Importance of CCL2-CCR2A/2B signaling for monocyte migration into spheroids of breast cancer-derived fibroblasts

Immunobiology

Volumn 215, Issue 9-10, 2010, Pages 737-747

  Ksiazkiewicz, Magdalena ^a,b   Gottfried, Eva ^b   Kreutz, Marina ^b   Mack, Matthias ^b   Hofstaedter, Ferdinand ^b   Kunz Schughart, Leoni A ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Breast cancer; CCR2A 2B; MCP 1 CCL2; Migration; Monocytes; Multicellular spheroid; Spheroid co culture; Tumor associated fibroblast

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2A; CHEMOKINE RECEPTOR CCR2B; CHOLERA TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL INFILTRATION; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKOCYTE MIGRATION; LYMPHOCYTE SUBPOPULATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPHEROID CELL;

ANTIBODIES, BLOCKING; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINE CCL2; CHOLERA TOXIN; FEMALE; FIBROBLASTS; HUMANS; MONOCYTES; PERTUSSIS TOXIN; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR;

EID: 77955430115     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2010.05.019     Document Type: Article

References (61)

1. al-Sarireh B., Eremin O. Tumour-associated macrophages (TAMs): disordered function, immune suppression and progressive tumour growth. JR Coll. Surg. Edinb. 2000, 45:1-16.
2. Allavena P., Sica A., Solinas G., Porta C., Mantovani A. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit. Rev. Oncol. Hematol. 2008, 66:1-9.
3. Ancuta P., Moses A., Gabuzda D. Transendothelial migration of CD16+ monocytes in response to fractalkine under constitutive and inflammatory conditions. Immunobiology 2004, 209:11-20.
4. Ancuta P., Rao R., Moses A., Mehle A., Shaw S.K., Luscinskas F.W., Gabuzda D. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J. Exp. Med. 2003, 197:1701-1707.
5. Andoh A., Takaya H., Saotome T., Shimada M., Hata K., Araki Y., Nakamura F., Shintani Y., Fujiyama Y., Bamba T. Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 2000, 119:211-219.
6. Balkwill F. Cancer and the chemokine network. Nat. Rev. Cancer 2004, 4:540-550.
7. Bingle L., Brown N.J., Lewis C.E. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 2002, 196:254-265.
8. Bottazzi B., Polentarutti N., Acero R., Balsari A., Boraschi D., Ghezzi P., Salmona M., Mantovani A. Regulation of the macrophage content of neoplasms by chemoattractants. Science 1983, 220:210-212.
9. Buckley C.D., Pilling D., Lord J.M., Akbar A.N., Scheel-Toellner D., Salmon M. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 2001, 22:199-204.
10. Cambien B., Pomeranz M., Millet M.A., Rossi B., Schmid-Alliana A. Signal transduction involved in MCP-1-mediated monocytic transendothelial migration. Blood 2001, 97:359-366.
11. Coffelt S.B., Hughes R., Lewis C.E. Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim. Biophys. Acta. 2009.
12. Crowther M., Brown N.J., Bishop E.T., Lewis C.E. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J. Leukoc. Biol. 2001, 70:478-490.
13. Falk W., Leonard E.J. Human monocyte chemotaxis: migrating cells are a subpopulation with multiple chemotaxin specificities on each cell. Infect. Immun. 1980, 29:953-959.
14. Friedrich J., Seidel C., Ebner R., Kunz-Schughart L.A. Spheroid-based drug screen: considerations and practical approach. Nat. Protoc. 2009, 4:309-324.
15. Fujimoto H., Sangai T., Ishii G., Ikehara A., Nagashima T., Miyazaki M., Ochiai A. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int. J. Cancer 2009, 125:1276-1284.
16. Galindo M., Santiago B., Alcami J., Rivero M., Martin-Serrano J., Pablos J.L. Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts. Clin. Exp. Immunol. 2001, 123:36-41.
17. Goede V., Brogelli L., Ziche M., Augustin H.G. Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1. Int. J. Cancer 1999, 82:765-770.
18. Gonzalez-Cuadrado S., Bustos C., Ruiz-Ortega M., Ortiz A., Guijarro C., Plaza J.J., Egido J. Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis. Clin. Exp. Immunol. 1996, 106:518-522.
19. Goswami S., Sahai E., Wyckoff J.B., Cammer M., Cox D., Pixley F.J., Stanley E.R., Segall J.E., Condeelis J.S. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res. 2005, 65:5278-5283.
20. Gottfried E., Faust S., Fritsche J., Kunz-Schughart L.A., Andreesen R., Miyake K., Kreutz M. Identification of genes expressed in tumor-associated macrophages. Immunobiology 2003, 207(5):351-359.
21. Gottfried E., Kunz-Schughart L.A., Andreesen R., Kreutz M. Brave little world: spheroids as an in vitro model to study tumor-immune-cell interactions. Cell Cycle 2006, 5:691-695.
22. Gottfried E., Kunz-Schughart L.A., Weber A., Rehli M., Peuker A., Muller A., Kastenberger M., Brockhoff G., Andreesen R., Kreutz M. Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. 2008, 67:453-463.
23. Gouwy M., Struyf S., Noppen S., Schutyser E., Springael J.Y., Parmentier M., Proost P., Van Damme J. Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol. Pharmacol. 2008, 74:485-495.
24. Heimdal J.H., Aarstad H.J., Olsnes C., Olofsson J. Human autologous monocytes and monocyte-derived macrophages in co-culture with carcinoma F-spheroids secrete IL-6 by a non-CD14-dependent pathway. Scand. J. Immunol. 2001, 53:162-170.
25. Konur A., Kreutz M., Knuchel R., Krause S.W., Andreesen R. Cytokine repertoire during maturation of monocytes to macrophages within spheroids of malignant and non-malignant urothelial cell lines. Int. J. Cancer 1998, 78:648-653.
26. Krause S.W., Kreutz M., Andreesen R. Isolation, characterization and cultivation of human monocytes and macrophages. Meth. Microbiol. 1998, 25:663-684.
27. Kunisch E., Fuhrmann R., Roth A., Winter R., Lungershausen W., Kinne R.W. Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry. Ann. Rheum. Dis. 2004, 63:774-784.
28. Kunz-Schughart L.A., Heyder P., Schroeder J., Knuechel R. A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation. Exp. Cell Res. 2001, 266:74-86.
29. Kunz-Schughart L.A., Knuechel R. Tumor-associated-fibroblasts (part II): functional impact on tumor tissue. Histol. Histopathol. 2002, 17:623-637.
30. Lebrecht A., Grimm C., Lantzsch T., Ludwig E., Hefler L., Ulbrich E., Koelbl H. Monocyte chemoattractant protein-1 serum levels in patients with breast cancer. Tumour Biol. 2004, 25:14-17.
31. Leek R.D., Hunt N.C., Landers R.J., Lewis C.E., Royds J.A., Harris A.L. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 2000, 190:430-436.
32. Leek R.D., Lewis C.E., Whitehouse R., Greenall M., Clarke J., Harris A.L. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 1996, 56:4625-4629.
33. Lewis C.E., Hughes R. Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Res. 2007, 9:209.
34. Lewis C.E., Pollard J.W. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 2006, 66:605-612.
35. Lin E.Y., Li J.F., Gnatovskiy L., Deng Y., Zhu L., Grzesik D.A., Qian H., Xue X.N., Pollard J.W. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 2006, 66:11238-11246.
36. Lin E.Y., Nguyen A.V., Russell R.G., Pollard J.W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 2001, 193:727-740.
37. Loberg R.D., Ying C., Craig M., Day L.L., Sargent E., Neeley C., Wojno K., Snyder L.A., Yan L., Pienta K.J. Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res. 2007, 67:9417-9424.
38. Loberg R.D., Ying C., Craig M., Yan L., Snyder L.A., Pienta K.J. CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration. Neoplasia 2007, 9:556-562.
39. Mantovani A., Bottazzi B., Colotta F., Sozzani S., Ruco L. The origin and function of tumor-associated macrophages. Immunol. Today 1992, 13:265-270.
40. Mantovani A., Schioppa T., Porta C., Allavena P., Sica A. Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metastasis Rev. 2006, 25:315-322.
41. Mestdagt M., Polette M., Buttice G., Noel A., Ueda A., Foidart J.M., Gilles C. Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells. Int. J. Cancer 2006, 118:35-42.
42. Nakagawa H., Liyanarachchi S., Davuluri R.V., Auer H., Martin E.W., de la C.A., Frankel W.L. Role of cancer-associated stromal fibroblasts in metastatic colon cancer to the liver and their expression profiles. Oncogene 2004, 23:7366-7377.
43. Ohta M., Kitadai Y., Tanaka S., Yoshihara M., Yasui W., Mukaida N., Haruma K., Chayama K. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas. Int. J. Oncol. 2003, 22:773-778.
44. Owen C.A., Campbell M.A., Boukedes S.S., Campbell E.J. Monocytes recruited to sites of inflammation express a distinctive proinflammatory (P) phenotype. Am. J. Physiol. 1994, 267:L786-L796.
45. Porta C., Subhra Kumar B., Larghi P., Rubino L., Mancino A., Sica A. Tumor promotion by tumor-associated macrophages. Adv. Exp. Med. Biol. 2007, 604:67-86.
46. Rolfe M.W., Kunkel S.L., Standiford T.J., Orringer M.B., Phan S.H., Evanoff H.L., Burdick M.D., Strieter R.M. Expression and regulation of human pulmonary fibroblast-derived monocyte chemotactic peptide-1. Am. J. Physiol. 1992, 263:L536-L545.
47. Saji H., Koike M., Yamori T., Saji S., Seiki M., Matsushima K., Toi M. Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer 2001, 92:1085-1091.
48. Silzle T., Kreutz M., Dobler M.A., Brockhoff G., Knuechel R., Kunz-Schughart L.A. Tumor-associated fibroblasts recruit blood monocytes into tumor tissue. Eur. J. Immunol. 2003, 33:1311-1320.
49. Silzle T., Randolph G.J., Kreutz M., Kunz-Schughart L.A. The fibroblast: sentinel cell and local immune modulator in tumor tissue. Int. J. Cancer 2004, 108:173-180.
50. Smith R.S., Smith T.J., Blieden T.M., Phipps R.P. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am. J. Pathol. 1997, 151:317-322.
51. Soria G., Ben-Baruch A. The inflammatory chemokines CCL2 and CCL5 in breast cancer. Cancer Lett. 2008, 267:271-285.
52. Sporri B., Muller K.M., Wiesmann U., Bickel M. Soluble IL-6 receptor induces calcium flux and selectively modulates chemokine expression in human dermal fibroblasts. Int. Immunol. 1999, 11:1053-1058.
53. Struyf S., Van Collie E., Paemen L., Put W., Lenaerts J.P., Proost P., Opdenakker G., Van Damme J. Synergistic induction of MCP-1 and -2 by IL-1beta and interferons in fibroblasts and epithelial cells. J. Leukoc. Biol. 1998, 63:364-372.
54. Tobita K., Kijima H., Dowaki S., Oida Y., Kashiwagi H., Ishii M., Sugio Y., Sekka T., Ohtani Y., Tanaka M., Inokuchi S., Makuuchi H. Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Int. J. Oncol. 2002, 21:1189-1195.
55. Tsutsui S., Yasuda K., Suzuki K., Tahara K., Higashi H., Era S. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol. Rep. 2005, 14:425-431.
56. Ueno T., Toi M., Saji H., Muta M., Bando H., Kuroi K., Koike M., Inadera H., Matsushima K. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin. Cancer Res. 2000, 6:3282-3289.
57. Valkovic T., Lucin K., Krstulja M., Dobi-Babic R., Jonjic N. Expression of monocyte chemotactic protein-1 in human invasive ductal breast cancer. Pathol. Res. Pract. 1998, 194:335-340.
58. Waugh D.J., Wilson C. The interleukin-8 pathway in cancer. Clin. Cancer Res. 2008, 14:6735-6741.
59. Weber C., Belge K.U., von Hundelshausen P., Draude G., Steppich B., Mack M., Frankenberger M., Weber K.S., Ziegler-Heitbrock H.W. Differential chemokine receptor expression and function in human monocyte subpopulations. J. Leukoc. Biol. 2000, 67:699-704.
60. Ziegler-Heitbrock H.W. Definition of human blood monocytes. J. Leukoc. Biol. 2000, 67:603-606.
61. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J. Leukoc. Biol. 2007, 81:584-592.