-
5
-
-
66149139320
-
-
Nafissi, M, Ragan, J. A, DeVries, K. M, Eds, American Chemical Society: Washington, DC
-
(e) From Bench to Pilot Plant. Process Research in the Pharmaceutical Industry, Nafissi, M.; Ragan, J. A., DeVries, K. M., Eds.; American Chemical Society: Washington, DC, 2002.
-
(2002)
From Bench to Pilot Plant. Process Research in the Pharmaceutical Industry
-
-
-
6
-
-
0036884563
-
Start small, think big - The art of process R&D
-
(f) Federsel, H.-J. Start small, think big - The art of process R&D. Nat. Rev. Drug Discovery 2001, 1 (12), 1013.
-
(2001)
Nat. Rev. Drug Discovery
, vol.1
, Issue.12
, pp. 1013
-
-
Federsel, H.-J.1
-
7
-
-
0042067947
-
Logistics of process R&D: Transforming laboratory methods to manufacturing scale
-
(g) Federsel, H.-J. Logistics of process R&D: Transforming laboratory methods to manufacturing scale. Nat. Rev. Drug Discovery 2003, 2(8), 654-664.
-
(2003)
Nat. Rev. Drug Discovery
, vol.2
, Issue.8
, pp. 654-664
-
-
Federsel, H.-J.1
-
8
-
-
33746889033
-
Process Chemistry
-
Guest Editors, 7
-
(h) Lipton, M. F.; Barrett, A. G. M., Guest Editors, Process Chemistry, Chem. Rev. 2006, 106 (7), 2581-3027.
-
(2006)
Chem. Rev
, vol.106
, pp. 2581-3027
-
-
-
10
-
-
0003859037
-
-
Gadamasetti, K, Braish, T. F, Eds, CRC Press: Boca Raton, FL
-
(j) Process Chemistry in the Pharmaceutical Industry, Vol. 2, Challenges in an Ever Changing Climate; Gadamasetti, K.; Braish, T. F., Eds.; CRC Press: Boca Raton, FL, 2008.
-
(2008)
Process Chemistry in the Pharmaceutical Industry, Vol. 2, Challenges in an Ever Changing Climate
-
-
-
11
-
-
66149124545
-
-
Org. Process Res. Dev.; Laird, T., Ed.; this journal is entirely devoted to publishing work from the process R&D arena since 1997; see journal homepage http://pubs.acs.org/journal/oprdfk/.
-
(k) Org. Process Res. Dev.; Laird, T., Ed.; this journal is entirely devoted to publishing work from the process R&D arena since 1997; see journal homepage http://pubs.acs.org/journal/oprdfk/.
-
-
-
-
12
-
-
33645733070
-
The integration of process R&D in drug discovery - Challenges and opportunities
-
(a) Federsel, H.-J. The integration of process R&D in drug discovery - Challenges and opportunities. Comb. Chem. High Throughout Screening 2006, 9(2), 79-86.
-
(2006)
Comb. Chem. High Throughout Screening
, vol.9
, Issue.2
, pp. 79-86
-
-
Federsel, H.-J.1
-
13
-
-
64349088801
-
-
Strategy and Drug Research; Moos, W. H, Ed, Elsevier: Oxford, U.K
-
(b) Comprehensive Medicinal Chemistry II, Vol. 2, Strategy and Drug Research; Moos, W. H., Ed.; Elsevier: Oxford, U.K., 2007.
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.2
-
-
-
14
-
-
39649084919
-
The FDA critical path initiative and its influence on new drug development
-
(c) Woodcock, J.; Woosley, R. The FDA critical path initiative and its influence on new drug development. Annu. Rev. Med 2008, 59, 1-12.
-
(2008)
Annu. Rev. Med
, vol.59
, pp. 1-12
-
-
Woodcock, J.1
Woosley, R.2
-
15
-
-
51349158805
-
Handing over the baton: Connecting medicinal chemistry with process R&D
-
(d) Federsel, H.-J. Handing over the baton: Connecting medicinal chemistry with process R&D. Drug News Perspect. 2008, 21 (4), 193-199.
-
(2008)
Drug News Perspect
, vol.21
, Issue.4
, pp. 193-199
-
-
Federsel, H.-J.1
-
16
-
-
0034345196
-
Development of a process for a chiral aminochroman antidepressant: A case story
-
Federsel, H.-J. Development of a process for a chiral aminochroman antidepressant: A case story. Org. Process Res. Dev. 2000, 4 (5), 362-369.
-
(2000)
Org. Process Res. Dev
, vol.4
, Issue.5
, pp. 362-369
-
-
Federsel, H.-J.1
-
17
-
-
0035341789
-
Drug discoverers - you need us
-
(a) Federsel, H.-J. Drug discoverers - you need us. Drug Discovery Todav 2001, 6 (8), 397-398.
-
(2001)
Drug Discovery Todav
, vol.6
, Issue.8
, pp. 397-398
-
-
Federsel, H.-J.1
-
18
-
-
2942716691
-
The role of process R&D in drug discovery - Evolution of an interface
-
(b) Federsel, H.-J. The role of process R&D in drug discovery - Evolution of an interface. Chim. Oggi/Chem. Todav 2004, 22 (3/4), 9-12.
-
(2004)
Chim. Oggi/Chem. Todav
, vol.22
, Issue.3-4
, pp. 9-12
-
-
Federsel, H.-J.1
-
19
-
-
13844271915
-
Timely synthetic support for medicinal chemists
-
(c) Potoski, J. Timely synthetic support for medicinal chemists. Drug Discovery Today 2005, 10 (2), 115-120.
-
(2005)
Drug Discovery Today
, vol.10
, Issue.2
, pp. 115-120
-
-
Potoski, J.1
-
20
-
-
33750217203
-
In search of sustainability: Process R&D in light of current pharmaceutical industry challenges
-
Federsel, H.-J. In search of sustainability: Process R&D in light of current pharmaceutical industry challenges. Drug Discovery Today 2006, 11 (21/22), 966-974.
-
(2006)
Drug Discovery Today
, vol.11
, Issue.21-22
, pp. 966-974
-
-
Federsel, H.-J.1
-
21
-
-
33745079610
-
Analysis of the reactions used for the preparation of drug candidate molecules
-
Carey, J. S.; Laffan, D.; Thomson, C.; Williams, M. T. Analysis of the reactions used for the preparation of drug candidate molecules. Org. Biomol. Chem. 2006, 4(12), 2337-2347.
-
(2006)
Org. Biomol. Chem
, vol.4
, Issue.12
, pp. 2337-2347
-
-
Carey, J.S.1
Laffan, D.2
Thomson, C.3
Williams, M.T.4
-
22
-
-
0002312023
-
Drug chirality - scale-up manufacturing, and control
-
(a) Federsel, H.-J. Drug chirality - scale-up manufacturing, and control. CHEMTECH 1993, 23 (12), 24-33.
-
(1993)
CHEMTECH
, vol.23
, Issue.12
, pp. 24-33
-
-
Federsel, H.-J.1
-
23
-
-
0041663784
-
Facing chirality in the 21st century: Approaching the challenges in the pharmaceutical industry
-
(b) Federsel, H.-J. Facing chirality in the 21st century: Approaching the challenges in the pharmaceutical industry. Chirality 2003, 15 (S1), S128-S142.
-
(2003)
Chirality
, vol.15
, Issue.S1
-
-
Federsel, H.-J.1
-
24
-
-
0347719507
-
Searching for scalable processes: Addressing the challenge in times of increasing complexity
-
(c) Federsel, H.-J. Searching for scalable processes: Addressing the challenge in times of increasing complexity. Curr. Opin. Drug Discovery Dev. 2003, 6(6), 838-847.
-
(2003)
Curr. Opin. Drug Discovery Dev
, vol.6
, Issue.6
, pp. 838-847
-
-
Federsel, H.-J.1
-
25
-
-
1842578074
-
Industrial methods for the production of optically active intermediates
-
(d) Breuer, M.; Ditrich, K.; Habicher, T.; Hauer, B.; Kesseler, M.; Stürmer, R.; Zelinski, T. Industrial methods for the production of optically active intermediates. Angew. Chem., Int. Ed. 2004, 43(1), 788-824.
-
(2004)
Angew. Chem., Int. Ed
, vol.43
, Issue.1
, pp. 788-824
-
-
Breuer, M.1
Ditrich, K.2
Habicher, T.3
Hauer, B.4
Kesseler, M.5
Stürmer, R.6
Zelinski, T.7
-
26
-
-
38049056138
-
Chiral Drug Discovery and Development - From Concept Stage to Market Launch
-
Strategy and Drug Research; Moos, W. H, Ed, Elsevier: Oxford, U.K, Chapter 2.17, pp
-
(e) Federsel, H.-J. Chiral Drug Discovery and Development - From Concept Stage to Market Launch. Comprehensive Medicinal Chemistry II, Vol. 2, Strategy and Drug Research; Moos, W. H., Ed.; Elsevier: Oxford, U.K., 2007; Chapter 2.17, pp 713-736.
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.2
, pp. 713-736
-
-
Federsel, H.-J.1
-
27
-
-
0035560855
-
Enantioselective catalysis in fine chemicals production
-
(a) Blaser, H.-U.; Spindler, F.; Studer, M. Enantioselective catalysis in fine chemicals production. APPL. Catal. A 2001, 221 (1-2), 119-143.,
-
(2001)
APPL. Catal. A
, vol.221
, Issue.1-2
, pp. 119-143
-
-
Blaser, H.-U.1
Spindler, F.2
Studer, M.3
-
28
-
-
23844489138
-
Asymmetry on large scale: The roadmap to stereoselective processes
-
(b) Federsel, H.-J. Asymmetry on large scale: The roadmap to stereoselective processes. Nat. Rev. Drug Discovery 2005, 4 (8), 685-697.
-
(2005)
Nat. Rev. Drug Discovery
, vol.4
, Issue.8
, pp. 685-697
-
-
Federsel, H.-J.1
-
29
-
-
0034697497
-
-
Blaser, H.-U, Schmidt, E, Eds, Wiley-VCH: Weinheim, Germany
-
(c) Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions; Blaser, H.-U., Schmidt, E., Eds.; Wiley-VCH: Weinheim, Germany, 2004.
-
(2004)
Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions
-
-
-
30
-
-
14844293909
-
Progress in enantioselective catalysis assessed from an industrial point of view
-
(d) Blaser, H.-U.; Pugin, B.; Spindler, F. Progress in enantioselective catalysis assessed from an industrial point of view. J. Mol. Catal. A: Chem. 2005, 231 (1-2), 1-20.
-
(2005)
J. Mol. Catal. A: Chem
, vol.231
, Issue.1-2
, pp. 1-20
-
-
Blaser, H.-U.1
Pugin, B.2
Spindler, F.3
-
31
-
-
85018200009
-
Stereoselective Synthesis of Drugs - An Industrial Perspective
-
Francotte, E, Lindner, W, Eds, Wiley-VCH: Weinheim, Germany, Chapter 2, pp
-
(e) Federsel, H.-J. Stereoselective Synthesis of Drugs - An Industrial Perspective. In Chirality in Drug Research; Francotte, E., Lindner, W., Eds.; Wiley-VCH: Weinheim, Germany, 2006; Chapter 2, pp 29-65.
-
(2006)
Chirality in Drug Research
, pp. 29-65
-
-
Federsel, H.-J.1
-
32
-
-
0002164532
-
The chiral switch of (S)-metolachlor: A personal account of an industrial Odyssey in asymmetric catalysis
-
(a) Blaser, H.-U. The chiral switch of (S)-metolachlor: A personal account of an industrial Odyssey in asymmetric catalysis. Adv. Synth. Catal. 2002, 344 (1), 17-31.
-
(2002)
Adv. Synth. Catal
, vol.344
, Issue.1
, pp. 17-31
-
-
Blaser, H.-U.1
-
33
-
-
33644786436
-
The chiral switch of metolachlor: The development of a large-scale enantioselective catalytic process
-
Blaser, H.-U, Schmidt, E, Eds, Wiley-VCH: Weinheim, Germany
-
(b) Blaser, H.-U.; Hanreich, R.; Schneider, H.-D.; Spindler, F.; Steinacher, B. The chiral switch of metolachlor: The development of a large-scale enantioselective catalytic process. Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions; Blaser, H.-U., Schmidt, E., Eds.; Wiley-VCH: Weinheim, Germany, 2004, pp 55-70.
-
(2004)
Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions
, pp. 55-70
-
-
Blaser, H.-U.1
Hanreich, R.2
Schneider, H.-D.3
Spindler, F.4
Steinacher, B.5
-
34
-
-
0042115562
-
An Innovative Asymmetric Sulfide Oxidation: The Process Development History Behind the New Antiulcer Agent Esomeprazole
-
Blaser, H.-U, Schmidt, E, Eds, Wiley-VCH: Weinheim, Germany
-
(a) Federsel, H.-J.; Larsson, M. An Innovative Asymmetric Sulfide Oxidation: The Process Development History Behind the New Antiulcer Agent Esomeprazole. Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions; Blaser, H.-U., Schmidt, E., Eds.; Wiley-VCH: Weinheim, Germany, 2004, pp 413-436.
-
(2004)
Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions
, pp. 413-436
-
-
Federsel, H.-J.1
Larsson, M.2
-
35
-
-
34548239125
-
Factors influencing the selectivity in asymmetric oxidation of sulfides attached to nitrogen containing heterocycles
-
(b) Seenivasaperumal, M.; Federsel, H.-J.; Ertan, A.; Szabó, K. J. Factors influencing the selectivity in asymmetric oxidation of sulfides attached to nitrogen containing heterocycles. Chem. Commun. 2007, 2187-2189.,
-
(2007)
Chem. Commun
, pp. 2187-2189
-
-
Seenivasaperumal, M.1
Federsel, H.-J.2
Ertan, A.3
Szabó, K.J.4
-
36
-
-
65249172112
-
Mechanism of the asymmetric sulfoxidation in the esomeprazole process. Effects of the imidazole backbone for the enantioselection
-
in press
-
(c) Seenivasaperumal, M.; Federsel, H.-J.; Szabó, K. J. Mechanism of the asymmetric sulfoxidation in the esomeprazole process. Effects of the imidazole backbone for the enantioselection. Adv. Synth. Catal. 2009, in press.
-
(2009)
Adv. Synth. Catal
-
-
Seenivasaperumal, M.1
Federsel, H.-J.2
Szabó, K.J.3
-
38
-
-
40849141939
-
Helping science to succeed: Improving processes in R&D
-
Sewing, A.; Winchester, T.; Carnell, P.; Hampton, D.; Keighley, W. Helping science to succeed: Improving processes in R&D. Drug Discovery Today 2008, 13 (5/6), 227-233.
-
(2008)
Drug Discovery Today
, vol.13
, Issue.5-6
, pp. 227-233
-
-
Sewing, A.1
Winchester, T.2
Carnell, P.3
Hampton, D.4
Keighley, W.5
-
39
-
-
46849091140
-
Research initiatives to support science-based pharmaceutical manufacturing
-
Romañach, R. J. Research initiatives to support science-based pharmaceutical manufacturing. Pharm. Technol. Eur. 2007, 19 (10), 47-51.
-
(2007)
Pharm. Technol. Eur
, vol.19
, Issue.10
, pp. 47-51
-
-
Romañach, R.J.1
-
40
-
-
33746908147
-
Critical assessment of pharmaceutical processes - A rationale for changing the synthetic route
-
Butters, M.; Catterick, D.; Craig, A.; Curzons, A.; Dale, D.; Gillmore, A.; Green, S. P.; Marziano, I.; Sherlock, J.-P.; White, W. Critical assessment of pharmaceutical processes - A rationale for changing the synthetic route. Chem. Rev. 2006, 106 (7), 3002-3027.
-
(2006)
Chem. Rev
, vol.106
, Issue.7
, pp. 3002-3027
-
-
Butters, M.1
Catterick, D.2
Craig, A.3
Curzons, A.4
Dale, D.5
Gillmore, A.6
Green, S.P.7
Marziano, I.8
Sherlock, J.-P.9
White, W.10
-
41
-
-
0036736355
-
Origins, current status, and future challenges of green chemistry
-
Anastas, P. T.; Kirchhoff, M. M. Origins, current status, and future challenges of green chemistry. Acc. Chem. Res. 2002, 35 (9), 686-694.
-
(2002)
Acc. Chem. Res
, vol.35
, Issue.9
, pp. 686-694
-
-
Anastas, P.T.1
Kirchhoff, M.M.2
-
42
-
-
0026418434
-
The atom economy - a search for synthetic efficiency
-
(a) Trost, B. M. The atom economy - a search for synthetic efficiency. Science 1991, 254 (5037), 1471-1477.
-
(1991)
Science
, vol.254
, Issue.5037
, pp. 1471-1477
-
-
Trost, B.M.1
-
43
-
-
0036739952
-
On inventing reactions for atom economy
-
(b) Trost, B. M. On inventing reactions for atom economy. Acc. Chem. Res. 2002, 35 (9), 695-705.
-
(2002)
Acc. Chem. Res
, vol.35
, Issue.9
, pp. 695-705
-
-
Trost, B.M.1
-
44
-
-
75149121105
-
-
Anastas, P. T.; Zimmerman, J. B. The twelve principles of green engineering as a foundation for sustainability. In Sustainability Science and Engineering 1: Defining principles; Abraham, M. A., Ed.; Elsevier: Amsterdam, 2006; 1, Chapter 2, pp 11-32.
-
(a) Anastas, P. T.; Zimmerman, J. B. The twelve principles of green engineering as a foundation for sustainability. In Sustainability Science and Engineering Volume 1: Defining principles; Abraham, M. A., Ed.; Elsevier: Amsterdam, 2006; Vol 1, Chapter 2, pp 11-32.
-
-
-
-
45
-
-
52749083381
-
From vision to action
-
1/2
-
(b) Mours, M. SusChem: From vision to action. ChemSusChem 2008, 1 (1/2), 59-62.
-
(2008)
ChemSusChem
, vol.1
, pp. 59-62
-
-
Mours, M.S.1
-
46
-
-
84882150356
-
-
Federsel, H.-J.; Sveno, A. To overcome the hurdles: coping with the synthesis of robalzotan, a complex chroman antidepressant. Process Chemistry in the Pharmaceutical Industry, 2, Challenges in an Ever Changing Climate; Gadamasetti, K.; Braish, T. F., Eds.; CRC Press: Boca Raton, FL, 2008; Chapter 7, pp 111-135.
-
Federsel, H.-J.; Sveno, A. To overcome the hurdles: coping with the synthesis of robalzotan, a complex chroman antidepressant. Process Chemistry in the Pharmaceutical Industry, Vol. 2, Challenges in an Ever Changing Climate; Gadamasetti, K.; Braish, T. F., Eds.; CRC Press: Boca Raton, FL, 2008; Chapter 7, pp 111-135.
-
-
-
-
47
-
-
0035817076
-
Increase in intricacy - a tool for evaluating organic syntheses
-
Fuchs, P. L. Increase in intricacy - a tool for evaluating organic syntheses. Tetrahedron 2001, 57 (32), 6855-6875.
-
(2001)
Tetrahedron
, vol.57
, Issue.32
, pp. 6855-6875
-
-
Fuchs, P.L.1
-
48
-
-
53749090735
-
Continuous flow reactors, a tool for the modern synthetic chemist
-
Wiles, C.; Watts, P. Continuous flow reactors, a tool for the modern synthetic chemist. Eur. J. Org. Chem. 2008, 1655-1671.
-
(2008)
Eur. J. Org. Chem
, pp. 1655-1671
-
-
Wiles, C.1
Watts, P.2
-
49
-
-
0037358014
-
-
Ainge, D.; Ennis, D.; Gidlund, M.; Stefinovic, M.; Vaz, L.-M. Rapid development of an enantioselective synthesis of (R)-1-hydroxy-7-methoxy- 1,2,3,4-tetrahvdronaDhthalene-1-carboxvlic acid. Org. Process Res. Dev. 2003, 7(2), 198-201.
-
Ainge, D.; Ennis, D.; Gidlund, M.; Stefinovic, M.; Vaz, L.-M. Rapid development of an enantioselective synthesis of (R)-1-hydroxy-7-methoxy- 1,2,3,4-tetrahvdronaDhthalene-1-carboxvlic acid. Org. Process Res. Dev. 2003, 7(2), 198-201.
-
-
-
-
51
-
-
44649166965
-
The use of routine process capability for the determination of process parameter criticality in small-molecule API synthesis
-
Seibert, K. D.; Sethuraman, S.; Mitchell, J. D.; Griffiths, K. L.; McGarvey, B. The use of routine process capability for the determination of process parameter criticality in small-molecule API synthesis. J. Pharm. Innovation 2008, 3, 105-112.
-
(2008)
J. Pharm. Innovation
, vol.3
, pp. 105-112
-
-
Seibert, K.D.1
Sethuraman, S.2
Mitchell, J.D.3
Griffiths, K.L.4
McGarvey, B.5
|