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Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5775-5794

Process R&D under the magnifying glass: Organization, business model, challenges, and scientific context

(1) Federsel, Hans Jürgen a

a ASTRAZENECA R AND D (Sweden)

Author keywords

Organic synthesis; Pharmaceuticals; Process design; Process R D; Scale up

Indexed keywords

AR A2; CHROMAN DERIVATIVE; EBALZOTAN; ESOMEPRAZOLE; FLUOXETINE; MONOCLONAL ANTIBODY; OMEPRAZOLE; POTASSIUM CARBONATE; ROBALZOTAN; ROPIVACAINE; SEROTONIN 1B ANTAGONIST; UNCLASSIFIED DRUG; ZIMELDINE;

CHEMOMETRICS; CLINICAL TRIAL; COMMERCIAL PHENOMENA; COMPUTER PROGRAM; COST EFFECTIVENESS ANALYSIS; DENSITY FUNCTIONAL THEORY; DRUG COST; DRUG DESIGN; DRUG INDUSTRY; DRUG MARKETING; DRUG RESEARCH; DRUG SAFETY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENVIRONMENTAL FACTOR; FRIEDEL CRAFTS REACTION; HEALTH CARE COST; HEALTH CARE NEED; HUMAN; MOLECULAR WEIGHT; ORGANIZATION; PATENT; PRODUCTIVITY; QUALITY CONTROL; REVIEW; STEREOCHEMISTRY; STEREOISOMERISM;

CHEMISTRY, PHARMACEUTICAL; DRUG INDUSTRY; RESEARCH;

EID: 77955471836 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.06.029 Document Type: Review

Times cited : (26)

References (55)

1
- 51349158805
- H.-J. Federsel Drug News Perspect. 21 2008 193
- (2008) Drug News Perspect. , vol.21 , pp. 193
- Federsel, H.-J.¹

2
- 73449139146
- M. Goodman Nat. Rev. Drug Disc. 8 2009 927
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 927
- Goodman, M.¹

3
- 38349090575
- I. Kola Clin. Pharmacol. Ther. 83 2008 227
- (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 227
- Kola, I.¹

4
- 67149140372
- M. Goodman Nat. Rev. Drug Disc. 8 2009 443
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 443
- Goodman, M.¹

5
- 68249096185
- E. David, T. Tramontin, and R. Zemmel Nat. Rev. Drug Disc. 8 2009 609
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 609
- David, E.¹ Tramontin, T.² Zemmel, R.³

6
- 66149123969
- H.-J. Federsel Acc. Chem. Res. 42 2009 671
- (2009) Acc. Chem. Res. , vol.42 , pp. 671
- Federsel, H.-J.¹

7
- 68449088265
- I.W. Davies, and C.J. Welch Science 325 2009 701
- (2009) Science , vol.325 , pp. 701
- Davies, I.W.¹ Welch, C.J.²

8
- 77955467450
- J.-P. Garnier Harvard Bus. Rev. South Asia 2008 49
- (2008) Harvard Bus. Rev. South Asia , pp. 49
- Garnier, J.-P.¹

9
- 0037374498
- J.A. DiMasi, R.W. Hansen, and H.G. Grabowski J. Health Econ. 22 2003 151
- (2003) J. Health Econ. , vol.22 , pp. 151
- Dimasi, J.A.¹ Hansen, R.W.² Grabowski, H.G.³

10
- 84887360252
- University of California Press
- M. Goozner The $800 Million Pill: The Truth Behind the Cost of New Drugs 2004 University of California Press
- (2004) The $800 Million Pill: The Truth behind the Cost of New Drugs
- Goozner, M.¹

11
- 73449101512
- B. Munos Nat. Rev. Drug Disc. 8 2009 959
- (2009) Nat. Rev. Drug Disc. , vol.8 , pp. 959
- Munos, B.¹

12
- 33750579770
- P. Cuatrecasas J. Clin. Invest. 116 2006 2837
- (2006) J. Clin. Invest. , vol.116 , pp. 2837
- Cuatrecasas, P.¹

13
- 0036884563
- H.-J. Federsel Nat. Rev. Drug Disc. 1 2002 1013
- (2002) Nat. Rev. Drug Disc. , vol.1 , pp. 1013
- Federsel, H.-J.¹

14
- 0042067947
- H.-J. Federsel Nat. Rev. Drug Disc. 2 2003 654
- (2003) Nat. Rev. Drug Disc. , vol.2 , pp. 654
- Federsel, H.-J.¹

15
- 62749152193
- G. Vanhoenacker, E. Dumont, F. David, A. Baker, and P. Sandra J. Chromatogr., A 1216 2009 3563
- (2009) J. Chromatogr., A , vol.1216 , pp. 3563
- Vanhoenacker, G.¹ Dumont, E.² David, F.³ Baker, A.⁴ Sandra, P.⁵

16
- 46849091140
- R.J. Romañach Pharm. Technol. Eur. 19 2007 47
- (2007) Pharm. Technol. Eur. , vol.19 , pp. 47
- Romañach, R.J.¹

17
- 1042264120
- L.X. Yu, R.A. Lionberger, A.S. Raw, R. D'Costa, H. Wu, and A.S. Hussain Adv. Drug Delivery Rev. 56 2004 349
- (2004) Adv. Drug Delivery Rev. , vol.56 , pp. 349
- Yu, L.X.¹ Lionberger, R.A.² Raw, A.S.³ D'Costa, R.⁴ Wu, H.⁵ Hussain, A.S.⁶

18
- 84891294270
- CRC Press London
- J. Sharp Good Pharmaceutical Manufacturing Practice: Rationale and Compliance 2005 CRC Press London 503 pp
- (2005) Good Pharmaceutical Manufacturing Practice: Rationale and Compliance
- Sharp, J.¹

19
- 0017359144
- S.B. Ross, and A.L. Renyi Neuropharmacology 16 1977 57
- (1977) Neuropharmacology , vol.16 , pp. 57
- Ross, S.B.¹ Renyi, A.L.²

20
- 0018376135
- A. Coppen, R. Rao, C. Swade, and K. Wood Psychopharmacology 63 1979 199
- (1979) Psychopharmacology , vol.63 , pp. 199
- Coppen, A.¹ Rao, R.² Swade, C.³ Wood, K.⁴

21
- 0019419687
- J. Lundström, T. Högberg, T. Gosztonyi, and T. de Paulis Arzneim.-Forsch. 31 1981 486
- (1981) Arzneim.-Forsch. , vol.31 , pp. 486
- Lundström, J.¹ Högberg, T.² Gosztonyi, T.³ De Paulis, T.⁴

22
- 0018676878
- K. Högberg, J.-E. Lindgren, T. Högberg, and B. Ulff Acta Pharm. Suec. 16 1979 299
- (1979) Acta Pharm. Suec. , vol.16 , pp. 299
- Högberg, K.¹ Lindgren, J.-E.² Högberg, T.³ Ulff, B.⁴

23
- 0020672616
- P.H. Rosenberg, and E. Heinonen Br. J. Anaesth. 55 1983 163
- (1983) Br. J. Anaesth. , vol.55 , pp. 163
- Rosenberg, P.H.¹ Heinonen, E.²

24
- 0000644342
- H.-J. Federsel, P. Jaksch, and R. Sandberg Acta Chem. Scand. Ser. B 41 1987 757
- (1987) Acta Chem. Scand. Ser. B , vol.41 , pp. 757
- Federsel, H.-J.¹ Jaksch, P.² Sandberg, R.³

25
- 0036572486
- E. Carlsson, P. Lindberg, and S. von Unge Chem. Br. 38 2002 42
- (2002) Chem. Br. , vol.38 , pp. 42
- Carlsson, E.¹ Lindberg, P.² Von Unge, S.³

26
- 0037313425
- L. Olbe, E. Carlsson, and P. Lindberg Nat. Rev. Drug Disc. 2 2003 132
- (2003) Nat. Rev. Drug Disc. , vol.2 , pp. 132
- Olbe, L.¹ Carlsson, E.² Lindberg, P.³

27
- 0034697497
- H.-J. Federsel, and M. Larsson H.-U. Blaser, E. Schmidt, Asymmetric Catalysis on Industrial Scale 2004 Wiley-VCH Weinheim 413 436
- (2004) Asymmetric Catalysis on Industrial Scale , pp. 413-436
- Federsel, H.-J.¹ Larsson, M.²

28
- 0000605228
- P. Pitchen, E. Duñach, M.N. Deshmukh, and H.B. Kagan J. Am. Chem. Soc. 106 1984 8188
- (1984) J. Am. Chem. Soc. , vol.106 , pp. 8188
- Pitchen, P.¹ Duñach, E.² Deshmukh, M.N.³ Kagan, H.B.⁴

29
- 0001361884
- J.M. Brunel, P. Diter, M. Duetsch, and H.B. Kagan J. Org. Chem. 60 1995 8086
- (1995) J. Org. Chem. , vol.60 , pp. 8086
- Brunel, J.M.¹ Diter, P.² Duetsch, M.³ Kagan, H.B.⁴

30
- 77955472232
- Patent Appl. WO 96/02535
- Larsson, M.; Stenhede, U.; Sörensen, H.; von Unge, S.; Cotton, H. Patent Appl. WO 96/02535, 1996.
- (1996)
- Larsson, M.¹ Stenhede, U.² Sörensen, H.³ Von Unge, S.⁴ Cotton, H.⁵

31
- 0034703164
- H. Cotton, T. Elebring, M. Larsson, L. Li, H. Sörensen, and S. von Unge Tetrahedron: Asymmetry 11 2000 3819
- (2000) Tetrahedron: Asymmetry , vol.11 , pp. 3819
- Cotton, H.¹ Elebring, T.² Larsson, M.³ Li, L.⁴ Sörensen, H.⁵ Von Unge, S.⁶

32
- 34548239125
- M. Seenivasaperumal, H.-J. Federsel, A. Ertan, and K.J. Szabó Chem. Commun. 2007 2187
- (2007) Chem. Commun. , pp. 2187
- Seenivasaperumal, M.¹ Federsel, H.-J.² Ertan, A.³ Szabó, K.J.⁴

33
- 65249172112
- M. Seenivasaperumal, H.-J. Federsel, and K.J. Szabó Adv. Synth. Catal. 351 2009 903
- (2009) Adv. Synth. Catal. , vol.351 , pp. 903
- Seenivasaperumal, M.¹ Federsel, H.-J.² Szabó, K.J.³

34
- 0034721173
- E. Hammarberg, G. Nordvall, R. Leideborg, M. Nylöf, S. Hanson, L. Johansson, S.-O. Thorberg, B.-R. Tolf, E. Jerning, E. Torell Svantesson, N. Mohell, C. Ahlgren, A. Westlind-Danielsson, I. Csöregh, and R. Johansson J. Med. Chem. 43 2000 2837
- (2000) J. Med. Chem. , vol.43 , pp. 2837
- Hammarberg, E.¹ Nordvall, G.² Leideborg, R.³ Nylöf, M.⁴ Hanson, S.⁵ Johansson, L.⁶ Thorberg, S.-O.⁷ Tolf, B.-R.⁸ Jerning, E.⁹ Torell Svantesson, E.¹⁰ Mohell, N.¹¹ Ahlgren, C.¹² Westlind-Danielsson, A.¹³ Csöregh, I.¹⁴ Johansson, R.¹⁵

35
- 0032878058
- L.A. Sorbera, P. Leeson, and J. Castañer Drugs Future 24 1999 740
- (1999) Drugs Future , vol.24 , pp. 740
- Sorbera, L.A.¹ Leeson, P.² Castañer, J.³

36
- 0023639854
- S.-O. Thorberg, H. Hall, C. kesson, K. Svensson, and J.L.G. Nilsson Acta Pharm. Suec. 24 1987 169
- (1987) Acta Pharm. Suec. , vol.24 , pp. 169
- Thorberg, S.-O.¹ Hall, H.² Kesson, C.³ Svensson, K.⁴ Nilsson, J.L.G.⁵

37
- 0034345196
- H.-J. Federsel Org. Process Res. Dev. 4 2000 362
- (2000) Org. Process Res. Dev. , vol.4 , pp. 362
- Federsel, H.-J.¹

38
- 77955466194
- Patent Appl. WO 99/59988
- Eriksson, M. Patent Appl. WO 99/59988, 1999.
- (1999)
- Eriksson, M.¹

39
- 84882150356
- H.-J. Federsel, and A. Sveno K. Gadamasetti, T. Braish, Process Chemistry in the Pharmaceutical Industry. Challenges in an Ever Changing Climate Vol. 2 2008 CRC Press Boca Raton 111 135
- (2008) Process Chemistry in the Pharmaceutical Industry. Challenges in An Ever Changing Climate , vol.2 , pp. 111-135
- Federsel, H.-J.¹ Sveno, A.²

40
- 84988130722
- E. Differding, and H. Ofner Synlett 1991 187
- (1991) Synlett , pp. 187
- Differding, E.¹ Ofner, H.²

41
- 0007770903
- A. Hassner, J.E. Kropp, and G.J. Kent J. Org. Chem. 34 1969 2628
- (1969) J. Org. Chem. , vol.34 , pp. 2628
- Hassner, A.¹ Kropp, J.E.² Kent, G.J.³

42
- 77955471690
- Patent Appl. WO 02/00575
- Paiocchi, M.; Belli, A.; Ponzini, F.; Villa, M. Patent Appl. WO 02/00575, 2002.
- (2002)
- Paiocchi, M.¹ Belli, A.² Ponzini, F.³ Villa, M.⁴

43
- 19344368990
- C. Ahlgren, A. Eriksson, P. Tellefors, S.B. Ross, C. Stenfors, and Malmberg Eur. J. Pharmacol. 499 2004 67
- (2004) Eur. J. Pharmacol. , vol.499 , pp. 67
- Ahlgren, C.¹ Eriksson, A.² Tellefors, P.³ Ross, S.B.⁴ Stenfors, C.⁵ Malmberg⁶

44
- 1642407941
- C. Stenfors, T. Hallerbäck, L.-G. Larsson, C. Wallsten, and S.B. Ross Naunyn-Schmiedeberg's Arch. Pharmacol. 369 2004 330
- (2004) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.369 , pp. 330
- Stenfors, C.¹ Hallerbäck, T.² Larsson, L.-G.³ Wallsten, C.⁴ Ross, S.B.⁵

45
- 38049049180
- H.-J. Federsel, M. Hedberg, F.R. Qvarnström, M.P.T. Sjögren, and W. Tian Acc. Chem. Res. 40 2007 1377
- (2007) Acc. Chem. Res. , vol.40 , pp. 1377
- Federsel, H.-J.¹ Hedberg, M.² Qvarnström, F.R.³ Sjögren, M.P.T.⁴ Tian, W.⁵

46
- 58149168532
- H.-J. Federsel, M. Hedberg, F.R. Qvarnström, and W. Tian Org. Process Res. Dev. 12 2008 512
- (2008) Org. Process Res. Dev. , vol.12 , pp. 512
- Federsel, H.-J.¹ Hedberg, M.² Qvarnström, F.R.³ Tian, W.⁴

47
- 0008861725
- J.J. Sims, L.H. Selman, and M. Cadogan Org. Synth. 51 1971 109
- (1971) Org. Synth. , vol.51 , pp. 109
- Sims, J.J.¹ Selman, L.H.² Cadogan, M.³

48
- 38049000699
- D.C. Hunden Org. Prep. Proced. Int. 16 1984 294
- (1984) Org. Prep. Proced. Int. , vol.16 , pp. 294
- Hunden, D.C.¹

49
- 0029153568
- D.M. Tschaen, L. Abramson, D. Cai, R. Desmond, U.-H. Dolling, L. Frey, S. Karady, Y.-J. Shi, and T.R. Verhoeven J. Org. Chem. 60 1995 4324
- (1995) J. Org. Chem. , vol.60 , pp. 4324
- Tschaen, D.M.¹ Abramson, L.² Cai, D.³ Desmond, R.⁴ Dolling, U.-H.⁵ Frey, L.⁶ Karady, S.⁷ Shi, Y.-J.⁸ Verhoeven, T.R.⁹

50
- 0035902397
- P. Dupau, A.-E. Hay, C. Bruneau, and P.H. Dixneuf Tetrahedron: Asymmetry 12 2001 863
- (2001) Tetrahedron: Asymmetry , vol.12 , pp. 863
- Dupau, P.¹ Hay, A.-E.² Bruneau, C.³ Dixneuf, P.H.⁴

51
- 77955468359
- Kanai, Y.; Saiyou, K.; Ueno, K. Jpn. Kokai Tokkyo Koho 10 072 411, 1998.
- (1998) Jpn. Kokai Tokkyo Koho , vol.10 , Issue.72 , pp. 411
- Kanai, Y.¹ Saiyou, K.² Ueno, K.³

52
- 33748621833
- A.S. Guram, R.A. Rennels, and S.L. Buchwald Angew. Chem., Int. Ed. Engl. 34 1995 1348
- (1995) Angew. Chem., Int. Ed. Engl. , vol.34 , pp. 1348
- Guram, A.S.¹ Rennels, R.A.² Buchwald, S.L.³

53
- 0029044538
- J. Louie, and J.F. Hartwig Tetrahedron Lett. 36 1995 3609
- (1995) Tetrahedron Lett. , vol.36 , pp. 3609
- Louie, J.¹ Hartwig, J.F.²

54
- 75949085017
- B. Hughes Nat. Rev. Drug Disc. 9 2010 89
- (2010) Nat. Rev. Drug Disc. , vol.9 , pp. 89
- Hughes, B.¹

55
- 77950623162
- A.I. Graul, L. Sorbera, P. Pina, M. Tell, E. Cruces, E. Rosa, M. Stringer, R. Castañer, and L. Revel Drug News Perspect. 23 2010 7
- (2010) Drug News Perspect. , vol.23 , pp. 7
- Graul, A.I.¹ Sorbera, L.² Pina, P.³ Tell, M.⁴ Cruces, E.⁵ Rosa, E.⁶ Stringer, M.⁷ Castañer, R.⁸ Revel, L.⁹

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