Human autologous monocytes and monocyte-derived macrophages in co-culture with carcinoma F-spheroids secrete IL-6 by a non-CD 14-dependent pathway

Scandinavian Journal of Immunology

Volumn 53, Issue 2, 2001, Pages 162-170

  Heimdal, J H ^a   Aarstad, H J ^a   Olsnes, C ^a   Olofsson, J ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIBODY; CD14 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INHIBITION KINETICS; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR CELL CULTURE; TUMOR IMMUNOLOGY; TUMOR SPHEROID;

ANTIGENS, CD14; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOPHARYNGEAL NEOPLASMS; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASM PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035128841     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2001.00853.x     Document Type: Article

References (33)

1. Effect of cyclophosphamide on survival of mice and incidence of metastatic tumor following intravenous and intracardial inoculation of tumor cells
2. Natural killer cells and tumor therapy
3. Tumour immunology: False hopes-new horizons?
4. Adoptive immunotherapy of cancer using monocyte-derived macrophages: Rationale, current status and perspectives
5. Tumour necrosis factor: Function, release and clearance
6. Recognition and destruction of neoplastic cells by activated macrophages: Discrimination of altered self
7. Monocytes secrete interleukin-6 when co-cultured in vitro with benign or malignant autologous fragment spheroids from squamous cell carcinoma patients
8. Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes
9. Development and heterogeneity of macrophages and their related cells through their differentiation pathways
10. Macrophage infiltration and tumor progression
11. Macrophage and dendritic cell infiltration in head and neck squamous-cell carcinoma; an immunohistochemical study
12. The origin and function of tumor-associated macrophages
13. Tumor-associated macrophages (TAM) in the stroma of squamous cell carcinomas of the ENT area studied using monoclonal antibodies
14. Monocyte-to-macrophage transition in vitro. A systematic study using human cells isolated by fractionation on Percol
15. Developmental regulation of thecytokine repertoire in human macrophages IL-1, IL-6, TNF-α M-CSF
16. Tumour immunology: Alternative perspectives
17. Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages
18. T-lymphocyte function in head and neck cancer patients
19. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
20. In vitro differentiation of human monocytes. Differences in monocyte phenotypes induced by cultivation on glass or on collagen
21. Regulation of cytokine mRNA expression in lipopolysaccharide-stimulated human macrophages
22. Comparison of in vivo and in vitro prostaglandin E2 production by squamous cell carcinoma of the head and neck
23. In vitro differentiation of human monocytes to macrophages: Change of PDÉ profile and its relationship to suppression of tumour necrosis factor-α release by PDE inhibitors
24. Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens
25. Interferon-gamma regulation of interleukin 6 in monocytic cells
26. Effects of adherence, activation and distinct serum proteins on the in vitro human monocyte maturation process
27. Differential effects of cell adherence on LPS-stimulated cytokine production by human monocytes and macrophages
28. Involvement of inflammatory mediators in macrophage antitumor activity
29. Ex vivo interleukin (IL)-1β, IL-6, IL-12 and tumor necrosis factor-α responsiveness with monocytes from patients with head and neck carcinoma
30. Interleukin-1 beta and interleukin-6 release by peripheral blood monocytes in head and neck cancer
31. Interleukin-6: An overview
32. Analysis of TCR usage in human tumors: A new tool for assessing tumor-specific immune responses
33. The biology of macrophages: I. General principles and properties