-
3
-
-
0347511689
-
Fluorescence readouts in HTS: No gain without pain?
-
Gribbon P, Sewing A (2003) Fluorescence readouts in HTS: no gain without pain? Drug Discovery Today 8:1035-1043.
-
(2003)
Drug Discovery Today
, vol.8
, pp. 1035-1043
-
-
Gribbon, P.1
Sewing, A.2
-
4
-
-
0037177352
-
Visualizing cellular phosphoinositide pools with GFP-fused protein modules
-
Balla T, Varnai P (2002) Visualizing cellular phosphoinositide pools with GFP-fused protein modules. Science STKE 125: 13.
-
(2002)
Science STKE
, vol.125
, pp. 13
-
-
Balla, T.1
Varnai, P.2
-
5
-
-
33751231711
-
Optical biosensors: Where next and how soon
-
Cooper MA (2006) Optical biosensors: where next and how soon. Drug Discovery Today 11: 1061-1067.
-
(2006)
Drug Discovery Today
, vol.11
, pp. 1061-1067
-
-
Cooper, M.A.1
-
6
-
-
33845902552
-
Higher-throughput, label-free, real-time molecular interaction analysis
-
Rich RL, Myszka DG (2007) Higher-throughput, label-free, real-time molecular interaction analysis. Anal Biochem 361:1-6.
-
(2007)
Anal Biochem
, vol.361
, pp. 1-6
-
-
Rich, R.L.1
Myszka, D.G.2
-
7
-
-
33845877164
-
Label-free cell-based assays with optical biosensors in drug discovery
-
Fang Y (2006) Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol 4:583-595.
-
(2006)
Assay Drug Dev Technol
, vol.4
, pp. 583-595
-
-
Fang, Y.1
-
8
-
-
36048969417
-
Non-invasive optical biosensor for probing cell signaling
-
Fang Y (2007) Non-invasive optical biosensor for probing cell signaling. Sensors 7: 2316-2329.
-
(2007)
Sensors
, vol.7
, pp. 2316-2329
-
-
Fang, Y.1
-
9
-
-
33947217218
-
Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells
-
Fang Y, Li G, Ferrie AM (2007) Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J Pharmacol Toxicol Methods 55:314-322.
-
(2007)
J Pharmacol Toxicol Methods
, vol.55
, pp. 314-322
-
-
Fang, Y.1
Li, G.2
Ferrie, A.M.3
-
10
-
-
39649108870
-
Label-free optical biosensor for ligand-directed functional selectivity acting on β2 adrenoceptor in living cells
-
Fang Y, Ferrie AM (2008) Label-free optical biosensor for ligand-directed functional selectivity acting on β2 adrenoceptor in living cells. FEBS Lett 582:558-564.
-
(2008)
FEBS Lett
, vol.582
, pp. 558-564
-
-
Fang, Y.1
Ferrie, A.M.2
-
11
-
-
24644496122
-
Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors
-
Fang Y, Ferrie AM, Fontaine NH, Yuen PK (2005) Characteristics of dynamic mass redistribution of EGF receptor signaling in living cells measured with label free optical biosensors. Anal Chem 77:5720-5725.
-
(2005)
Anal Chem
, vol.77
, pp. 5720-5725
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Yuen, P.K.4
-
12
-
-
27744501166
-
Optical biosensor provides insights for bradykinin β2 receptor signaling in A431 cells
-
Fang Y, Li G, Peng J (2005) Optical biosensor provides insights for bradykinin β2 receptor signaling in A431 cells. FEBS Lett 579:6365-6374.
-
(2005)
FEBS Lett
, vol.579
, pp. 6365-6374
-
-
Fang, Y.1
Li, G.2
Peng, J.3
-
13
-
-
33748469378
-
Resonant waveguide grating biosensor for living cell sensing
-
Fang Y, Ferrie AM, Fontaine NH, Mauro J, Balakrishnan J (2006) Resonant waveguide grating biosensor for living cell sensing. Biophys J 91: 1925-1940.
-
(2006)
Biophys J
, vol.91
, pp. 1925-1940
-
-
Fang, Y.1
Ferrie, A.M.2
Fontaine, N.H.3
Mauro, J.4
Balakrishnan, J.5
-
14
-
-
43049140200
-
Surface plasmon resonance biosensor detects the downstream events of active PKC b in antigen-stimulated mast cells
-
Tanaka M, Hiragun T, Tsutsui T, Yanase Y, Suzuki H, Hide M (2008) Surface plasmon resonance biosensor detects the downstream events of active PKC b in antigen-stimulated mast cells. Biosens Bioelectron 23:1652-1658.
-
(2008)
Biosens Bioelectron
, vol.23
, pp. 1652-1658
-
-
Tanaka, M.1
Hiragun, T.2
Tsutsui, T.3
Yanase, Y.4
Suzuki, H.5
Hide, M.6
-
15
-
-
17044408028
-
Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing
-
Horath R, Pedersen HC, Skivesen N, Selmeczi D, Larsen NB (2005) Monitoring of living cell attachment and spreading using reverse symmetry waveguide sensing. Appl Phys Lett 86: e071101.
-
(2005)
Appl Phys Lett
, vol.86
-
-
Horath, R.1
Pedersen, H.C.2
Skivesen, N.3
Selmeczi, D.4
Larsen, N.B.5
-
16
-
-
84975543308
-
Sensitivity of grating couplers as integrated-optical chemical sensors
-
Tiefenthaler K, Lukosz W (1989) Sensitivity of grating couplers as integrated-optical chemical sensors. J Opt Soc Am B 6:209-220.
-
(1989)
J Opt Soc Am B
, vol.6
, pp. 209-220
-
-
Tiefenthaler, K.1
Lukosz, W.2
-
17
-
-
33746918047
-
Label-free profiling of endogenous G protein-coupled receptors using a cell-based high throughput screening technology
-
Li G, Ferrie AM, Fang Y (2006) Label-free profiling of endogenous G protein-coupled receptors using a cell-based high throughput screening technology. J Assoc Lab Automat 11:181-187.
-
(2006)
J Assoc Lab Automat
, vol.11
, pp. 181-187
-
-
Li, G.1
Ferrie, A.M.2
Fang, Y.3
-
18
-
-
35548958205
-
Plasma losses by fast electrons in thin films
-
Ritchie RH (1957) Plasma losses by fast electrons in thin films. Phys Rev 106: 874-881.
-
(1957)
Phys Rev
, vol.106
, pp. 874-881
-
-
Ritchie, R.H.1
-
19
-
-
0001700782
-
Refractometry of living cells. Part I. Basic principles
-
Barer R, Joseph S (1954) Refractometry of living cells. Part I. Basic principles. Quart J Microsc Science 95:399-423.
-
(1954)
Quart J Microsc Science
, vol.95
, pp. 399-423
-
-
Barer, R.1
Joseph, S.2
-
20
-
-
40749084402
-
Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed G protein-coupled receptors
-
Lee PH, Gao A, van Staden C, Ly J, Salon J, Xu A, Fang Y, Verkleeren R (2008) Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed G protein-coupled receptors. Assay Drug Develop Technol 6:83-94.
-
(2008)
Assay Drug Develop Technol
, vol.6
, pp. 83-94
-
-
Lee, P.H.1
Gao, A.2
van Staden, C.3
Ly, J.4
Salon, J.5
Xu, A.6
Fang, Y.7
Verkleeren, R.8
-
21
-
-
59449089513
-
The C-terminal tail of CRTH2 is a key molecular determinant that constrains G aiand downstream-signaling cascade activation
-
Schroeder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E (2009) The C-terminal tail of CRTH2 is a key molecular determinant that constrains G aiand downstream-signaling cascade activation. J Biol Chem. 284:1324-1336.
-
(2009)
J Biol Chem
, vol.284
, pp. 1324-1336
-
-
Schroeder, R.1
Merten, N.2
Mathiesen, J.M.3
Martini, L.4
Kruljac-Letunic, A.5
Krop, F.6
Blaukat, A.7
Fang, Y.8
Tran, E.9
Ulven, T.10
Drewke, C.11
Whistler, J.12
Pardo, L.13
Gomeza, J.14
Kostenis, E.15
-
22
-
-
0036500494
-
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
-
Zaccolo M, Pozzan T (2002) Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295:1711-1715.
-
(2002)
Science
, vol.295
, pp. 1711-1715
-
-
Zaccolo, M.1
Pozzan, T.2
-
23
-
-
0038608273
-
Four-dimensional organization of protein kinase signaling cascades: The roles of diffusion, endocytosis and molecular motors
-
Kholodenko BN (2003) Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors. J Exper Biol 206:2073-2082.
-
(2003)
J Exper Biol
, vol.206
, pp. 2073-2082
-
-
Kholodenko, B.N.1
-
24
-
-
54249124501
-
Learning biological networks: From modules to dynamics
-
Bonneau R (2008) Learning biological networks: from modules to dynamics. Nat Chem Biol 4:658-664.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 658-664
-
-
Bonneau, R.1
-
25
-
-
0032875356
-
Physiological regulation of G protein-linked signaling
-
Morris AJ, Malbon CC (1999) Physiological regulation of G protein-linked signaling. Physiol Rev 79:1373-1430.
-
(1999)
Physiol Rev
, vol.79
, pp. 1373-1430
-
-
Morris, A.J.1
Malbon, C.C.2
-
27
-
-
0035976622
-
Location, location, location: Membrane targeting directed by PX domains
-
Sato TK, Overduin M, Emr SD (2001) Location, location, location: membrane targeting directed by PX domains. Science 294:1881-1885.
-
(2001)
Science
, vol.294
, pp. 1881-1885
-
-
Sato, T.K.1
Overduin, M.2
Emr, S.D.3
-
28
-
-
6444236841
-
Bradykinin receptor ligands: Therapeutic perspectives
-
Marceau F, Regoli D (2004) Bradykinin receptor ligands: therapeutic perspectives. Nat Rev Drug Discov 3:845-852.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 845-852
-
-
Marceau, F.1
Regoli, D.2
-
29
-
-
0029670977
-
Dual bradykinin β2 receptor signalling in A431 human epidermoid carcinoma cells: Activation of protein kinase C is counteracted by a Gs-mediated stimulation of the cyclic AMP pathway
-
Liebmann C, Graness A, Ludwig B, Adomeit A, Boehmer A, Boehmer F-D, Nürnberg B, Wetzker R (1996) Dual bradykinin β2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a Gs-mediated stimulation of the cyclic AMP pathway. Biochem J 313:109-118.
-
(1996)
Biochem J
, vol.313
, pp. 109-118
-
-
Liebmann, C.1
Graness, A.2
Ludwig, B.3
Adomeit, A.4
Boehmer, A.5
Boehmer, F.-D.6
Nürnberg, B.7
Wetzker, R.8
-
30
-
-
0034655749
-
Protein-tyrosine-phosphatasemediated epidermal growth factor (EGF) receptor transinactivation and EGF receptor-independent stimulation of mitogen-activated protein kinase by bradykinin in A431 cells
-
Graness A, Hanke S, Boehmer F-D, Presek P, Liebmann C (2000) Protein-tyrosine-phosphatasemediated epidermal growth factor (EGF) receptor transinactivation and EGF receptor-independent stimulation of mitogen-activated protein kinase by bradykinin in A431 cells. Biochem J 347: 441-447.
-
(2000)
Biochem J
, vol.347
, pp. 441-447
-
-
Graness, A.1
Hanke, S.2
Boehmer, F.-D.3
Presek, P.4
Liebmann, C.5
-
31
-
-
34447626644
-
Ligand-selective signaling and high content for GPCR drugs
-
Mailman R. B. (2007) Ligand-selective signaling and high content for GPCR drugs. Trends in Pharmacol Sci 8:390-396.
-
(2007)
Trends In Pharmacol Sci
, vol.8
, pp. 390-396
-
-
Mailman, R.B.1
-
32
-
-
0027513982
-
A mutation-induced activated state of the β2-adrenergic receptor. Extending the ternary complex model
-
Samama P, Cotecchia S, Costa T, Lefkowitz RJ (1993) A mutation-induced activated state of the β2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4636.
-
(1993)
J Biol Chem
, vol.268
, pp. 4625-4636
-
-
Samama, P.1
Cotecchia, S.2
Costa, T.3
Lefkowitz, R.J.4
-
33
-
-
0038540318
-
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
-
Hermans E (2003) Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors. Pharmacol Ther 99:25-44.
-
(2003)
Pharmacol Ther
, vol.99
, pp. 25-44
-
-
Hermans, E.1
-
34
-
-
17644402459
-
Transduction of receptor signaling by b-arrestins
-
Lefkowitz RJ, Shenoy SK (2005) Transduction of receptor signaling by b-arrestins. Science 308:512-517.
-
(2005)
Science
, vol.308
, pp. 512-517
-
-
Lefkowitz, R.J.1
Shenoy, S.K.2
-
35
-
-
0141593597
-
B-arrestinmediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, Pineyro G (2003) b -arrestinmediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci USA 100:11406-11411.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 11406-11411
-
-
Azzi, M.1
Charest, P.G.2
Angers, S.3
Rousseau, G.4
Kohout, T.5
Bouvier, M.6
Pineyro, G.7
-
36
-
-
33846245114
-
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
-
Sun Y, Huang J, Xiang Y, Bastepe M, Juppner H, Kobilka BK, Zhang JJ, Huang XY (2007) Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J 26:53-64.
-
(2007)
EMBO J
, vol.26
, pp. 53-64
-
-
Sun, Y.1
Huang, J.2
Xiang, Y.3
Bastepe, M.4
Juppner, H.5
Kobilka, B.K.6
Zhang, J.J.7
Huang, X.Y.8
-
37
-
-
33846909764
-
"Phenotypic" pharmacology: The influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology
-
Nelson CP, Challiss RAJ (2007) "Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology. Biochem Pharmacol 73: 737-751.
-
(2007)
Biochem Pharmacol
, vol.73
, pp. 737-751
-
-
Nelson, C.P.1
Challiss, R.A.J.2
-
38
-
-
2142703828
-
Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the β2 adrenergic receptor
-
Liapakis G, Chan WC, Papadokostaki M, Javitch JA (2004) Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the β2 adrenergic receptor. Mol Pharmacol 65:1181-1190.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1181-1190
-
-
Liapakis, G.1
Chan, W.C.2
Papadokostaki, M.3
Javitch, J.A.4
-
39
-
-
20444499405
-
Probing the β2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists
-
Swaminath G, Deupi X, Lee TW, Zhu W, Thian FS, Kobilka TS, Kobilka B (2005) Probing the β2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists. J Biol Chem 280:22165-22171.
-
(2005)
J Biol Chem
, vol.280
, pp. 22165-22171
-
-
Swaminath, G.1
Deupi, X.2
Lee, T.W.3
Zhu, W.4
Thian, F.S.5
Kobilka, T.S.6
Kobilka, B.7
-
40
-
-
58149391231
-
Duplexed label-free G protein-coupled receptor assays for high throughput screening
-
Tran E, Fang Y (2008) Duplexed label-free G protein-coupled receptor assays for high throughput screening. J Biomol Screening 13:975-985.
-
(2008)
J Biomol Screening
, vol.13
, pp. 975-985
-
-
Tran, E.1
Fang, Y.2
|