State-dependent blockade of human ether-a-go-go-related gene (hERG) K + channels by changrolin in stably transfected HEK293 cells

Acta Pharmacologica Sinica

Volumn 31, Issue 8, 2010, Pages 915-922

  Chen, Wei Hai ^a,b   Wang, Wen Yi ^a   Zhang, Jie ^a   Yang, Ding ^a,b   Wang, Yi Ping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

anti arrhythmic agent; changrolin; human ether a go go related gene; torsades de pointes; whole cell patch clamp

Indexed keywords

CHANGROLIN; POTASSIUM CHANNEL HERG;

ARTICLE; CELL STRAIN HEK293; DRUG EFFECT; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IN VITRO STUDY; INHIBITION KINETICS; NUCLEOTIDE SEQUENCE; PATCH CLAMP; STEADY STATE;

ANTI-ARRHYTHMIA AGENTS; CELL LINE; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; PATCH-CLAMP TECHNIQUES; QUINAZOLINES; TRANSFECTION;

EID: 77955441026     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.84     Document Type: Article

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