Synthesis, structure-activity relationship and antiviral activity of 3′-N,N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 3787-3793

  Singh, Ramendra K ^a   Yadav, Dipti ^a   Rai, Diwakar ^a   Kumari, Garima ^a   Pannecouque, C ^b   De Clercq, Erik ^b  

^a UNIVERSITY OF ALLAHABAD   (India)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Dideoxythymidine; HIV 1; HIV 1 RT; MTT assay; NRTIs; VSV

Indexed keywords

3' N,N DIMETHYLAMINO 2',3' DIDEOXYTHYMIDINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 5' (N ALPHA BOC LEVO PHENYLALANYL) 3' N,N DIMETHYLAMINO 2',3' DIDEOXYTHYMIDINE; 5' DECANOYL 3' N,N DIMETHYLAMINO 2',3' DIDEOXYTHYMIDINE; 5' LEVO PHENYLALANYL 3' N,N DIMETHYLAMINO 2',3' DIDEOXYTHYMIDINE; 9 (2,3 DIHYDROXYPROPYL)ADENINE; AMANTADINE; GANCICLOVIR; OSELTAMIVIR; RIBAVIRIN; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRUCTURE; COMPUTER PROGRAM; CONTROLLED STUDY; CORONAVIRUS; COXSACKIE VIRUS B4; CYTOTOXICITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG POTENTIATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS B; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PARAINFLUENZA VIRUS 3; REOVIRUS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SINDBIS VIRUS; STRUCTURE ACTIVITY RELATION; VACCINIA VIRUS; VERO CELL; VESICULAR STOMATITIS VIRUS; VIRUS CONCENTRATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DIDEOXYNUCLEOTIDES; HIV REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUSES;

EID: 77955550508     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.05.028     Document Type: Article

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