-
1
-
-
0033614446
-
Chronic myeloid leukemia
-
10.1056/NEJM199904293401706, 10219069
-
Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999, 340:1330-1340. 10.1056/NEJM199904293401706, 10219069.
-
(1999)
N Engl J Med
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
2
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
10.1056/NEJM200104053441401, 11287972
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001, 344:1031-1037. 10.1056/NEJM200104053441401, 11287972.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
3
-
-
0034614637
-
The hallmarks of cancer
-
10.1016/S0092-8674(00)81683-9, 10647931
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100:57-70. 10.1016/S0092-8674(00)81683-9, 10647931.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
4
-
-
35548968518
-
Cancer: mixing cocktails
-
10.1038/449993a, 17960228
-
Sawyers CL. Cancer: mixing cocktails. Nature 2007, 449:993-996. 10.1038/449993a, 17960228.
-
(2007)
Nature
, vol.449
, pp. 993-996
-
-
Sawyers, C.L.1
-
5
-
-
34848871080
-
Targeted agents: the rules of combination
-
10.1158/1078-0432.CCR-07-1385, 17875749
-
Kwak EL, Clark JW, Chabner B. Targeted agents: the rules of combination. Clin Cancer Res 2007, 13:5232-5237. 10.1158/1078-0432.CCR-07-1385, 17875749.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5232-5237
-
-
Kwak, E.L.1
Clark, J.W.2
Chabner, B.3
-
6
-
-
59349083179
-
Mechanisms of drug combinations: interaction and network perspectives
-
10.1038/nrd2683, 19180105
-
Jia J, Zhu F, Ma X, Cao Z, Li Y, Chen YZ. Mechanisms of drug combinations: interaction and network perspectives. Nat Rev Drug Discov 2009, 8:111-128. 10.1038/nrd2683, 19180105.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 111-128
-
-
Jia, J.1
Zhu, F.2
Ma, X.3
Cao, Z.4
Li, Y.5
Chen, Y.Z.6
-
7
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
10.1126/science.1145720, 17932254
-
Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007, 318:1108-1113. 10.1126/science.1145720, 17932254.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
Leary, R.J.6
Shen, D.7
Boca, S.M.8
Barber, T.9
Ptak, J.10
Silliman, N.11
Szabo, S.12
Dezso, Z.13
Ustyanksky, V.14
Nikolskaya, T.15
Nikolsky, Y.16
Karchin, R.17
Wilson, P.A.18
Kaminker, J.S.19
Zhang, Z.20
Croshaw, R.21
Willis, J.22
Dawson, D.23
Shipitsin, M.24
Willson, J.K.25
Sukumar, S.26
Polyak, K.27
Park, B.H.28
Pethiyagoda, C.L.29
Pant, P.V.30
more..
-
8
-
-
55849099654
-
Integrated analysis of homozygous deletions focal amplifications and sequence alterations in breast and colorectal cancers
-
10.1073/pnas.0808041105, 2571022, 18852474
-
Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjoblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Integrated analysis of homozygous deletions focal amplifications and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci USA 2008, 105:16224-16229. 10.1073/pnas.0808041105, 2571022, 18852474.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 16224-16229
-
-
Leary, R.J.1
Lin, J.C.2
Cummins, J.3
Boca, S.4
Wood, L.D.5
Parsons, D.W.6
Jones, S.7
Sjoblom, T.8
Park, B.H.9
Parsons, R.10
Willis, J.11
Dawson, D.12
Willson, J.K.13
Nikolskaya, T.14
Nikolsky, Y.15
Kopelovich, L.16
Papadopoulos, N.17
Pennacchio, L.A.18
Wang, T.L.19
Markowitz, S.D.20
Parmigiani, G.21
Kinzler, K.W.22
Vogelstein, B.23
Velculescu, V.E.24
more..
-
9
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
10.1038/nature06358, 2538683, 17982442
-
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007, 450:893-898. 10.1038/nature06358, 2538683, 17982442.
-
(2007)
Nature
, vol.450
, pp. 893-898
-
-
Weir, B.A.1
Woo, M.S.2
Getz, G.3
Perner, S.4
Ding, L.5
Beroukhim, R.6
Lin, W.M.7
Province, M.A.8
Kraja, A.9
Johnson, L.A.10
Shah, K.11
Sato, M.12
Thomas, R.K.13
Barletta, J.A.14
Borecki, I.B.15
Broderick, S.16
Chang, A.C.17
Chiang, D.Y.18
Chirieac, L.R.19
Cho, J.20
Fujii, Y.21
Gazdar, A.F.22
Giordano, T.23
Greulich, H.24
Hanna, M.25
Johnson, B.E.26
Kris, M.G.27
Lash, A.28
Lin, L.29
Lindeman, N.30
more..
-
10
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
10.1038/nature07423, 2694412, 18948947
-
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008, 455:1069-1075. 10.1038/nature07423, 2694412, 18948947.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
Cibulskis, K.6
Sougnez, C.7
Greulich, H.8
Muzny, D.M.9
Morgan, M.B.10
Fulton, L.11
Fulton, R.S.12
Zhang, Q.13
Wendl, M.C.14
Lawrence, M.S.15
Larson, D.E.16
Chen, K.17
Dooling, D.J.18
Sabo, A.19
Hawes, A.C.20
Shen, H.21
Jhangiani, S.N.22
Lewis, L.R.23
Hall, O.24
Zhu, Y.25
Mathew, T.26
Ren, Y.27
Yao, J.28
Scherer, S.E.29
Clerc, K.30
more..
-
11
-
-
74449085934
-
A small-cell lung cancer genome with complex signatures of tobacco exposure
-
10.1038/nature08629, 2880489, 20016488
-
Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A, Jones D, Lin ML, Beare D, Lau KW, Greenman C, Varela I, Nik-Zainal S, Davies HR, Ordonez GR, Mudie LJ, Latimer C, Edkins S, Stebbings L, Chen L, Jia M, Leroy C, Marshall J, Menzies A, Butler A, Teague JW, Mangion J, Sun YA, McLaughlin SF, Peckham HE, Tsung EF, et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463:184-190. 10.1038/nature08629, 2880489, 20016488.
-
Nature
, vol.463
, pp. 184-190
-
-
Pleasance, E.D.1
Stephens, P.J.2
O'Meara, S.3
McBride, D.J.4
Meynert, A.5
Jones, D.6
Lin, M.L.7
Beare, D.8
Lau, K.W.9
Greenman, C.10
Varela, I.11
Nik-Zainal, S.12
Davies, H.R.13
Ordonez, G.R.14
Mudie, L.J.15
Latimer, C.16
Edkins, S.17
Stebbings, L.18
Chen, L.19
Jia, M.20
Leroy, C.21
Marshall, J.22
Menzies, A.23
Butler, A.24
Teague, J.W.25
Mangion, J.26
Sun, Y.A.27
McLaughlin, S.F.28
Peckham, H.E.29
Tsung, E.F.30
more..
-
12
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
10.1038/nature07385, 2671642, 18772890
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068. 10.1038/nature07385, 2671642, 18772890.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
13
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
10.1126/science.1164382, 2820389, 18772396
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008, 321:1807-1812. 10.1126/science.1164382, 2820389, 18772396.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Siu, I.M.9
Gallia, G.L.10
Olivi, A.11
McLendon, R.12
Rasheed, B.A.13
Keir, S.14
Nikolskaya, T.15
Nikolsky, Y.16
Busam, D.A.17
Tekleab, H.18
Diaz, L.A.19
Hartigan, J.20
Smith, D.R.21
Strausberg, R.L.22
Marie, S.K.23
Shinjo, S.M.24
Yan, H.25
Riggins, G.J.26
Bigner, D.D.27
Karchin, R.28
Papadopoulos, N.29
Parmigiani, G.30
more..
-
14
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
10.1126/science.1164368, 2848990, 18772397
-
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008, 321:1801-1806. 10.1126/science.1164368, 2848990, 18772397.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Kamiyama, H.9
Jimeno, A.10
Hong, S.M.11
Fu, B.12
Lin, M.T.13
Calhoun, E.S.14
Kamiyama, M.15
Walter, K.16
Nikolskaya, T.17
Nikolsky, Y.18
Hartigan, J.19
Smith, D.R.20
Hidalgo, M.21
Leach, S.D.22
Klein, A.P.23
Jaffee, E.M.24
Goggins, M.25
Maitra, A.26
Iacobuzio-Donahue, C.27
Eshleman, J.R.28
Kern, S.E.29
Hruban, R.H.30
more..
-
15
-
-
39749106670
-
Identifying breast cancer druggable oncogenic alterations: leasons learned and future options
-
10.1158/1078-0432.CCR-07-1630, 18281527
-
Ocana A, Pandiella A. Identifying breast cancer druggable oncogenic alterations: leasons learned and future options. Clin Cancer Res 2008, 14:961-970. 10.1158/1078-0432.CCR-07-1630, 18281527.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 961-970
-
-
Ocana, A.1
Pandiella, A.2
-
16
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
10.1038/nature08658, 20016485
-
Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, Greenman CD, Varela I, Lin ML, Ordonez GR, Bignell GR, Ye K, Alipaz J, Bauer MJ, Beare D, Butler A, Carter RJ, Chen L, Cox AJ, Edkins S, Kokko-Gonzales PI, Gormley NA, Grocock RJ, Haudenschild CD, Hims MM, James T, Jia M, Kingsbury Z, Leroy C, Marshall J, Menzies A, et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463:191-196. 10.1038/nature08658, 20016485.
-
Nature
, vol.463
, pp. 191-196
-
-
Pleasance, E.D.1
Cheetham, R.K.2
Stephens, P.J.3
McBride, D.J.4
Humphray, S.J.5
Greenman, C.D.6
Varela, I.7
Lin, M.L.8
Ordonez, G.R.9
Bignell, G.R.10
Ye, K.11
Alipaz, J.12
Bauer, M.J.13
Beare, D.14
Butler, A.15
Carter, R.J.16
Chen, L.17
Cox, A.J.18
Edkins, S.19
Kokko-Gonzales, P.I.20
Gormley, N.A.21
Grocock, R.J.22
Haudenschild, C.D.23
Hims, M.M.24
James, T.25
Jia, M.26
Kingsbury, Z.27
Leroy, C.28
Marshall, J.29
Menzies, A.30
more..
-
17
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
10.1038/nature07485, 2603574, 18987736
-
Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, Smith S, Hawkins A, Abbott S, Locke D, Hillier LW, Miner T, Fulton L, Magrini V, Wylie T, Glasscock J, Conyers J, Sander N, Shi X, Osborne JR, Minx P, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008, 456:66-72. 10.1038/nature07485, 2603574, 18987736.
-
(2008)
Nature
, vol.456
, pp. 66-72
-
-
Ley, T.J.1
Mardis, E.R.2
Ding, L.3
Fulton, B.4
McLellan, M.D.5
Chen, K.6
Dooling, D.7
Dunford-Shore, B.H.8
McGrath, S.9
Hickenbotham, M.10
Cook, L.11
Abbott, R.12
Larson, D.E.13
Koboldt, D.C.14
Pohl, C.15
Smith, S.16
Hawkins, A.17
Abbott, S.18
Locke, D.19
Hillier, L.W.20
Miner, T.21
Fulton, L.22
Magrini, V.23
Wylie, T.24
Glasscock, J.25
Conyers, J.26
Sander, N.27
Shi, X.28
Osborne, J.R.29
Minx, P.30
more..
-
18
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
10.1056/NEJMoa0903840, 19657110
-
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, Reed JS, Robinson JS, Wylie T, Smith SM, Carmichael L, Eldred JM, Harris CC, Walker J, Peck JB, Du F, Dukes AF, Sanderson GE, Brummett AM, Clark E, McMichael JF, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009, 361:1058-1066. 10.1056/NEJMoa0903840, 19657110.
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
Koboldt, D.C.7
Fulton, R.S.8
Delehaunty, K.D.9
McGrath, S.D.10
Fulton, L.A.11
Locke, D.P.12
Magrini, V.J.13
Abbott, R.M.14
Vickery, T.L.15
Reed, J.S.16
Robinson, J.S.17
Wylie, T.18
Smith, S.M.19
Carmichael, L.20
Eldred, J.M.21
Harris, C.C.22
Walker, J.23
Peck, J.B.24
Du, F.25
Dukes, A.F.26
Sanderson, G.E.27
Brummett, A.M.28
Clark, E.29
McMichael, J.F.30
more..
-
19
-
-
64749094310
-
The cancer genome
-
10.1038/nature07943, 2821689, 19360079
-
Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature 2009, 458:719-724. 10.1038/nature07943, 2821689, 19360079.
-
(2009)
Nature
, vol.458
, pp. 719-724
-
-
Stratton, M.R.1
Campbell, P.J.2
Futreal, P.A.3
-
20
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
10.1038/nature05610, 2712719, 17344846
-
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007, 446:153-158. 10.1038/nature05610, 2712719, 17344846.
-
(2007)
Nature
, vol.446
, pp. 153-158
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
Davies, H.7
Teague, J.8
Butler, A.9
Stevens, C.10
Edkins, S.11
O'Meara, S.12
Vastrik, I.13
Schmidt, E.E.14
Avis, T.15
Barthorpe, S.16
Bhamra, G.17
Buck, G.18
Choudhury, B.19
Clements, J.20
Cole, J.21
Dicks, E.22
Forbes, S.23
Gray, K.24
Halliday, K.25
Harrison, R.26
Hills, K.27
Hinton, J.28
Jenkinson, A.29
Jones, D.30
more..
-
21
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
10.1056/NEJMoa0808710, 2820383, 19228619
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009, 360:765-773. 10.1056/NEJMoa0808710, 2820383, 19228619.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
Kos, I.7
Batinic-Haberle, I.8
Jones, S.9
Riggins, G.J.10
Friedman, H.11
Friedman, A.12
Reardon, D.13
Herndon, J.14
Kinzler, K.W.15
Velculescu, V.E.16
Vogelstein, B.17
Bigner, D.D.18
-
22
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
10.1038/nature08822, 20164920
-
Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, et al. The landscape of somatic copy-number alteration across human cancers. Nature 463:899-905. 10.1038/nature08822, 20164920.
-
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
Barretina, J.7
Boehm, J.S.8
Dobson, J.9
Urashima, M.10
Mc Henry, K.T.11
Pinchback, R.M.12
Ligon, A.H.13
Cho, Y.J.14
Haery, L.15
Greulich, H.16
Reich, M.17
Winckler, W.18
Lawrence, M.S.19
Weir, B.A.20
Tanaka, K.E.21
Chiang, D.Y.22
Bass, A.J.23
Loo, A.24
Hoffman, C.25
Prensner, J.26
Liefeld, T.27
Gao, Q.28
Yecies, D.29
Signoretti, S.30
more..
-
23
-
-
12144288006
-
A resource for large-scale RNA-interference-based screens in mammals
-
10.1038/nature02370, 15042091
-
Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJ. A resource for large-scale RNA-interference-based screens in mammals. Nature 2004, 428:427-431. 10.1038/nature02370, 15042091.
-
(2004)
Nature
, vol.428
, pp. 427-431
-
-
Paddison, P.J.1
Silva, J.M.2
Conklin, D.S.3
Schlabach, M.4
Li, M.5
Aruleba, S.6
Balija, V.7
O'Shaughnessy, A.8
Gnoj, L.9
Scobie, K.10
Chang, K.11
Westbrook, T.12
Cleary, M.13
Sachidanandam, R.14
McCombie, W.R.15
Elledge, S.J.16
Hannon, G.J.17
-
24
-
-
47049120726
-
IRF4 addiction in multiple myeloma
-
10.1038/nature07064, 2542904, 18568025
-
Shaffer AL, Emre NC, Lamy L, Ngo VN, Wright G, Xiao W, Powell J, Dave S, Yu X, Zhao H, Zeng Y, Chen B, Epstein J, Staudt LM. IRF4 addiction in multiple myeloma. Nature 2008, 454:226-231. 10.1038/nature07064, 2542904, 18568025.
-
(2008)
Nature
, vol.454
, pp. 226-231
-
-
Shaffer, A.L.1
Emre, N.C.2
Lamy, L.3
Ngo, V.N.4
Wright, G.5
Xiao, W.6
Powell, J.7
Dave, S.8
Yu, X.9
Zhao, H.10
Zeng, Y.11
Chen, B.12
Epstein, J.13
Staudt, L.M.14
-
25
-
-
66649137944
-
RNAi screen for rapid therapeutic target identification in leukemia patients
-
10.1073/pnas.0903233106, 2680429, 19433805
-
Tyner JW, Deininger MW, Loriaux MM, Chang BH, Gotlib JR, Willis SG, Erickson H, Kovacsovics T, O'Hare T, Heinrich MC, Druker BJ. RNAi screen for rapid therapeutic target identification in leukemia patients. Proc Natl Acad Sci USA 2009, 106:8695-8700. 10.1073/pnas.0903233106, 2680429, 19433805.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8695-8700
-
-
Tyner, J.W.1
Deininger, M.W.2
Loriaux, M.M.3
Chang, B.H.4
Gotlib, J.R.5
Willis, S.G.6
Erickson, H.7
Kovacsovics, T.8
O'Hare, T.9
Heinrich, M.C.10
Druker, B.J.11
-
26
-
-
58149521944
-
Highly parallel identification of essential genes in cancer cells
-
10.1073/pnas.0810485105, 2629277, 19091943
-
Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, Piqani B, Li C, Golub TR, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci USA 2008, 105:20380-20385. 10.1073/pnas.0810485105, 2629277, 19091943.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20380-20385
-
-
Luo, B.1
Cheung, H.W.2
Subramanian, A.3
Sharifnia, T.4
Okamoto, M.5
Yang, X.6
Hinkle, G.7
Boehm, J.S.8
Beroukhim, R.9
Weir, B.A.10
Mermel, C.11
Barbie, D.A.12
Awad, T.13
Zhou, X.14
Nguyen, T.15
Piqani, B.16
Li, C.17
Golub, T.R.18
Meyerson, M.19
Hacohen, N.20
Hahn, W.C.21
Lander, E.S.22
Sabatini, D.M.23
Root, D.E.24
more..
-
27
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
10.1038/nature08460, 2783335, 19847166
-
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Frohling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009, 462:108-112. 10.1038/nature08460, 2783335, 19847166.
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
Kim, S.Y.4
Moody, S.E.5
Dunn, I.F.6
Schinzel, A.C.7
Sandy, P.8
Meylan, E.9
Scholl, C.10
Frohling, S.11
Chan, E.M.12
Sos, M.L.13
Michel, K.14
Mermel, C.15
Silver, S.J.16
Weir, B.A.17
Reiling, J.H.18
Sheng, Q.19
Gupta, P.B.20
Wadlow, R.C.21
Le, H.22
Hoersch, S.23
Wittner, B.S.24
Ramaswamy, S.25
Livingston, D.M.26
Sabatini, D.M.27
Meyerson, M.28
Thomas, R.K.29
Lander, E.S.30
more..
-
28
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
10.1016/j.ccr.2007.08.030, 17936563
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12:395-402. 10.1016/j.ccr.2007.08.030, 17936563.
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
van de Vijver, M.J.13
Bernards, R.14
-
29
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients
-
10.1016/j.ccr.2004.06.022, 15324695
-
Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, Yu D. PTEN activation contributes to tumor inhibition by trastuzumab and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004, 6:117-127. 10.1016/j.ccr.2004.06.022, 15324695.
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
Tan, M.4
Esteva, F.J.5
Sahin, A.A.6
Klos, K.S.7
Li, P.8
Monia, B.P.9
Nguyen, N.T.10
Hortobagyi, G.N.11
Hung, M.C.12
Yu, D.13
-
30
-
-
56449111358
-
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
-
10.1158/0008-5472.CAN-08-1740, 2587064, 19010894
-
Eichhorn PJ, Gili M, Scaltriti M, Serra V, Guzman M, Nijkamp W, Beijersbergen RL, Valero V, Seoane J, Bernards R, Baselga J. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res 2008, 68:9221-9230. 10.1158/0008-5472.CAN-08-1740, 2587064, 19010894.
-
(2008)
Cancer Res
, vol.68
, pp. 9221-9230
-
-
Eichhorn, P.J.1
Gili, M.2
Scaltriti, M.3
Serra, V.4
Guzman, M.5
Nijkamp, W.6
Beijersbergen, R.L.7
Valero, V.8
Seoane, J.9
Bernards, R.10
Baselga, J.11
-
31
-
-
66549124708
-
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor in chronic lymphocytic leukemia
-
10.1182/blood-2008-12-190256, 2680368, 19234140
-
Chen R, Wierda WG, Chubb S, Hawtin RE, Fox JA, Keating MJ, Gandhi V, Plunkett W. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor in chronic lymphocytic leukemia. Blood 2009, 113:4637-4645. 10.1182/blood-2008-12-190256, 2680368, 19234140.
-
(2009)
Blood
, vol.113
, pp. 4637-4645
-
-
Chen, R.1
Wierda, W.G.2
Chubb, S.3
Hawtin, R.E.4
Fox, J.A.5
Keating, M.J.6
Gandhi, V.7
Plunkett, W.8
-
32
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
2518073, 18725988
-
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008, 118:3065-3074. 2518073, 18725988.
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
Egia, A.7
Sasaki, A.T.8
Thomas, G.9
Kozma, S.C.10
Papa, A.11
Nardella, C.12
Cantley, L.C.13
Baselga, J.14
Pandolfi, P.P.15
-
33
-
-
68049085887
-
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
-
10.1158/1078-0432.CCR-09-0317, 19567590
-
Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K, Januario T, Savage H, Punnoose E, Truong T, Zhou W, Berry L, Murray L, Amler L, Belvin M, Friedman LS, Lackner MR. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009, 15:4649-4664. 10.1158/1078-0432.CCR-09-0317, 19567590.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4649-4664
-
-
Hoeflich, K.P.1
O'Brien, C.2
Boyd, Z.3
Cavet, G.4
Guerrero, S.5
Jung, K.6
Januario, T.7
Savage, H.8
Punnoose, E.9
Truong, T.10
Zhou, W.11
Berry, L.12
Murray, L.13
Amler, L.14
Belvin, M.15
Friedman, L.S.16
Lackner, M.R.17
-
34
-
-
34147220392
-
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
-
10.1038/nature05760, 17429393
-
Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massague J. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 2007, 446:765-770. 10.1038/nature05760, 17429393.
-
(2007)
Nature
, vol.446
, pp. 765-770
-
-
Gupta, G.P.1
Nguyen, D.X.2
Chiang, A.C.3
Bos, P.D.4
Kim, J.Y.5
Nadal, C.6
Gomis, R.R.7
Manova-Todorova, K.8
Massague, J.9
-
35
-
-
23144461051
-
Genes that mediate breast cancer metastasis to lung
-
10.1038/nature03799, 1283098, 16049480
-
Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massague J. Genes that mediate breast cancer metastasis to lung. Nature 2005, 436:518-524. 10.1038/nature03799, 1283098, 16049480.
-
(2005)
Nature
, vol.436
, pp. 518-524
-
-
Minn, A.J.1
Gupta, G.P.2
Siegel, P.M.3
Bos, P.D.4
Shu, W.5
Giri, D.D.6
Viale, A.7
Olshen, A.B.8
Gerald, W.L.9
Massague, J.10
-
36
-
-
67649300721
-
Genes that mediate breast cancer metastasis to the brain
-
10.1038/nature08021, 2698953, 19421193
-
Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massague J. Genes that mediate breast cancer metastasis to the brain. Nature 2009, 459:1005-1009. 10.1038/nature08021, 2698953, 19421193.
-
(2009)
Nature
, vol.459
, pp. 1005-1009
-
-
Bos, P.D.1
Zhang, X.H.2
Nadal, C.3
Shu, W.4
Gomis, R.R.5
Nguyen, D.X.6
Minn, A.J.7
van de Vijver, M.J.8
Gerald, W.L.9
Foekens, J.A.10
Massague, J.11
-
37
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
-
10.1126/science.1142946, 17872411
-
Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007, 318:287-290. 10.1126/science.1142946, 17872411.
-
(2007)
Science
, vol.318
, pp. 287-290
-
-
Stommel, J.M.1
Kimmelman, A.C.2
Ying, H.3
Nabioullin, R.4
Ponugoti, A.H.5
Wiedemeyer, R.6
Stegh, A.H.7
Bradner, J.E.8
Ligon, K.L.9
Brennan, C.10
Chin, L.11
DePinho, R.A.12
-
38
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
10.1038/nature05474, 17206155
-
Sergina NV, Rausch M, Wang D, Blair J, Hann B, Shokat KM, Moasser MM. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007, 445:437-441. 10.1038/nature05474, 17206155.
-
(2007)
Nature
, vol.445
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
Blair, J.4
Hann, B.5
Shokat, K.M.6
Moasser, M.M.7
-
39
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
10.1126/science.1141478, 17463250
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Janne PA. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043. 10.1126/science.1141478, 17463250.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
40
-
-
67449152488
-
Cancer genome sequencing--an interim analysis
-
10.1158/0008-5472.CAN-09-1231, 2699895, 19509220
-
Fox EJ, Salk JJ, Loeb LA. Cancer genome sequencing--an interim analysis. Cancer Res 2009, 69:4948-4950. 10.1158/0008-5472.CAN-09-1231, 2699895, 19509220.
-
(2009)
Cancer Res
, vol.69
, pp. 4948-4950
-
-
Fox, E.J.1
Salk, J.J.2
Loeb, L.A.3
-
41
-
-
33749435816
-
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
-
10.1172/JCI28656, 1570180, 16906227
-
Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borras AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, Janne PA. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest 2006, 116:2695-2706. 10.1172/JCI28656, 1570180, 16906227.
-
(2006)
J Clin Invest
, vol.116
, pp. 2695-2706
-
-
Engelman, J.A.1
Mukohara, T.2
Zejnullahu, K.3
Lifshits, E.4
Borras, A.M.5
Gale, C.M.6
Naumov, G.N.7
Yeap, B.Y.8
Jarrell, E.9
Sun, J.10
Tracy, S.11
Zhao, X.12
Heymach, J.V.13
Johnson, B.E.14
Cantley, L.C.15
Janne, P.A.16
-
42
-
-
68749099671
-
Identification of selective inhibitors of cancer stem cells by high-throughput screening
-
10.1016/j.cell.2009.06.034, 19682730
-
Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, Lander ES. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659. 10.1016/j.cell.2009.06.034, 19682730.
-
(2009)
Cell
, vol.138
, pp. 645-659
-
-
Gupta, P.B.1
Onder, T.T.2
Jiang, G.3
Tao, K.4
Kuperwasser, C.5
Weinberg, R.A.6
Lander, E.S.7
-
43
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
10.1158/0008-5472.CAN-06-4158, 17363584
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S, Bardelli A. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007, 67:2643-2648. 10.1158/0008-5472.CAN-06-4158, 17363584.
-
(2007)
Cancer Res
, vol.67
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
Siena, S.7
Bardelli, A.8
-
44
-
-
65349101151
-
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
10.1016/j.ccr.2009.03.020, 19411071
-
Junttila TT, Akita RW, Parsons K, Fields C, Lewis Phillips GD, Friedman LS, Sampath D, Sliwkowski MX. Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 2009, 15:429-440. 10.1016/j.ccr.2009.03.020, 19411071.
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parsons, K.3
Fields, C.4
Lewis Phillips, G.D.5
Friedman, L.S.6
Sampath, D.7
Sliwkowski, M.X.8
-
45
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
10.1056/NEJMoa0804385, 18946061
-
Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC, Simes RJ, Chalchal H, Shapiro JD, Robitaille S, Price TJ, Shepherd L, Au HJ, Langer C, Moore MJ, Zalcberg JR. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765. 10.1056/NEJMoa0804385, 18946061.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
O'Callaghan, C.J.4
Tu, D.5
Tebbutt, N.C.6
Simes, R.J.7
Chalchal, H.8
Shapiro, J.D.9
Robitaille, S.10
Price, T.J.11
Shepherd, L.12
Au, H.J.13
Langer, C.14
Moore, M.J.15
Zalcberg, J.R.16
-
46
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
10.1200/JCO.2007.14.7116, 18316791
-
Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634. 10.1200/JCO.2007.14.7116, 18316791.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
Juan, T.7
Sikorski, R.8
Suggs, S.9
Radinsky, R.10
Patterson, S.D.11
Chang, D.D.12
-
47
-
-
70349939382
-
Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
-
10.1093/jnci/djp280, 2758310, 19738166
-
Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J, Bardelli A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst 2009, 101:1308-1324. 10.1093/jnci/djp280, 2758310, 19738166.
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1308-1324
-
-
Siena, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Balfour, J.4
Bardelli, A.5
-
48
-
-
77955277111
-
Effects of KRAS BRAF, NRAS and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P, Penault-Llorca F, Rougier P, Vincenzi B, Santini D, Tonini G, Cappuzzo F, Frattini M, Molinari F, Saletti P, De Dosso S, Martini M, Bardelli A, Siena S, Sartore-Bianchi A, Tabernero J, Macarulla T, Di Fiore F, Gangloff AO, Ciardiello F, Pfeiffer P, et al. Effects of KRAS BRAF, NRAS and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010,
-
(2010)
Lancet Oncol
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
De Schutter, J.4
Biesmans, B.5
Fountzilas, G.6
Kalogeras, K.T.7
Kotoula, V.8
Papamichael, D.9
Laurent-Puig, P.10
Penault-Llorca, F.11
Rougier, P.12
Vincenzi, B.13
Santini, D.14
Tonini, G.15
Cappuzzo, F.16
Frattini, M.17
Molinari, F.18
Saletti, P.19
De Dosso, S.20
Martini, M.21
Bardelli, A.22
Siena, S.23
Sartore-Bianchi, A.24
Tabernero, J.25
Macarulla, T.26
Di Fiore, F.27
Gangloff, A.O.28
Ciardiello, F.29
Pfeiffer, P.30
more..
-
49
-
-
77950542260
-
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity
-
10.1038/nm.2112, 20228816
-
McMillin DW, Delmore J, Weisberg E, Negri JM, Geer DC, Klippel S, Mitsiades N, Schlossman RL, Munshi NC, Kung AL, Griffin JD, Richardson PG, Anderson KC, Mitsiades CS. Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med 16:483-489. 10.1038/nm.2112, 20228816.
-
Nat Med
, vol.16
, pp. 483-489
-
-
McMillin, D.W.1
Delmore, J.2
Weisberg, E.3
Negri, J.M.4
Geer, D.C.5
Klippel, S.6
Mitsiades, N.7
Schlossman, R.L.8
Munshi, N.C.9
Kung, A.L.10
Griffin, J.D.11
Richardson, P.G.12
Anderson, K.C.13
Mitsiades, C.S.14
-
50
-
-
56449128746
-
New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings
-
10.1016/S1470-2045(08)70304-8, 19038762
-
Ocio EM, Mateos MV, Maiso P, Pandiella A, San-Miguel JF. New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. Lancet Oncol 2008, 9:1157-1165. 10.1016/S1470-2045(08)70304-8, 19038762.
-
(2008)
Lancet Oncol
, vol.9
, pp. 1157-1165
-
-
Ocio, E.M.1
Mateos, M.V.2
Maiso, P.3
Pandiella, A.4
San-Miguel, J.F.5
-
51
-
-
68749106908
-
Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors
-
10.1038/leu.2009.65, 19357701
-
Garayoa M, Garcia JL, Santamaria C, Garcia-Gomez A, Blanco JF, Pandiella A, Hernandez JM, Sanchez-Guijo FM, del Canizo MC, Gutierrez NC, San Miguel JF. Mesenchymal stem cells from multiple myeloma patients display distinct genomic profile as compared with those from normal donors. Leukemia 2009, 23:1515-1527. 10.1038/leu.2009.65, 19357701.
-
(2009)
Leukemia
, vol.23
, pp. 1515-1527
-
-
Garayoa, M.1
Garcia, J.L.2
Santamaria, C.3
Garcia-Gomez, A.4
Blanco, J.F.5
Pandiella, A.6
Hernandez, J.M.7
Sanchez-Guijo, F.M.8
del Canizo, M.C.9
Gutierrez, N.C.10
San Miguel, J.F.11
-
52
-
-
34948896045
-
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
-
10.1038/nature06188, 17914389
-
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007, 449:557-563. 10.1038/nature06188, 17914389.
-
(2007)
Nature
, vol.449
, pp. 557-563
-
-
Karnoub, A.E.1
Dash, A.B.2
Vo, A.P.3
Sullivan, A.4
Brooks, M.W.5
Bell, G.W.6
Richardson, A.L.7
Polyak, K.8
Tubo, R.9
Weinberg, R.A.10
-
53
-
-
77950862042
-
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
-
10.1038/nature08851, 20305640
-
Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464:852-857. 10.1038/nature08851, 20305640.
-
Nature
, vol.464
, pp. 852-857
-
-
Raaijmakers, M.H.1
Mukherjee, S.2
Guo, S.3
Zhang, S.4
Kobayashi, T.5
Schoonmaker, J.A.6
Ebert, B.L.7
Al-Shahrour, F.8
Hasserjian, R.P.9
Scadden, E.O.10
Aung, Z.11
Matza, M.12
Merkenschlager, M.13
Lin, C.14
Rommens, J.M.15
Scadden, D.T.16
-
54
-
-
42149162212
-
Transcriptome sequencing of malignant pleural mesothelioma tumors
-
10.1073/pnas.0712399105, 2265129, 18303113
-
Sugarbaker DJ, Richards WG, Gordon GJ, Dong L, De Rienzo A, Maulik G, Glickman JN, Chirieac LR, Hartman ML, Taillon BE, Du L, Bouffard P, Kingsmore SF, Miller NA, Farmer AD, Jensen RV, Gullans SR, Bueno R. Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci USA 2008, 105:3521-3526. 10.1073/pnas.0712399105, 2265129, 18303113.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3521-3526
-
-
Sugarbaker, D.J.1
Richards, W.G.2
Gordon, G.J.3
Dong, L.4
De Rienzo, A.5
Maulik, G.6
Glickman, J.N.7
Chirieac, L.R.8
Hartman, M.L.9
Taillon, B.E.10
Du, L.11
Bouffard, P.12
Kingsmore, S.F.13
Miller, N.A.14
Farmer, A.D.15
Jensen, R.V.16
Gullans, S.R.17
Bueno, R.18
-
55
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
10.1038/nature08672, 2820242, 20054297
-
Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S, Hardy C, Latimer C, Teague J, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Forbes S, Jia M, Jones D, Knott H, Kok CY, Lau KW, Leroy C, Lin ML, McBride DJ, Maddison M, Maguire S, McLay K, Menzies A, Mironenko T, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463:360-363. 10.1038/nature08672, 2820242, 20054297.
-
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
Chen, L.4
Bignell, G.5
Butler, A.6
Davies, H.7
Edkins, S.8
Hardy, C.9
Latimer, C.10
Teague, J.11
Andrews, J.12
Barthorpe, S.13
Beare, D.14
Buck, G.15
Campbell, P.J.16
Forbes, S.17
Jia, M.18
Jones, D.19
Knott, H.20
Kok, C.Y.21
Lau, K.W.22
Leroy, C.23
Lin, M.L.24
McBride, D.J.25
Maddison, M.26
Maguire, S.27
McLay, K.28
Menzies, A.29
Mironenko, T.30
more..
-
56
-
-
67649406102
-
Mutation of FOXL2 in granulosa-cell tumors of the ovary
-
10.1056/NEJMoa0902542, 19516027
-
Shah SP, Kobel M, Senz J, Morin RD, Clarke BA, Wiegand KC, Leung G, Zayed A, Mehl E, Kalloger SE, Sun M, Giuliany R, Yorida E, Jones S, Varhol R, Swenerton KD, Miller D, Clement PB, Crane C, Madore J, Provencher D, Leung P, DeFazio A, Khattra J, Turashvili G, Zhao Y, Zeng T, Glover JN, Vanderhyden B, Zhao C, et al. Mutation of FOXL2 in granulosa-cell tumors of the ovary. N Engl J Med 2009, 360:2719-2729. 10.1056/NEJMoa0902542, 19516027.
-
(2009)
N Engl J Med
, vol.360
, pp. 2719-2729
-
-
Shah, S.P.1
Kobel, M.2
Senz, J.3
Morin, R.D.4
Clarke, B.A.5
Wiegand, K.C.6
Leung, G.7
Zayed, A.8
Mehl, E.9
Kalloger, S.E.10
Sun, M.11
Giuliany, R.12
Yorida, E.13
Jones, S.14
Varhol, R.15
Swenerton, K.D.16
Miller, D.17
Clement, P.B.18
Crane, C.19
Madore, J.20
Provencher, D.21
Leung, P.22
DeFazio, A.23
Khattra, J.24
Turashvili, G.25
Zhao, Y.26
Zeng, T.27
Glover, J.N.28
Vanderhyden, B.29
Zhao, C.30
more..
-
57
-
-
70449722853
-
Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: Current status and future directions
-
Ocana A, Amir E. Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: Current status and future directions. Cancer Treat Rev 2009, 35:686-691.
-
(2009)
Cancer Treat Rev
, vol.35
, pp. 686-691
-
-
Ocana, A.1
Amir, E.2
-
58
-
-
0035863314
-
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux
-
Erlichman C, Boerner SA, Hallgren CG, Spieker R, Wang XY, James CD, Scheffer GL, Maliepaard M, Ross DD, Bible KC, Kaufmann SH. The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. Cancer Res 2001, 61:739-748.
-
(2001)
Cancer Res
, vol.61
, pp. 739-748
-
-
Erlichman, C.1
Boerner, S.A.2
Hallgren, C.G.3
Spieker, R.4
Wang, X.Y.5
James, C.D.6
Scheffer, G.L.7
Maliepaard, M.8
Ross, D.D.9
Bible, K.C.10
Kaufmann, S.H.11
-
59
-
-
58849132314
-
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
-
10.1073/pnas.0808930106, 2626727, 19122144
-
Perera SA, Li D, Shimamura T, Raso MG, Ji H, Chen L, Borgman CL, Zaghlul S, Brandstetter KA, Kubo S, Takahashi M, Chirieac LR, Padera RF, Bronson RT, Shapiro GI, Greulich H, Meyerson M, Guertler U, Chesa PG, Solca F, Wistuba II, Wong KK. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci USA 2009, 106:474-479. 10.1073/pnas.0808930106, 2626727, 19122144.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 474-479
-
-
Perera, S.A.1
Li, D.2
Shimamura, T.3
Raso, M.G.4
Ji, H.5
Chen, L.6
Borgman, C.L.7
Zaghlul, S.8
Brandstetter, K.A.9
Kubo, S.10
Takahashi, M.11
Chirieac, L.R.12
Padera, R.F.13
Bronson, R.T.14
Shapiro, G.I.15
Greulich, H.16
Meyerson, M.17
Guertler, U.18
Chesa, P.G.19
Solca, F.20
Wistuba, I.I.21
Wong, K.K.22
more..
-
60
-
-
2542582261
-
Antitumor activity of HKI-272, an orally active irreversible inhibitor of the HER-2 tyrosine kinase
-
10.1158/0008-5472.CAN-03-2868, 15173008
-
Rabindran SK, Discafani CM, Rosfjord EC, Baxter M, Floyd MB, Golas J, Hallett WA, Johnson BD, Nilakantan R, Overbeek E, Reich MF, Shen R, Shi X, Tsou HR, Wang YF, Wissner A. Antitumor activity of HKI-272, an orally active irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004, 64:3958-3965. 10.1158/0008-5472.CAN-03-2868, 15173008.
-
(2004)
Cancer Res
, vol.64
, pp. 3958-3965
-
-
Rabindran, S.K.1
Discafani, C.M.2
Rosfjord, E.C.3
Baxter, M.4
Floyd, M.B.5
Golas, J.6
Hallett, W.A.7
Johnson, B.D.8
Nilakantan, R.9
Overbeek, E.10
Reich, M.F.11
Shen, R.12
Shi, X.13
Tsou, H.R.14
Wang, Y.F.15
Wissner, A.16
-
61
-
-
65249170861
-
A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor in patients with solid tumors
-
10.1158/1078-0432.CCR-08-1978, 19318484
-
Wong KK, Fracasso PM, Bukowski RM, Lynch TJ, Munster PN, Shapiro GI, Janne PA, Eder JP, Naughton MJ, Ellis MJ, Jones SF, Mekhail T, Zacharchuk C, Vermette J, Abbas R, Quinn S, Powell C, Burris HA. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor in patients with solid tumors. Clin Cancer Res 2009, 15:2552-2558. 10.1158/1078-0432.CCR-08-1978, 19318484.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2552-2558
-
-
Wong, K.K.1
Fracasso, P.M.2
Bukowski, R.M.3
Lynch, T.J.4
Munster, P.N.5
Shapiro, G.I.6
Janne, P.A.7
Eder, J.P.8
Naughton, M.J.9
Ellis, M.J.10
Jones, S.F.11
Mekhail, T.12
Zacharchuk, C.13
Vermette, J.14
Abbas, R.15
Quinn, S.16
Powell, C.17
Burris, H.A.18
-
62
-
-
65249122512
-
Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
-
10.1158/1078-0432.CCR-08-1306, 19318488
-
Eder JP, Vande Woude GF, Boerner SA, LoRusso PM. Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 2009, 15:2207-2214. 10.1158/1078-0432.CCR-08-1306, 19318488.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2207-2214
-
-
Eder, J.P.1
Vande Woude, G.F.2
Boerner, S.A.3
LoRusso, P.M.4
-
63
-
-
49249100382
-
MetMAb, the one-armed 5D5 anti-c-Met antibody inhibits orthotopic pancreatic tumor growth and improves survival
-
10.1158/0008-5472.CAN-07-5960, 18519697
-
Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H, Carano RA, Kasman I, Mai E, Young J, Zha J, Zhang Z, Ross S, Schwall R, Colbern G, Merchant M. MetMAb, the one-armed 5D5 anti-c-Met antibody inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 2008, 68:4360-4368. 10.1158/0008-5472.CAN-07-5960, 18519697.
-
(2008)
Cancer Res
, vol.68
, pp. 4360-4368
-
-
Jin, H.1
Yang, R.2
Zheng, Z.3
Romero, M.4
Ross, J.5
Bou-Reslan, H.6
Carano, R.A.7
Kasman, I.8
Mai, E.9
Young, J.10
Zha, J.11
Zhang, Z.12
Ross, S.13
Schwall, R.14
Colbern, G.15
Merchant, M.16
-
64
-
-
34547100778
-
Discovery and validation of biomarkers that respond to treatment with brivanib alaninate a small-molecule VEGFR-2/FGFR-1 antagonist
-
10.1158/0008-5472.CAN-06-4555, 17638901
-
Ayers M, Fargnoli J, Lewin A, Wu Q, Platero JS. Discovery and validation of biomarkers that respond to treatment with brivanib alaninate a small-molecule VEGFR-2/FGFR-1 antagonist. Cancer Res 2007, 67:6899-6906. 10.1158/0008-5472.CAN-06-4555, 17638901.
-
(2007)
Cancer Res
, vol.67
, pp. 6899-6906
-
-
Ayers, M.1
Fargnoli, J.2
Lewin, A.3
Wu, Q.4
Platero, J.S.5
-
65
-
-
47249097988
-
BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells
-
10.1158/1541-7786.MCR-07-2001, 18458053
-
Sala E, Mologni L, Truffa S, Gaetano C, Bollag GE, Gambacorti-Passerini C. BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells. Mol Cancer Res 2008, 6:751-759. 10.1158/1541-7786.MCR-07-2001, 18458053.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 751-759
-
-
Sala, E.1
Mologni, L.2
Truffa, S.3
Gaetano, C.4
Bollag, G.E.5
Gambacorti-Passerini, C.6
-
66
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
10.1158/1535-7163.MCT-08-0017, 18606717
-
Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chene P, De Pover A, Schoemaker K, Fabbro D, Gabriel D, Simonen M, Murphy L, Finan P, Sellers W, Garcia-Echeverria C. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008, 7:1851-1863. 10.1158/1535-7163.MCT-08-0017, 18606717.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
Stauffer, F.2
Brueggen, J.3
Furet, P.4
Schnell, C.5
Fritsch, C.6
Brachmann, S.7
Chene, P.8
De Pover, A.9
Schoemaker, K.10
Fabbro, D.11
Gabriel, D.12
Simonen, M.13
Murphy, L.14
Finan, P.15
Sellers, W.16
Garcia-Echeverria, C.17
-
67
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
10.1158/0008-5472.CAN-08-1385, 18829560
-
Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M, Botero ML, Llonch E, Atzori F, Di Cosimo S, Maira M, Garcia-Echeverria C, Parra JL, Arribas J, Baselga J. NVP-BEZ235, a dual PI3K/mTOR inhibitor prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008, 68:8022-8030. 10.1158/0008-5472.CAN-08-1385, 18829560.
-
(2008)
Cancer Res
, vol.68
, pp. 8022-8030
-
-
Serra, V.1
Markman, B.2
Scaltriti, M.3
Eichhorn, P.J.4
Valero, V.5
Guzman, M.6
Botero, M.L.7
Llonch, E.8
Atzori, F.9
Di Cosimo, S.10
Maira, M.11
Garcia-Echeverria, C.12
Parra, J.L.13
Arribas, J.14
Baselga, J.15
-
68
-
-
67749122122
-
Targeting PI3K signalling in cancer: opportunities challenges and limitations
-
10.1038/nrc2664, 19629070
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities challenges and limitations. Nat Rev Cancer 2009, 9:550-562. 10.1038/nrc2664, 19629070.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
69
-
-
39149123820
-
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126 with antitumor and antiangiogenic activity
-
10.1158/0008-5472.CAN-07-0669, 18172313
-
Garlich JR, De P, Dey N, Su JD, Peng X, Miller A, Murali R, Lu Y, Mills GB, Kundra V, Shu HK, Peng Q, Durden DL. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126 with antitumor and antiangiogenic activity. Cancer Res 2008, 68:206-215. 10.1158/0008-5472.CAN-07-0669, 18172313.
-
(2008)
Cancer Res
, vol.68
, pp. 206-215
-
-
Garlich, J.R.1
De, P.2
Dey, N.3
Su, J.D.4
Peng, X.5
Miller, A.6
Murali, R.7
Lu, Y.8
Mills, G.B.9
Kundra, V.10
Shu, H.K.11
Peng, Q.12
Durden, D.L.13
-
70
-
-
76249092302
-
Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors
-
10.1158/0008-5472.CAN-09-2525, 20103642
-
Edgar KA, Wallin JJ, Berry M, Lee LB, Prior WW, Sampath D, Friedman LS, Belvin M. Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Cancer Res 70:1164-1172. 10.1158/0008-5472.CAN-09-2525, 20103642.
-
Cancer Res
, vol.70
, pp. 1164-1172
-
-
Edgar, K.A.1
Wallin, J.J.2
Berry, M.3
Lee, L.B.4
Prior, W.W.5
Sampath, D.6
Friedman, L.S.7
Belvin, M.8
-
71
-
-
77955503929
-
Study Evaluating HKI-272 in Combination With Vinorelbine in Subjects With Solid Tumors and Metastatic Breast Cancer
-
Accessed March 25, 2010
-
Study Evaluating HKI-272 in Combination With Vinorelbine in Subjects With Solid Tumors and Metastatic Breast Cancer. Accessed March 25, 2010., http://clinicaltrialsgov/ct2/show/NCT00706030
-
-
-
-
72
-
-
2542547908
-
Perifosine, a novel alkylphospholipid inhibits protein kinase B activation
-
Kondapaka SB, Singh SS, Dasmahapatra GP, Sausville EA, Roy KK. Perifosine, a novel alkylphospholipid inhibits protein kinase B activation. Mol Cancer Ther 2003, 2:1093-1103.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 1093-1103
-
-
Kondapaka, S.B.1
Singh, S.S.2
Dasmahapatra, G.P.3
Sausville, E.A.4
Roy, K.K.5
-
73
-
-
33646577479
-
Perifosine, an oral bioactive novel alkylphospholipid inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
-
10.1182/blood-2005-08-3434, 1895278, 16418332
-
Hideshima T, Catley L, Yasui H, Ishitsuka K, Raje N, Mitsiades C, Podar K, Munshi NC, Chauhan D, Richardson PG, Anderson KC. Perifosine, an oral bioactive novel alkylphospholipid inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 2006, 107:4053-4062. 10.1182/blood-2005-08-3434, 1895278, 16418332.
-
(2006)
Blood
, vol.107
, pp. 4053-4062
-
-
Hideshima, T.1
Catley, L.2
Yasui, H.3
Ishitsuka, K.4
Raje, N.5
Mitsiades, C.6
Podar, K.7
Munshi, N.C.8
Chauhan, D.9
Richardson, P.G.10
Anderson, K.C.11
-
74
-
-
9344270514
-
A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer
-
10.1158/1078-0432.CCR-03-0406, 15569974
-
Van Ummersen L, Binger K, Volkman J, Marnocha R, Tutsch K, Kolesar J, Arzoomanian R, Alberti D, Wilding G. A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer. Clin Cancer Res 2004, 10:7450-7456. 10.1158/1078-0432.CCR-03-0406, 15569974.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7450-7456
-
-
Van Ummersen, L.1
Binger, K.2
Volkman, J.3
Marnocha, R.4
Tutsch, K.5
Kolesar, J.6
Arzoomanian, R.7
Alberti, D.8
Wilding, G.9
-
75
-
-
42049115641
-
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity
-
10.1158/0008-5472.CAN-07-5783, 18381444
-
Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, McConnell RT, Gilmer TM, Zhang SY, Robell K, Kahana JA, Geske RS, Kleymenova EV, Choudhry AE, Lai Z, Leber JD, Minthorn EA, Strum SL, Wood ER, Huang PS, Copeland RA, Kumar R. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res 2008, 68:2366-2374. 10.1158/0008-5472.CAN-07-5783, 18381444.
-
(2008)
Cancer Res
, vol.68
, pp. 2366-2374
-
-
Rhodes, N.1
Heerding, D.A.2
Duckett, D.R.3
Eberwein, D.J.4
Knick, V.B.5
Lansing, T.J.6
McConnell, R.T.7
Gilmer, T.M.8
Zhang, S.Y.9
Robell, K.10
Kahana, J.A.11
Geske, R.S.12
Kleymenova, E.V.13
Choudhry, A.E.14
Lai, Z.15
Leber, J.D.16
Minthorn, E.A.17
Strum, S.L.18
Wood, E.R.19
Huang, P.S.20
Copeland, R.A.21
Kumar, R.22
more..
-
76
-
-
52449089445
-
Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]o xy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase
-
10.1021/jm8004527, 18800763
-
Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]o xy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem 2008, 51:5663-5679. 10.1021/jm8004527, 18800763.
-
(2008)
J Med Chem
, vol.51
, pp. 5663-5679
-
-
Heerding, D.A.1
Rhodes, N.2
Leber, J.D.3
Clark, T.J.4
Keenan, R.M.5
Lafrance, L.V.6
Li, M.7
Safonov, I.G.8
Takata, D.T.9
Venslavsky, J.W.10
Yamashita, D.S.11
Choudhry, A.E.12
Copeland, R.A.13
Lai, Z.14
Schaber, M.D.15
Tummino, P.J.16
Strum, S.L.17
Wood, E.R.18
Duckett, D.R.19
Eberwein, D.20
Knick, V.B.21
Lansing, T.J.22
McConnell, R.T.23
Zhang, S.24
Minthorn, E.A.25
Concha, N.O.26
Warren, G.L.27
Kumar, R.28
more..
-
77
-
-
61849181403
-
AK Tinhibitor GSK690693 induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines
-
10.1182/blood-2008-02-137737, 19064730
-
Levy DS, Kahana JA, Kumar R. AK Tinhibitor GSK690693 induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood 2009, 113:1723-1729. 10.1182/blood-2008-02-137737, 19064730.
-
(2009)
Blood
, vol.113
, pp. 1723-1729
-
-
Levy, D.S.1
Kahana, J.A.2
Kumar, R.3
-
78
-
-
23944439944
-
Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
-
10.1200/JCO.2005.14.415, 16009947
-
Lorusso PM, Adjei AA, Varterasian M, Gadgeel S, Reid J, Mitchell DY, Hanson L, DeLuca P, Bruzek L, Piens J, Asbury P, Van Becelaere K, Herrera R, Sebolt-Leopold J, Meyer MB. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J Clin Oncol 2005, 23:5281-5293. 10.1200/JCO.2005.14.415, 16009947.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5281-5293
-
-
Lorusso, P.M.1
Adjei, A.A.2
Varterasian, M.3
Gadgeel, S.4
Reid, J.5
Mitchell, D.Y.6
Hanson, L.7
DeLuca, P.8
Bruzek, L.9
Piens, J.10
Asbury, P.11
Van Becelaere, K.12
Herrera, R.13
Sebolt-Leopold, J.14
Meyer, M.B.15
-
79
-
-
14844285975
-
Multicenter phase II study of the oral MEK inhibitor CI-1040 in patients with advanced non-small-cell lung breast, colon and pancreatic cancer
-
10.1200/JCO.2004.01.185, 15483017
-
Rinehart J, Adjei AA, Lorusso PM, Waterhouse D, Hecht JR, Natale RB, Hamid O, Varterasian M, Asbury P, Kaldjian EP, Gulyas S, Mitchell DY, Herrera R, Sebolt-Leopold JS, Meyer MB. Multicenter phase II study of the oral MEK inhibitor CI-1040 in patients with advanced non-small-cell lung breast, colon and pancreatic cancer. J Clin Oncol 2004, 22:4456-4462. 10.1200/JCO.2004.01.185, 15483017.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
Lorusso, P.M.3
Waterhouse, D.4
Hecht, J.R.5
Natale, R.B.6
Hamid, O.7
Varterasian, M.8
Asbury, P.9
Kaldjian, E.P.10
Gulyas, S.11
Mitchell, D.Y.12
Herrera, R.13
Sebolt-Leopold, J.S.14
Meyer, M.B.15
-
80
-
-
43749103335
-
Phase I pharmacokinetic and pharmacodynamic study of the oral small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
10.1200/JCO.2007.14.4956, 2718422, 18390968
-
Adjei AA, Cohen RB, Franklin W, Morris C, Wilson D, Molina JR, Hanson LJ, Gore L, Chow L, Leong S, Maloney L, Gordon G, Simmons H, Marlow A, Litwiler K, Brown S, Poch G, Kane K, Haney J, Eckhardt SG. Phase I pharmacokinetic and pharmacodynamic study of the oral small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol 2008, 26:2139-2146. 10.1200/JCO.2007.14.4956, 2718422, 18390968.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
Morris, C.4
Wilson, D.5
Molina, J.R.6
Hanson, L.J.7
Gore, L.8
Chow, L.9
Leong, S.10
Maloney, L.11
Gordon, G.12
Simmons, H.13
Marlow, A.14
Litwiler, K.15
Brown, S.16
Poch, G.17
Kane, K.18
Haney, J.19
Eckhardt, S.G.20
more..
-
81
-
-
70449535638
-
Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study
-
10.1038/sj.bjc.6605371, 19861964
-
Board RE, Ellison G, Orr MC, Kemsley KR, McWalter G, Blockley LY, Dearden SP, Morris C, Ranson M, Cantarini MV, Dive C, Hughes A. Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study. Br J Cancer 2009, 101:1724-1730. 10.1038/sj.bjc.6605371, 19861964.
-
(2009)
Br J Cancer
, vol.101
, pp. 1724-1730
-
-
Board, R.E.1
Ellison, G.2
Orr, M.C.3
Kemsley, K.R.4
McWalter, G.5
Blockley, L.Y.6
Dearden, S.P.7
Morris, C.8
Ranson, M.9
Cantarini, M.V.10
Dive, C.11
Hughes, A.12
-
82
-
-
27144434812
-
Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death
-
10.1182/blood-2005-04-1678, 1895272, 15972445
-
Chen R, Keating MJ, Gandhi V, Plunkett W. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood 2005, 106:2513-2519. 10.1182/blood-2005-04-1678, 1895272, 15972445.
-
(2005)
Blood
, vol.106
, pp. 2513-2519
-
-
Chen, R.1
Keating, M.J.2
Gandhi, V.3
Plunkett, W.4
-
83
-
-
33750429279
-
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-diflu oro-6-methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity
-
10.1021/jm0606138, 17064073
-
Chu XJ, DePinto W, Bartkovitz D, So SS, Vu BT, Packman K, Lukacs C, Ding Q, Jiang N, Wang K, Goelzer P, Yin X, Smith MA, Higgins BX, Chen Y, Xiang Q, Moliterni J, Kaplan G, Graves B, Lovey A, Fotouhi N. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-diflu oro-6-methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. J Med Chem 2006, 49:6549-6560. 10.1021/jm0606138, 17064073.
-
(2006)
J Med Chem
, vol.49
, pp. 6549-6560
-
-
Chu, X.J.1
DePinto, W.2
Bartkovitz, D.3
So, S.S.4
Vu, B.T.5
Packman, K.6
Lukacs, C.7
Ding, Q.8
Jiang, N.9
Wang, K.10
Goelzer, P.11
Yin, X.12
Smith, M.A.13
Higgins, B.X.14
Chen, Y.15
Xiang, Q.16
Moliterni, J.17
Kaplan, G.18
Graves, B.19
Lovey, A.20
Fotouhi, N.21
more..
-
84
-
-
33750469601
-
In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials
-
10.1158/1535-7163.MCT-06-0355, 17121911
-
DePinto W, Chu XJ, Yin X, Smith M, Packman K, Goelzer P, Lovey A, Chen Y, Qian H, Hamid R, Xiang Q, Tovar C, Blain R, Nevins T, Higgins B, Luistro L, Kolinsky K, Felix B, Hussain S, Heimbrook D. In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials. Mol Cancer Ther 2006, 5:2644-2658. 10.1158/1535-7163.MCT-06-0355, 17121911.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2644-2658
-
-
DePinto, W.1
Chu, X.J.2
Yin, X.3
Smith, M.4
Packman, K.5
Goelzer, P.6
Lovey, A.7
Chen, Y.8
Qian, H.9
Hamid, R.10
Xiang, Q.11
Tovar, C.12
Blain, R.13
Nevins, T.14
Higgins, B.15
Luistro, L.16
Kolinsky, K.17
Felix, B.18
Hussain, S.19
Heimbrook, D.20
more..
-
85
-
-
74949088096
-
Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe
-
10.1158/1078-0432.CCR-09-2151, 20028770
-
Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E. Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe. Clin Cancer Res 16:109-120. 10.1158/1078-0432.CCR-09-2151, 20028770.
-
Clin Cancer Res
, vol.16
, pp. 109-120
-
-
Galimberti, F.1
Thompson, S.L.2
Liu, X.3
Li, H.4
Memoli, V.5
Green, S.R.6
DiRenzo, J.7
Greninger, P.8
Sharma, S.V.9
Settleman, J.10
Compton, D.A.11
Dmitrovsky, E.12
-
86
-
-
33644836549
-
Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies
-
10.1200/JCO.2005.01.9679, 16330674
-
O'Connor OA, Heaney ML, Schwartz L, Richardson S, Willim R, MacGregor-Cortelli B, Curly T, Moskowitz C, Portlock C, Horwitz S, Zelenetz AD, Frankel S, Richon V, Marks P, Kelly WK. Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. J Clin Oncol 2006, 24:166-173. 10.1200/JCO.2005.01.9679, 16330674.
-
(2006)
J Clin Oncol
, vol.24
, pp. 166-173
-
-
O'Connor, O.A.1
Heaney, M.L.2
Schwartz, L.3
Richardson, S.4
Willim, R.5
MacGregor-Cortelli, B.6
Curly, T.7
Moskowitz, C.8
Portlock, C.9
Horwitz, S.10
Zelenetz, A.D.11
Frankel, S.12
Richon, V.13
Marks, P.14
Kelly, W.K.15
-
87
-
-
38949144400
-
Tolerability, pharmacodynamics and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes
-
10.1158/1078-0432.CCR-07-0318, 18245545
-
Klimek VM, Fircanis S, Maslak P, Guernah I, Baum M, Wu N, Panageas K, Wright JJ, Pandolfi PP, Nimer SD. Tolerability, pharmacodynamics and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes. Clin Cancer Res 2008, 14:826-832. 10.1158/1078-0432.CCR-07-0318, 18245545.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 826-832
-
-
Klimek, V.M.1
Fircanis, S.2
Maslak, P.3
Guernah, I.4
Baum, M.5
Wu, N.6
Panageas, K.7
Wright, J.J.8
Pandolfi, P.P.9
Nimer, S.D.10
-
88
-
-
0035525781
-
Inhibitor of histone deacetylation depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report
-
10.1182/blood.V98.9.2865, 11675364
-
Piekarz RL, Robey R, Sandor V, Bakke S, Wilson WH, Dahmoush L, Kingma DM, Turner ML, Altemus R, Bates SE. Inhibitor of histone deacetylation depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report. Blood 2001, 98:2865-2868. 10.1182/blood.V98.9.2865, 11675364.
-
(2001)
Blood
, vol.98
, pp. 2865-2868
-
-
Piekarz, R.L.1
Robey, R.2
Sandor, V.3
Bakke, S.4
Wilson, W.H.5
Dahmoush, L.6
Kingma, D.M.7
Turner, M.L.8
Altemus, R.9
Bates, S.E.10
-
89
-
-
38949096781
-
Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
-
10.1182/blood-2007-06-098061, 17962510
-
Garcia-Manero G, Yang H, Bueso-Ramos C, Ferrajoli A, Cortes J, Wierda WG, Faderl S, Koller C, Morris G, Rosner G, Loboda A, Fantin VR, Randolph SS, Hardwick JS, Reilly JF, Chen C, Ricker JL, Secrist JP, Richon VM, Frankel SR, Kantarjian HM. Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008, 111:1060-1066. 10.1182/blood-2007-06-098061, 17962510.
-
(2008)
Blood
, vol.111
, pp. 1060-1066
-
-
Garcia-Manero, G.1
Yang, H.2
Bueso-Ramos, C.3
Ferrajoli, A.4
Cortes, J.5
Wierda, W.G.6
Faderl, S.7
Koller, C.8
Morris, G.9
Rosner, G.10
Loboda, A.11
Fantin, V.R.12
Randolph, S.S.13
Hardwick, J.S.14
Reilly, J.F.15
Chen, C.16
Ricker, J.L.17
Secrist, J.P.18
Richon, V.M.19
Frankel, S.R.20
Kantarjian, H.M.21
more..
-
90
-
-
33748063974
-
A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor in patients with refractory hematologic malignancies
-
10.1158/1078-0432.CCR-06-0511, 16899611
-
Giles F, Fischer T, Cortes J, Garcia-Manero G, Beck J, Ravandi F, Masson E, Rae P, Laird G, Sharma S, Kantarjian H, Dugan M, Albitar M, Bhalla K. A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor in patients with refractory hematologic malignancies. Clin Cancer Res 2006, 12:4628-4635. 10.1158/1078-0432.CCR-06-0511, 16899611.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4628-4635
-
-
Giles, F.1
Fischer, T.2
Cortes, J.3
Garcia-Manero, G.4
Beck, J.5
Ravandi, F.6
Masson, E.7
Rae, P.8
Laird, G.9
Sharma, S.10
Kantarjian, H.11
Dugan, M.12
Albitar, M.13
Bhalla, K.14
-
91
-
-
51649126841
-
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
-
10.1158/1078-0432.CCR-07-4262, 18628465
-
Ellis L, Pan Y, Smyth GK, George DJ, McCormack C, Williams-Truax R, Mita M, Beck J, Burris H, Ryan G, Atadja P, Butterfoss D, Dugan M, Culver K, Johnstone RW, Prince HM. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res 2008, 14:4500-4510. 10.1158/1078-0432.CCR-07-4262, 18628465.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4500-4510
-
-
Ellis, L.1
Pan, Y.2
Smyth, G.K.3
George, D.J.4
McCormack, C.5
Williams-Truax, R.6
Mita, M.7
Beck, J.8
Burris, H.9
Ryan, G.10
Atadja, P.11
Butterfoss, D.12
Dugan, M.13
Culver, K.14
Johnstone, R.W.15
Prince, H.M.16
-
92
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised open-label, phase III study
-
10.1016/S1470-2045(09)70003-8, 19230772
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, Schoch R, Gattermann N, Sanz G, List A, Gore SD, Seymour JF, Bennett JM, Byrd J, Backstrom J, Zimmerman L, McKenzie D, Beach C, Silverman LR. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised open-label, phase III study. Lancet Oncol 2009, 10:223-232. 10.1016/S1470-2045(09)70003-8, 19230772.
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
Santini, V.4
Finelli, C.5
Giagounidis, A.6
Schoch, R.7
Gattermann, N.8
Sanz, G.9
List, A.10
Gore, S.D.11
Seymour, J.F.12
Bennett, J.M.13
Byrd, J.14
Backstrom, J.15
Zimmerman, L.16
McKenzie, D.17
Beach, C.18
Silverman, L.R.19
-
93
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
-
10.1200/JCO.2002.04.117, 12011120
-
Silverman LR, Demakos EP, Peterson BL, Kornblith AB, Holland JC, Odchimar-Reissig R, Stone RM, Nelson D, Powell BL, DeCastro CM, Ellerton J, Larson RA, Schiffer CA, Holland JF. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002, 20:2429-2440. 10.1200/JCO.2002.04.117, 12011120.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
Kornblith, A.B.4
Holland, J.C.5
Odchimar-Reissig, R.6
Stone, R.M.7
Nelson, D.8
Powell, B.L.9
DeCastro, C.M.10
Ellerton, J.11
Larson, R.A.12
Schiffer, C.A.13
Holland, J.F.14
-
94
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
-
10.1002/cncr.21792, 16532500
-
Kantarjian H, Issa JP, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, Klimek V, Slack J, de Castro C, Ravandi F, Helmer R, Shen L, Nimer SD, Leavitt R, Raza A, Saba H. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006, 106:1794-1803. 10.1002/cncr.21792, 16532500.
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
Bennett, J.M.4
Albitar, M.5
DiPersio, J.6
Klimek, V.7
Slack, J.8
de Castro, C.9
Ravandi, F.10
Helmer, R.11
Shen, L.12
Nimer, S.D.13
Leavitt, R.14
Raza, A.15
Saba, H.16
-
95
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
10.1056/NEJMoa0900212, 19553641
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009, 361:123-134. 10.1056/NEJMoa0900212, 19553641.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
Mortimer, P.7
Swaisland, H.8
Lau, A.9
O'Connor, M.J.10
Ashworth, A.11
Carmichael, J.12
Kaye, S.B.13
Schellens, J.H.14
de Bono, J.S.15
-
96
-
-
59449085305
-
Phase I study of the poly(ADP-ribose) polymerase inhibitor AG014699 in combination with temozolomide in patients with advanced solid tumors
-
10.1158/1078-0432.CCR-08-1223, 2652879, 19047122
-
Plummer R, Jones C, Middleton M, Wilson R, Evans J, Olsen A, Curtin N, Boddy A, McHugh P, Newell D, Harris A, Johnson P, Steinfeldt H, Dewji R, Wang D, Robson L, Calvert H. Phase I study of the poly(ADP-ribose) polymerase inhibitor AG014699 in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res 2008, 14:7917-7923. 10.1158/1078-0432.CCR-08-1223, 2652879, 19047122.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7917-7923
-
-
Plummer, R.1
Jones, C.2
Middleton, M.3
Wilson, R.4
Evans, J.5
Olsen, A.6
Curtin, N.7
Boddy, A.8
McHugh, P.9
Newell, D.10
Harris, A.11
Johnson, P.12
Steinfeldt, H.13
Dewji, R.14
Wang, D.15
Robson, L.16
Calvert, H.17
-
97
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
10.1158/0008-5472.CAN-04-2727, 15604286
-
Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 2004, 64:9152-9159. 10.1158/0008-5472.CAN-04-2727, 15604286.
-
(2004)
Cancer Res
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C.J.3
Green, S.J.4
Martin, N.M.5
Orr, A.I.6
Reaper, P.M.7
Jackson, S.P.8
Curtin, N.J.9
Smith, G.C.10
-
98
-
-
70449732503
-
Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer
-
10.1200/JCO.2009.23.5556, 19738110
-
Roy R, Yang J, Moses MA. Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol 2009, 27:5287-5297. 10.1200/JCO.2009.23.5556, 19738110.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5287-5297
-
-
Roy, R.1
Yang, J.2
Moses, M.A.3
-
99
-
-
0038546557
-
Phase I/II trial of the safety and efficacy of AE-941 (Neovastat) in the treatment of non-small-cell lung cancer
-
10.3816/CLC.2003.n.003, 14624712
-
Latreille J, Batist G, Laberge F, Champagne P, Croteau D, Falardeau P, Levinton C, Hariton C, Evans WK, Dupont E. Phase I/II trial of the safety and efficacy of AE-941 (Neovastat) in the treatment of non-small-cell lung cancer. Clin Lung Cancer 2003, 4:231-236. 10.3816/CLC.2003.n.003, 14624712.
-
(2003)
Clin Lung Cancer
, vol.4
, pp. 231-236
-
-
Latreille, J.1
Batist, G.2
Laberge, F.3
Champagne, P.4
Croteau, D.5
Falardeau, P.6
Levinton, C.7
Hariton, C.8
Evans, W.K.9
Dupont, E.10
-
100
-
-
20044388325
-
Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer
-
10.1200/JCO.2005.03.170, 15681529
-
Bissett D, O'Byrne KJ, von Pawel J, Gatzemeier U, Price A, Nicolson M, Mercier R, Mazabel E, Penning C, Zhang MH, Collier MA, Shepherd FA. Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer. J Clin Oncol 2005, 23:842-849. 10.1200/JCO.2005.03.170, 15681529.
-
(2005)
J Clin Oncol
, vol.23
, pp. 842-849
-
-
Bissett, D.1
O'Byrne, K.J.2
von Pawel, J.3
Gatzemeier, U.4
Price, A.5
Nicolson, M.6
Mercier, R.7
Mazabel, E.8
Penning, C.9
Zhang, M.H.10
Collier, M.A.11
Shepherd, F.A.12
-
101
-
-
10744222424
-
Phase I and pharmacokinetic study of prinomastat a matrix metalloprotease inhibitor
-
10.1158/1078-0432.CCR-0981-3, 14871966
-
Hande KR, Collier M, Paradiso L, Stuart-Smith J, Dixon M, Clendeninn N, Yeun G, Alberti D, Binger K, Wilding G. Phase I and pharmacokinetic study of prinomastat a matrix metalloprotease inhibitor. Clin Cancer Res 2004, 10:909-915. 10.1158/1078-0432.CCR-0981-3, 14871966.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 909-915
-
-
Hande, K.R.1
Collier, M.2
Paradiso, L.3
Stuart-Smith, J.4
Dixon, M.5
Clendeninn, N.6
Yeun, G.7
Alberti, D.8
Binger, K.9
Wilding, G.10
|