Unconventional transcriptional response to environmental enrichment in a mouse model of rett syndrome

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Kerr, Bredford ^a   Silva, Pamela A ^a,b   Walz, Katherina ^a,b,c   Young, Juan I ^a,c  

^a CENTRO DE ESTUDIOS CIENTÍFICOS CECS   (Chile)

^b UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYL CPG BINDING PROTEIN 2; MECP2 PROTEIN, MOUSE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; COORDINATION DISORDER; DOWN REGULATION; ENVIRONMENTAL ENRICHMENT; GENE EXPRESSION; GENETIC TRANSCRIPTION; MALE; MARKER GENE; MAZE TEST; MOTOR PERFORMANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN FIELD TEST; PHENOTYPE; RETT SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; DISEASE MODEL; ENVIRONMENT; GENETICS; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; ENVIRONMENT; MAZE LEARNING; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, MUTANT STRAINS; PHENOTYPE; RANDOM ALLOCATION; RETT SYNDROME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77955368265     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011534     Document Type: Article

References (37)

1. Hagberg B, Aicardi J, Dias K, Ramos O (1983) A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann Neurol 14: 471-479. 10.1002/ ana.410140412 [doi].
2. Rett A (1986) Rett syndrome. History and general overview. Am J Med Genet Suppl 1: 21-25.
3. Chahrour M, Zoghbi HY (2007) The story of Rett syndrome: from clinic to neurobiology. Neuron 56: 422-437. S0896-6273(07)00756-8 [pii];10.1016/j. neuron.2007.10.001 [doi].
4. Laurvick CL, de KN, Bower C, Christodoulou J, Ravine D, et al. (2006) Rett syndrome in Australia: a review of the epidemiology. J Pediatr 148: 347-352. S0022-3476(05)01030-9 [pii];10.1016/j.jpeds.2005.10.037 [doi].
5. Guy J, Hendrich B, Holmes M, Martin JE, Bird A (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27: 322-326. 10.1038/85899 [doi].
6. Chen RZ, Akbarian S, Tudor M, Jaenisch R (2001) Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27: 327-331. 10.1038/85906 [doi].
7. Pelka GJ, Watson CM, Radziewic T, Hayward M, Lahooti H, et al. (2006) Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 129: 887-898. awl022 [pii];10.1093/brain/awl022 [doi].
8. Luikenhuis S, Giacometti E, Beard CF, Jaenisch R (2004) Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A 101: 6033-6038. 10.1073/pnas.0401626101 [doi];0401626101 [pii].
9. Asaka Y, Jugloff DG, Zhang L, Eubanks JH, Fitzsimonds RM (2006) Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiol Dis 21: 217-227. S0969-9961(05)00204-4 [pii];10.1016/j.nbd.2005.07.005 [doi].
10. Moretti P, Levenson JM, Battaglia F, Atkinson R, Teague R, et al. (2006) Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J Neurosci 26: 319-327. 26/1/319 [pii];10.1523/JNEUROSCI. 2623-05.2006 [doi].
11. Dani VS, Chang Q, Maffei A, Turrigiano GG, Jaenisch R, et al. (2005) Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A 102: 12560-12565. 0506071102 [pii];10.1073/pnas.0506071102 [doi].
12. Nelson ED, Kavalali ET, Monteggia LM (2006) MeCP2-dependent transcriptional repression regulates excitatory neurotransmission. Curr Biol 16: 710-716. S0960-9822(06)01262-0 [pii];10.1016/j.cub.2006.02.062 [doi].
13. Chao HT, Zoghbi HY, Rosenmund C (2007) MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron 56: 58-65. S0896-6273(07)00647-2 [pii];10.1016/j.neuron.2007.08.018 [doi].
14. Chen WG, Chang Q, Lin Y, Meissner A, West AE, et al. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302: 885-889. 10.1126/science.1086446 [doi];302/5646/885 [pii].
15. Martinowich K, Hattori D, Wu H, Fouse S, He F, et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.Science 302: 890-893. 10.1126/science.1090842 [doi];302/5646/ 890 [pii].
16. Chahrour M, Jung SY, Shaw C, Zhou X, Wong ST, et al. (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320: 1224-1229. 320/5880/1224 [pii];10.1126/science.1153252 [doi].
17. Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, et al. (2006) Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52: 255-269. S0896- 6273(06)00775-6 [pii];10.1016/j.neuron.2006.09.037 [doi].
18. Miyano M, Horike S, Cai S, Oshimura M, Kohwi-Shigematsu T (2008) DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex. J Cell Mol Med 12: 1188-1191. JCMM377 [pii];10.1111/j.1582- 4934.2008.00377.x [doi].
19. Deng V, Matagne V, Banine F, Frerking M, Ohliger P, et al. (2007) FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice. Hum Mol Genet 16: 640-650. ddm007 [pii];10.1093/ hmg/ddm007 [doi].
20. Lewis MH (2004) Environmental complexity and central nervous system development and function. Ment Retard Dev Disabil Res Rev 10: 91-95. 10.1002/mrdd.20017 [doi].
21. Hockly E, Cordery PM, Woodman B, Mahal A, van DA, et al. (2002) Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Ann Neurol 51: 235-242. 10.1002/ana.10094 [pii].
22. van DA, Blakemore C, Deacon R, York D, Hannan AJ (2000) Delaying the onset of Huntington's in mice. Nature 404: 721-722. 10.1038/35008142 [doi].
23. Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, et al. (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120: 701-713. S0092-8674(05)00089-9 [pii];10.1016/ j.cell.2005.01.015 [doi].
24. Kondo M, Gray LJ, Pelka GJ, Christodoulou J, Tam PP, et al. (2008) Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome-Mecp2 gene dosage effects and BDNF expression. Eur J Neurosci 27: 3342-3350. EJN6305 [pii];10.1111/j.1460-9568. 2008.06305.x [doi].
25. Nag N, Moriuchi JM, Peitzman CG, Ward BC, Kolodny NH, et al. (2009) Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice. Behav Brain Res 196: 44-48. S0166-4328(08)00362-8 [pii];10.1016/j.bbr.2008.07.008 [doi].
26. Stearns NA, Schaevitz LR, Bowling H, Nag N, Berger UV, et al. (2007) Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome. Neuroscience 146: 907-921. S0306-4522(07)00182-0 [pii];10.1016/j.neuroscience.2007.02.009 [doi].
27. Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, et al. (2007) Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176: 4-20. S0166-4328(06)00443-8 [pii];10.1016/j.bbr.2006.07.030 [doi].
28. Guy J, Gan J, Selfridge J, Cobb S, Bird A (2007) Reversal of neurological defects in a mouse model of Rett syndrome. Science 315: 1143-1147. 1138389 [pii];10.1126/science.1138389 [doi].
29. Giacometti E, Luikenhuis S, Beard C, Jaenisch R (2007) Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2. Proc Natl Acad Sci U S A 104: 1931-1936. 0610593104 [pii];10.1073/pnas.0610593104 [doi].
30. Alvarez-Saavedra M, Saez MA, Kang D, Zoghbi HY, Young JI (2007) Cellspecific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis. Hum Mol Genet 16: 2315-2325. ddm185 [pii]; 10.1093/hmg/ddm185 [doi].
31. Ballas N, Lioy DT, Grunseich C, Mandel G (2009) Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology. Nat Neurosci 12: 311-317. nn.2275 [pii];10.1038/nn.2275 [doi].
32. Mount RH, Charman T, Hastings RP, Reilly S, Cass H (2002) The Rett Syndrome Behaviour Questionnaire (RSBQ): refining the behavioural phenotype of Rett syndrome. J Child Psychol Psychiatry 43: 1099-1110.
33. McGill BE, Bundle SF, Yaylaoglu MB, Carson JP, Thaller C, et al. (2006) Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.Proc Natl Acad Sci U S A 103: 18267-18272. 0608702103 [pii];10.1073/pnas.0608702103 [doi].
34. Nithianantharajah J, Levis H, Murphy M (2004) Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteinsNeurobiol Learn Mem 81: 200-210. 10.1016/j.nlm.2004.02.002 [doi];S1074742704000206 [pii].
35. Sale A, Berardi N, Maffei L (2009) Enrich the environment to empower the brain. Trends Neurosci 32: 233-239. S0166-2236(09)00026-5 [pii];10.1016/ j.tins.2008.12.004 [doi].
36. Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (2007) Recovery of learning and memory is associated with chromatin remodelling. Nature 447: 178-182. nature05772 [pii];10.1038/nature05772 [doi].
37. Trachtenberg JT, Chen BE, Knott GW, Feng G, Sanes JR, et al. (2002) Longterm in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420: 788-794. 10.1038/nature01273 [doi];nature01273 [pii].