The learned safety paradigm as a mouse model for neuropsychiatric research

Nature Protocols

Volumn 5, Issue 5, 2010, Pages 954-964

  Pollak, Daniela D ^a   Monje, Francisco J ^a   Lubec, Gert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; C57BL MOUSE; ELECTRIC SHOCK; FEAR; LEARNING; MALE; MOUSE; NEUROPSYCHOLOGICAL TEST;

ANIMALS; ELECTROSHOCK; FEAR; LEARNING; MALE; MICE; MICE, INBRED C57BL; NEUROPSYCHOLOGICAL TESTS;

EID: 77955479944     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2010.64     Document Type: Article

References (58)

1. Davis, M., Shi, C., The extended amygdala: are the central nucleus of the amygdala and the bed nucleus of the stria terminalis differentially involved in fear versus anxiety? Ann. NY Acad. Sci. 877, 281-291 (1999).
2. LeDoux, J.E. Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184 (2000).
3. Phelps, E.A., LeDoux, J.E. Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48, 175-187 (2005).
4. Rescorla, R.A. Conditioned inhibition of fear resulting from negative CS-US contingencies. J. Comp. Pavlov, I.P. Conditioned Reflexes (Dover, New York, 1927). Physiol. Psychol. 67, 504-509 (1969).
5. Vouimba, R.M., Garcia, R., Baudry, M., Thompson, R.F. Potentiation of conditioned freezing following dorsomedial prefrontal cortex lesions does not interfere with fear reduction in mice. Behav. Neurosci. 114, 720-724 (2000).
6. Heldt, S.A., Falls, W.A. Destruction of the inferior colliculus disrupts the production and inhibition of fear conditioned to an acoustic stimulus. Behav. Brain Res. 144, 175-185 (2003).
7. Pollak, D.D. et al. An animal model of a behavioral intervention for depression. Neuron 60, 149-161 (2008).
8. Rogan, M.T., Leon, K.S., Perez, D.L., Kandel, E.R. Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse. Neuron 46, 309-320 (2005).
9. Watkins, L.R. et al. Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat. Pain 71, 237-247 (1997).
10. Watkins, L.R. et al. Neurocircuitry of conditioned inhibition of analgesia effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behav. Neurosci. 112, 360-378 (1998).
11. Dinsmoor, J.A. Stimuli inevitably generated by behavior that avoids electric shock are inherently reinforcing. J. Exp. Anal. Behav. 75, 311-333 (2001).
12. Rescorla, R.A. Establishment of a positive reinforcer through contrast with shock. J. Comp. Physiol. Psychol. 67, 260-263 (1969).
13. Santarelli, L. et al. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc. Natl Acad. Sci. USA 98, 1912-1917 (2001).
14. Sahay, A., Hen, R. Adult hippocampal neurogenesis in depression. Nat. Neurosci. 10, 1110-1115 (2007).
15. Maren, S. The amygdala, synaptic plasticity, and fear memory. Ann. NY Acad. Sci. 985, 106-113 (2003).
16. LaBar, K.S., Cabeza, R. Cognitive neuroscience of emotional memory. Nat. Rev. Neurosci. 7, 54-64 (2006).
17. Maren, S., Quirk, G.J. Neuronal signalling of fear memory. Nat. Rev. Neurosci. 5, 844-852 (2004).
18. Anderson, A.K. et al. Dissociated neural representations of intensity and valence in human olfaction. Nat. Neurosci. 6, 196-202 (2003).
19. Weiner, I., Arad, M. Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment Behav. Brain Res. 204, 369-386 (2009).
20. Swerdlow, N.R., Weber, M., Qu, Y., Light, G.A., Braff, D.L. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology (Berl) 199, 331-388 (2008).
21. van Gaalen, M.M., Steckler, T. Behavioural analysis of four mouse strains in an anxiety test battery. Behav. Brain Res. 115, 95-106 (2000).
22. Brinks, V., de Kloet, E.R., Oitzl, M.S. Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice Prog. Brain Res. 167, 257-261 (2008).
23. Schweizer, M.C., Henniger, M.S., Sillaber, I. Chronic mild stress (CMS) in mice: of anhedonia, ‘anomalous anxiolysis’ and activity. PLoS One 4, e4326 (2009).
24. Milner, L.C., Crabbe, J.C. Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav. 7, 496-505 (2008).
25. Holmes, A., Wrenn, C.C., Harris, A.P., Thayer, K.E., Crawley, J.N. Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice. Genes Brain Behav. 1, 55-69 (2002).
26. Griebel, G., Belzung, C., Perrault, G., Sanger, D.J. Differences in anxietyrelated behaviours and in sensitivity to diazepam in inbred and outbred strains of mice. Psychopharmacology (Berl) 148, 164-170 (2000).
27. Trullas, R., Skolnick, P. Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology (Berl) 111, 323-331 (1993).
28. Schaefer, T.L., Vorhees, C.V., Williams, M.T. Mouse plasmacytomaexpressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness. Neuroscience 164, 1431-1443 (2009).
29. Bortolato, M., Godar, S.C., Davarian, S., Chen, K., Shih, J.C. Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology 34, 2746-2757 (2009).
30. Welch, J.M. et al. Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 448, 894-900 (2007).
31. Klemenhagen, K.C., Gordon, J.A., David, D.J., Hen, R., Gross, C.T. Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology 31, 101-111 (2006).
32. Shumyatsky, G.P. et al. Stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell 123, 697-709 (2005).
33. Gross, C. et al. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416, 396-400 (2002).
34. Rupprecht, R. et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 325, 490-493 (2009).
35. Yokoyama, F. et al. Anxiolytic-like profiles of histamine H3 receptor agonists in animal models of anxiety: a comparative study with antidepressants and benzodiazepine anxiolytic. Psychopharmacology (Berl) 205, 177-187 (2009).
36. Hovatta, I. et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature 438, 662-666 (2005).
37. Rudolph, U. et al. Benzodiazepine actions mediated by specific gammaaminobutyric acid(A) receptor subtypes. Nature 401, 796-800 (1999).
38. Rutten, K. et al. Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice. Eur. J. Neurosci. 28, 625-632 (2008).
39. Matzel, L.D., Babiarz, J., Townsend, D.A., Grossman, H.C., Grumet, M. Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity. Genes Brain Behav. 7, 470-480 (2008).
40. Reijmers, L.G. et al. A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learn Mem. 13, 143-149 (2006).
41. Chiba, S., Nishiyama, T., Yoshikawa, M., Yamada, Y. The antinociceptive effects of midazolam on three different types of nociception in mice. J. Pharmacol. Sci. 109, 71-77 (2009).
42. Noble, F., Benturquia, N., Bilkei-Gorzo, A., Zimmer, A., Roques, B.P. Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours. Psychopharmacology (Berl) 196, 327-335 (2008).
43. Kabbaj, M., Devine, D.P., Savage, V.R., Akil, H. Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules. J. Neurosci. 20, 6983-6988 (2000).
44. Joels, M., Pu, Z., Wiegert, O., Oitzl, M.S., Krugers, H.J. Learning under stress: how does it work? Trends Cogn. Sci. 10, 152-158 (2006).
45. Sandi, C., Pinelo-Nava, M.T. Stress and memory: behavioral effects and neurobiological mechanisms. Neural. Plast. 2007, 78970 (2007).
46. Luksys, G., Gerstner, W., Sandi, C. Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning. Nat. Neurosci. 12, 1180-1186 (2009).
47. Lu, A. et al. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol. Psychiatry 13, 1028-1042 (2008).
48. Tschenett, A. et al. Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur. J. Neurosci. 18, 143-148 (2003).
49. Campbell, T., Lin, S., DeVries, C., Lambert, K. Coping strategies in male and female rats exposed to multiple stressors. Physiol. Behav. 78, 495-504 (2003).
50. Steiner, M.A. et al. Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology 33, 54-67 (2008).
51. Bowers, S.L., Bilbo, S.D., Dhabhar, F.S., Nelson, R.J. Stressor-specific alterations in corticosterone and immune responses in mice. Brain Behav. Immun. 22, 105-113 (2008).
52. Yang, R.J. et al. Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning. Neuropsychopharmacology 33, 2595-2604 (2008).
53. Deacon, R.M. Housing, Husbandry and handling of rodents for behavioural experiments. Nat. Protoc. 1, 936-946 (2006).
54. Crabbe, J.C., Wahlsten, D., Dudek, B.C. Genetics of mouse behavior: interactions with laboratory environment. Science 284, 1670-1672 (1999).
55. Chesler, E.J., Wilson, S.G., Lariviere, W.R., Rodriguez-Zas, S.L., Mogil, J.S. Influences of laboratory environment on behavior. Nat. Neurosci. 5, 1101-1102 (2002).
56. Oxenkrug, G.F. Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging. Ann. NY Acad. Sci. 1122, 35-49 (2007).
57. Pollak, D.D. et al. A translational bridge between mouse and human models of learned safety. Ann. Med. 42, 127-134 (2010).
58. Uyttenhove, C. et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase. Nat. Med. 9, 1269-1274 (2003)