-
1
-
-
84944045237
-
-
Katritzky, A. R., Rees, C. W., Scriven, E. F. V., Eds.; Pergamon: Oxford
-
Guillaumet. G. Comprehensive Heterocyclic Chemistry II, 1st ed.; Katritzky, A. R., Rees, C. W., Scriven, E. F. V., Eds.; Pergamon: Oxford, 1996; Vol. 6, p 447.
-
(1996)
Comprehensive Heterocyclic Chemistry II, 1st Ed.
, vol.6
, pp. 447
-
-
Guillaumet, G.1
-
2
-
-
0021865411
-
-
Stillings, M. R.; Chapleo, C. B.; Butler, R. C. M.; Davis, J. A.; England, C. D.; Myers, M.; Tweddle, N.; Welbourn, A. P.; Doxey, J. C.; Smith, C. F. C. J. Med. Chem. 1985, 28, 1054.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 1054
-
-
Stillings, M.R.1
Chapleo, C.B.2
Butler, R.C.M.3
Davis, J.A.4
England, C.D.5
Myers, M.6
Tweddle, N.7
Welbourn, A.P.8
Doxey, J.C.9
Smith, C.F.C.10
-
3
-
-
0023073702
-
-
Campbell, S. F.; Davey, M. J.; Hardstone, J. D.; Lewis, B. N.; Palmer, M. J. J. Med. Chem. 1987, 30, 49.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 49
-
-
Campbell, S.F.1
Davey, M.J.2
Hardstone, J.D.3
Lewis, B.N.4
Palmer, M.J.5
-
4
-
-
0029113808
-
-
Ruffolo, R. R., Jr.; Bondinell, W.; Hieble, J. P. J. Med. Chem. 1995, 38, 3681.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3681
-
-
Ruffolo Jr., R.R.1
Bondinell, W.2
Hieble, J.P.3
-
5
-
-
0029946175
-
-
Khouili, M.; Guillaumet, G.; Coudert, G.; Pujol, M. D. Il Farmaco 1996, 51, 175.
-
(1996)
Il Farmaco
, vol.51
, pp. 175
-
-
Khouili, M.1
Guillaumet, G.2
Coudert, G.3
Pujol, M.D.4
-
6
-
-
0033615029
-
-
and referenes cited therein
-
Quaglia, W.; Pigini, M.; Piergentili, A.; Giannella, M.; Marucci, G.; Poggesi, E.; Leonardi, A.; Melchiorre, C. J. Med. Chem. 1999, 42, 2961 and referenes cited therein.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 2961
-
-
Quaglia, W.1
Pigini, M.2
Piergentili, A.3
Giannella, M.4
Marucci, G.5
Poggesi, E.6
Leonardi, A.7
Melchiorre, C.8
-
7
-
-
0023915093
-
-
Hibert, M. F.; Gittos, M. W.; Milddlemiss, D. N.; Mir, A. K.; Fozard, J. R. J. Med. Chem. 1988, 31, 1087.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 1087
-
-
Hibert, M.F.1
Gittos, M.W.2
Milddlemiss, D.N.3
Mir, A.K.4
Fozard, J.R.5
-
8
-
-
0023748365
-
-
Nikam, S. S.; Martin, A. R.; Nelson, D. L. J. Med. Chem. 1988, 31, 1965.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 1965
-
-
Nikam, S.S.1
Martin, A.R.2
Nelson, D.L.3
-
9
-
-
0030614322
-
-
Kuipers, W.; Kouse, C. G.; Van Wijngaarden, I.; Standaar, P. J.; Tulp, M. Th. M.; Veldman, N.; Spek, A. L.; Ijzerman, A. P. J. Med. Chem. 1997, 40, 300.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 300
-
-
Kuipers, W.1
Kouse, C.G.2
Van Wijngaarden, I.3
Standaar, P.J.4
Tulp, M.Th.M.5
Veldman, N.6
Spek, A.L.7
Ijzerman, A.P.8
-
10
-
-
0029559169
-
-
Uchida, M.; Kentaro, I.; Tameda, C.; Miyauchi, T. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 1995, 19, 1201.
-
(1995)
Prog. Neuro-Psychopharmacol. Biol. Psychiatry
, vol.19
, pp. 1201
-
-
Uchida, M.1
Kentaro, I.2
Tameda, C.3
Miyauchi, T.4
-
11
-
-
0038574040
-
-
Matsuda, T.; Yoshikawa, T.; Suzuki, M.; Asano, S.; Somboonthum, P.; Takuma, K.; Nakano, Y.; Morita, T.; Nakasu, Y.; Kim, H. S.; Egawa, M.; Tobe, A.; Baba, A. Jpn. J. Pharmacol. 1995, 69, 366.
-
(1995)
Jpn. J. Pharmacol.
, vol.69
, pp. 366
-
-
Matsuda, T.1
Yoshikawa, T.2
Suzuki, M.3
Asano, S.4
Somboonthum, P.5
Takuma, K.6
Nakano, Y.7
Morita, T.8
Nakasu, Y.9
Kim, H.S.10
Egawa, M.11
Tobe, A.12
Baba, A.13
-
12
-
-
0033606948
-
-
and references therein
-
Birch, A. M.; Bradley, P. A.; Gill, J. C.; Kerrigan, F.; Needham, P. L. J. Med. Chem. 1999, 42, 3342 and references therein.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3342
-
-
Birch, A.M.1
Bradley, P.A.2
Gill, J.C.3
Kerrigan, F.4
Needham, P.L.5
-
13
-
-
8044241591
-
-
Munk, S. A.; Harcourt, D. A.; Arasasingham, P. N.; Burke, J. A.; Kharlamb, A. R.; Manlapaz, C. A.; Padillo, E. U.; Roberts, D.; Runde, E.; Williams, L.; Wheeler, L. A.; Garst, M. E. J. Med. Chem. 1997, 40, 18.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 18
-
-
Munk, S.A.1
Harcourt, D.A.2
Arasasingham, P.N.3
Burke, J.A.4
Kharlamb, A.R.5
Manlapaz, C.A.6
Padillo, E.U.7
Roberts, D.8
Runde, E.9
Williams, L.10
Wheeler, L.A.11
Garst, M.E.12
-
14
-
-
0029014681
-
-
Satoh, Y.; Powers, C.; Toledo, L. M.; Kowalski, T. J.; Peters, P. A.; Kimble, E. F. J. Med. Chem. 1995, 38, 68.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 68
-
-
Satoh, Y.1
Powers, C.2
Toledo, L.M.3
Kowalski, T.J.4
Peters, P.A.5
Kimble, E.F.6
-
16
-
-
0026540989
-
-
Fukuyama, Y.; Hasegawa, T.; Toda, M.; Kodama, M.; Okazaki, H. Chem. Pharm. Bull. 1992, 40, 252.
-
(1992)
Chem. Pharm. Bull.
, vol.40
, pp. 252
-
-
Fukuyama, Y.1
Hasegawa, T.2
Toda, M.3
Kodama, M.4
Okazaki, H.5
-
19
-
-
0442283646
-
-
Eur. Pat. 227932, 1986
-
(c) Cross, B.; Los, M.; Doehner, R. F.; Ladner, D. W.; Johnson, J. L.; Jung, M. E.; Kamhi, W. M.; Tseng, S. S.; Finn, J. M.; Wepplo, P. J. Eur. Pat. 227932, 1986; Chem. Abstr. 1988, 108, 21884e.
-
-
-
Cross, B.1
Los, M.2
Doehner, R.F.3
Ladner, D.W.4
Johnson, J.L.5
Jung, M.E.6
Kamhi, W.M.7
Tseng, S.S.8
Finn, J.M.9
Wepplo, P.J.10
-
20
-
-
85060508705
-
-
(c) Cross, B.; Los, M.; Doehner, R. F.; Ladner, D. W.; Johnson, J. L.; Jung, M. E.; Kamhi, W. M.; Tseng, S. S.; Finn, J. M.; Wepplo, P. J. Eur. Pat. 227932, 1986; Chem. Abstr. 1988, 108, 21884e.
-
(1988)
Chem. Abstr.
, vol.108
-
-
-
21
-
-
0033408487
-
-
(a) Comoy, C.; Benarab, A.; Leinot, M.; Monteil, A.; Guillaumet, G. Il Farmaco. 1999, 54, 791.
-
(1999)
Il Farmaco.
, vol.54
, pp. 791
-
-
Comoy, C.1
Benarab, A.2
Leinot, M.3
Monteil, A.4
Guillaumet, G.5
-
22
-
-
0001061904
-
-
(b) Comoy, C.; Benarab, A.; Monteil, A.; Leinot, M.; Massingham, R.; Guillaumet, G. Med. Chem. Res. 1996, 6, 392.
-
(1996)
Med. Chem. Res.
, vol.6
, pp. 392
-
-
Comoy, C.1
Benarab, A.2
Monteil, A.3
Leinot, M.4
Massingham, R.5
Guillaumet, G.6
-
23
-
-
0001673497
-
-
(c) Benarab, A.; Comoy, C.; Guillaumet, G. Heterocycles 1994, 38, 1641.
-
(1994)
Heterocycles
, vol.38
, pp. 1641
-
-
Benarab, A.1
Comoy, C.2
Guillaumet, G.3
-
24
-
-
0038235291
-
-
(d) Benarab, A.; Poirot, P.; Guillaumet, G. Heterocycles 1993, 36, 1589.
-
(1993)
Heterocycles
, vol.36
, pp. 1589
-
-
Benarab, A.1
Poirot, P.2
Guillaumet, G.3
-
26
-
-
0442315133
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-
note
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Epoxide 1 was prepared by condensation of the anion of 2-nitro-3-hydroxypyridine on epichlorohydrin in DMF at 60°C in 81% yield.
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-
-
-
29
-
-
0031585032
-
-
Kotsuki, H.; Ohishi, T.; Araki, T. Tetrahedron Lett. 1997, 38, 12, 2129.
-
(1997)
Tetrahedron Lett.
, vol.38
, Issue.12
, pp. 2129
-
-
Kotsuki, H.1
Ohishi, T.2
Araki, T.3
-
30
-
-
0002930096
-
-
(a) Truce, W. E.; Kreider, E. M.; Brand, W. W. Org. React. 1970, 18, 99.
-
(1970)
Org. React.
, vol.18
, pp. 99
-
-
Truce, W.E.1
Kreider, E.M.2
Brand, W.W.3
-
31
-
-
0027769721
-
-
(b) Proudfoot, J. R.; Patel, U. R.; Campbell, S. J. J. Org. Chem. 1993, 58, 6996.
-
(1993)
J. Org. Chem.
, vol.58
, pp. 6996
-
-
Proudfoot, J.R.1
Patel, U.R.2
Campbell, S.J.3
-
32
-
-
0028898871
-
-
(c) Proudfoot, J. R.; Patel, U. R.; Kapadia, S. R.; Hargrave, K. D. J. Med. Chem. 1995, 38, 1406.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 1406
-
-
Proudfoot, J.R.1
Patel, U.R.2
Kapadia, S.R.3
Hargrave, K.D.4
-
33
-
-
85088882701
-
-
note
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18
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34
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85088883392
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note
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2/MeOH: 95/5).
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35
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0442315130
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note
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+ + 1).
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