Handing over the baton: Connecting medicinal chemistry with process R & D

Drug News and Perspectives

Volumn 21, Issue 4, 2008, Pages 193-199

  Federsel, Hans Jürgen ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISCODERMOLIDE;

ARTICLE; COMPUTER PROGRAM; DRUG APPROVAL; DRUG DESIGN; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG MARKETING; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PRODUCT DEVELOPMENT; SCALE UP;

CHEMISTRY, PHARMACEUTICAL; DRUG APPROVAL; DRUG DESIGN; DRUG INDUSTRY; TECHNOLOGY, PHARMACEUTICAL;

EID: 51349158805     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2008.21.4.1213348     Document Type: Article

References (12)

1. Federsel, H.-J. Handing over the baton - Connecting medicinal chemistry with process R&D. Drugs Fut [19th Int Symp Med Chem (Aug 29-Sept 2, Istanbul) 2006] 2006, 31(Suppl. A): Abst L67.
2. Federsel, H.-J. Logistics of process R&D: Transforming laboratory methods to manufacturing scale. Nat Rev Drug Discov 2003, 2(8): 654-64.
3. Federsel, H.-J. Drug discoverers - you need us! Drug Discov Today 2001, 6(8): 397-8.
4. Federsel, H.-J. The role of process R&D in drug discovery - Evolution of an interface. Chim Oggi/Chem Today 2004, 22(3/4): 9-12.
5. Potoski, J. Timely synthetic support for medicinal chemists. Drug Discov Today 2005, 10(2): 115-20.
6. Federsel, H.-J. The integration of process R&D in drug discovery - Challenges and opportunities. Comb Chem High Throughput Screen 2006, 9(2): 79-86.
7. Freemantle, M. Scaled-up synthesis of discodermolide. Chem Eng News 2004, 82(9): 33-5.
8. Federsel, H.-J. Chemical process design in transition: Current trends in the pharmaceutical industry. PharmaChem 2005, 4(11/12): 4-9.
9. Federsel, H.-J. In search of sustainability: process R&D in light of current pharmaceutical industry challenges. Drug Discov Today 2006, 11(21/22): 966-74.
10. Federsel, H.-J. and Jakupovic, E. A highly optimized and concise large scale synthesis of a purine bronchodilator. In: Process Chemistry in the Pharmaceutical Industry. K. Gadamasetti (Ed). Marcel Dekker: New York, 1999, 91-106.
11. Federsel, H.-J., Hedberg, M., Qvarnström, F.R., Sjögren, M.P.T. and Tian, W. Construction of a chiral central nervous system (CNS)-active aminotetralin drug compound based on a synthesis strategy using multitasking properties of (S)-1-phenylethylamine. Acc Chem Res 2007, 40(12): 1377-84.
12. Federsel, H.-J. and Sveno, A. To overcome the hurdles: Coping with the synthesis of Robalzotan, a complex chroman antidepressant. In: Process Chemistry in the Pharmaceutical Industry, Vol. 2. Challenges in an Ever Changing Climate. K. Gadamasetti, T. Braish (Eds.). CRC Press: Boca Raton, 2008, 111-35.