Regioselective synthesis of 2,3-dihydrospiro[1,4]dioxino[2,3-b]pyridine derivatives

Tetrahedron Letters

Volumn 51, Issue 33, 2010, Pages 4350-4353

  Tony, Kurissery A ^a   Chittimalla, Santhosh Kumar ^a   Abraham Rajkumar, G ^a   Chakrabarti, Anjan ^a  

^a AMRI Singapore Research Centre   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROPYRIDINE DERIVATIVE; 2,2' SPIRO 1,4 BENZODIOXIN DERIVATIVE; 2,3 DIHYDROSPIRO[1,4]DIOXINO[2,3 B]PYRIDINE DERIVATIVE; ARYLBROMIDE; BENZODIOXIN; BROMINE DERIVATIVE; CARBON; OXYGEN; PALLADIUM; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 77955421273     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.06.061     Document Type: Article

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40. 4. The solvent was evaporated under reduced pressure and purification by silica-gel chromatography using EtOAc/hexanes eluent systems afforded 7a-h.
41. 3 (0.60 mmol) were added and the mixture was heated at 125 °C for 5-8 h. When the reaction was complete, the mixture was filtered through a short pad of Celite. The filtrate was concentrated in vacuo and purified by silica-gel chromatography to give compounds 8a-h.