Promoter hypomethylation contributes to the expression of MUC3A in cancer cells

Biochemical and Biophysical Research Communications

Volumn 397, Issue 2, 2010, Pages 333-339

  Kitamoto, Sho ^a   Yamada, Norishige ^a   Yokoyama, Seiya ^a   Houjou, Izumi ^a   Higashi, Michiyo ^a   Yonezawa, Suguru ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Epigenetic marker; Hypomethylation; MUC3A; Mucin

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MESSENGER RNA; MUCIN; MUCIN 3A; TRICHOSTATIN A; UNCLASSIFIED DRUG; AZACITIDINE; DRUG DERIVATIVE; HYDROXAMIC ACID; MUC3A PROTEIN, HUMAN; MUCIN 3;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL STRAIN MCF 7; COLON ADENOCARCINOMA; CPG ISLAND; DNA FLANKING REGION; DNA METHYLATION; GENE MAPPING; HUMAN; HUMAN CELL; LUNG CANCER; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; BIOSYNTHESIS; CARCINOMA; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; TUMOR CELL LINE;

5' FLANKING REGION; AZACITIDINE; CARCINOMA; CELL LINE, TUMOR; DNA METHYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; HYDROXAMIC ACIDS; MUCIN-3; RNA, MESSENGER;

EID: 77955500951     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.124     Document Type: Article

References (37)

1. K.R. Bhaskar, P. Garik, B.S. Turner, J.D. Bradley, R. Bansil, H.E. Stanley, J.T. LaMont, Viscous fingering of HCl through gastric mucin, Nature 360 (1992) 458-461.
2. S.B. Ho, L.A. Dvorak, R.E. Moor, A.C. Jacobson, M.R. Frey, J. Corredor, D.B. Polk, L.L. Shekels, Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing, Gastroenterology 131 (2006) 1501-1517.
3. S. Linden, J. Mahdavi, J. Hedenbro, T. Boren, I. Carlstedt, Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins, Biochem. J. 384 (2004) 263-270.
4. S.K. Linden, P. Sutton, N.G. Karlsson, V. Korolik, M.A. McGuckin, Mucins in the mucosal barrier to infection, Mucosal. Immunol. 1 (2008) 183-197.
5. M.A. Hollingsworth, B.J. Swanson, Mucins in cancer: protection and control of the cell surface, Nat. Rev. Cancer 4 (2004) 45-60.
6. D.W. Kufe, Mucins in cancer: function, prognosis and therapy, Nat. Rev. Cancer 9 (2009) 874-885.
7. S. Yonezawa, M. Goto, N. Yamada, M. Higashi, M. Nomoto, Expression profiles of MUC1, MUC2, and MUC4 mucins in human neoplasms and their relationship with biological behavior, Proteomics 8 (2008) 3329-3341.
8. M. Osako, S. Yonezawa, B. Siddiki, J. Huang, J.J. Ho, Y.S. Kim, E. Sato, Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors, Cancer 71 (1993) 2191-2199.
9. S. Yonezawa, E. Sato, Expression of mucin antigens in human cancers and its relationship with malignancy potential, Pathol. Int. 47 (1997) 813-830.
10. G.E. Kim, H.I. Bae, H.U. Park, S.F. Kuan, S.C. Crawley, J.J. Ho, Y.S. Kim, Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas, Gastroenterology 123 (2002) 1052-1060.
11. S. Yonezawa, M. Higashi, N. Yamada, S. Yokoyama, M. Goto, Significance of mucin expression in pancreatobiliary neoplasms, J. Hepatobiliary Pancreat. Sci. 17 (2010) 108-124.
12. S.C. Crawley, J.R. Gum Jr., J.W. Hicks, W.S. Pratt, J.P. Aubert, D.M. Swallow, Y.S. Kim, Genomic organization and structure of the 30 region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin, Biochem. Biophys. Res. Commun. 263 (1999) 728-736.
13. J.R. Gum, J.W. Hicks, D.M. Swallow, R.L. Lagace, J.C. Byrd, D.T. Lamport, B. Siddiki, Y.S. Kim, Molecular cloning of cDNAs derived from a novel human intestinal mucin gene, Biochem. Biophys. Res. Commun. 171 (1990) 407-415.
14. J.R. Gum Jr., J.J. Ho, W.S. Pratt, J.W. Hicks, A.S. Hill, L.E. Vinall, A.M. Roberton, D.M. Swallow, Y.S. Kim, MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region, J. Biol. Chem. 272 (1997) 26678-26686.
15. X. Leroy, V. Gouyer, C. Ballereau, F. Zerimech, G. Huet, M.C. Copin, J.P. Aubert, N. Porchet, Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis, Urology 62 (2003) 771-775.
16. H.U. Park, J.W. Kim, G.E. Kim, H.I. Bae, S.C. Crawley, S.C. Yang, J.R. Gum Jr., S.K. Batra, K. Rousseau, D.M. Swallow, M.H. Sleisenger, Y.S. Kim, Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia, Pancreas 26 (2003) e48- 54.
17. E.A. Rakha, R.W. Boyce, D. Abd El-Rehim, T. Kurien, A.R. Green, E.C. Paish, J.F. Robertson, I.O. Ellis, Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer, Mod. Pathol. 18 (2005) 1295-1304.
18. R.Q. Wang, D.C. Fang, Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features, J. Clin. Pathol. 56 (2003) 378-384.
19. J.R. Gum Jr., J.W. Hicks, S.C. Crawley, C.M. Dahl, S.C. Yang, A.M. Roberton, Y.S. Kim, Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus, J. Biol. Chem. 278 (2003) 49600-49609.
20. N. Yamada, T. Hamada, M. Goto, H. Tsutsumida, M. Higashi, M. Nomoto, S. Yonezawa, MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer, Int. J. Cancer. 119 (2006) 1850-1857.
21. N. Yamada, Y. Nishida, H. Tsutsumida, M. Goto, M. Higashi, M. Nomoto, S. Yonezawa, Promoter CpG methylation in cancer cells contributes to the regulation of MUC4, Br. J. Cancer 100 (2009) 344-351.
22. N. Yamada, Y. Nishida, H. Tsutsumida, T. Hamada, M. Goto, M. Higashi, M. Nomoto, S. Yonezawa, MUC1 expression is regulated by DNA methylation andhistone H3 lysine 9 modification in cancer cells, Cancer Res. 68 (2008) 2708-2716.
23. N. Yamada, Y. Nishida, S. Yokoyama, H. Tsutsumida, A.I. Houjou, S. Kitamoto, M. Goto, M. Higashi, S. Yonezawa, Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells, J. Hepatobiliary Pancreat. Sci. (2010), in press.
24. A. Bird, The essentials of DNA methylation, Cell 70 (1992) 5-8.
25. C. Stirzaker, J.Z. Song, B. Davidson, S.J. Clark, Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells, Cancer Res. 64 (2004) 3871-3877.
26. A.P. Wolffe, M.A. Matzke, Epigenetics: regulation through repression, Science 286 (1999) 481-486.
27. M. Ehrich, M.R. Nelson, P. Stanssens, M. Zabeau, T. Liloglou, G. Xinarianos, C.R. Cantor, J.K. Field, D. Van den Boom, Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry, Proc. Natl. Acad. Sci. USA 102 (2005) 15785-15790.
28. N. Haraguchi, M. Ohkuma, H. Sakashita, S. Matsuzaki, F. Tanaka, K. Mimori, Y. Kamohara, H. Inoue, M. Mori, CD133+CD44+ population efficiently enriches colon cancer initiating cells, Ann. Surg. Oncol. 15 (2008) 2927-2933.
29. B.J. van Klinken, E. Oussoren, J.J. Weenink, G.J. Strous, H.A. Buller, J. Dekker, A.W. Einerhand, The human intestinal cell lines Caco-2 and LS174T as models to study cell-type specific mucin expression, Glycoconj. J. 13 (1996) 757-768.
30. Y. Kondo, L. Shen, J.P. Issa, Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer, Mol. Cell Biol. 23 (2003) 206-215.
31. C.Y. Ren, Y. Akiyama, S. Miyake, Y. Yuasa, Transcription factor GATA-5 selectively up-regulates mucin gene expression, J. Cancer Res. Clin. Oncol. 130 (2004) 245-252.
32. B. Hendrich, J. Guy, B. Ramsahoye, V.A. Wilson, A. Bird, Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development, Genes Dev. 15 (2001) 710-723.
33. S. Mulero-Navarro, M. Esteller, Epigenetic biomarkers for human cancer: the time is now, Crit. Rev. Oncol. Hematol. 68 (2008) 1-11.
34. M. Toyota, H. Suzuki, T. Yamashita, K. Hirata, K. Imai, T. Tokino, Y. Shinomura, Cancer epigenomics: implications of DNA methylation in personalized cancer therapy, Cancer Sci 100 (2009) 787-791.
35. C.A. Eads, K.D. Danenberg, K. Kawakami, L.B. Saltz, C. Blake, D. Shibata, P.V. Danenberg, P.W. Laird, MethyLight: a high-throughput assay to measure DNA methylation, Nucleic Acids Res. 28 (2000) E32.
36. M. Li, W.D. Chen, N. Papadopoulos, S.N. Goodman, N.C. Bjerregaard, S. Laurberg, B. Levin, H. Juhl, N. Arber, H. Moinova, K. Durkee, K. Schmidt, Y. He, F. Diehl, V.E. Velculescu, S. Zhou, L.A. Diaz Jr., K.W. Kinzler, S.D. Markowitz, B. Vogelstein, Sensitive digital quantification of DNA methylation in clinical samples, Nat. Biotechnol. 27 (2009) 858-863.
37. E. Arai, S. Ushijima, H. Fujimoto, F. Hosoda, T. Shibata, T. Kondo, S. Yokoi, I. Imoto, J. Inazawa, S. Hirohashi, Y. Kanai, Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome, Carcinogenesis 30 (2009) 214-221.