Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis

Annals of the Rheumatic Diseases

Volumn 69, Issue 8, 2010, Pages 1511-1518

  Frey, Oliver ^a   Reichel, Andreas ^a   Bonhagen, Kerstin ^a   Morawietz, Lars ^b   Rauchhaus, Una ^c   Kamradt, Thomas ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Novosom AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD25 ANTIBODY; CD4 ANTIBODY; CD4 ANTIGEN; CLODRONIC ACID; GLUCOSE 6 PHOSPHATE ISOMERASE; LIPOSOME; LYMPHOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CD4+ T LYMPHOCYTE; CHRONIC INFLAMMATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE SEVERITY; FLOW CYTOMETRY; HELPER CELL; HISTOPATHOLOGY; IMMUNIZATION; INFLAMMATION; LYMPHOCYTE DEPLETION; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ACUTE DISEASE; ANIMALS; ARTHRITIS, EXPERIMENTAL; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; DISEASE PROGRESSION; GLUCOSE-6-PHOSPHATE ISOMERASE; IMMUNIZATION; IMMUNOGLOBULIN G; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED DBA; T-LYMPHOCYTES, REGULATORY;

EID: 77955462438     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.123422     Document Type: Article

References (37)

1. Schubert D, Maier B, Morawietz L, et al. Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol 2004;172:4503-9. (Pubitemid 38375267)
2. Bockermann R, Schubert D, Kamradt T, et al. Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase. Arthritis Res Ther 2005;7:R1316-24.
3. Bruns L, Frey O, Morawietz L, et al. Immunization with an immunodominant selfpeptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Arthritis Res Ther 2009;11:R117.
4. Iwanami K, Matsumoto I, Tanaka-Watanabe Y, et al. Crucial role of the interleukin-6/ interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum 2008;58:754-63. (Pubitemid 351364873)
5. Malek TR, Yu A, Zhu L, et al. IL-2 family of cytokines in T regulatory cell development and homeostasis. J Clin Immunol 2008;28:635-9.
6. Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol 2008;8:523-32.
7. Morgan ME, Sutmuller RP, Witteveen HJ, et al. CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum 2003;48:1452-60.
8. McGeachy MJ, Stephens LA, Anderton SM. Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J Immunol 2005;175:3025-32.
9. Oldenhove G, de Heusch M, Urbain-Vansanten G, et al. CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J Exp Med 2003;198:259-66. (Pubitemid 36987851)
10. Frentsch M, Arbach O, Kirchhoff D, et al. Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 2005;11:1118-24. (Pubitemid 41486836)
11. Chattopadhyay PK, Yu J, Roederer M. A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med 2005;11:1113-17. (Pubitemid 41486835)
12. Ehrenstein MR, Evans JG, Singh A, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004;200:277-85. (Pubitemid 39031247)
13. van Amelsfort JM, Jacobs KM, Bijlsma JW, et al. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004;50:2775-85.
14. van Amelsfort JM, van Roon JA, Noordegraaf M, et al. Proinflammatory mediatorinduced reversal of CD4+, CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 2007;56:732-42. (Pubitemid 46399420)
15. Kelchtermans H, De Klerck B, Mitera T, et al. Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthritis Res Ther 2005;7:R402-15.
16. Kelchtermans H, Geboes L, Mitera T, et al. Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis. Ann Rheum Dis 2009;68:744-50.
17. Morgan ME, Flierman R, van Duivenvoorde LM, et al. Effective treatment of collageninduced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis Rheum 2005;52:2212-21. (Pubitemid 40994344)
18. Frey O, Petrow PK, Gajda M, et al. The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther 2005;7:R291-301.
19. Huehn J, Siegmund K, Lehmann JC, et al. Developmental stage, phenotype, and migration distinguish naive-and effector/memory-like CD4+ regulatory T cells. J Exp Med 2004;199:303-13.
20. Nguyen LT, Jacobs J, Mathis D, et al. Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum 2007;56:509-20.
21. Bardos T, Czipri M, Vermes C, et al. CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. Arthritis Res Ther 2003;5:R106-13.
22. Frey O, Meisel J, Hutloff A, et al. ICOS-blockade inhibits accumulation of polyfunctional Th1/Th17 cells and mitigates autoimmune arthritis. Ann Rheum Dis 2010 (in press). doi:10.1136/ard.2009.119164.
23. Matsumoto I, Zhang H, Yasukochi T, et al. Therapeutic effects of antibodies to tumor necrosis factor-alpha, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis. Arthritis Res Ther 2008;10:R66.
24. Moon JJ, Chu HH, Pepper M, et al. Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 2007;27:203-13.
25. Iwanami K, Matsumoto I, Tanaka Y, et al. Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis. Arthritis Res Ther 2008;10:R130.
26. Lahl K, Loddenkemper C, Drouin C, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 2007;204:57-63.
27. McHugh RS, Shevach EM. Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol 2002;168:5979-83.
28. Takeuchi M, Keino H, Kezuka T, et al. Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice. Invest Ophthalmol Vis Sci 2004;45:1879-86.
29. Frith JC, Mönkkönen J, Auriola S, et al. The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis. Arthritis Rheum 2001;44:2201-10.
30. Zaiss MM, Axmann R, Zwerina J, et al. Treg cells suppress osteoclast formation: a new link between the immune system and bone. Arthritis Rheum 2007;56:4104-12.
31. Udagawa N. The mechanism of osteoclast differentiation from macrophages: possible roles of T lymphocytes in osteoclastogenesis. J Bone Miner Metab 2003;21:337-43.
32. Kong YY, Feige U, Sarosi I, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999;402:304-9.
33. Li P, Schwarz EM, O'Keefe RJ, et al. Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11b high osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum 2004;50:265-76.
34. Karlson EW, Chibnik LB, Tworoger SS, et al. Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum 2009;60:641-52.
35. Berglin E, Padyukov L, Sundin U, et al. A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis. Arthritis Res Ther 2004;6:R303-8.
36. Rantapää-Dahlqvist S, de Jong BA, Berglin E, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003;48:2741-9.
37. Frey O, Brauer R. Regulatory T cells: magic bullets for immunotherapy? Arch Immunol Ther Exp (Warsz) 2006;54:33-43.