Bioactivity and pharmacokinetics of two human serum albumin-thymosin α1-fusion proteins, rHSA-Tα1 and rHSA-L-Tα1, expressed in recombinant Pichia pastoris

Cancer Immunology, Immunotherapy

Volumn 59, Issue 9, 2010, Pages 1335-1345

  Chen, Jian Hua ^a   Zhang, Xin Guo ^a   Jiang, Yu Tao ^a   Yan, Lu Ying ^a   Tang, Li ^a   Yin, Yi Wei ^a   Cheng, Dai Shuang ^a   Chen, Jing ^a   Wang, Min ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bioactivity; Fusion protein; Human serum albumin; Pharmacokinetics; Thymosin 1

Indexed keywords

CONCANAVALIN A; DEXAMETHASONE; HYBRID PROTEIN; HYDROCORTISONE; MALONALDEHYDE; RECOMBINANT HUMAN SERUM ALBUMIN THYMOSIN ALPHA1 PROTEIN; SUPEROXIDE DISMUTASE; THYMOSIN ALPHA1; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL MATURATION; CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; FEMALE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IMMUNE DEFICIENCY; ION INTERACTION CHROMATOGRAPHY; LYMPHOCYTE PROLIFERATION; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RAT; SINGLE DRUG DOSE; SPLEEN CELL; THYMOCYTE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ALDEHYDES; ANIMALS; APOPTOSIS; BODY WEIGHT; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HUMANS; IMMUNIZATION; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; PICHIA; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SERUM ALBUMIN; SUPEROXIDE DISMUTASE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMOSIN;

EID: 77955512340     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0862-9     Document Type: Article

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