Osteopontin overproduction is associated with progression of glomerular fibrosis in a rat model of anti-glomerular basement membrane glomerulonephritis

American Journal of Nephrology

Volumn 32, Issue 3, 2010, Pages 262-271

  Merszei, Justin ^a   Wu, Jean ^b   Torres, Lisa ^b   Hicks, John M ^b   Bartkowiak, Todd ^b   Tan, Filemon ^c   Lou, Ya Huan ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Anti glomerular basement membrane disease; Extracellular matrix; Fibroblast; Fibrosis; Inflammation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; OSTEOPONTIN; RNA; THY 1 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA MICROARRAY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GLOMERULONEPHRITIS; KIDNEY FIBROSIS; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; GENE EXPRESSION; KIDNEY GLOMERULUS; OSTEOPONTIN; RATS; RATS, INBRED WKY; UP-REGULATION;

EID: 77955528870     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000319238     Document Type: Article

References (33)

1. Chatziantoniou C, Boffa JJ, Tharaux PL, Flamant M, Ronco P, Dussaule JC: Progression and regression in renal vascular and glomerular fibrosis. Int J Exp Pathol 2004; 85: 1-11.
2. Liu Y: Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 2006; 69: 213-217.
3. Eddy AA: Molecular basis of renal fibrosis. Pediatr Nephrol 2000; 15: 290-301.
4. Boffa JJ, Lu Y, Placier S, Stefanski A, Dussaule JC, Chatziantoniou C: Regression of renal vascular and glomerular fibrosis: role of angiotensin II receptor antagonism and matrix metalloproteinases. J Am Soc Nephrol 2003; 14: 1132-1144.
5. François H, Placier S, Flamant M, Tharaux PL, Chansel D, Dussaule JC, Chatziantoniou C: Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. FASEB J 2004; 18: 926-928.
6. Franzén A, Heinegård D. Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J 1985; 232: 715-724.
7. Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS: Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 2001; 107: 1055-1061.
8. O'Regan AW, Nau GJ, Chupp GL, Berman JS: Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks. Immunol Today 2000; 21: 475-478.
9. Giachelli CM, Scatena M, Wada T: Osteopontin: Potential roles in vascular function and dystrophic calcification. J Bone Miner Metab 1997; 15: 179-183.
10. Bird L: Asthma and allergy: opposing roles for osteopontin. Nature Rev Immunol 2007; 7: 417.
11. Chabas D, Baranzini SE, Mitchell M, Bernard CCA, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L: The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2001; 294: 1731-1735.
12. Pardo A, Gibson K, Cisneros J, Richards TJ, Yang Y, Becerril C, Yousem S, Herrera I, Ruiz V, Selman M, Kaminski N: Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS Med 2005; 2:e251.
13. Zahradka P: Novel role for osteopontin in cardiac fibrosis. Circ Res 2008; 102: 270-272.
14. Mori R, Shaw TJ, Martin P: Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. J Exp Med 2008; 205: 43-51.
15. Liaw L, Birk DE, Ballas CB, Whitsitt JS, Davidson JM, Hogan BL: Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest 1998; 101: 1468-1478.
16. Lenga Y, Koh A, Perera AS, McCulloch CA, Sodek J, Zohar R: Osteopontin expression is required for myofibroblast differentiation. Circ Res 2008; 102: 319-327.
17. Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, Gejyo F: Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney Int 2001; 60: 1645-1657.
18. Mazzali M, Kipari T, Ophascharoensuk V, Wesson JA, Johnson R, Hughes J: Osteopontin - a molecule for all seasons. Q J Med 2002; 95: 3-13.
19. Yu XQ, Fan JM, Nikolic-Paterson DJ, Yang N, Mu W, Pichler R, Johnson RJ, Atkins RC, Lan HY: IL-1 up-regulates osteopontin expression in experimental crescentic glomerulonephritis in the rat. Am J Pathol 1999; 154: 833-841.
20. Yu XQ, Nikolic-Paterson DJ, Mu W, Giachelli CM, Atkins RC, Johnson RJ, Lan HY: A functional role for osteopontin in experimental crescentic glomerulonephritis in the rat. Proc Assoc Am Phys 1998; 110: 50-64.
21. Bonvini JM, Schatzmann U, Beck-Schimmer B, Sun LK, Rittling SR, Denhardt DT, Le Hir M, Wüthrich RP: Lack of in vivo function of osteopontin in experimental anti-GBM nephritis. J Am Soc Nephrol 2000; 11: 1647-1655.
22. Yoo KH, Thornhill BA, Forbes MS, Coleman CM, Marcinko ES, Liaw L, Chevalier RL: Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. Kidney Int 2006; 70: 1735-1741.
23. Wolak T, Kim H, Ren Y, Kim J, Vaziri ND, Nicholas SB: Osteopontin modulates angiotensin- II-induced inflammation, oxidative stress, and fibrosis of the kidney. Kidney Int 2009; 76: 32-43.
24. Susztak K, Böttinger E, Novetsky A, Liang D, Zhu Y, Ciccone E, Wu D, Dunn S, McCue P, Sharma K: Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease. Diabetes 2004; 53: 784-794.
25. Lorenzen J, Shah R, Biser A, Staicu SA, Niranjan T, Garcia AM, Gruenwald A, Thomas DB, Shatat IF, Supe K, Woroniecki RP, Susztak K: The role of osteopontin in the development of albuminuria. J Am Soc Nephrol 2008; 19: 884-890.
26. Wu J, Hicks J, Borillo J, Glass WF 2nd, Lou YH: CD4 + T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis. J Clin Invest 2002; 109: 517-524.
27. Wu J, Hicks J, Borillo J, Glass WF 2nd, Lou YH: T cell epitope of glomerular basement membrane antigen induces severe glomerulonephritis. Kidney Int 2003; 64: 1292-1301.
28. Da Costa CET, Annels NE, Faaij Claudia MJM, Forsyth RG, Hogendoorn PCW, Egeler RM: Presence of osteoclast-like multinucleated giant cells in the bone and non-ostotic lesions of Langerhans' cell histiocytosis. J Exp Med 2005; 201: 687-693.
29. Remuzzi A, Mazerska M, Gephardt GN, Novick AC, Brenner BM, Remuzzi G: Threedimensional analysis of glomerular morphology in patients with subtotal nephrectomy. Kidney Int 1995; 48: 155-162.
30. Lan HY, Yu XQ, Yang N, Nikolic-Paterson DJ, Mu W, Pichler R, Johnson RJ, Atkins RC: De novo glomerular osteopontin expression in rat crescentic glomerulonephritis. Kidney Int 1998; 53: 136-145.
31. Yu XQ, Wu LL, Huang XR, Yang N, Gilbert RE, Cooper ME, Johnson RJ, Lai KN, Lan HY: Osteopontin expression in progressive renal injury in remnant kidney: role of angiotensin II. Kidney Int 2000; 58: 1469-1480.
32. Hagood JS, Prabhakaran P, Kumbla P, Salazar L, MacEwen MW, Barker TH, Ortiz LA, Schoeb T, Siegal GP, Alexander CB, Pardo A, Selman M: Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol 2005; 167: 365-379.
33. Mulder GD, Vande Berg JS: Cellular senescence and matrix metalloproteinase activity in chronic wounds. J Am Podiatr Med Assoc 2000; 92: 34-37.