Contributions of the pedunculopontine region to normal and altered REM sleep

Sleep

Volumn 20, Issue 9, 1997, Pages 757-788

  Rye, David B ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine; Acoustic startle; Auditory evoked potentials; Basal ganglia; Midbrain extrapyramidal area; Muscarinic receptors; Narcolepsy; Neurodegenerative disease; REM sleep behavior disorder; Retrorubral field; Schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ACETYLCHOLINE; DOPAMINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MUSCARINIC RECEPTOR; SEROTONIN;

AFFECTIVE NEUROSIS; BASAL GANGLION; BRAIN STEM; CHOLINERGIC NERVE; DEGENERATIVE DISEASE; DEPRESSION; EVOKED AUDITORY RESPONSE; FOREBRAIN; GABAERGIC SYSTEM; HUMAN; NARCOLEPSY; NONHUMAN; PONS; PRIORITY JOURNAL; REM SLEEP; REVIEW; SCHIZOPHRENIA; SLEEP DISORDER; STARTLE REFLEX; TEGMENTUM;

EID: 0030666931     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/20.9.757     Document Type: Review

References (344)

1. Moruzzi G, Magoun HW. Brainstem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1949;1:455-73.
2. Scheibel ME. Scheibel AB. Structural substrates for integrative patterns in the brainstem reticular core. In: Jasper HH, Proctor LD, Knighton RS, Noshay WC, Costelo RT, eds. Reticular formation of the brain. Boston: Little Brown, 1958:31-68.
3. Ramon-Moliner E, Nauta WJH. The isodendritic core of the brain stem. J Comp Neurol 1966;126:311-36.
4. Vogel G. Studies in psychophysiology of dreams. III. The dream of narcolepsy. Arch Gen Psychiatry 1960;3:421-8.
5. Rechtschaffen A, Wolpert E, Dement W. Nocturnal sleep of narcoleptics. Electroencephalogr Clin Neurophysiol 1963;15: 599-609.
6. Dement W, Rechtschaffen A, Gulevich G. The nature of the narcoleptic sleep attack. Neurology 1966;16:18-33.
7. Hobson J, McCarley R, Wyzinski P. Sleep cycle oscillation: reciprocal discharge by two brain stem neuronal groups. Science 1975;189:55-8.
8. Steriade M, McCarley R. Brainstem control of wakefulness and sleep. New York: Plenum Press, 1990.
9. Jacobsohn L. Uber die kerne des menschlichen hirnstamms. Berlin: Verlag der Konigl Akademie der Wisenschaftern, 1909.
10. Mesulam M-M, Mufson EJ, Wainer BH, Levey AI. Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience 1983;10: 1185-1201.
11. Mesulam M-M, Mufson EJ, Levey AI, Wainer BH. Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Neuroscience 1984;12:669-86.
12. Rye D, Saper C, Lee H, Wainer B. Pedunculopontine tegmental nucleus of the rat: cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum. J Comp Neurol 1987;259:483-528.
13. Olszewski J, Baxter D. Cytoarchitecture of the human brain stem. Philadelphia: J.B. Lippincott, 1954.
14. Olszewski J, Baxter D. Cytoarchitecture of the human brain stem. Basel: S. Karger AG, 1982.
15. Jones BE, Beaudet A. Distribution of acetylcholine and catecholamine neurons in the cat brainstem: a choline acetyltransferase and tyrosine hydroxylase immunohistochemical study. J Comp Neurol 1987;261:15-32.
16. Karson C, Garcia-Rill E, Biedermann J, Mrak R, Husain M, Skinner R. The brain stem reticular formation in schizophrenia. Psychiatry Res 1991;40:31-48.
17. Garcia-Rill E, Biedermann J, Chambers T, et al. Mesopontine neurons in schizophrenia. Neuroscience 1995;66:321-35.
18. Standaert D, Saper C, Rye D, Wainer B. Colocalization of atriopeptin-like immunoreactivity with choline acetyltransferase- and substance-P-like immunoreactivity in the pedunculopontine and laterodorsal tegmental nuclei in the rat. Brain Res 1986;382:163-8.
19. Vincent SR, Satoh K, Armstrong DM, Panula P, Vale W, Fibiger HC. Neuropeptides and NADPH-diaphorase activity in the ascending cholinergic reticular system of the rat. Neuroscience 1986;17:167-82.
20. Vincent S, Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 1992;46:755-84.
21. Austin M, Rice P, Mann J, Arango V. Localization of corticotropin-releasing hormone in the human locus coeruleus and pedunculopontine tegmental nucleus: an immunocytochemical and in situ hybridization study. Neuroscience 1995;64:713-27.
22. Clements J, Grant S. Glutamate-like immunoreactivity in neurons of the laterodorsal tegmental and pedunculopontine nuclei in the rat. Neurosci Lett 1990;120:70-3.
23. Lai Y, Clements J, Siegel J. Glutamatergic and cholinergic projections to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry. J Comp Neurol 1993;336:321-30.
24. Lavoie B, Parent A. Pedunculopontine nucleus in the squirrel monkey: distribution of cholinergic and monoaminergic neurons in the mesopontine tegmentum with evidence for the presence of glutamate in cholinergic neurons. J Comp Neurol 1994;344:190-209.
25. Wainer B, Mesulam M-M. Ascending cholinergic pathways in the rat brain. In: Steriade M, Biesold D, eds. Brain cholinergic systems. New York: Oxford University Press, 1990:65-119.
26. Jourdain A, Semba K, Fibiger H. Basal forebrain and mesopontine tegmental projections to the reticular thalmic nucleus: an axonal collateralization and immunohistochemical study in the rat. Brain Res 1989;505:55-65.
27. Spreafico R, Amadeo A, Angoscini P, Panzica F, Battaglia G. Branching projections from mesopontine nuclei to the nucleus reticularis and related thalamic nuclei: a double labelling study in the rat. J Comp Neurol 1993;336:481-92.
28. Shiromani P, Floyd C, Velazquez-Moctezuma J. Pontine cholinergic neurons simultaneously innervate two thalamic targets. Brain Res 1990;532:317-22.
29. Semba K, Reiner P, Fibiger H. Single cholinergic mesopontine tegmental neurons project to both the pontine reticular formation and the thalamus in the rat. Neuroscience 1990;38:643-54.
30. Surkis A, Taylor B, Peskin CS, Leonard CS. Quantitative morphology of physiologically identified and intracellularly labeled neurons from the guinea-pig laterodorsal tegmental nucleus in vitro. Neuroscience 1996;74:375-92.
31. Scheibel A. Session chairman's overview: anatomical and physiological substrates of arousal. In: Hobson J, Brazier M, eds. The reticular formation revisited: specifying function for a nonspecific system, vol. 6. New York: Raven Press, 1980: 55-66.
32. Vaucher E, Hamel E. Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry. J Neurosci 1995;15:7427-41.
33. Dauphin F, Hamel E. Identification of multiple muscarinic binding site subtypes in cat and human cerebral vasculature. J Pharmacol Exp Ther 1992;260:660-7.
34. Dauphin F, Ting V, Payette P, Dennis M, Hamel E. Vasocontractile muscarinic M1 receptors in cat cerebral arteries: pharmacological identification and detection of mRNA. Eur J Pharmacol 1991;207:319-27.
35. 3 pharmacology. Eur J Pharmacol 1990;178:203-13.
36. Steriade M, Datta S, Pare D, Oakson G, Dossi RC. Neuronal activities in brainstem cholinergic nuclei related to tonic activation processes in thalamocortical systems. J Neurosci 1990; 10:2541-59.
37. Steininger T, Wainer B, Rye D. An ultrastructural study of cholinergic and noncholinergic neurons in the pars compacta of the rat pedunculopontine tegmental nucleus. J Comp Neurol 1997;382:285-301.
38. Bevan M, Bolam J. Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat. J Neurosci 1995;15:7105-20.
39. Lee HJ, Rye DB, Hallanger AE, Levey AI, Wainer BH. Cholinergic vs. noncholinergic efferents from the mesopontine tegmentum to the extrapyramidal motor system nuclei. J Comp Neurol 1988;275:469-92.
40. Malin A, Ciliax B, Rye D. Organization of the mesopontine tegmental-striatal pathway in the rat. Soc Neurosci Abstr 1993; 19:557.
41. Carpenter MB, Jayaraman A. Subthalamic nucleus of the monkey: connections and immunocytochemical features of afferents. J Hirnforsch 1990;31:653-68.
42. Wirtshafter D. FOS-like-immunoreactivity in basal ganglia outputs following administration of dopamine agonists. Soc Neurosci Abstr 1994;20:1190.
43. Paxinos G, Watson C, eds. The rat brain in stereotaxic coordinates. Orlando: Academic Press, 1986.
44. Crutcher M, Turner R, Perez J, Rye D. Relationship of the primate pedunculopontine nucleus (PPN) to tegmental connections with the internal pallidum (GPi). Soc Neurosci Abstr 1994;20:334.
45. Rye D, Turner R, Vitek J, Bakay R, Crutcher M, DeLong M. Anatomical investigations of the pallidotegmental pathway in monkey and man. In: Ohye H, Kimura M, McKenzie J, eds. Basal Ganglia V. New York: Plenum, 1996:59-75.
46. Rye D, Vitek J, Bakay R, et al. Termination of pallidofugal pathways in man. Soc Neurosci Abstr 1995;21:676.
47. Smith Y, Shink F. The pedunculopontine nucleus (PPN): a potential target for the convergence of information arising from different functional territories of the internal pallidum (GPi) in primates. Soc Neurosci Abstr 1995;21:677.
48. Jones BE. The relationship among acetylcholine, norepinephrine and GABA neurons within the pons of the rat. Anat Rec 1989;223:57-60.
49. Jones BE. Paradoxical sleep and its chemical/structural substrates in the brain. Neuroscience 1991;40:637-56.
50. Hallanger AE, Levey AI, Lee HJ, Rye DB, Wainer BH. The origins of cholinergic and other subcortical afferents to the thalamus in the rat. J Comp Neurol 1987;262:105-24.
51. Pare D, Smith Y, Parent A, Steriade M. Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei. Neuroscience 1988; 25:69-86.
52. Rye D, Lee H, Saper C, Wainer B. Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat. J Comp Neurol 1988; 269:315-41.
53. Dahlstrom A, Fuxe K. Evidence for the existence of monoamine-containing neurones in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurones. Acta Physiol Scand Suppl 1964;232:1-55.
54. Reiner PB, Vincent SR. Topographic relations of cholinergic and noradrenergic neurons in the feline pontomesencephalic tegmentum: an immunohistochemical study. Brain Res Bull 1987;19:705-14.
55. Kang Y, Kitai S. Electrophysiological properties of pedunculopontine neurons and their postsynaptic responses following stimulation of substantia nigra reticulata. Brain Res 1990;535: 79-95.
56. Steriade M, Paré D, Datta S, Oakson G, Dossi RC. Different cellular types in mesopontine cholinergic nuclei related to ponto-geniculo-occipital waves. J Neurosci 1990;10:2560-79.
57. Hallanger AE, Wainer BH. Ascending projections from the pedunculopontine tegmental nucleus and the adjacent mesopontine tegmentum in the rat. J Comp Neurol 1988;274:483-515.
58. Oakman S, Faris P, Kerr P, Cozzari C, Hartman B. Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J Neurosci 1995;15:5859-69.
59. Levey AI, Hallanger AE, Wainer BH. Choline acetyltransferase immunoreactivity in the rat thalamus. J Comp Neurol 1987; 257:317-32.
60. Rye D. The cytoarchitecture, cytochemistry, and some connectivity of the pedunculopontine tegmental nucleus in the rat. Thesis. University of Chicago, Chicago, 1986.
61. Woolf N, Butcher L. Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain. Brain Res Bull 1986;16:603-37.
62. Hallanger AE, Price SD, Steininger T, Wainer BH. Mesopontine tegmental projections to the nucleus basalis of Meynert: an ultrastructural study. Soc Neurosci Abstr 1988;14:1184.
63. Semba K, Reiner P, McGeer E, Fibiger H. Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat. J Comp Neurol 1988;267:433-53.
64. Jones BE, Cuello AC. Afferents to the basal forebrain cholinergic cell area from pontomesencephalic-catecholamine, serotonin, and acetylcholine-neurons. Neuroscience 1989;31:37-61.
65. Ford B, Holmes C, Mainville L, Jones B. GABAergic neurons in the rat pontomesencephalic tegmentum: codistribution with cholinergic and other tegmental neurons projecting to the posterior lateral hypothalamus. J Comp Neurol 1995;363:177-96.
66. Bina K, Rusak B, Semba K. Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat. J Comp Neurol 1993;335:295-307.
67. Beninato M, Spencer R. A cholinergic projection to the rat superior colliculus demonstrated by retrograde transport of horseradish peroxidase and choline acetyltransferase immunohistochemistry. J Comp Neurol 1986;253:525-38.
68. Mesulam M-M, Mash D, Hersh L, Bothwell M, Geula C. Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus. J Comp Neurol 1992;323:252-68.
69. Mitani A, Ito K, Hallanger A, Wainer B, Kataoka K, McCarley R. Cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei to the pontine gigantocellular tegmental field in the cat. Brain Res 1988;451:397-402.
70. Shiromani P, Lai Y, Siegel J. Descending projections from the dorsolateral pontine tegmentum to the paramedian reticular nucleus of the caudal medulla in the cat. Brain Res 1990;517: 224-8.
71. Semba K. Aminergic and cholinergic afferents to REM sleep induction regions of the pontine reticular formation in the rat. J Comp Neurol 1993;330:543-56.
72. Yasui Y, Cechetto D, Saper C. Evidence for a cholinergic projection from the pedunculopontine tegmental nucleus to the rostral ventrolateral medulla in the rat. Brain Res 1990;517: 19-24.
73. Hallanger A, Wainer B. Ultrastructure of ChAT-immunoreactive synaptic terminals in the thalamic reticular nucleus of the rat. J Comp Neurol 1988;278:486-97.
74. Hallanger AE, Price SD, Lee HJ, Steininger TL, Wainer BH. The ultrastructure of cholinergic synaptic terminals in the thalamic anteroventral, ventroposterior, and dorsal lateral geniculate nuclei of the rat. J Comp Neurol 1990;299:482-92.
75. Bolam JP, Francis CM, Henderson Z. Cholinergic input to dopaminergic neurons in the substantia nigra: a double immunocytochemical study. Neuroscience 1991;41:483-94.
76. De Lima AD, Singer W. The brainstem projection to the lateral geniculate nucleus in the cat: identification of cholinergic and monoaminergic elements. J Comp Neurol 1987;259:92-121.
77. Goldsmith M, VanderKooy D. Separate non-cholinergic descending projections and cholinergic ascending projections from the nucleus tegmenti pedunculopontinus. Brain Res 1988; 445:386-91.
78. Saper C. Diffuse cortical projection systems: anatomical organization and role in cortical function. In: Brookhart J and Mountcastle V, eds. Handbook of physiology - the nervous system. Bethesda, MD: American Physiological Society, 1987: 169-210.
79. Szymusiak R. State of the art review. Magnocellular nuclei of the basal forebrain: substrates of sleep and arousal regulation. Sleep 1995;18(6):478-500.
80. Lavoie B, Parent A. Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra. J Comp Neurol 1994;344:232-41.
81. Tokuna H, Moriizumi T, Kudo M, Nakamura Y. A morphological evidence for monosynaptic projections from the nucleus tegmenti pedunculopontinus pars compacta (TPC) to nigrostriatal projection neurons. Neurosci Lett 1988;85:1-4.
82. Scarnati E, Hajdu F, Pacitti C, Tombol T. An EM and Golgi study on the connection between the nucleus tegmenti pedunculopontinus and the pars compacta of the substantia nigra in the rat. J Hirnforsch 1988;29:95-105.
83. Fallon JH, Loughlin SE. Substantia nigra. In: Paxinos G, ed. The rat nervous system. Orlando: Academic Press, 1985:353-74.
84. Moriizumi T, Nakamura Y, Kitao Y, Kudo M. Ultrastructural analyses of afferent terminals in the subthalamic nucleus of the cat with a combined degeneration and horseradish peroxidase tracing method. J Comp Neurol 1987;265:159-74.
85. Scarnati E, Compana E, Pacitti C. Pedunculopontine-evoked excitation of substantia nigra neurons in the rat. Brain Res 1984;304:351-61.
86. Scarnati E, Prioa A, Campana E, Pacitti C. A microiontophoretic study on the nature of the putative synaptic neurotransmitter in the pedunculopontine-substantia nigra pars compacta excitatory pathway of the rat. Exp Brain Res 1986;62:470-8.
87. Clarke P, Hommer D, Pert A, Skirboll L. Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. J Neurosci 1987;23:1011-9.
88. Di Loreto S, Florio T, Scarnati E. Evidence that non-NMDA receptors are involved in the excitatory pathway from the pedunculopontine region to nigrostriatal dopaminergic neurons. Exp Brain Res 1992;89:79-86.
89. Hammond C, Rouzaire-Dubois B, Feger J, Jackson A, Crossman A. Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat. Neuroscience 1983;9:41-52.
90. Gonya-Magee T, Anderson M. An electrophysiological characterization of projections from the pedunculopontine area to entopeduncular nucleus and globus pallidus in the cat. Exp Brain Res 1983;49:269-79.
91. Scarnati E, Loreto SD, Prioa A, Galli G. The functional role of the pedunculopontine nucleus in the regulation of the electrical activity of entopeduncular neurons in the rat. Arch Ital Biol 1988;126:145-63.
92. DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends Neurosci 1990;13:281-5.
93. von Krosigk M, Smith Y, Bolam J, Smith A. Synaptic organization of gabaergic inputs from the striatum and the globus pallidus onto neurons in the sustantia nigra and retrorubral field which project to the medullary reticular formation. Neuroscience 1992;50:531-49.
94. Nakamura Y, Tokuno H, Moriizumi T, Kitao Y, Kudo M. Monosynpatic nigral inputs to the pedunculopontine tegmental nucleus neurons which send their axons to the medial reticular formation in the medulla oblongata. An electron microscopic study in the cat. Neurosci Lett 1989;103:145-50.
95. Sleekler T, Inglis W, Winn P, Sahgal A. The pedunculopontine tegmental nucleus: a role in cognitive processes? Brain Res Rev 1994;19:298-318.
96. Futami T, Takakusaki K, Kitai S. Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta. Neurosci Res 1995;21:331-42.
97. Deutch A, Goldstein M, Baldino F, Roth R. Telencephalic projections of the A8 dopamine cell group. Ann NY Acad Sci 1988;537:27-50.
98. Shammah-Lagnado S, Costa M, Goto M, Peracoli A. Canteras N. Efferent connections of the retrorubral field (A8): a PHA-L study in the rat. Soc Neurosci Abstr 1993;19:1434.
99. Alheid G, Beltramino C, Braun A, Miselis R, Francois C, deOlmos J. Transition areas of the striatopallidal system with the extended amygdala in the rat and primate: observations from histochemistry and experiments with mono- and transsynaptic tracers. In: Percheron G, McKenzie J, Feger J, eds. Basal ganglia IV. New data and concepts on the structure and function of the basal ganglia. New York: Plenum Press, 1994: 95-107.
100. Moga MM, Herbert H, Hurley KM, Yasui Y, Gray TS, Saper CB. Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat. J Comp Neurol 1990;295:624-61.
101. Scarnati E, Prioa A, Loreto SD, Pacitti C. The reciprocal electrophysiological influence between the nucleus tegmenti pedunculopontinus and the substantia nigra in normal and decorticated rats. Brain Res 1987;423:116-24.
102. Swanson L, Mogenson G, Gerfen C, Robinson P. Evidence for a projection from the lateral preoptic area and substantia innominata to the 'mesencephalic locomotor region' in the rat. Brain Res 1984;295:161-78.
103. Granata A, Kitai S. Inhibitory substantia nigra inputs to the pedunculopontine neurons. Exp Brain Res 1991;86:459-66.
104. Noda T, Oka H. Distribution and morphology of tegmental neurons receiving nigral inhibitory inputs in the cat: an intracellular HRP study. J Comp Neurol 1986;244:254-66.
105. Semba K, Fibiger H. Afferent connections of the laterodorsal and the pedunculopontine tegmental nuclei in the cat: a retro- and antero-grade transport and immunohistochemical study. J Comp Neurol 1992;323:387-410.
106. Steininger T. Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies. J Comp Neurol 1992;321:515-43.
107. Groenewegen H, Russchen F. Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: a tracing and immunohistochemical study in the cat. J Comp Neurol 1984;223:347-67.
108. Revay R, Grant S. Medial prefrontal cortex projects directly to cholinergic neurons of the meso-pontine tegmentum. Soc Neurosci Abstr 1992;18:974.
109. Hartmann-von Monakow K, Akert K, Kunzle H. Projections of precentral and premotor cortex to the red nucleus and other midbrain areas in macaca fasicularis. Exp Brain Res 1979;34: 91-105.
110. Hazrati L-N, Parent A. Projection from the deep cerebellar nuclei to the pedunculopontine nucleus in the squirrel monkey. Brain Res 1992;585:267-71.
111. Steininger TL, Wainer BH, Blakely RD, Rye DB. Dorsal raphe nucleus projections to cholinergic and noncholinergic neurons of the pedunculopontine tegmental nucleus: a light and electron microscopic anterograde tracing study. J Comp Neurol 1997;382:302-22.
112. Lin J-S, Hou Y, Sakai K, Jouvet M. Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat. J Neurosci 1996;16:1523-37.
113. Nauta W, Mehler W. Projections of the lentiform nucleus in the monkey. Brain Res 1966;1:3-42.
114. Spann BM, Grofova I. Cholinergic and non-cholinergic neurons in the rat pedunculopontine tegmental nucleus. Anat Embryol 1992;186:215-27.
115. Grofova I, Zhou M. Nigral innervation of cholinergic and non-cholinergic cells in the rat mesopontine tegmentum: a double label EM study. Soc Neurosci Abstr 1993;19:1433.
116. Gerfen CR, Engber TM, Mahan LC, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 1990;250:1429-32.
117. Graybiel AM. Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 1990;13:244-54.
118. Gerfen CR, McGinty JF, Young WS III. Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis. J. Neurosci 1991;11:1016-31.
119. Bergstrom D, Walters J. Dopamine attenuates the effects of GABA on single unit activity in the globus pallidus. Brain Res 1984;310:23-33.
120. Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic P. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature 1996;381: 245-8.
121. Harnois C, Filion M. Pallidofugal projections to thalamus and midbrain: a quantitative antidromic activation study in monkeys and cats. Exp Brain Res 1982;47:277-85.
122. Parent A, DeBellefeuille L. Organization of efferent projections from the internal segment of globus pallidus in primate as revealed by fluorescence retrograde labeling method. Brain Res 1982;245:201-13.
123. Parent A, Pare D, Smith Y, Steriade M. Basal forebrain cholinergic and noncholinergic projections to the thalamus and brainstem in cats and monkeys. J Comp Neurol 1988;277:281-301.
124. Lai Y, Siegel J. Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation. J Neurosci 1990;10:2727-34.
125. Milner K, Mogenson G. Electrical and chemical activation of the mesencephalic and subthalamic locomotor regions in freely moving rats. Brain Res 1988;452:273-85.
126. Brudzynski S, Wu M, Mogenson G. Modulation of locomotor activity induced by injections of carbachol into the tegmental pedunculopontine nucleus and adjacent areas in the rat. Brain Res 1988;451:119-25.
127. Steriade M. Basic mechanisms of sleep generation. Neurology 1992;Suppl 6:9-18.
128. Kodama T, Takahashi Y, Honda Y. Enhancement of ACh release during paradoxical sleep in the dorsal tegmental field of the cat brain stem. Neurosci Lett 1990;114:277-82.
129. Lydic R, Baghdoyan H. Cholinergic pontine mechanisms causing state-dependent respiratory depression. NIPS 1992;7:220-4.
130. Lydic R, Keifer J, Baghdoyan H, Becker B. Microdialysis of the pontine reticular formation reveals inhibition of acetylcholine release by morphine. Anesthesiology 1993;79:1003-12.
131. Williams J, Comisarow J, Day J, Fibiger H, Reiner P. State-dependent release of acetylcholine in rat thalamus measured by in vivo microdialysis. J Neurosci 1994;14:5236-42.
132. Thakkar M, Portas C, McCarley R. Chronic low-amplitude electrical stimulation of the laterdorsal tegmental nucleus of freely moving cats increases REM sleep. Brain Res 1996;723: 223-7.
133. Webster H, Jones B. Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. II. Effects upon sleep-waking states. Brain Res 1988;458: 285-302.
134. Shouse M, Siegel J. Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep. Brain Res 1992;571:50-63.
135. Laurent JP, Alayaguerrero F. Reversible suppression of pontogeniculo-occipital waves by localized cooling during paradoxical sleep in cat. Exp Neurol 1975;49:356-69.
136. Velazquez-Moctezuma J, Gillin J, Shiromani P. Effect of specific M1, M2 muscarinic receptor agonists on REM sleep generation. Brain Res 1989;503:128-31.
137. McCormick D. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends Neurosci 1989;12:215-21.
138. McCormick DA. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. J Neurosci 1992;12:278-89.
139. Steriade M, McCormick D, Sejnowski T. Thalamocortical oscillations in the sleeping and aroused brain. Science 1993;262: 679-84.
140. McCormick DA, Prince DA. Pirenzepine discriminates among ionic responses to acetylcholine in guinea-pig cerebral cortex and reticular nucleus of thalamus. Trends Pharmacol Sci 1986; 7:72-7.
141. McCarley RW, Nelson JP, Hobson JA. Ponto-geniculo-occipital (PGO) burst neurons: correlative evidence for neuronal generators of PGO waves. Science 1978;201:269-72.
142. Hu B, Steriade M, Deschênes M. The cellular mechanism of thalamic ponto-geniculo-occipital waves. Neuroscience 1989; 31:25-35.
143. Hu B, Bouhassira D, Steriade M, Deschenes M. The blockage of ponto-geniculo-occipital waves in the cat lateral geniculate nucleus by nicotinic antagonists. Brain Res 1988;437:394-7.
144. Kitsikis A, Steriade M. Immediate behavioral effects of kainic acid injections into the midbrain reticular core. Behav Brain Res 1981;3:361-80.
145. Bowker R, Morrison A. The startle reflex and PGO spikes. Brain Res 1976;102:185-90.
146. Muhlethaler M, Khateb A, Serafin M. Effects of monoamines and opiates on pedunculopontine neurones. In: Mancia M, Marini G, eds. The diencephalon and sleep. New York: Raven Press, 1990:31-48.
147. Leonard C, Llinas R. Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling REM sleep: an in vitro electrophysiological study. Neuroscience 1994;59: 309-30.
148. Rainnie D, Grunze H, McCarley R, Greene R. Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal. Science 1994;263:689-92.
149. Williams J, Reiner P. Noradrenaline hyperpolarizes identified rat mesopontine cholinergic neurons in vitro. J Neurosci 1993; 13:3878-83.
150. Sanchez R, Kahteb A, Måhlether M, Leonard C. Glutamate and NMDA actions on mesopontine cholinergic neurons in vitro. Soc Neurosci Abstr 1991;17:256.
151. Sanchez R, Leonard CS. NMDA-receptor-mediated synaptic currents in guinea pig laterodorsal tegmental neurons in vitro. J Neurophysiol 1996;76:1101-11.
152. Dorje F, Weiss J, Lambrecht G, Tacke R, Mutschler E, Brann M. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 1991;256:727-33.
153. Vilaro MT, Wiederhold KH, Palacios JM, Mengod G. Muscarinic m2 receptor mRNA expression and receptor binding in cholinergic and non-cholinergic cells in the rat brain: a correlative study using in situ hybridization histochemistry and receptor autoradiography. Neuroscience 1992;47:367-93.
154. Vilaro M, Mengod G, Palacios J. Advances and limitations of the molecular neuroanatomy of cholinergic receptors: the example of multiple muscarinic receptors. Prog Brain Res 1993; 98:95-101.
155. Vilaro MT Palacios JM, Mengod G. Multiplicity of muscarinic autoreceptor subtypes? Comparison of the distribution of cholinergic cells and cells containing mRNA for five subtypes of muscarinic receptors in the rat brain. Brain Res Mol Brain Res 1994;21:30-46.
156. Rye D, Thomas J, Levey A. Distribution of molecular muscarinic (m1-m4) receptor subtypes and choline acetyltransferase in the pontine reticular formation of man and non-human primates. Sleep Res 1995;24:59.
157. Leonard CS, Rao S, Sanchez RM. Patterns of neuromodulation and the nitric oxide signaling pathway in mesopontine cholinergic neurons. The Neurosciences 1995;7:319-28.
158. Inglis W, Semba K. Colocalization of ionotropic glutamate receptor subunits with NADPH-diaphorase-containing neurons in the rat mesopontine tegmentum. J Comp Neurol 1996;368: 17-32.
159. Sanchez R, Leonard C. NMDA receptor-mediated synaptic input to nitric oxide synthase-containing neurons of the guinea pig mesopontine tegmentum in vitro. Neurosci Lett 1994;179: 141-4.
160. Onoe H, Sakai K. Kainate receptors: a novel mechanism in paradoxical (REM) sleep generation. Neuroreport 1995;6: 353-6.
161. Luebke J, Greene R, Semba K, Kamondi A, McCarley R, Reiner P. Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro. Proc Natl Acad Sci USA 1992;89:743-7.
162. McGinty D, Harper R. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 1976;101:569-75.
163. Trulson ME, Jacobs BL, Morrison AR. Raphe unit activity across the sleep-waking cycle in normal cats and in pontine lesioned cats displaying REM sleep without atonia. Brain Res 1981;226:75-91.
164. Luebke J, McCarley R, Greene R. Inhibitory action of muscarinic agonists on neurons in the rat laterodorsal tegmental nucleus in vitro. J Neurophysiol 1993;70:2128-35.
165. Datta S, Dossi RC, Pare D, Oakson G, Steriade M. Substantia nigra reticulata neurons during sleep-waking states: relation with ponto-geniculo-occipital waves. Brain Res 1991;566: 344-7.
166. Rye D, Bliwise D. Movement disorders specific to sleep and the nocturnal manifestations of waking movement disorders. In: Watts R, Koller W, eds. Movement disorders: neurologic principles and practice. New York: McGraw-Hill, 1997:687-713.
167. Dement WC, Mittler MM, Henriksen SJ. Sleep changes during chronic administration of parachlorophenylalanine. Rev Can Biol 1972;31:239-46.
168. Jouvet M. The role of monoamine and acetylcholine-containing neurons in the regulation of the sleep-wake cycle. Ergbn Physiol 1972;64:166-307.
169. Simon RP, Gershon MP, Brooks DC. The role of the raphe nuclei in the regulation of ponto-geniculo-occipital wave activity. Brain Res 1973;58:313-30.
170. Sakai K, Jouvet M. Brain stem PGO-on cells projecting directly to the cat dorsal lateral geniculate nucleus. Brain Res 1980;194:500-5.
171. Nelson J, McCarley R, Hobson J. REM sleep burst neurons, PGO waves, and eye movement information. J Neurophysiol 1983;50:784-96.
172. Sakai K. Anatomical and physiological basis of paradoxical sleep. In: McGinty DJ, Drucker-Colin R, Morrison A, Parmeggiani PL, eds. Brain mechanisms of sleep. New York: Raven Press; 1985:111-37.
173. Bickford M, Günlük A, Godwin D, Gnadt J, Sherman S. Subcortical extraretinal projections to the monkey LGN. Soc Neurosci Abstr 1995;21:658.
174. Wilson J, Hendrickson A, Sherk H, Tigges J. Sources of subcortical afferents to the macaque's dorsolateral geniculate nucleus. Anat Rec 1995;242:566-74.
175. Ruch-Monachon MA, Jalfre M, Haefely W. Drugs and PGO waves in the lateral geniculate body of the curarized cat. IV. The effects of acetylcholine. GABA and benzodiazepines on PGO wave activity. Arch Int Pharmacodyn 1976;219:308-25.
176. Sakai K. Some anatomical and physiological properties of ponto-mesencephalic tegmental neurons with special reference to the PGO waves and postural atonia during paradoxical sleep in the cat. In: Hobson JA, Brazier MAB, eds. The reticular formation revisited: specifying function for a nonspecific system, vol. 6. New York: Raven Press, 1980:427-47.
177. Honda T, Semba K. Serotonergic synaptic input to cholinergic neurons in the rat mesopontine tegmentum. Brain Res 1994; 647:299-306.
178. Chase M, Morales F. The control of motoneurons during sleep. In: Kryger M. Roth T, Dement W, eds. Principles and practice of sleep medicine. Philadelphia: W.B. Saunders, 1994:163-75.
179. Lydic R, Baghdoyan H, Wertz R, White D. Cholinergic reticular mechanisms influence state-dependent ventilatory response to hypercapnia. Am J Physiol 1991;261:R738-46.
180. Karni A, Tanne D, Rubenstein B, Askenasay J, Sagi D. Dependence on REM sleep of overnight improvement of a perceptual skill. Science 1994;265:679-82.
181. Aldrich M. Narcolepsy. Curr Concepts 1990;323:389-94.
182. Aldrich M. Narcolepsy. Neurology 1992;Suppl 6:34-43.
183. Baghdoyan H, Monaco A, Rodrigo-Angulo M, Assens F, McCarley R, Hobson J. Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs. J Pharmacol Exp Ther 1984;231:173-80.
184. Baghdoyan H, Rodrigo-Angulo M, McCarley R, Hobson J. A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs. Brain Res 1987;414:245-61.
185. Baghdoyan H, Lydic R, Callaway C, Hobson J. The carbachol-induced enhancement of desynchronized sleep signs is dope dependent and antagonized by centrally administered atropine. Neuropsychopharmacology 1989;2:67-79.
186. Vanni-Mercier G, Sakai K, Lin J, Jouvet M. Mapping of cholinoceptive brainstem structures responsible for the generation of paradoxical sleep in the cat. Arch Ital Biol 1989;127:133-64.
187. Yamamoto K, Mamelak A, Quattrochi J, Hobson J. A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: locus of the sensitive region. Neuroscience 1990;39:279-93.
188. Nishino S, Reid M, Dement W, Mignot E. Neuropharmacology and neurochemistry of canine narcolepsy. Sleep 1994;17:S84-92.
189. Reid MS, Siegel JM, Dement WC, Mignot E. Cholinergic mechanisms in canine narcolepsy - II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy. Neuroscience 1994;59:523-30.
190. Bowersox S, Kilduff T, Dement W, Ciaranello R. Brainstem cholinergic receptor abnormalities in canine narcolepsy are not associated with abnormalities in acetylcholinesterase, choline acetyltransferase, or choline uptake. Sleep Res 1987;16:313.
191. Bowersox S, Dement W, Ciaranello R. Brainstem muscarinic receptor abnormalities fail to predict severity of cataplexy in narcoleptic canines. Sleep Res 1987;16:312.
192. Boehme R, Baker T, Mefford I, Barchas J, Dement W, Ciaranello R. Narcolepsy: cholinergic receptor changes in an animal model. Life Sci 1984;34:1825-8.
193. Kilduff T, Bowersox S, Kaitin K, Baker T, Ciaranello R, Dement W. Muscarinic cholinergic receptors and the canine model of narcolepsy. Sleep 1986;9:102-6.
194. Aldrich M, Desmond T, Frey K. Muscarinic receptor autoradiography of human narcoleptic brainstem. Sleep Res 1994;23: 215.
195. Aldrich M. The neurobiology of narcolepsy. Trends Neurosci 1991;14:235-9.
196. Cortes R, Probst A, Palacios J. Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain. Neuroscience 1984;12:1003-26.
197. Mash D, Potter L. Autoradiographic localization of M1 and M2 muscarine receptors in the rat brain. Neuroscience 1986; 19:551-64.
198. Baghdoyan H, Mallios V, Duckrow R, Mash D. Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. Neuroreport 1994;5:1631-4.
199. Bonner T, Buckley N, Young A, Brann M. Identification of a family of muscarinic acetylcholine receptor genes. Science 1987;237:527-32.
200. Peralta E, Ashkenazi A, Winslow J, Smith D, Ramachandran J, Capon D. Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J 1987;6:3923-9.
201. Bonner T, Young A, Brann M, Buckley N. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron 1988;1:403-10.
202. Reid M, Tafti M, Nishino S, Siegel J, Dement W, Mignot E. Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors. Sleep 1994;17:424-35.
203. Shuman S, Capece M, Baghdoyan H, Lydic R. Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression. Am J Physiol 1995;269:R308-17.
204. Velazquez-Moctezuma J, Shiromani P, Gillin J. Acetylcholine and acetylcholine receptor subtypes in REM sleep generation. Prog Brain Res 1990;84:407-13.
205. 3 muscarinic antagonists on the sleep-wake cycle. Neuroreport 1991;2:383-5.
206. Imeri L, Bianchi S, Angeli P, Mancia M. Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle. Brain Res 1994;636:68-72.
207. Greene R, McCarley R. Cholinergic transmission in the brainstem: implications for behavioral state control. In: Steriade M, Biesold D, eds. Brain cholinergic systems. New York: Oxford University Press, 1990:224-35.
208. Gerber U, Stevens D, McCarley R, Greene R. Muscarinic agonists activate an inwardly rectifying potassium conductance in medial pontine reticular formation neurons of the rat in vitro. J. Neurosci 1991;11:3861-7.
209. Caulfield M. Muscarinic receptors: characterization, coupling and function. Pharmacol Ther 1993;58:319-79.
210. Roth M, Fleegal M, Lydic R, Baghdoyan H. Muscarinic autoreceptors modulate acetylcholine (ACh) release in cat medial pontine reticular formation (mPRF). Soc Neurosci Abstr 1996: 1988.
211. Gilmor M, Nash NR, Roghani A, et al. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J Neurosci 1996;16: 2179-90.
212. Levey A, Kitt A, Simonds W, Price D, Brann M. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 1991;11: 3218-26.
213. Levey AI. Immunological localization of muscarinic receptor subtypes in peripheral tissues and in brain. Life Sci 1993;52: 441-8.
214. Peralta E, Ashkenazi A, Winslow J, Ramachandran J, Capon D. Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature 1988;334:434-7.
215. McKinney M. Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems. Prog Brain Res 1993;98:333-40.
216. Caulfield M, Robbins J, Higashida H, Brown D. Postsynaptic actions of acetylcholine: the coupling of muscarinic receptor subtypes to neuronal ion channels. Prog Brain Res 1993;98: 293-301.
217. Sandmann J, Peralta E, Wurtman R. Coupling of transfected muscarinic acetylcholine receptor subtypes to phospholipase D. Biol Chem 1991;266:6031-4.
218. Ernsberger P, Arneric S, Arango V, Reis D. Quantitative distribution of muscarinic receptors and choline acetyltransferase in rat medulla: examination of transmitter-receptor mismatch. Brain Res 1988;452:336-44.
219. Raiteri M, Marchi M, Maura G, Bonanno G. Presynaptic regulation of acetylcholine release in the CNS. Cell Biol Int Rep 1989;13:1109-18.
220. Raiteri M, Marchi M, Paudice P, Pittaluga A. Muscarinic receptors mediating inhibition of gamma-aminobutyric acid release in rat corpus striatum and their pharmacological characterization. J Pharmacol Exp Ther 1990;254:496-501.
221. Raiteri M, Marchi M, Paudice P. Presynaptic muscarinic receptors in the central nervous system. Ann NY Acad Sci 1990; 604:113-29.
222. Raiteri M, Marchi M, Costi A, Volpe G. Endogenous aspartate release in the rat hippocampus is inhibited by M2 'cardiac' muscarinic receptors. Eur J Pharmacol 1990;177:181-7.
223. Raiteri M, Garrone B, Pittaluga A. N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. II. Evidence for functional cooperation and for coexistence on the same axon terminal. J Pharmacol Exp Ther 1992;260:238-42.
224. Groenewegen H, Ahlenius S, Haber S, Kowall N, Nauta W. Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat. J Comp Neurol 1986;249:65-102.
225. Leichnetz G, Carlton S, Katayama Y, et al. Afferent and efferent connections of the cholinoceptive medil pontine reticular formation (region of the ventral tegmental nucleus) in the cat. Brain Res Bull 1989;22:665-8.
226. Büttner-Ennever J, Büttner U. The reticular formation. In: Büttner-Ennever J, ed. Neuroanatomy of the oculomotor system, vol. 2. Amsterdam: Elsevier Science Publishers BV, 1988: 119-76.
227. Van Dongen P, Broekkamp C, Cools A. Atonia after carbachol injections near the locus ceruleus in cats. Pharmacol Biochem Behav 1978;8:527-32.
228. Tafti M, Nishino S, Liao W, Dement W, Mignot E. Mesopontine organization of cholinergic and catecholaminergic cell groups in canine narcolepsy. Sleep Res 1995;24:17.
229. Nitz D, Andersen A, Fahringer H, Nienhuis R, Mignot E, Siegel J. Altered distribution of cholinergic cells in the narcoleptic dog. Neuroreport 1995;6:1521-4.
230. Mefford I, Baker T, Boehme R, et al. Narcolepsy: biogenic amine deficits in an animal model. Science 1982;220:629-32.
231. Bowersox S, Kilduff T, Faull K, Zeller-DeAmicis L, Dement W, Ciaranello R. Brain dopamine receptor levels elevated in canine narcolepsy. Brain Res 1987;402:44-7.
232. Kish S, Mamelak M, Slimovitch C, et al. Brain neurotransmitter changes in human narcolepsy. Neurology 1992;42:229-34.
233. 11C-raclopride. Neurology 1994;44:2101-4.
234. Mignot E, Reid M, Tafti M, Nishino S, Sampathkumaran R, Dement W. Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in narcoleptic canines. Sleep Res 1995;24:298.
235. Leverenz J, Petito C, Morgello S. Neuropathologic change in a patient with narcolepsy. Neurology 1988;Suppl 1:307.
236. McKee A, Levine D, Kowall N, Richardson E. Peduncular hallucinosis associated with isolated infarction of the substantia nigra pars reticulata. Ann Neurol 1990;27:500-4.
237. Lavoie B, Smith Y, Parent A. Dopaminergic innervation of the basal ganglia in the squirrel monkey as revealed by tyrosine hydroxylase immunohistochemistry. J Comp Neurol 1989;289: 36-52.
238. Blum A, Girke W. Marked increase in REM sleep produced by a new antipsychotic compound. Clin Electroencephalogr 1973;4:80-4.
239. Blum A. Triad of hyperthermia, increased REM sleep, and cataplexy during clozapine treatment? J Clin Psychiatr 1990;51: 259-60.
240. Ciliax B, Greenamyre J, Levey A. Functional biochemistry and molecular neuropharmacology of the basal ganglia and motor systems. In: Watts R, Koller W, eds. Movement disorders: neurologic principles and practice. New York: McGraw-Hill, 1997:99-116.
241. Guilleminault C, Mignot E, Aldrich M. Prazosin contraindicated in patients with narcolepsy. Lancet 1988;2:511.
242. Aldrich M, Rogers A. Exacerbation of human cataplexy by prazosin. Sleep 1989;12:254-6.
243. Baghdoyan H, Spotts J, Snyder S. Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep. J Neurosci 1993;13:229-42.
244. Nishino S, Tafti M, Reid M, et al. Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy. J Neurosci 1995; 15:4806-14.
245. Fuchino S, Sanford L, Ross R, Morrison A. Effects of microinjections of the Alpha-1 adrenergic agonist, methoxamine, into the central nucleus of the amygdala on sleep-wake states. Sleep Res 1996;25:6.
246. Sanford L, Mann G, Schulkin J, Wehr T, Ross R, Morrison A. Prolactin microinjections into the amygdaloid central nucleus modulate behavioral state. Sleep Res 1996;25:24.
247. Siegel J, Nienhuis R, Mignot E, Fahringer H, Jamgochian G. Neuronal degeneration in the amygdala of the narcoleptic dog. Sleep Res 1996;25:370.
248. Mahowald M, Schenck C. REM sleep behavior disorder. In: Kryger M, Roth T, Dement W, eds. Principles and practice of sleep medicine. Philadelphia: W.B. Saunders, 1994:574-88.
249. Schenck C, Bundlie S, Mahowald M. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder. Neurology 1996;46:388-93.
250. Tison F, Wenning G, Quinn N, Smith S. REM sleep behaviour disorder as the presenting symptom of multiple system atrophy. J Neurol Neurosurg Psychiatry 1995;58:379-85.
251. Shimizu T, Inami Y, Sugita Y, et al. REM sleep without muscle atonia (stage 1-REM) and its relation to delirious behavior during sleep in patients with degenerative diseases involving the brain stem. Jpn J Psychiatr Neurol 1990;44:681-92.
252. Comella C, Nardine T, Diederich N, Stebbins G. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology 1997;48:A539.
253. Schenck C, Mahowald M. Motor dyscontrol in narcolepsy: rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorder. Ann Neurol 1992;32:3-10.
254. Jones B, Webster H. Neurotoxic lesions of the dorsolateral pontomesencephalic tegmentum-cholinergic cell area in the cat. I. Effects upon the cholinergic innervation of the brain. Brain Res 1988;451:13-32.
255. Culebras A, Moore J. Magnetic resonance findings in REM sleep behavior disorder. Neurology 1989;39:1519-23.
256. Magoun H, Rhines R. An inhibitory mechanism in the bulbar reticular formation. J Neurophysiol 1946;9:165-71.
257. Lai Y, Siegel J. Medullary regions mediating atonia. J Neurosci 1988;8:4790-6.
258. Toyahma M, Sakai K, Salvert D, Touret M, Jouvet M. Spinal projections from the lower brain stem in the cat as demonstrated by the horseradish peroxidase technique. I. Origins of the reticulospinal tracts and their funicular trajectories. Brain Res 1979;173:383-403.
259. Holmes C, Webster H, Zikman S, Jones B. Quisqualic acid lesions of the ventromedial medullar reticular formation: effects upon sleep-wakefulness states. Soc Neurosci Abstr 1988; 14:308.
260. DeLong M. Activity of pallidal neurons in the monkey during movement and sleep. Physiologist 1969;12:207.
261. Vitek J, Kaneoke Y, Turner R, Baron M, Bakay R, DeLong M. Neuronal activity in the internal (GPi) and external (GPe) segments of the globus pallidus (GP) of parkinsonian patients is similar to that in the MPTP-treated primate model of parkinsonism. Soc Neurosci Abstr 1993;19:1584.
262. Jellinger K. The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease. J Neurol Neurosurg Psychiatry 1988;51:540-3.
263. Mufson E, Mash D, Hersh L. Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease. Ann Neurol 1988;24:623-9.
264. Zweig R, Whitehouse P, Casanova M, Walker L, Jankel W, Price D. Loss of pedunculopontine neurons in progressive supranuclear palsy. Ann Neurol 1987;22:18-25.
265. Hirsch E, Graybiel A, Duyckaerts C, Jovoy-Agid F. Neuronal loss in Parkinson's disease and in progressive supranucleur palsy. Proc Natl Acad Sci USA 1987;84:5976-80.
266. Jellinger K. Overview of morphological changes in Parkinson's disease. Adv Neurol 1987;45:1-18.
267. Jellinger K. Pathology of Parkinson's disease. Mol Chem Neuropathol 1991;14:153-97.
268. Jellinger K. Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway. Mol Chem Neuropathol 1991; 14:153-97.
269. Vitello M, Poceta J, Prinz P. Sleep in Alzheimer's disease and other dementing disorders. Can J Psychol 1991;45:221-39.
270. Bliwise D, Tinklenberg J, Yesavage J, et al. REM latency in Alzheimer's disease. Biol Psychiatry 1989;25:320-8.
271. Mahowald M, Schenck C. REM sleep behavior disorder. In: Kryger M, Roth T, Dement W, eds. Principles and practice of sleep medicine. Philadelphia: W.B. Saunders, 1989:389-401.
272. Askenasy J. Sleep in Parkinson's disease. Acta Neurol Scand 1993;87:167-70.
273. Aldrich M, Foster N, White R, Bluemlein L, Prokopowic G. Sleep abnormalities in progressive supranuclear palsy. Ann Neurol 1989;25:577-81.
274. Kupfer D, Foster F. Interval between onset of sleep and rapid eye movement as an indicator of depression. Lancet 1972;2: 684-6.
275. Kupfer D, Foster F, Reich L. EEG sleep changes as predictors in depression. Am J Psychiatry 1976;133:622-6.
276. Reynolds C, Newton T, Shaw D, et al. Electroencephalographic sleep findings in depressed outpatients. Psychiatr Res 1982;6: 65-75.
277. Reynolds CF, Christiansen CL, Taska LS, Coble PA, Kupfer DJ. Sleep in narcolepsy and depression - Does it all look alike? J Nerv Ment Dis 1983;171:290-5.
278. Kupfer D, Gillin C, Coble P, et al. REM sleep, naps, and depression. Psychiatr Res 1981;5:193-203.
279. Benca R. Mood disorders. In: Kryger M, Roth T, Dement W, eds. Principles and practice of sleep medicine. Philadelphia: W.B. Saunders, 1994:899-913.
280. McCarley R. REM sleep and depression: common neurobiological control mechanisms. Am J Psychiatry 1982;139:565-70.
281. Gillin J, Sitaram N, Duncan W. Muscarinic supersensitivity: a possible model for the sleep disturbance of primary depression? Psychiatr Res 1979;1:17-22.
282. Gillin JC, Sutton L, Ruiz C, et al. The cholinergic rapid eye movement induction test with arecoline in depression. Arch Gen Psychiatry 1991;48:264-70.
283. Schreiber W. Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders. Biol Psychiatry 1992;32: 79-90.
284. Yavari P, Vogel G, Neill D. Decreased raphe unit activity in a rat model of endogenous depression. Brain Res 1993;611:31-6.
285. Gillin J, Wyatt J. Schizophrenia: perchance a dream? Int Rev Neurobiol 1975;17:297-342.
286. Sours J. Narcolepsy and other disturbances in the sleep-waking rhythm: a study of 115 cases with review of the literature. J Nerv Ment Dis 1963;137:525-42.
287. Zarcone V. Narcolepsy. N Engl J Med 1973;288:1156-66.
288. Douglass A, Hays P, Pazderka F, Russell J. A schizophrenic variant of narcolepsy. Sleep Res 1989;18:173.
289. Douglass A, Hays P, Pazderka E, Russell J. Florid refractory schizophrenia that turns out to be treatable variants of HLA-associated narcolepsy. J Nerv Ment Dis 1991;179:12-7.
290. Douglass AB, Shipley JE, Haines RF, Scholten RC, Dudley E, Tapp A. Schizophrenia, narcolepsy, HLA-DR14, DQ6. Biol Psychiatry 1993;34:773-80.
291. Jackson C, Bachman D. Narcolepsy-related psychosis misinterpreted as schizophrenia. Neuropsychiatry Neuropsychol Behav Neurol 1996;9:139-40.
292. Zarcone V, Benson K, Berger P Abnormal rapid eye movement latencies in schizophrenia. Arch Gen Psychiatry 1987;44:45-8.
293. Taylor S, Tandon R, Shipley J, Eiser A, Goodson J. Sleep onset REM periods in schizophrenic patients. Biol Psychiatry 1991; 30:205-9.
294. Tandon R, Greden J. Cholinergic hyperactivity and negative schizophrenic symptoms. Arch Gen Psychiatry 1989;46:745-53.
295. Yeomans J. Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia. Neuropsychopharmacology 1995;12:3-16.
296. Karson C, Casanova M, Kleinman J, Griffin W. Choline acetyltransferase in schizophrenia. Am J Psychiatry 1993;150: 454-9.
297. Zweig R, Manaye K, Cook C, Swiergiel T, German D. Preliminary investigation of the pedunculopontine nucleus in schizophrenia. Soc Neurosci Abstr 1994;20:622.
298. Deutch A. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. J Neural Transm 1993; 91:197-221.
299. Modell J, Mountez J, Curtis G, Greden J. Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenic mechanism of obsessive compulsive disorder. J Neuropsychiatry 1989;1:27-36.
300. Singer H, Walkup J. Tourette syndrome and other tic disorders: diagnosis, pathophysiology, and treatment. Medicine 1991;70: 15-32.
301. Salloway S, Cummings J. Subcortical structures and neuropsychiatric illness. Neuroscientist 1996;2:66-75.
302. Insel T, Gillin J, Moore A, Mendelson W, Loewenstcin R, Murphy D. The sleep of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 1982;39:1372-7.
303. Glaze D, Frost J, Jankovic J. Sleep in Gilles de la Tourette's syndrome: disorder of arousal. Neurology 1983;33:586-92.
304. Reese N, Garcia-Rill E, Skinner R. The pedunculopontine nucleus-auditory input, arousal, and pathophysiology. Prog Neurobiol 1995;42:105-33.
305. Swerdlow N. Cortico-striatal substrates of cognitive, motor, and sensory gating: speculations and implications for psychological function and dysfunction. In: Panksepp J, ed. Advances in biological psychiatry, vol. 2. Greenwich CT: JAI Press, 1996:179-207.
306. Erwin R, Buchwald J. Midlatency auditory evoked responses: differential effects of sleep in the human. Electroencephalogr Clin Neurophysiol 1986;65:383-92.
307. Harrison J, Woolf N, Buchwald J. Cholinergic neurons of the feline pontomesencephalon. I. Essential role in 'Wave A' generation. Brain Res 1990;520:43-54.
308. Buchwald J, Erwin R, Read S, Lancker DV, Cummings J. Mid-latency auditory evoked responses: differential abnormality of P1 in Alzheimer's disease. Electroencephalogr Clin Neurophysiol 1989;74:378-84.
309. O'Mahony D, Rowan M, Feely J, Walsh J, Coakley D. Primary auditory pathway and reticular activating system dysfunction in Alzheimer's disease. Neurology 1994;44:2089-94.
310. Green J, Elder W, Freed D. The P1 component of the middle latency auditory evoked potential predicts a practice effect during clinical trials in Alzheimer's disease. Neurology 1995;45: 962-6.
311. Broughton R, Low R, Valley V, Costa BD, Liddiard S. Auditory evoked potentials compared to EEG and performance measures in the assessment of impaired vigilance in narcolepsy-cataplexy. Sleep Res 1981;10:184.
312. Rye D, Irbe D, Epstein C, Bliwise D. Middle latency auditory evoked responses in narcolepsy and hypersomnia. Sleep Res 1995;24:332.
313. Boop R, Garcia-Rill E, Dykman R, Oglesby M, Galbraith R, Griebel M. Reduced P1 potential in narcolepsy. Sleep Res 1994;23:237.
314. 1: insights into attention and arousal. Pediatr Neurosurg 1994;20: 57-62.
315. Freeman W, Adler L, Waldo M, Pachtman E, Franks R. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biol Psychiatry 1983;18:537-51.
316. Glover A, Ghilardi M, Bodis-Wollner I, Onofrj M. Alterations in event-related potentials (ERPs) of MPTP-treated monkeys. Electroencephalogr Clin Neurophysiol 1988;71:461-8.
317. Pungor K, Papp M, Kekesi K, Juhasz G. A novel effect of MPTP: the selective suppression of paradoxical sleep in cats. Brain Res 1990;525:310-4.
318. Teo C, Rasco L, Skinner R, Harik S, Boop F, Garcia-Rill E. The P1 latency auditory evoked response in Parkinson's disease. Sleep Res 1995;24:434.
319. Wilkins D, Hallett M, Wess M. Audiogenic startle reflex of man and its relationship to startle syndromes. Brain 1986;109: 561-73.
320. Brown P, Rothwell J, Thompson P, Britton T, Day B, Marsden C. New observations on the normal auditory startle reflex in man. Brain 1991;114:1891-902.
321. Davis M, Gendelman D, Tischler M, Gendelman P. A primary acoustic startle circuit: lesion and stimulation studies. J Neurosci 1982;2:791-805.
322. Glenn L. Brainstem and spinal control of lower limb motoneurons with special reference to phasic events and startle reflexes. In: McGinty D, et al., eds. Brain mechanisms of sleep. New York: Raven Press, 1985:81-95.
323. Wu M, Mallick B, Siegel J. Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state. Brain Res 1989;499:7-17.
324. Koch M, Kungel M, Herbert H. Cholinergic neurons in the pedunculopontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat. Exp Brain Res 1993;97:71-82.
325. Swerdlow N, Geyer M. Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus. Behav Neuroscience 1993;107:104-17.
326. Swerdlow N, Braff D, Masten V, Geyer M. Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology 1990;101:414-20.
327. Swerdlow NR, Caine SB, Geyer MA. Sensorimotor gating of the startle reflex is mediated by ventral pallidal efferents to the pedunculopontine nucleus. Soc Neurosci Abstr 1991;17:1455.
328. Swerdlow N, Caine S, Geyer M. Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats. Psychopharmacology 1992;108:189-95.
329. Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. J Neuropsychiatry 1996;8:60-6.
330. Morton N, Chaudauri R, Ellis C, Gray N, Toone B. The effect of apomorphine and L-dopa challenge on prepulse inhibition in patients with Parkinson's disease. Schizophr Res 1995;15: 181-2.
331. Morilak D, Ciaranello R. 5-HT2 receptor immunoreactivity on cholinergic neurons of the pontomesencephalic tegmentum shown by double immunofluorescence. Brain Res 1993;627: 49-54.
332. Morilak DA, Garlow SJ, Ciaranello RD. Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brain. Neuroscience 1993;54:701-17.
333. Wyzinski P, McCarley R, Hobson J. Discharge properties of pontine reticulospinal neurons during the sleep-waking cycle. J Neurophysiol 1978;41:821-34.
334. Evarts E. Temporal patterns of discharge of pyramidal tract neurons during sleep and waking in the monkey. J Neurophysiol 1963;27:152-71.
335. Montplaisir J, Godbout R, Doghen D, DeChamplain J, Young S, Lapierre G. Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study. Neurology 1985;35:130-4.
336. Montplaisir J, Godbout R. Restless legs syndrome and periodic movements during sleep. In: Kryger M, Roth T, Dement W, eds. Principles and practice of sleep medicine. Philadelphia: W.B. Saunders, 1994:402-9.
337. Staedt J, Stoppe G, Kogler A, et al. Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus). J Neural Transm 1993;93:71-4.
338. Staedt J, Stoppe G, Kogler A, et al. Nocturnal myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration. Eur Arch Psychiatr Clin Neurosci 1995;245:8-10.
339. Schenck C, Bundlie S, Patterson A, Mahowald M. Rapid eye movement sleep behavior disorder: a treatable parasomnia affecting older adults. JAMA 1987;257:1786-9.
340. Schenck C, Bundlie S, Ettinger M, Mahowald M. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 1986;9:293-308.
341. Schenck C, Bundlie S, Patterson A, Ettinger M, Mahowald M. Five years of clinical experience with 21 patients having chronic REM sleep behavior disorder (RBD). Sleep Res 1987; 16:424.
342. Schenck C, Hopwood J, Duncan E, Mahowald M. Preservation and loss of REM-atonia in human idiopathic REM sleep behavior disorder (RBD): quantitative polysomnographic (PSG) analyses in 17 patients. Sleep Res 1992;21:16.
343. Baker T, Guilleminault C, Nino-Murcia G, Dement W. Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia. Sleep 1986;9:232-42.
344. Aldrich M, Hollingsworth Z, Penney J. Dopamine-receptor autoradiography of human narcoleptic brain. Neurology 1992;42: 410-5.