Cord blood genomic analysis highlights the role of redox balance

Free Radical Biology and Medicine

Volumn 49, Issue 6, 2010, Pages 992-996

  Maron, Jill L ^a   Johnson, Kirby L ^a   Parkin, Christopher ^b   Iyer, Lakshamanan ^b   Davis, Jonathan M ^a   Bianchi, Diana W ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Free radicals; Genomics; Neonate; Oxidative stress; Redox balance; Umbilical cord blood

Indexed keywords

ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; FERRITIN; GLUTATHIONE PEROXIDASE 1; HYPOXIA INDUCIBLE FACTOR; MESSENGER RNA; PEROXIREDOXIN; TRANSCRIPTION FACTOR NF E2; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2;

ARTICLE; BIOINFORMATICS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOME ANALYSIS; GESTATIONAL AGE; HUMAN; INFANT; MALE; MICROARRAY ANALYSIS; MITOCHONDRION; MOLECULAR DYNAMICS; NEWBORN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PREGNANCY; PRIORITY JOURNAL; RNA ANALYSIS; RNA EXTRACTION; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD;

EID: 77955515260     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.05.026     Document Type: Article

References (33)

1. Saugstad O.D. Update on oxygen radical disease in neonatology. Curr. Opin. Obstet. Gynecol. 2001, 13:147-153.
2. Friel J.K., Friesen R.W., Harding S.V., Roberts L.J. Evidence of oxidative stress in full-term healthy infants. Pediatr. Res. 2004, 56:878-882.
3. 2-isoprostanes and oxidative stress in newborns: role of nonprotein-bound iron. Pediatr. Res. 2008, 63:287-291.
4. O'Donovan D.J., Fernandes C.J. Free radicals and disease in premature infants. Antioxid. Redox Signal. 2004, 6:169-176.
5. Saugstad O.D. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr. Res. 1988, 23:143-150.
6. Nassi N., Ponziani V., Becatti M., Galvan P., Donzelli G. Anti-oxidant enzymes and related elements in term and preterm newborns. Pediatr. Int. 2009, 51:183-187.
7. Gveric-Ahmetasevic S., Sunjic S.B., Skala H., Andristic L., Stoser M., Zarkovic K., Skrablin S., Tatzber F., Cikpak A., Jaganjac M., Waeg G., Gveric T., Zarkovic N. Oxidative stress in small-for-gestational age (SGA) term newborns and their mothers. Free Radic. Res. 2009, 43:376-384.
8. O'Donovan D.J., Fernandes C.J. Mitochondrial glutathione and oxidative stress: implications for pulmonary oxygen toxicity in premature infants. Mol. Genet. Metab. 2000, 71:352-358.
9. Wagenaar G.T.M., ter Horst S.A.J., van Gastelen M.A., Leijser L.M., Mauad T., van der Velden P.A., de Heer E., Hiemstra P.S., Poorthuis B.J.H.M., Walther F.J. Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. Free Radic. Biol. Med. 2003, 15:782-801.
10. Papp A., Németh I., Karg E. Glutathione status in retinopathy of prematurity. Free Radic. Biol. Med. 1999, 27:738-743.
11. Hall N.J., Ali J., Pierro A., Eaton S. Total glutathione is not decreased in infants with necrotizing enterocolitis. J. Pediatr. Surg. 2005, 40:769-773.
12. Haynes R.L., Folkerth R.D., Keefe R.J., Sung I., Swzeda L.I., Rosenberg P.A., Volpe J.J., Kinney H.C. Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia. J. Neuropathol. Exp. Neurol. 2003, 62:441-450.
13. Baba L., McGrath J.M. Oxygen free radicals: effects in the newborn period. Adv. Neonatal Care 2008, 8:256-264.
14. Suzuki Y.J., Forman H.J., Sevanian A. Oxidants as stimulators of signal transduction. Free Radic. Biol. Med. 1997, 22:269-285.
15. Robinson K.A., Stewart C.A., Pye Q.N., Nguyen X., Kenney L., Salzman S., Floyd R.A., Hensley K. Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture. J. Neurosci. Res. 1999, 55:724-732.
16. Van Gelder R.N., Von Zashow M.E., Yool A., Dement W.C., Barchas J.D., Eberwine J.H. Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc. Natl. Acad. Sci. USA 1990, 87:1663-1667.
17. Maron J.L., Johnson K.L., Slonim D., Lai C.-Q., Ramoni M., Alterovitz G., Jarrah Z., Yang Z., Bianchi D.W. Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood. J. Clin. Invest. 2007, 117:3007-3019.
18. Gautier L., Cope L., Bolstad B.M., Irizarry R.A. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004, 12:307-315.
19. Jiménez-Marín Á., Melania C.-R., Ramirez-Boo M., Arce C., Garrido J.J. Biological pathway analysis by ArrayUnlock and Ingenuity Pathway Analysis. BMC Proc. 2009, 3(Suppl. 4):S6.
20. Boutet M., Roland L., Thomas N., Bilodeau J.-F. Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood. Am. J. Obstet. Gynecol. 2009, 200(530):e-1-e-7.
21. Merkerova M., Vasikova A., Bruchova H., Libalova H., Topinka J., Balascak I., Sram R.J., Brdicka R. Differential gene expression in umbilical cord blood and maternal peripheral blood. Eur. J. Haematol. 2009, 83:183-190.
22. Haak P.T., Busik J.V., Kort E.J., Tikhonenko M., Paneth N., Resau J.H. Archived unfrozen neonatal blood spots are amenable to quantitative gene expression analysis. Neonatology 2009, 95:210-216.
23. Imhoff B.R., Hansen J.M. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. Biochem. J. 2009, 424:491-500.
24. Tsuji Y. JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. Oncogene 2005, 24:7567-7578.
25. Das K.C. Thioredoxin system in premature and newborn biology. Antioxid. Redox Signal. 2004, 6:177-184.
26. Nakamura K. Thioredoxin as a key molecule in redox signaling. Antioxid. Redox Signal. 2004, 6:15-17.
27. Das K. Thioredoxin and its role in premature newborn biology. Antioxid. Redox Signal. 2004, 7:1740-1743.
28. Brand M.D., Esteves T.C. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005, 2:85-93.
29. Echtay K.S. Mitochondrial uncoupling proteins-what is their physiological role?. Free Radic. Biol. Med. 2007, 43:1351-1371.
30. Derdak Z., Garcia T.A., Baffy G. Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis. Methods Mol. Biol. 2009, 559:205-217.
31. Inanc F., Kilinc M., Krian G., Guven A., Kurutas E.B., Cikim I.G., Akyol O. Relationship between oxidative stress in cord blood and route of delivery. Fetal Diagn. Ther. 2005, 20:450-453.
32. Vakillan K., Ranjbar A., Zarganjfard A. Mortazavi, M; Vosough-Ghanbari, S.; Mashalee, S.; Abdollahi, M. On the relation of oxidative stress in delivery mode in pregnant women: a toxicological concern. Toxicol. Mech. Methods 2009, 19:94-99.
33. Fogel I., Pinchuk I., Kupferminc J.J., Lichtenberg D., Fainaru O. Oxidative stress in the fetal circulation does not depend on mode of delivery. Am. J. Obstet. Gynecol. 2005, 193:241-246.