 2:945-956. (Pubitemid 37323215)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 945-956
    • Niiro, H.1    Clark, E.A.2
  • 11
    • 1842681652 scopus 로고    scopus 로고
    • Feedback regulation of lymphocyte signalling
    • Reth M, Brummer T (2004) Feedback regulation of lymphocyte signalling. Nat Rev Immunol 4:269-277.
    • (2004) Nat Rev Immunol , vol.4 , pp. 269-277
    • Reth, M.1    Brummer, T.2
  • 14
    • 2942584865 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Revelations from the B-cell receptor
    • DOI 10.1182/blood-2003-12-4312
    • Stevenson FK, Caligaris-Cappio F (2004) Chronic lymphocytic leukemia: Revelations from the B-cell receptor. Blood 103:4389-4395. (Pubitemid 38745961)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4389-4395
    • Stevenson, F.K.1    Caligaris-Cappio, F.2
  • 15
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Küppers R (2005) Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5: 251-262.
    • (2005) Nat Rev Cancer , vol.5 , pp. 251-262
    • Küppers, R.1
  • 16
    • 33646492861 scopus 로고    scopus 로고
    • Cutting edge: Constitutive B cell receptor signaling is critical for basal growth of B lymphoma
    • Gururajan M, Jennings CD, Bondada S (2006) Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma. J Immunol 176:5715-5719.
    • (2006) J Immunol , vol.176 , pp. 5715-5719
    • Gururajan, M.1    Jennings, C.D.2    Bondada, S.3
  • 17
    • 0036530010 scopus 로고    scopus 로고
    • Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma
    • DOI 10.1182/blood.V99.7.2562
    • Zhu D, et al. (2002) Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 99:2562-2568. (Pubitemid 34525446)
    • (2002) Blood , vol.99 , Issue.7 , pp. 2562-2568
    • Zhu, D.1    McCarthy, H.2    Ottensmeier, C.H.3    Johnson, P.4    Hamblin, T.J.5    Stevenson, F.K.6
  • 18
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam KP, Kühn R, Rajewsky K (1997) In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073-1083.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kühn, R.2    Rajewsky, K.3
  • 19
    • 70350304558 scopus 로고    scopus 로고
    • PI3 kinase signals BCR-dependent mature B cell survival
    • Srinivasan L, et al. (2009) PI3 kinase signals BCR-dependent mature B cell survival. Cell 139:573-586.
    • (2009) Cell , vol.139 , pp. 573-586
    • Srinivasan, L.1
  • 20
    • 38949164405 scopus 로고    scopus 로고
    • Lentiviral (HIV)-based RNA interference screen in human B-cell receptor regulatory networks reveals MCL1-induced oncogenic pathways
    • DOI 10.1182/blood-2007-09-110601
    • Ruiz-Vela A, et al. (2008) Lentiviral (HIV)-based RNA interference screen in human B-cell receptor regulatory networks reveals MCL1-induced oncogenic pathways. Blood 111:1665-1676. (Pubitemid 351213458)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1665-1676
    • Ruiz-Vela, A.1    Aggarwal, M.2    De La Cueva, P.3    Treda, C.4    Herreros, B.5    Martin-Perez, D.6    Dominguez, O.7    Piris, M.A.8
  • 21
    • 0141606902 scopus 로고    scopus 로고
    • Caspase activation by BCR cross-linking in immature B cells: Differential effects on growth arrest and apoptosis
    • Brás A, Ruiz-Vela A, González de Buitrago G, Martinez-A C (1999) Caspase activation by BCR cross-linking in immature B cells: Differential effects on growth arrest and apoptosis. FASEB J 13:931-944. (Pubitemid 29220705)
    • (1999) FASEB Journal , vol.13 , Issue.8 , pp. 931-944
    • Bras, A.1    Ruiz-Vela, A.2    Gonzalez De Buitrago, G.3    Martinez-A, C.4
  • 22
    • 33751195937 scopus 로고    scopus 로고
    • Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells
    • Irish JM, Czerwinski DK, Nolan GP, Levy R (2006) Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells. Blood 108:3135-3142.
    • (2006) Blood , vol.108 , pp. 3135-3142
    • Irish, J.M.1    Czerwinski, D.K.2    Nolan, G.P.3    Levy, R.4
  • 23
    • 0023877768 scopus 로고
    • Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation
    • Ngan BY, Chen-Levy Z, Weiss LM, Warnke RA, Cleary ML (1988) Expression in non- Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. N Engl J Med 318:1638-1644.
    • (1988) N Engl J Med , vol.318 , pp. 1638-1644
    • Ngan, B.Y.1    Chen-Levy, Z.2    Weiss, L.M.3    Warnke, R.A.4    Cleary, M.L.5
  • 24
    • 7944233465 scopus 로고    scopus 로고
    • Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
    • Silva CM (2004) Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 23:8017-8023.
    • (2004) Oncogene , vol.23 , pp. 8017-8023
    • Silva, C.M.1
  • 25
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • DOI 10.1038/nrc969
    • Downward J (2003) Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3:11-22. (Pubitemid 37328883)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 26
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 27
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: Linking inflammation and immunity to cancer development and progression
    • DOI 10.1038/nri1703
    • Karin M, Greten FR (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5:749-759. (Pubitemid 41400849)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.10 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 29
    • 17644427718 scopus 로고    scopus 로고
    • Causal protein-signaling networks derived from multiparameter single-cell data
    • DOI 10.1126/science.1105809
    • Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP (2005) Causal protein-signaling networks derived from multiparameter single-cell data. Science 308: 523-529. (Pubitemid 40570578)
    • (2005) Science , vol.308 , Issue.5721 , pp. 523-529
    • Sachs, K.1    Perez, O.2    Pe'Er, D.3    Lauffenburger, D.A.4    Nolan, G.P.5
  • 30
    • 33646036758 scopus 로고    scopus 로고
    • The response of human epithelial cells to TNF involves an inducible autocrine cascade
    • Janes KA, et al. (2006) The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell 124:1225-1239.
    • (2006) Cell , vol.124 , pp. 1225-1239
    • Janes, K.A.1
  • 31
    • 0015292761 scopus 로고
    • Advanced lymphosarcoma: Intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone
    • Bagley CM, Jr, Devita VT, Jr, Berard CW, Canellos GP (1972) Advanced lymphosarcoma: Intensive cyclical combination chemotherapy with cyclophosphamide, vincristine, and prednisone. Ann Intern Med 76:227-234.
    • (1972) Ann Intern Med , vol.76 , pp. 227-234
    • Bagley Jr., C.M.1    Devita Jr., V.T.2    Berard, C.W.3    Canellos, G.P.4
  • 33
    • 63449105305 scopus 로고    scopus 로고
    • PLC-gamma2 is essential for formation and maintenance of memory B cells
    • Hikida M, et al. (2009) PLC-gamma2 is essential for formation and maintenance of memory B cells. J Exp Med 206:681-689.
    • (2009) J Exp Med , vol.206 , pp. 681-689
    • Hikida, M.1
  • 36
    • 0021792139 scopus 로고
    • Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies
    • Meeker T, et al. (1985) Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies. N Engl J Med 312:1658-1665. (Pubitemid 15068572)
    • (1985) New England Journal of Medicine , vol.312 , Issue.26 , pp. 1658-1665
    • Meeker, T.1    Lowder, J.2    Cleary, M.L.3
  • 37
    • 33746214828 scopus 로고    scopus 로고
    • Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry
    • Irish JM, Czerwinski DK, Nolan GP, Levy R (2006) Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J Immunol 177: 1581-1589.
    • (2006) J Immunol , vol.177 , pp. 1581-1589
    • Irish, J.M.1    Czerwinski, D.K.2    Nolan, G.P.3    Levy, R.4
  • 38
    • 0036911138 scopus 로고    scopus 로고
    • Hydrogen peroxide as second messenger in lymphocyte activation
    • DOI 10.1038/ni1202-1129
    • Reth M (2002) Hydrogen peroxide as second messenger in lymphocyte activation. Nat Immunol 3:1129-1134. (Pubitemid 35469696)
    • (2002) Nature Immunology , vol.3 , Issue.12 , pp. 1129-1134
    • Reth, M.1
  • 39
    • 17444377916 scopus 로고    scopus 로고
    • The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal
    • Singh DK, et al. (2005) The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121:281-293.
    • (2005) Cell , vol.121 , pp. 281-293
    • Singh, D.K.1
  • 40
    • 33751198728 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation
    • Chen L, Juszczynski P, Takeyama K, Aguiar RC, Shipp MA (2006) Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation. Blood 108:3428-3433.
    • (2006) Blood , vol.108 , pp. 3428-3433
    • Chen, L.1    Juszczynski, P.2    Takeyama, K.3    Aguiar, R.C.4    Shipp, M.A.5
  • 41
    • 33751197936 scopus 로고    scopus 로고
    • R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
    • Braselmann S, et al. (2006) R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther 319:998-1008.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 998-1008
    • Braselmann, S.1
  • 43
    • 17844368292 scopus 로고    scopus 로고
    • B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates IkappaB kinase/IkappaBalpha/NF- kappaB without the need for PI3K and phospholipase Cgamma
    • Mizuno T, Rothstein TL (2005) B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma. J Immunol 174:6062-6070. (Pubitemid 40663794)
    • (2005) Journal of Immunology , vol.174 , Issue.10 , pp. 6062-6070
    • Mizuno, T.1    Rothstein, T.L.2
  • 44
    • 0027467486 scopus 로고
    • Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor
    • Wheeler K, Pound JD, Gordon J, Jefferis R (1993) Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor. Eur J Immunol 23: 1165-1168. (Pubitemid 23120182)
    • (1993) European Journal of Immunology , vol.23 , Issue.5 , pp. 1165-1168
    • Wheeler, K.1    Pound, J.D.2    Gordon, J.3    Jefferis, R.4
  • 45
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney DG, et al. (1997) IDEC-C2B8 (Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 90: 2188-2195.
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1
  • 46
    • 53749085410 scopus 로고    scopus 로고
    • Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma
    • Marcus R, et al. (2008) Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol 26:4579-4586.
    • (2008) J Clin Oncol , vol.26 , pp. 4579-4586
    • Marcus, R.1
  • 47
    • 63749097149 scopus 로고    scopus 로고
    • Maintenance rituximab after cyclophosphamide, vincristine, and prednisone prolongs progression-free survival in advanced indolent lymphoma: Results of the randomized phase III ECOG1496 Study
    • Hochster H, et al. (2009) Maintenance rituximab after cyclophosphamide, vincristine, and prednisone prolongs progression-free survival in advanced indolent lymphoma: Results of the randomized phase III ECOG1496 Study. J Clin Oncol 27:1607-1614.
    • (2009) J Clin Oncol , vol.27 , pp. 1607-1614
    • Hochster, H.1
  • 48
    • 65549126032 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma: Reduced CD20 expression is associated with an inferior survival
    • Johnson NA, et al. (2009) Diffuse large B-cell lymphoma: Reduced CD20 expression is associated with an inferior survival. Blood 113:3773-3780.
    • (2009) Blood , vol.113 , pp. 3773-3780
    • Johnson, N.A.1
  • 49
    • 0026636759 scopus 로고
    • Clonal evolution of a follicular lymphoma: Evidence for antigen selection
    • Bahler DW, Levy R (1992) Clonal evolution of a follicular lymphoma: Evidence for antigen selection. Proc Natl Acad Sci USA 89:6770-6774.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6770-6774
    • Bahler, D.W.1    Levy, R.2
  • 50
    • 0026768775 scopus 로고
    • Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection
    • Zelenetz AD, Chen TT, Levy R (1992) Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med 176:1137-1148.
    • (1992) J Exp Med , vol.176 , pp. 1137-1148
    • Zelenetz, A.D.1    Chen, T.T.2    Levy, R.3
  • 51
    • 34247116573 scopus 로고    scopus 로고
    • Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor
    • Radcliffe CM, et al. (2007) Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. J Biol Chem 282:7405-7415.
    • (2007) J Biol Chem , vol.282 , pp. 7405-7415
    • Radcliffe, C.M.1


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