Ventrolateral pons mediates short-term depression of respiratory frequency after brief hypoxia

Respiration Physiology

Volumn 121, Issue 2-3, 2000, Pages 87-100

  Dick, Thomas E ^a   Coles, Sharon K ^b  

^a Div Pulmon and Critical Care Med   (United States)

^b Div Basic Biomed Sci Univ S D   (United States)

Author keywords

Control of breathing, hypoxia; Hypoxia, dynamic ventilatory response; Mammals, rat; Respiratory frequency, short term depression, post hypoxic frequency decline; Ventrolateral pons, hypoxic response

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DIZOCILPINE; EXCITATORY AMINO ACID; GLUTAMIC ACID; GUANABENZ; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; BREATHING PATTERN; HYPOXIA; MEDULLA OBLONGATA; NONHUMAN; PONS; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; REVIEW; TIDAL VOLUME;

EID: 0033837358     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(00)00121-3     Document Type: Article

References (36)

1. Andresen M.C., Yang M.Y. Non-NMDA receptors mediate synaptic transmission in mNTS. Am. J. Physiol. 259:1990;H1307-H1311.
2. 2-adrenoreceptor antagonism. Brain Res. 817:1999;25-33.
3. Bolme P., Fuxe K. Pharmacological studies on a possible role of central noradrenaline neurons in respiratory control. J. Pharm. Pharmacol. 25:1973;351-352.
4. Chamberlin N.L., Saper C.B. Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J. Neurosci. 14:1994;6500-6510.
5. Chamberlin N.L., Saper C.B. A brainstem network mediating apneic reflexes in the rat. J. Neurosci. 18:1998;6048-6056.
6. Clark F.S., von Euler C. On the regulation of depth and rate of breathing. J. Physiol. Lond. 222:1972;267-295.
7. Coles S.K., Dick T.E. Neurones in the ventrolateral pons are required for post-hypoxic frequency decline in rats. J. Physiol. Lond. 497:1996;79-94.
8. Coles, S.K., Dick, T.E. Dorsolateral pons modulates the respiratory response to hypoxia in rats: comparison with the ventrolateral pons. Submitted for publication.
9. 2-adrenergic receptors in the adult rat. Brain Res. 794:1998;267-273.
10. Coles S.K., Ernsberger P., Dick T.E. A role for NMDA receptors in posthypoxic frequency decline in the rat. Am. J. Physiol. 274:1998;R1546-R1555.
11. Dick T.E., Coles S.K., Jodkowski J.S. A 'pneumotaxic centre' in the ventrolateral pons of adult rats. Trouth O., Millis R.M., Kiwull-Schöne H., Schläfke M.E. Ventral Brainstem Mechanisms and Control Functions. 1995;723-740 Marcel Dekker, New York.
12. Foutz A.S., Champagnat J., Denavit-Saubie M. Involvement of N-methyl-D-aspartate (NMDA) receptors in respiratory rhythmogenesis. Brain Res. 500:1989;199-208.
13. Freeman B.K., Kunze D.L., Coles S.K., Dick T.E. Carotid body afferents terminate on nTS neurons project to the ventrolateral pons. FASEB J. 14:2000;A392.
14. Guyenet P.G., Koshiya N., Huangfu D., Verberne A.J.M., Riley T.A. Central respiratory control of A5 and A6 pontine noradrenergic neurons. Am. J. Physiol. 264:1993;R1035-R1044.
15. Haxhiu M.A., Strohl K.P., Cherniack N.S. The N-methyl-D-aspartate receptor pathway is involved in hypoxia-induced c-Fos protein expression in the rat nucleus of the solitary tract. J. Auton. Nerv. Syst. 55:1995;65-68.
16. Hayashi F., Coles S.K., Bach K.B., Mitchell G.S., McCrimmon D.R. Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats. Am. J. Physiol. 265:1993;R811-R819.
17. 2-adrenoceptors in awake and anesthetized goats. J. Appl. Physiol. 77:1994;742-750.
18. Hilaire G., Monteau R., Errchidi S. Possible modulation of the medullary respiratory rhythm generator by the noradrenergic A5 area: an in vitro study in the newborn rat. Brain Res. 485:1989;325-332.
19. Hilaire G., Monteau R., Errchidi S., Morin D., Cottel-Emard J.M. Noradrenergic modulation of the medullary respiratory rhythm generator by the pontine A5 area. Speck D.F., Dekin M.S., Revelette W.R., Frazier D.T. Respiratory Control: Central and Peripheral Mechanisms. 1993;43-46 The University Press of Kentucky, Lexington, KY.
20. Jodkowski J.S., Coles S.K., Dick T.E. A 'pneumotaxic centre' in rats. Neurosci. Lett. 172:1994;67-72.
21. Jodkowski J.S., Coles S.K., Dick T.E. Prolongation in expiration evoked from ventrolateral pons of adult rats. J. Appl. Physiol. 82:1997;377-381.
22. Koshiya N., Guyenet P.G. Role of the pons in the carotid sympathetic chemoreflex. Am. J. Physiol. 267:1994;R508-R518.
23. Koshiya N., Guyenet P.G. A5 noradrenergic neurons and the carotid sympathetic chemoreflex. Am. J. Physiol. 267:1994;R519-R526.
24. Lumsden T. Observations on the respiratory centres in the cat. J. Physiol., Lond. 57:1923;153-160.
25. Mizusawa A., Ogawa H., Kikuchi Y., Hida W., Kurosawa H., Okabe S., Takishima T., Shirato K. In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J. Physiol., Lond. 478:1994;55-66.
26. Mizusawa A., Ogawa H., Kikuchi Y., Hida W., Shirato K. Role of the parabrachial nucleus in ventilatory responses of awake rats. J. Physiol., Lond. 489:1995;877-884.
27. Monteau R., Gauthier P., Rega P., Hilaire G. Effects of N-methyl-D-aspartate (NMDA) antagonist MK-801 on breathing pattern in rats. Neurosci. Lett. 109:1990;134-139.
28. Morrison S.F., Cravo S.L., Wilfehrt H.M. Pontine lesions produce apneusis in the rat. Brain Res. 652:1994;83-86.
29. Powell F.L., Milsom W.K., Mitchell G.S. Time domains of the hypoxic ventilatory response. Respir. Physiol. 112:1998;123-134.
30. Robbins P.A. Hypoxic ventilatory decline: site of action. J. Appl. Physiol. 78:1995;373-374.
31. Stella G. On the mechanism of production and the physiological significance of 'apneusis'. J. Physiol., Lond. 93:1938;10-23.
32. St. Jacques R., St. John W.M. Transient, reversible apnoea following ablation of the pre-Botzinger complex in rats. J. Physiol., Lond. 520:1999;303-314.
33. St. John W.M. Neurogenesis of patterns of automatic ventilatory activity. Prog. Neurobiol. 56:1998;97-117.
34. Vardhan A., Karchoo A., Sapru H.N. Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses. Am. J. Physiol. 264:1993;R41-R50.
35. Wagner P.G., Eldridge F.L. Development of short-term potentiation of respiration. Respir. Physiol. 83:1991;129-139.
36. Wang W., Fung M.L., St. John W.M. Pontile regulation of ventilatory activity in the adult rat. J. Appl. Physiol. 74:1993;2801-2811.