Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 4300-4306

  Yang, Yongchong ^a   Shang, Peihua ^a   Cheng, Changmei ^a   Wang, Dongchun ^b   Yang, Ping ^a   Zhang, Feng ^c   Li, Tianwen ^a   Lu, Aijun ^b   Zhao, Yufen ^a  

^a TSINGHUA UNIVERSITY   (China)

^b Jiangsu Key Laboratory of Molecular Targeted Antitumor Drug Research   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cytotoxic activity; N phenyl dichloroacetamide; Sodium dichloroacetate (DCA)

Indexed keywords

ANTINEOPLASTIC AGENT; N (2 CHLOROPHENYL) 2,2 DICHLOROACETAMIDE; N (2 FLUOROPHENYL) 2,2 DICHLOROACETAMIDE; N (2 METHYLPHENYL) 2,2 DICHLOROACETAMIDE; N (3 BROMOPHENYL) 2,2 DICHLOROACETAMIDE; N (3 CHLOROPHENYL) 2,2 DICHLOROACETAMIDE; N (3 CYANOPHENYL) 2,2 DICHLOROACETAMIDE; N (3 ETHYNYLPHENYL) 2,2 DICHLOROACETAMIDE; N (3 FLUOROPHENYL) 2,2 DICHLOROACETAMIDE; N (3 IODOPHENYL) 2,2 DICHLOROACETAMIDE; N (3 METHOXYCARBONYLPHENYL) 2,2 DICHLOROACETAMIDE; N (3 METHOXYPHENYL) 2,2 DICHLOROACETAMIDE; N (3 NITROPHENYL) 2,2 DICHLOROACETAMIDE; N (4 BROMOPHENYL) 2,2 DICHLOROACETAMIDE; N (4 CHLOROPHENYL) 2,2 DICHLOROACETAMIDE; N (4 FLUOROPHENYL) 2,2 DICHLOROACETAMIDE; N (4 IODOPHENYL) 2,2 DICHLOROACETAMIDE; N (4 METHOXYPHENYL) 2,2 DICHLOROACETAMIDE; N (4 METHYLPHENYL) 2,2 DICHLOROACETAMIDE; N (4 NITROPHENYL) 2,2 DICHLOROACETAMIDE; N [3 (2,2 DICHLOROACETAMIDO)PHENYL] 2,2 DICHLOROACETAMIDE; N [3 (2,2 DICHLOROACETOXY)PHENYL] 2,2 DICHLOROACETAMIDE; N [3 (TRIFLUOROMETHOXY) PHENYL] 2,2 DICHLOROACETAMID; N [3 (TRIFLUOROMETHOXY) PHENYL] 2,2 DICHLOROACETAMIDE; N [3 (TRIFLUOROMETHYL) PHENYL] 2,2 DICHLOROACETAMIDE; N [3 (TRIFLUOROMETHYLTHIO) PHENYL) 2,2 DICHLOROACETAMIDE; N [3 (TRIFLUOROMETHYLTHIO) PHENYL] 2,2 DICHLOROACETAMIDE; N [3 [3 (2,2 DICHLOROACETAMIDO) PHENYLSULFONYL]PHENYL] 2,2 DICHLOROACETAMID; N PHENYL 2,2 DICHLOROACETAMID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CLINICAL EVALUATION; CYTOTOXICITY TEST; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LD 50; MOUSE; NONHUMAN;

ACETAMIDES; ACETANILIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LETHAL DOSE 50; MALE; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955559505     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.06.032     Document Type: Article

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