The expression of matrix metalloproteinases-9, transforming growth factor-β1 and transforming growth factor-β receptor I in human atherosclerotic plaque and their relationship with plaque stability

Chinese Medical Journal

Volumn 117, Issue 12, 2004, Pages 1825-1829

  Jiang, Xin ^a   Zeng, He Song ^a   Guo, Yi ^b   Zhou, Zhi Bin ^b   Tang, Bing Shan ^b   Li, Fu Kang ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Atherosclerotic plaque; Matrix metalloproteinases 9; Transforming growth factor beta1

Indexed keywords

EOSIN; GELATINASE B; HEMATOXYLIN; PARAFFIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORRELATION ANALYSIS; ENDARTERECTOMY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROTEIN EXPRESSION; PROTEIN FUNCTION; UNSTABLE ANGINA PECTORIS;

ACTIVIN RECEPTORS, TYPE I; CORONARY ARTERIOSCLEROSIS; EXTRACELLULAR MATRIX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 11344266568     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Rether MD. Collagen synthesis in atherosclerosis: too much and not enough. Cardiovasc Res 1999;41:378-384.
2. Reiner Z, Tedeschi-Reiner E. New information on the pathophysiology of atherosclerosis. Lijec Vjesn 2001;123:26-31.
3. Chen S, Zhou ZB, Guo Y, et al. Serum matrix metalloproteinase-9: a potential clinical marker for prognosis of cerebral infarction. Cerebrovasc Dis Foreign Med Sci 2004;4:260-263.
4. Lutgens E, Cleutjens KB, Heeneman S, et al. Both early and delayed anti-CD40L antibody treatment induce a stable plaque phenotype. Proc Natl Acad Sci USA 2000;97:7494-7499.
5. Chen SY, Robert J. Transforming growth factor: induced differentiation of smooth muscle from a neural crest stem cell line. Circ Res 2004;94:1195-1202.
6. Hansson GK, Robertson AKL, Grainger DJ. TGF-β in atherosclerosis. Arterioscler Thromb Vasc 2004; 24: e137-e138.
7. Grainger DJ. Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol 2004; 24: 399-404.
8. Wei LX, Shi HY, Guo AT, et al. Morphologic discrepancies of emanary atherosclerotic lesions between patients with stable and unstable angina plus acute myocardial infarction. Chin J Pathol (Chin) 1998;27:168-170.
9. Hong BK, Kwon HM, Lee BK, et al. Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions. Yonsei Med J 2000;41:82.
10. Delay AM, Brinekerhoff CE. Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibrobiasis. J Cell Biochem 1992;50:400-410.
11. Lutgens E, van Suylen RJ, Faber BC, et al. Atherosclerotic plaque rupture: local or systemic process? Arterioseler Thromb Vasc Biol 2003;23:2123-2130.
12. Morten AK, Pernille H, Kim H, et al. Transforming growth factor-β controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J Biol Chem 2003;278:44975-44987.
13. Bobik A, Agrotis A, Kanellakis P, et al. Distinct patterns of transforming growth factor-β isoform and receptor expression in human atherosclerotic lesions: colocalization implicates TGF-β in fibrofatty lesion development. Circulation 1999;99: 2883-2891.
14. Mallat Z, Gojova A, Marchiol-Fournigault C, et al. Inhibition of transforming growth factor-β signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 2001;89:930-934.
15. Feinberg MW, Watanabe M, Lebedeva MA, et al. Transforming growth factor-{ beta } 1 inhibition of vascular smooth muscle cell activation is mediated via smad3. J Biol Chem 2004;279:16388-16393.
16. Lutgens E, Gijbel M, Smook M, et al. Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol 2002;22:975-982.
17. Cipollone F, Fazia M, Mincione G, et al. Increased expression of transforming growth factor-β1 as a stabilizing factor in human atherosclerotic plaques. Stroke 2004; 35: 2253-2257.