Cellular senescence and matrix metalloproteinase activity in chronic wounds: Relevance to debridement and new technologies

Journal of the American Podiatric Medical Association

Volumn 92, Issue 1, 2002, Pages 34-37

  Mulder, Gerit D ^a   Vande Berg, Jerry S ^b  

^a UCSD MEDICAL CENTER   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE;

CHRONIC DISEASE; DEBRIDEMENT; HUMAN; INJURY; METABOLISM; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PODIATRY; PROGNOSIS; REVIEW; RISK ASSESSMENT; RISK FACTOR; WOUND HEALING;

CHRONIC DISEASE; DEBRIDEMENT; HUMANS; MATRIX METALLOPROTEINASES; PODIATRY; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0036356612     PISSN: 87507315     EISSN: None     Source Type: Journal    
DOI: 10.7547/87507315-92-1-34     Document Type: Review

References (20)

1. LAZARUS GS, COOPER DM, KNIGHTON DR, ET AL: Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 130: 489, 1994.
2. The Wound Product Sourcebook 2001, 3rd Ed, Kestrel Health Information, Williston, VT, 2001.
3. 2000 Ostomy Wound Management Buyers Guide. Ostomy Wound Manage 46: 5, 2001.
4. MULDER GD, HABEROR PA, JETER KF (EDS): Clinician's Pocket Guide to Chronic Wound Repair. Wound Care Communications Network, Springhouse Corp, Springhouse, PA, 1998.
5. THOMAS S: Update: a guide to dressing selection. J Wound Care 6: 479, 1997.
6. STEED DL: Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers: Diabetic Ulcer Study Group. J Vasc Surg 21: 71, 1995.
7. SIHL N: Diabetes and wound healing. J Wound Care 7: 47, 1998.
8. PECORARO R, AHRONI JH, BOYKO EJ, ET AL: Chronology and determination of tissue repair in diabetic lower-extremity ulcers. Diabetes 40: 1305, 1991.
9. ROBSON MC, HILL DP, SMITH PD, ET AL: Sequential cytokine therapy for pressure ulcers: clinical and mechanistic response. Ann Surg 231: 600, 2000.
10. BELLO Y, PHILLIPS TJ: Predictors of wound healing. J Clin Dermatol 2: 39, 1999.
11. VANDE BERG JS, RUDOLPH R, HOLLAN C, ET AL: Fibroblast senescence in pressure ulcers. Wound Repair Regen 6: 38, 1998.
12. MENDEZ MV, RAFFETTO JD, PHILLIPS T, ET AL: The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: a potential mechanism for senescence in venous ulcers. J Vasc Surg 30: 734, 1999.
13. VANDE BERG JS, SMITH PD, MUNSON AB, ET AL: Influence of single and sequential cytokine therapy on the cell cycle of pressure ulcer fibroblasts. Wound Rep Regen, in press.
14. VANDE BERG JS, SMITH PD, HAYWOOD-REID PL, ET AL: Dynamic forces in the cell cycle affecting fibroblasts in pressure ulcers. Wound Repair Regen 9: 19, 2001.
15. NWOMEH BC, LIANG HX, DIEGELMANN RF, ET AL: MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers. J Surg Res 81: 189, 1999.
16. NWOMEH BC, LIANG HX, DIEGELMANN RF, ET AL: Dynamics of matrix metalloproteinases MMP-1 and MMP-8 in acute open human dermal wounds. Wound Repair Regen 6: 127, 1998.
17. WOESSNER JF, JR: The family of matrix metalloproteinases. Ann N Y Acad Sci 732: 11, 1994.
18. AGREN MS: Gelatinase activity during wound healing. Br J Dermatol 131: 634, 1994.
19. TARNUZZER RW, SCHULTZ GS: Biochemical analysis of acute and chronic wound environments. Wound Rep Regen 4: 321, 1996.
20. MAST BA, SCHULTZ GS: Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Rep Regen 4: 411, 1996.