ATTEMPTS: A heparin/protamine-based prodrug approach for delivery of thrombolytic drugs

Journal of Controlled Release

Volumn 72, Issue 1-3, 2001, Pages 145-156

  Liang, Jun Feng ^a   Park, Yoon Jeong ^a   Song, Hui ^a   Li, Yong Tao ^a   Yang, Victor Chi Min ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

ATTEMPTS; Heparin; Prodrug; Protamine; Thrombolytic therapy; Tissue type plasminogen activator

Indexed keywords

ALTEPLASE; ANTIBODY; ARGININE; CATION; ENZYME; FIBRINOGEN; FIBRINOLYTIC AGENT; HEPARIN; HEPARIN ANTAGONIST; IMMUNOGLOBULIN G; N SUCCINIMIDY 3 (2 PYRIDYLDITHIO)PROPIONATE; PRODRUG; PROPIONIC ACID DERIVATIVE; PROTAMINE; RECOMBINANT DNA; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ARTICLE; BLEEDING; BLOOD CLOT LYSIS; CATALYSIS; CHEMICAL MODIFICATION; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; REACTION ANALYSIS; TOXICITY;

ANTIFIBRINOLYTIC AGENTS; ANTIPLASMIN; DRUG DELIVERY SYSTEMS; FIBRIN; FIBRINOGEN; FIBRINOLYTIC AGENTS; HEPARIN; HEPARIN ANTAGONISTS; HUMANS; IMMUNOGLOBULIN G; PLASMINOGEN; PLASMINOGEN ACTIVATORS; PRODRUGS; PROTAMINES; RECOMBINANT PROTEINS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 0035858295     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00270-X     Document Type: Article

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