Altered phenotype and function of dendritic cells in children with type 1 diabetes

Clinical and Experimental Immunology

Volumn 142, Issue 2, 2005, Pages 341-346

  Angelini, Federica ^a,c   Del Duca, E ^a   Piccinini, S ^a   Pacciani, V ^a   Rossi, P ^a,b   Bitti, M L Manca ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

B7.1 B7.2; Dendritic cells; Type 1 diabetes

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; THYMIDINE; TRITIUM;

ADOLESCENT; AGE DISTRIBUTION; ARTICLE; BLOOD CELL; CELL CULTURE; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELL STIMULATION; CHILD; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENDRITIC CELL; DNA SYNTHESIS; FEMALE; FLUORESCENCE; HEALTH STATUS; HUMAN; HUMAN CELL; IMMUNITY; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOLECULE; MONOCYTE; PATHOGENESIS; PEDIATRICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPERNATANT; T LYMPHOCYTE; TIME; UMBILICAL CORD BLOOD;

ADOLESCENT; ANTIGENS, CD80; ANTIGENS, CD86; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; IMMUNOPHENOTYPING; INFANT; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MALE; SELF TOLERANCE; T-LYMPHOCYTES;

EID: 27644491043     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02916.x     Document Type: Article

References (27)

1. Eisenbarth GS. Type 1 diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986; 314:1360-8.
2. Eisenbarth GS. Insulin autoimmunity: immunogenetics/immunopathogenesis of type IA diabetes. Ann NY Acad Sci 2003; 1005:109-18.
3. Yoon JW, Jun HS, Santamaria PS. Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 1998; 27:109-22.
4. Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767-811.
5. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell co-stimulation. Ann Rev Immunol 1996; 14:233-58.
6. Buelens C, Willems F, Delvaux A et al. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995; 25:2668-72.
7. Buelens C, Verhasselt V, De Groote D et al. Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10. Eur J Immunol 1997; 27:1848-52.
8. Hathcock KS, Laszlo G, Pucillo C et al. Comparative analysis of B7-1 and B7-2 co-stimulatory ligands: expression and function. J Exp Med 1994; 180:631-40.
9. Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol 2002; 2:116-26.
10. Sharpe AH. Analysis of lymphocyte co-stimulation in vivo using transgenic and 'knockout' mice. Curr Opin Immunol 1995; 7:389-95.
11. Lenschow DJ, Ho SC, Sattar H et al. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med 1995; 181:1145-55.
12. Langmuir PB, Bridgett MM, Bothwell AL et al. Bone marrow abnormalities in the non-obese diabetic mouse. Int Immunol 1993; 5:169-77.
13. Serreze DV, Gaskins HR, Leiter EH. Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J Immunol 1993; 150:2534-43.
14. Takahashi M, Honeyman MC, Harrison LC. Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes. J Immunol 1998; 161:2629-35.
15. Spatz M, Eibl N, Hink S et al. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Cell Immunol 2003; 221:15-26.
16. Steinbrink K, Wolfl M, Jonuleit H et al. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159:4772-80.
17. Brunet JF, Denizot F, Luciani MF et al. A new member of the immunoglobulin superfamily-CTLA-4. Nature 1987; 328:267-70.
18. Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002; 16:23-35.
19. Tivol EA, Borriello F, Schweitzer AN et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3:541-7.
20. Luhder F, Hoglund P, Allison JP et al. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J Exp Med 1998; 187:427-32.
21. Garchon HJ, Bedossa P, Eloy L, Bach JF. Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice. Nature 1991; 353:260-2.
22. Wicker LS, Chamberlain G, Hunter K et al. Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the non-obese diabetic mouse. J Immunol 2004; 173:164-73.
23. Dahlen E, Hedlund G, Dawe K. Low CD86 expression in the non-obese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. J Immunol 2000; 164:2444-56.
24. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12:431-40.
25. Lohr J, Knoechel B, Jiang S et al. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol 2003; 4:664-9.
26. Tarner IH, Slavin AJ, McBride J et al. Treatment of autoimmune disease by adoptive cellular gene therapy. Ann NY Acad Sci 2003; 998:512-9.
27. Morita Y, Yang J, Gupta R et al. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest 2001; 107:1275-84.