Chronic mild stress (CMS) in mice: Of anhedonia, 'anomalous anxiolysis' and activity

PLoS ONE

Volumn 4, Issue 1, 2009, Pages

  Schweizer, Martin C ^a   Henniger, Markus S H ^a   Sillaber, Inge ^a,b  

^a Affectis Pharmaceutical AG   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SACCHARIN;

ANHEDONIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR DISORDER; BODY WEIGHT; CHRONIC STRESS; CIRCADIAN RHYTHM; CONTROLLED STUDY; DEPRESSION; DISEASE COURSE; DISEASE SEVERITY; FOOD INTAKE; ILLUMINATION; MALE; MOUSE; NONHUMAN; RISK ASSESSMENT; RISK FACTOR; ANIMAL; CHRONIC DISEASE; DRINKING BEHAVIOR; LIGHT; MENTAL STRESS; METABOLISM; NEUROPSYCHOLOGICAL TEST; RADIATION EXPOSURE; TIME; WEIGHT GAIN;

ANIMALIA; MUS; RATTUS;

ANIMALS; ANXIETY; BODY WEIGHT; CHRONIC DISEASE; CONSUMMATORY BEHAVIOR; DRINKING BEHAVIOR; LIGHT; MALE; MICE; NEUROPSYCHOLOGICAL TESTS; SACCHARIN; STRESS, PSYCHOLOGICAL; TIME FACTORS; WEIGHT GAIN;

EID: 59849096319     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004326     Document Type: Article

References (53)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorder (DSM-IV). Washington, DC.
2. Kendler KS, Karkowski LM, Prescott CA (1999) Causal relationship between stressful life events and the onset of major depression. Am J Psychiatry 156: 837-841.
3. Kessler RC (1997) The effects of stressful life events on depression. Annu Rev Psychol 48: 191-214.
4. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93: 358-364.
5. Anisman H, Matheson K (2005) Stress, depression, and anhedonia: caveats concerning animal models. Neurosci Biobehav Rev 29: 525-546.
6. Henn FA, Vollmayr B (2005) Stress models of depression: forming genetically vulnerable strains. Neurosci Biobehav Rev 29: 799-804.
7. Fuchs E (2005) Social stress in tree shrews as an animal model of depression: an example of a behavioral model of a CNS disorder. CNS Spectr 10: 182-190.
8. Schmidt MV, Sterlemann V, Ganea K, Liebl C, Alam S, et al. (2007) Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence. Psychoneuroendocrinology 32: 417-429.
9. Anisman H, Merali Z, Hayley S (2008) Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders. Prog Neurobiol 85: 1-74.
10. de Kloet ER, Joels M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6: 463-475.
11. Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23: 477-501.
12. Linthorst AC, Reul JM (2008) Stress and the brain: solving the puzzle using microdialysis. Pharmacol Biochem Behav 90: 163-173.
13. McEwen BS (2005) Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 54: 20-23.
14. Nemeroff CB (1988) The role of corticotropin-releasing factor in the pathogenesis of major depression. Pharmacopsychiatry 21: 76-82.
15. Sapolsky RM (2003) Stress and plasticity in the limbic system. Neurochem Res 28: 1735-1742.
16. Willner P (1997) Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134: 319-329.
17. Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52: 90-110.
18. Strekalova T, Spanagel R, Dolgov O, Bartsch D (2005) Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice. Behav Pharmacol 16: 171-180.
19. Griffiths J, Shanks N, Anisman H (1992) Strain-specific alterations in consumption of a palatable diet following repeated stressor exposure. Pharmacol Biochem Behav 42: 219-227.
20. Ibarguen-Vargas Y, Surget A, et al. (2008) Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology doi:10 1016/j psyneuen 2008 07 010.
21. Pothion S, Bizot JC, Trovero F, Belzung C (2004) Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress. Behav Brain Res 155: 135-146.
22. Ducottet C, Aubert A, Belzung C (2004) Susceptibility to subchronic unpredictable stress is related to individual reactivity to threat stimuli in mice. Behav Brain Res 155: 291-299.
23. Ducottet C, Belzung C (2004) Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice. Physiol Behav 81: 417-426.
24. Mineur YS, Belzung C, Crusio WE (2006) Effects of unpredictable chronic mild stress on anxiety and depression-like behavior inmice. Behav Brain Res 175: 43-50.
25. Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P (2004) Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 29: 2007-2017.
26. Griebel G, Stemmelin J, Scatton B (2005) Effects of the cannabinoid CB1 receptor antagonist rimonabant in models of emotional reactivity in rodents. Biol Psychiatry 57: 261-267.
27. Elizalde N, Gil-Bea FJ, Ramirez MJ, Aisa B, Lasheras B, et al. (2008) Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: effect of antidepressant treatment. Psychopharmacology (Berl) 199: 1-14.
28. Griebel G, Simiand J, Serradeil-Le GC, Wagnon J, Pascal M, et al. (2002) Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders. Proc Natl Acad Sci U S A 99: 6370-6375.
29. Li S, Wang C, Wang W, Dong H, Hou P, et al. (2008) Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior. Life Sci 82: 934-942.
30. Harkin A, Houlihan DD, Kelly JP (2002) Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine. J Psychopharmacol 16: 115-123.
31. D'Aquila PS, Newton J, Willner P (1997) Diurnal variation in the effect of chronic mild stress on sucrose intake and preference. Physiol Behav 62: 421-426.
32. Ohl F, Holsboer F, Landgraf R (2001) The modified hole board as a differential screen for behavior in rodents. Behav Res Methods Instrum Comput 33: 392-397.
33. Thoeringer CK, Sillaber I, Roedel A, Erhardt A, Mueller MB, et al. (2007) The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice. Psychoneuroendocrinology 32: 746-757.
34. Tanaka M, Nakamura F, Mizokawa S, Matsumura A, Nozaki S, et al. (2003) Establishment and assessment of a rat model of fatigue. Neurosci Lett 352: 159-162.
35. Gorka Z, Moryl E, Papp M (1996) Effect of chronic mild stress on circadian rhythms in the locomotor activity in rats. Pharmacol Biochem Behav 54: 229-234.
36. Moreau JL, Scherschlicht R, Jenck F, Martin JR (1995) Chronic mild stress-induced anhedonia model of depression; sleep abnormalities and curative effects of electroshock treatment. Behav Pharmacol 6: 682-687.
37. Cheeta S, Ruigt G, van PJ, Willner P (1997) Changes in sleep architecture following chronic mild stress. Biol Psychiatry 41: 419-427.
38. Papp M, Gruca P, Boyer PA, Mocaer E (2003) Effect of agomelatine in the chronic mild stress model of depression in the rat. Neuropsychopharmacology 28: 694-703.
39. Wehr TA, Wirz-Justice A (1982) Circadian rhythm mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatria 15: 31-39.
40. Kopp C (2001) Locomotor activity rhythm in inbred strains of mice: implications for behavioural studies. Behav Brain Res 125: 93-96.
41. Tang X, Xiao J, Parris BS, Fang J, Sanford LD (2005) Differential effects of two types of environmental novelty on activity and sleep in BALB/cJ and C57BL/6J mice. Physiol Behav 85: 419-429.
42. Cabib S, Puglisi-Allegra S (1996) Stress, depression and the mesolimbic dopamine system. Psychopharmacology (Berl) 128: 331-342.
43. Bachmanov AA, Tordoff MG, Beauchamp GK (2001) Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 26: 905-913.
44. Cabib S, Puglisi-Allegra S (1996) Different effects of repeated stressful experiences on mesocortical and mesolimbic dopamine metabolism. Neuroscience 73: 375-380.
45. Cryan JF, Mombereau C (2004) In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9: 326-357.
46. D'Aquila PS, Brain P, Willner P (1994) Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression. Physiol Behav 56: 861-867.
47. Gronli J, Murison R, Fiske E, Bjorvatn B, Sorensen E, et al. (2005) Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiol Behav 84: 571-577.
48. Ducottet C, Griebel G, Belzung C (2003) Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry 27: 625-631.
49. Rossler AS, Joubert C, Chapouthier G (2000) Chronic mild stress alleviates anxious behaviour in female mice in two situations. Behav Processes 49: 163-165.
50. Li S, Wang C, Wang M, Li W, Matsumoto K, et al. (2007) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci 80: 1373-1381.
51. Kopp C, Vogel E, Rettori MC, Delagrange P, Misslin R (1999) The effects of melatonin on the behavioural disturbances induced by chronic mild stress in C3H/He mice. Behav Pharmacol 10: 73-83.
52. Kompagne H, Bardos G, Szenasi G, Gacsalyi I, Harsing LG, et al. (2008) Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. Behav Brain Res 193: 311-314.
53. Cancela LM, Bregonzio C, Molina VA (1995) Anxiolytic-like effect induced by chronic stress is reversed by naloxone pretreatment. Brain Res Bull 36: 209-213.