Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultraperformance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry

Journal of Proteome Research

Volumn 9, Issue 8, 2010, Pages 3912-3922

  Tsutsui, Haruhito ^a   Maeda, Toshio ^a   Toyo'Oka, Toshimasa ^a   Min, Jun Zhe ^a   Inagaki, Shinsuke ^a   Higashi, Tatsuya ^a   Kagawa, Yoshiyuki ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

ddY; diabetes mellitus; electrospray ionization time of flight mass spectrometry (ESI TOF MS); metabolite profiling; metabonomics; orthogonal partial least squares discriminant analysis (OPLS DA); principal component analysis (PCA); ultraperformance liquid chromatography (UPLC)

Indexed keywords

BIOLOGICAL MARKER; LYSINE;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROSPRAY IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; ELECTROSPRAY MASS SPECTROMETRY; EXTRACTION; FEMALE; IMPAIRED GLUCOSE TOLERANCE; MALE; MASS SPECTROMETRY; METABOLITE; METABONOMICS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; ORTHOGONAL ROTATION; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEOMICS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS; DISCRIMINANT ANALYSIS; METABOLOMICS; MICE; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ANIMALIA; MUS;

EID: 77955436062     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100121k     Document Type: Article

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