Biodistribution of synthetic thymosin α1 in the serum, urine and major organs of mice

International Journal of Immunopharmacology

Volumn 19, Issue 2, 1997, Pages 59-66

  Badamchian, Mahnaz ^a   Mora, Carlos A ^a   Baumann, Christian A ^a   Paino, Javier E ^a   Goldstein, Allan L ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Biological response modifiers; Pharmacokinetics; Swiss Webster mice; Thymosin 1; Thymosins

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; THYMOSIN ALPHA1; THYMOSIN FRACTION 5;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; DRUG URINE LEVEL; ENZYME IMMUNOASSAY; FEMALE; HEART; INTRAPERITONEAL DRUG ADMINISTRATION; ISOELECTRIC POINT; KIDNEY; LIVER; LUNG; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OVARY; PRIORITY JOURNAL; SKELETAL MUSCLE; SPLEEN; THYMUS; URINARY EXCRETION;

ADIPOSE TISSUE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY; LUNG; MICE; OVARY; SPLEEN; THYMOSIN; THYMUS GLAND; TISSUE DISTRIBUTION;

EID: 0030796907     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(97)00007-6     Document Type: Article

References (22)

1. 4 from human thymus by reversed-phase high performance liquid chromatography. J. liquid Chromatogr., 13, 3439-3453.
2. 1 antagonizes induced apoptosis of developing thymocytes in vitro. Abstracts of the Thirty-fifth Annual Meeting of the American Society for Cell Biology. Washington, D.C. December 9-13, 1991. Abstract No. 2072. Mol. Biol. Cell 6 (Suppl.) 356(a).
3. 1. Eur. J. Immun., 17, 727-730.
4. Garaci, E., Rocchim, G., Perroni, L., D'Agostini, C., Soscia, F., Grelli, S., Mastino, A. & Favalli, C. (1994) Combination treatment with zidovudine, thymosin alpha 1 and interferon-alpha in human immunodeficiency virus infection. Int. J. clin. Lab. Res., 24, 23-28.
5. 4. J. Immun., 131, 821-825.
6. 1. J. Am. Geriatr. Soc., 37, 1-8.
7. 4: a ubiquitous peptide in rat and mouse tissues. Proc. natn Acad. Sci. U.S.A., 79, 2172-2175.
8. Lopez, M., Carpano, S., Cavaliere, R., Dilauro, L., Ameglio, F., Vitelli, G., Frasca, A. M., Vici, P., Pignatti, F., Rosselli, M., Rasi, G. & Garaci, E. (1994) Biochemotherapy with thymosin alpha-1, interleukin-2 and dacarbazine in patients with metastatic melanoma - clinical and immunological effects. Ann. Oncol., 5, 741-746.
9. 1 from calf thymus. J. biol. Chem., 254, 981-986.
10. 1. J. Immun., 128, 368-375.
11. 1 in normal and thymectomized mice. J. Immun., 131, 148-151.
12. Mutchnick, M. G., Appelman, H. D., Chung, H. T., Aragona, E., Gupta, T. P., Cummings, G. D., Waggoner, J. G., Hoofnagle, J. H. & Shafritz, D. A. (1991) Thymosin treatment of chronic hepatitis B: a placebo-controlled pilot trial. Hepatology, 14, 409-415.
13. 4 in serum: comparison of normal, cord, homosexual and AIDS serum. Int. J. Immunopharmac., 8, 667-676.
14. 1 following subcutaneous administration to human subjects. J. liquid Chromatogr., 17, 3541-3551.
15. 1 administration in patients with lung cancer. Preliminary results. In Thymic Hormones and Lymphokines (Ed. Goldstein, A. L.), pp. 601-613. Plenum Press, New York.
16. 1 in patients with lung cancer. J. biol. Res. Mod., 4, 147-158.
17. SciClone Pharmaceuticals, Inc. (1994) Zadaxin/Thymosin Alpha 1. Non-confidential report. Summary of pre-clinical and clinical experience. SciClone Pharmaceuticals, Inc., San Mateo, CA.
18. Sztein, M. B. & Serrate, S. A. (1989) Characterization of the immunoregulatory properties of thymosin alpha 1 on interleukin-2 production and interleukin-2 receptor expression in normal human lymphocytes. Int. J. Immunopharmac., 11, 789-800.
19. 1: comparison of whole and absorbed antisera. Int. J. Immunopharmac., 10, 795-801.
20. 1. J. Immun. Meth., 80, 45-53.
21. 4 in human serum. J. biol. Res. Mod., 7, 91-96.
22. 4 in large cohorts of healthy adults. Thymus, 19, 45-52.