LuxR-dependent quorum sensing: Computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4355-4358

  Soulère, Laurent ^a   Sabbah, Mohamad ^a   Fontaine, Fanny ^a   Queneau, Yves ^a   Doutheau, Alain ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

AHL; Antagonist; LuxR; Molecular docking; Quorum sensing; Virtual screening

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; ASPARTIC ACID; CALCITRIOL DERIVATIVE; CALMIDAZOLIUM; CLOFOCTOL; ESTRADIOL DERIVATIVE; FENDILINE; FENVALERATE; MANOALIDE; MITOTANE; N ACYLHOMOSERINE LACTONE; PIMETHIXENE; PROGESTERONE DERIVATIVE; RETINOL DERIVATIVE; SERTRALINE; TAMOXIFEN; TERFENADINE; TORASEMIDE; TRANSCRIPTION FACTOR LUXR; TRYPTOPHAN; TYROSINE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CALCULATION; CHEMICAL STRUCTURE; COMPUTER ANALYSIS; GENETIC ALGORITHM; IC 50; MOLECULAR DOCKING; QUORUM SENSING; VIRTUAL REALITY;

4-BUTYROLACTONE; ANALGESICS; BINDING SITES; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; IMIDAZOLES; QUORUM SENSING; REPRESSOR PROTEINS; SMALL MOLECULE LIBRARIES; TRANS-ACTIVATORS;

EID: 77955423189     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.081     Document Type: Article

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