Functional topography of respiratory, cardiovascular and pontine-wave responses to glutamate microstimulation of the pedunculopontine tegmentum of the rat

Respiratory Physiology and Neurobiology

Volumn 173, Issue 1, 2010, Pages 64-70

  Topchiy, Irina ^a,c   Waxman, Jonathan ^a,b   Radulovacki, Miodrag ^a   Carley, David W ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Illinois at Chicago   (United States)

^c SOUTHERN FEDERAL UNIVERSITY   (Russian Federation)

Author keywords

Apnea; Functional anatomy; Pedunculopontine tegmentum; Sleep

Indexed keywords

GLUTAMIC ACID;

ANIMAL EXPERIMENT; APNEA; ARTICLE; CARDIOVASCULAR FUNCTION; CHOLINERGIC NERVE CELL; ELECTROMYOGRAM; HISTOPATHOLOGY; HYPERTENSION; MALE; NONHUMAN; P WAVE; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PRIORITY JOURNAL; RAT; RESPIRATORY FUNCTION; SINUS TACHYCARDIA; STIMULATION; TACHYPNEA; TOPOGRAPHY;

ANIMALS; APNEA; BLOOD PRESSURE; BRAIN MAPPING; CARDIOVASCULAR DISEASES; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GLUTAMIC ACID; HEART RATE; MALE; MICROINJECTIONS; NADPH DEHYDROGENASE; NEURAL PATHWAYS; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; PONS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RESPIRATION; SLEEP DISORDERS;

EID: 77955471184     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.06.006     Document Type: Article

References (43)

1. Alderson H.L., Latimer M.P., Winn P. A functional dissociation of the anterior and posterior pedunculopontine tegmental nucleus: excitotoxic lesions have differential effects on locomotion and the response to nicotine. Brain Struct. Funct. 2008, 213:247-253.
2. Andero R., Torras-Garcia M., Quiroz-Padilla M.F., Costa-Miserachs D., Coll-Andreu M. Electrical stimulation of the pedunculopontine tegmental nucleus in freely moving awake rats: time- and site-specific effects on two-way active avoidance conditioning. Neurobiol. Learn. Mem. 2007, 87:510-521.
3. Calvo J.M., Datta S., Quattrochi J., Hobson J.A. Cholinergic microstimulation of the peribrachial nucleus in the cat. II. Delayed and prolonged increases in REM sleep. Arch. Ital. Biol. 1992, 130:285-301.
4. Carley D.W., Radulovacki M. REM sleep and apnea. Rapid Eye Movement Sleep 1999, 286-300. Narosa Publishing, New Delhi. B.N. Mallik, S. Inoue (Eds.).
5. Chamberlin N.L., Saper C.B. Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J. Neurosci. 1994, 14:6500-6510.
6. Datta S. Cellular basis of pontine ponto-geniculo-occipital wave generation and modulation. Cell. Mol. Neurobiol. 1997, 17:341-365.
7. Datta S., Calvo J.M., Quattrochi J.J., Hobson J.A. Long-term enhancement of REM sleep following cholinergic stimulation. Neuroreport 1991, 2:619-622.
8. Datta S., Hobson J.A. Suppression of ponto-geniculo-occipital waves by neurotoxic lesions of pontine caudo-lateral peribrachial cells. Neuroscience 1995, 67:703-712.
9. Datta S., Patterson E.H., Spoley E.E. Excitation of the pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat. J. Neurosci. Res. 2001, 66:109-116.
10. Datta S., Siwek D.F. Excitation of the brain stem pedunculopontine tegmentum cholinergic cells induces wakefulness and REM sleep. J. Neurophysiol. 1997, 77:2975-2988.
11. Datta S., Spoley E.E., Patterson E.H. Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 280:R752-759.
12. Dick T.E., Coles S.K. Ventrolateral pons mediates short-term depression of respiratory frequency after brief hypoxia. Respir. Physiol. 2000, 121:87-100.
13. Garcia-Rill E. The pedunculopontine nucleus. Prog. Neurobiol. 1991, 36:363-389.
14. Gilbert K.A., Lydic R. Cholinergic reticular mechanisms produce state-dependent decreases in parabrachial respiratory neuron discharge. Neurosci. Abstr. 1991, 17:620.
15. Henriksen S.J., Jacobs B.L., Dement W.C. Dependence of REM sleep PGO waves on cholinergic mechanisms. Brain Res. 1972, 48:412-416.
16. Herbert H., Moga M.M., Saper C.B. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J. Comp. Neurol. 1990, 293:540-580.
17. Honda T., Semba K. An ultrastructural study of cholinergic and non-cholinergic neurons in the laterodorsal and pedunculopontine tegmental nuclei in the rat. Neuroscience 1995, 68:837-853.
18. Lavoie B., Parent A. Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra. J. Comp. Neurol. 1994, 344:232-241.
19. Lavoie B., Parent A. Pedunculopontine nucleus in the squirrel monkey: distribution of cholinergic and monoaminergic neurons in the mesopontine tegmentum with evidence for the presence of glutamate in cholinergic neurons. J. Comp. Neurol. 1994, 344:190-209.
20. Lydic R., Baghdoyan H.A. Pedunculopontine stimulation alters respiration and increases ACh release in the pontine reticular formation. Am. J. Physiol. 1993, 264:R544-R554.
21. Nicholson C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res. 1985, 333:325-329.
22. Oakman S.A., Faris P.L., Kerr P.E., Cozzari C., Hartman B.K. Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J. Neurosci. 1995, 15:5859-5869.
23. Olszewski J., Baxter D. Cytoarchitecture of the Human Brainstem 1954, Lippincott Company, Philadelphia, Montreal. J.B. Karger (Ed.).
24. Padley J.R., Kumar N.N., Li Q., Nguyen T.B., Pilowsky P.M., Goodchild A.K. Central command regulation of circulatory function mediated by descending pontine cholinergic inputs to sympathoexcitatory rostral ventrolateral medulla neurons. Circ. Res. 2007, 100:284-291.
25. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2004, Academic Press, Sydney/New York.
26. Quattrochi J., Datta S., Hobson J.A. Cholinergic and non-cholinergic afferents of the caudolateral parabrachial nucleus: a role in the long-term enhancement of rapid eye movement sleep. Neuroscience 1998, 8:1123-1136.
27. Radulovacki M., Pavlovic S., Saponjic J., Carley D.W. Modulation of reflex and sleep related apnea by pedunculopontine tegmental and intertrigeminal neurons. Respir. Physiol. Neurobiol. 2004, 143:293-306.
28. Reese N.B., Garcia-Rill E., Skinner R.D. The pedunculopontine nucleus-auditory input, arousal and pathophysiology. Prog. Neurobiol. 1995, 47:105-133.
29. Rostron C.L., Farquhar M.J., Latimer M.P., Winn P. The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: do both have a role in sustained attention?. BMC Neurosci. 2008, 9:16.
30. Rukhadze I., Kubin L. Mesopontine cholinergic projections to the hypoglossal motor nucleus. Neurosci. Lett. 2007, 413:121-125.
31. Rye D.B. Contributions of the pedunculopontine region to normal and altered REM sleep. Sleep 1997, 20:757-788.
32. Rye D.B., Saper C.B., Lee H.J., Wainer B.H. Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J. Comp. Neurol. 1987, 259:483-528.
33. Saponjic J., Cvorovic J., Radulovacki M., Carley D.W. Serotonin and noradrenaline modulate respiratory pattern disturbances evoked by glutamate injection into the pedunculopontine tegmentum of anesthetized rats. Sleep 2005, 28:560-570.
34. Saponjic J., Radulovacki M., Carley D.W. Respiratory pattern modulation by the pedunculopontine tegmental nucleus. Respir. Physiol. Neurobiol. 2003, 138:223-237.
35. Saponjic J., Radulovacki M., Carley D.W. Modulation of respiratory pattern and upper airway muscle activity by the pedunculopontine tegmentum: role of NMDA receptors. Sleep Breath. 2006, 10:195-202.
36. Semba K., Fibiger H.C. Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the rat: a retro- and antero-grade transport and immunohistochemical study. J. Comp. Neurol. 1992, 323:387-410.
37. Shouse M.N., Siegel J.M. Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep. Brain Res. 1992, 571:50-63.
38. Steriade M., McCarley R.W. Brainstem Control of Wakefulness and Sleep 1990, Plenum Press, New York.
39. Takakusaki K., Shiroyama T., Yamamoto T., Kitai S.T. Cholinergic and noncholinergic tegmental pedunculopontine projection neurons in rats revealed by intracellular labeling. J. Comp. Neurol. 1996, 371:345-361.
40. Takayama K., Miura M. Respiratory responses to microinjection of excitatory amino acid agonists in ventrolateral regions of the lateral parabrachial nucleus in the cat. Brain Res. 1993, 604:217-223.
41. Vertes R.P., Colom L.V., Fortin W.J., Bland B.H. Brainstem sites for the carbachol elicitation of the hippocampal theta rhythm in the rat. Expl. Brain Res. 1993, 96:419-429.
42. Winn P. How best to consider the structure and function of the pedunculopontine tegmental nucleus: evidence from animal studies. J. Neurol. Sci. 2006, 248:234-250.
43. Yasui Y., Cechetto D.F., Saper C.B. Evidence for a cholinergic projection from the pedunculopontine tegmental nucleus to the rostral ventrolateral medulla in the rat. Brain Res. 1990, 517:19-24.