메뉴 건너뛰기




Volumn 42, Issue 5, 2009, Pages 671-680

Chemical process research and development in the 21st century: Challenges, strategies, and solutions from a pharmaceutical industry perspective

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHEMICAL STRUCTURE; DRUG INDUSTRY; METHODOLOGY;

EID: 66149123969     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar800257v     Document Type: Article
Times cited : (72)

References (51)
  • 6
    • 0036884563 scopus 로고    scopus 로고
    • Start small, think big - The art of process R&D
    • (f) Federsel, H.-J. Start small, think big - The art of process R&D. Nat. Rev. Drug Discovery 2001, 1 (12), 1013.
    • (2001) Nat. Rev. Drug Discovery , vol.1 , Issue.12 , pp. 1013
    • Federsel, H.-J.1
  • 7
    • 0042067947 scopus 로고    scopus 로고
    • Logistics of process R&D: Transforming laboratory methods to manufacturing scale
    • (g) Federsel, H.-J. Logistics of process R&D: Transforming laboratory methods to manufacturing scale. Nat. Rev. Drug Discovery 2003, 2(8), 654-664.
    • (2003) Nat. Rev. Drug Discovery , vol.2 , Issue.8 , pp. 654-664
    • Federsel, H.-J.1
  • 8
    • 33746889033 scopus 로고    scopus 로고
    • Process Chemistry
    • Guest Editors, 7
    • (h) Lipton, M. F.; Barrett, A. G. M., Guest Editors, Process Chemistry, Chem. Rev. 2006, 106 (7), 2581-3027.
    • (2006) Chem. Rev , vol.106 , pp. 2581-3027
  • 11
    • 66149124545 scopus 로고    scopus 로고
    • Org. Process Res. Dev.; Laird, T., Ed.; this journal is entirely devoted to publishing work from the process R&D arena since 1997; see journal homepage http://pubs.acs.org/journal/oprdfk/.
    • (k) Org. Process Res. Dev.; Laird, T., Ed.; this journal is entirely devoted to publishing work from the process R&D arena since 1997; see journal homepage http://pubs.acs.org/journal/oprdfk/.
  • 12
    • 33645733070 scopus 로고    scopus 로고
    • The integration of process R&D in drug discovery - Challenges and opportunities
    • (a) Federsel, H.-J. The integration of process R&D in drug discovery - Challenges and opportunities. Comb. Chem. High Throughout Screening 2006, 9(2), 79-86.
    • (2006) Comb. Chem. High Throughout Screening , vol.9 , Issue.2 , pp. 79-86
    • Federsel, H.-J.1
  • 13
    • 64349088801 scopus 로고    scopus 로고
    • Strategy and Drug Research; Moos, W. H, Ed, Elsevier: Oxford, U.K
    • (b) Comprehensive Medicinal Chemistry II, Vol. 2, Strategy and Drug Research; Moos, W. H., Ed.; Elsevier: Oxford, U.K., 2007.
    • (2007) Comprehensive Medicinal Chemistry II , vol.2
  • 14
    • 39649084919 scopus 로고    scopus 로고
    • The FDA critical path initiative and its influence on new drug development
    • (c) Woodcock, J.; Woosley, R. The FDA critical path initiative and its influence on new drug development. Annu. Rev. Med 2008, 59, 1-12.
    • (2008) Annu. Rev. Med , vol.59 , pp. 1-12
    • Woodcock, J.1    Woosley, R.2
  • 15
    • 51349158805 scopus 로고    scopus 로고
    • Handing over the baton: Connecting medicinal chemistry with process R&D
    • (d) Federsel, H.-J. Handing over the baton: Connecting medicinal chemistry with process R&D. Drug News Perspect. 2008, 21 (4), 193-199.
    • (2008) Drug News Perspect , vol.21 , Issue.4 , pp. 193-199
    • Federsel, H.-J.1
  • 16
    • 0034345196 scopus 로고    scopus 로고
    • Development of a process for a chiral aminochroman antidepressant: A case story
    • Federsel, H.-J. Development of a process for a chiral aminochroman antidepressant: A case story. Org. Process Res. Dev. 2000, 4 (5), 362-369.
    • (2000) Org. Process Res. Dev , vol.4 , Issue.5 , pp. 362-369
    • Federsel, H.-J.1
  • 17
    • 0035341789 scopus 로고    scopus 로고
    • Drug discoverers - you need us
    • (a) Federsel, H.-J. Drug discoverers - you need us. Drug Discovery Todav 2001, 6 (8), 397-398.
    • (2001) Drug Discovery Todav , vol.6 , Issue.8 , pp. 397-398
    • Federsel, H.-J.1
  • 18
    • 2942716691 scopus 로고    scopus 로고
    • The role of process R&D in drug discovery - Evolution of an interface
    • (b) Federsel, H.-J. The role of process R&D in drug discovery - Evolution of an interface. Chim. Oggi/Chem. Todav 2004, 22 (3/4), 9-12.
    • (2004) Chim. Oggi/Chem. Todav , vol.22 , Issue.3-4 , pp. 9-12
    • Federsel, H.-J.1
  • 19
    • 13844271915 scopus 로고    scopus 로고
    • Timely synthetic support for medicinal chemists
    • (c) Potoski, J. Timely synthetic support for medicinal chemists. Drug Discovery Today 2005, 10 (2), 115-120.
    • (2005) Drug Discovery Today , vol.10 , Issue.2 , pp. 115-120
    • Potoski, J.1
  • 20
    • 33750217203 scopus 로고    scopus 로고
    • In search of sustainability: Process R&D in light of current pharmaceutical industry challenges
    • Federsel, H.-J. In search of sustainability: Process R&D in light of current pharmaceutical industry challenges. Drug Discovery Today 2006, 11 (21/22), 966-974.
    • (2006) Drug Discovery Today , vol.11 , Issue.21-22 , pp. 966-974
    • Federsel, H.-J.1
  • 21
    • 33745079610 scopus 로고    scopus 로고
    • Analysis of the reactions used for the preparation of drug candidate molecules
    • Carey, J. S.; Laffan, D.; Thomson, C.; Williams, M. T. Analysis of the reactions used for the preparation of drug candidate molecules. Org. Biomol. Chem. 2006, 4(12), 2337-2347.
    • (2006) Org. Biomol. Chem , vol.4 , Issue.12 , pp. 2337-2347
    • Carey, J.S.1    Laffan, D.2    Thomson, C.3    Williams, M.T.4
  • 22
    • 0002312023 scopus 로고
    • Drug chirality - scale-up manufacturing, and control
    • (a) Federsel, H.-J. Drug chirality - scale-up manufacturing, and control. CHEMTECH 1993, 23 (12), 24-33.
    • (1993) CHEMTECH , vol.23 , Issue.12 , pp. 24-33
    • Federsel, H.-J.1
  • 23
    • 0041663784 scopus 로고    scopus 로고
    • Facing chirality in the 21st century: Approaching the challenges in the pharmaceutical industry
    • (b) Federsel, H.-J. Facing chirality in the 21st century: Approaching the challenges in the pharmaceutical industry. Chirality 2003, 15 (S1), S128-S142.
    • (2003) Chirality , vol.15 , Issue.S1
    • Federsel, H.-J.1
  • 24
    • 0347719507 scopus 로고    scopus 로고
    • Searching for scalable processes: Addressing the challenge in times of increasing complexity
    • (c) Federsel, H.-J. Searching for scalable processes: Addressing the challenge in times of increasing complexity. Curr. Opin. Drug Discovery Dev. 2003, 6(6), 838-847.
    • (2003) Curr. Opin. Drug Discovery Dev , vol.6 , Issue.6 , pp. 838-847
    • Federsel, H.-J.1
  • 26
    • 38049056138 scopus 로고    scopus 로고
    • Chiral Drug Discovery and Development - From Concept Stage to Market Launch
    • Strategy and Drug Research; Moos, W. H, Ed, Elsevier: Oxford, U.K, Chapter 2.17, pp
    • (e) Federsel, H.-J. Chiral Drug Discovery and Development - From Concept Stage to Market Launch. Comprehensive Medicinal Chemistry II, Vol. 2, Strategy and Drug Research; Moos, W. H., Ed.; Elsevier: Oxford, U.K., 2007; Chapter 2.17, pp 713-736.
    • (2007) Comprehensive Medicinal Chemistry II , vol.2 , pp. 713-736
    • Federsel, H.-J.1
  • 27
    • 0035560855 scopus 로고    scopus 로고
    • Enantioselective catalysis in fine chemicals production
    • (a) Blaser, H.-U.; Spindler, F.; Studer, M. Enantioselective catalysis in fine chemicals production. APPL. Catal. A 2001, 221 (1-2), 119-143.,
    • (2001) APPL. Catal. A , vol.221 , Issue.1-2 , pp. 119-143
    • Blaser, H.-U.1    Spindler, F.2    Studer, M.3
  • 28
    • 23844489138 scopus 로고    scopus 로고
    • Asymmetry on large scale: The roadmap to stereoselective processes
    • (b) Federsel, H.-J. Asymmetry on large scale: The roadmap to stereoselective processes. Nat. Rev. Drug Discovery 2005, 4 (8), 685-697.
    • (2005) Nat. Rev. Drug Discovery , vol.4 , Issue.8 , pp. 685-697
    • Federsel, H.-J.1
  • 30
    • 14844293909 scopus 로고    scopus 로고
    • Progress in enantioselective catalysis assessed from an industrial point of view
    • (d) Blaser, H.-U.; Pugin, B.; Spindler, F. Progress in enantioselective catalysis assessed from an industrial point of view. J. Mol. Catal. A: Chem. 2005, 231 (1-2), 1-20.
    • (2005) J. Mol. Catal. A: Chem , vol.231 , Issue.1-2 , pp. 1-20
    • Blaser, H.-U.1    Pugin, B.2    Spindler, F.3
  • 31
    • 85018200009 scopus 로고    scopus 로고
    • Stereoselective Synthesis of Drugs - An Industrial Perspective
    • Francotte, E, Lindner, W, Eds, Wiley-VCH: Weinheim, Germany, Chapter 2, pp
    • (e) Federsel, H.-J. Stereoselective Synthesis of Drugs - An Industrial Perspective. In Chirality in Drug Research; Francotte, E., Lindner, W., Eds.; Wiley-VCH: Weinheim, Germany, 2006; Chapter 2, pp 29-65.
    • (2006) Chirality in Drug Research , pp. 29-65
    • Federsel, H.-J.1
  • 32
    • 0002164532 scopus 로고    scopus 로고
    • The chiral switch of (S)-metolachlor: A personal account of an industrial Odyssey in asymmetric catalysis
    • (a) Blaser, H.-U. The chiral switch of (S)-metolachlor: A personal account of an industrial Odyssey in asymmetric catalysis. Adv. Synth. Catal. 2002, 344 (1), 17-31.
    • (2002) Adv. Synth. Catal , vol.344 , Issue.1 , pp. 17-31
    • Blaser, H.-U.1
  • 34
    • 0042115562 scopus 로고    scopus 로고
    • An Innovative Asymmetric Sulfide Oxidation: The Process Development History Behind the New Antiulcer Agent Esomeprazole
    • Blaser, H.-U, Schmidt, E, Eds, Wiley-VCH: Weinheim, Germany
    • (a) Federsel, H.-J.; Larsson, M. An Innovative Asymmetric Sulfide Oxidation: The Process Development History Behind the New Antiulcer Agent Esomeprazole. Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions; Blaser, H.-U., Schmidt, E., Eds.; Wiley-VCH: Weinheim, Germany, 2004, pp 413-436.
    • (2004) Asymmetric Catalysis on Industrial Scale. Challenges, Approaches and Solutions , pp. 413-436
    • Federsel, H.-J.1    Larsson, M.2
  • 35
    • 34548239125 scopus 로고    scopus 로고
    • Factors influencing the selectivity in asymmetric oxidation of sulfides attached to nitrogen containing heterocycles
    • (b) Seenivasaperumal, M.; Federsel, H.-J.; Ertan, A.; Szabó, K. J. Factors influencing the selectivity in asymmetric oxidation of sulfides attached to nitrogen containing heterocycles. Chem. Commun. 2007, 2187-2189.,
    • (2007) Chem. Commun , pp. 2187-2189
    • Seenivasaperumal, M.1    Federsel, H.-J.2    Ertan, A.3    Szabó, K.J.4
  • 36
    • 65249172112 scopus 로고    scopus 로고
    • Mechanism of the asymmetric sulfoxidation in the esomeprazole process. Effects of the imidazole backbone for the enantioselection
    • in press
    • (c) Seenivasaperumal, M.; Federsel, H.-J.; Szabó, K. J. Mechanism of the asymmetric sulfoxidation in the esomeprazole process. Effects of the imidazole backbone for the enantioselection. Adv. Synth. Catal. 2009, in press.
    • (2009) Adv. Synth. Catal
    • Seenivasaperumal, M.1    Federsel, H.-J.2    Szabó, K.J.3
  • 39
    • 46849091140 scopus 로고    scopus 로고
    • Research initiatives to support science-based pharmaceutical manufacturing
    • Romañach, R. J. Research initiatives to support science-based pharmaceutical manufacturing. Pharm. Technol. Eur. 2007, 19 (10), 47-51.
    • (2007) Pharm. Technol. Eur , vol.19 , Issue.10 , pp. 47-51
    • Romañach, R.J.1
  • 41
    • 0036736355 scopus 로고    scopus 로고
    • Origins, current status, and future challenges of green chemistry
    • Anastas, P. T.; Kirchhoff, M. M. Origins, current status, and future challenges of green chemistry. Acc. Chem. Res. 2002, 35 (9), 686-694.
    • (2002) Acc. Chem. Res , vol.35 , Issue.9 , pp. 686-694
    • Anastas, P.T.1    Kirchhoff, M.M.2
  • 42
    • 0026418434 scopus 로고
    • The atom economy - a search for synthetic efficiency
    • (a) Trost, B. M. The atom economy - a search for synthetic efficiency. Science 1991, 254 (5037), 1471-1477.
    • (1991) Science , vol.254 , Issue.5037 , pp. 1471-1477
    • Trost, B.M.1
  • 43
    • 0036739952 scopus 로고    scopus 로고
    • On inventing reactions for atom economy
    • (b) Trost, B. M. On inventing reactions for atom economy. Acc. Chem. Res. 2002, 35 (9), 695-705.
    • (2002) Acc. Chem. Res , vol.35 , Issue.9 , pp. 695-705
    • Trost, B.M.1
  • 44
    • 75149121105 scopus 로고    scopus 로고
    • Anastas, P. T.; Zimmerman, J. B. The twelve principles of green engineering as a foundation for sustainability. In Sustainability Science and Engineering 1: Defining principles; Abraham, M. A., Ed.; Elsevier: Amsterdam, 2006; 1, Chapter 2, pp 11-32.
    • (a) Anastas, P. T.; Zimmerman, J. B. The twelve principles of green engineering as a foundation for sustainability. In Sustainability Science and Engineering Volume 1: Defining principles; Abraham, M. A., Ed.; Elsevier: Amsterdam, 2006; Vol 1, Chapter 2, pp 11-32.
  • 45
    • 52749083381 scopus 로고    scopus 로고
    • From vision to action
    • 1/2
    • (b) Mours, M. SusChem: From vision to action. ChemSusChem 2008, 1 (1/2), 59-62.
    • (2008) ChemSusChem , vol.1 , pp. 59-62
    • Mours, M.S.1
  • 46
    • 84882150356 scopus 로고    scopus 로고
    • Federsel, H.-J.; Sveno, A. To overcome the hurdles: coping with the synthesis of robalzotan, a complex chroman antidepressant. Process Chemistry in the Pharmaceutical Industry, 2, Challenges in an Ever Changing Climate; Gadamasetti, K.; Braish, T. F., Eds.; CRC Press: Boca Raton, FL, 2008; Chapter 7, pp 111-135.
    • Federsel, H.-J.; Sveno, A. To overcome the hurdles: coping with the synthesis of robalzotan, a complex chroman antidepressant. Process Chemistry in the Pharmaceutical Industry, Vol. 2, Challenges in an Ever Changing Climate; Gadamasetti, K.; Braish, T. F., Eds.; CRC Press: Boca Raton, FL, 2008; Chapter 7, pp 111-135.
  • 47
    • 0035817076 scopus 로고    scopus 로고
    • Increase in intricacy - a tool for evaluating organic syntheses
    • Fuchs, P. L. Increase in intricacy - a tool for evaluating organic syntheses. Tetrahedron 2001, 57 (32), 6855-6875.
    • (2001) Tetrahedron , vol.57 , Issue.32 , pp. 6855-6875
    • Fuchs, P.L.1
  • 48
    • 53749090735 scopus 로고    scopus 로고
    • Continuous flow reactors, a tool for the modern synthetic chemist
    • Wiles, C.; Watts, P. Continuous flow reactors, a tool for the modern synthetic chemist. Eur. J. Org. Chem. 2008, 1655-1671.
    • (2008) Eur. J. Org. Chem , pp. 1655-1671
    • Wiles, C.1    Watts, P.2
  • 49
    • 0037358014 scopus 로고    scopus 로고
    • Ainge, D.; Ennis, D.; Gidlund, M.; Stefinovic, M.; Vaz, L.-M. Rapid development of an enantioselective synthesis of (R)-1-hydroxy-7-methoxy- 1,2,3,4-tetrahvdronaDhthalene-1-carboxvlic acid. Org. Process Res. Dev. 2003, 7(2), 198-201.
    • Ainge, D.; Ennis, D.; Gidlund, M.; Stefinovic, M.; Vaz, L.-M. Rapid development of an enantioselective synthesis of (R)-1-hydroxy-7-methoxy- 1,2,3,4-tetrahvdronaDhthalene-1-carboxvlic acid. Org. Process Res. Dev. 2003, 7(2), 198-201.
  • 51
    • 44649166965 scopus 로고    scopus 로고
    • The use of routine process capability for the determination of process parameter criticality in small-molecule API synthesis
    • Seibert, K. D.; Sethuraman, S.; Mitchell, J. D.; Griffiths, K. L.; McGarvey, B. The use of routine process capability for the determination of process parameter criticality in small-molecule API synthesis. J. Pharm. Innovation 2008, 3, 105-112.
    • (2008) J. Pharm. Innovation , vol.3 , pp. 105-112
    • Seibert, K.D.1    Sethuraman, S.2    Mitchell, J.D.3    Griffiths, K.L.4    McGarvey, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.