Relationship between the MTHFR C677T polymorphism and the outcome of hepatitis B virus infection

World Chinese Journal of Digestology

Volumn 18, Issue 15, 2010, Pages 1555-1562

  Liu, Juan Juan ^a   Gao, Ying Tang ^b   Du, Zhi ^b   Yang, Bin ^b   Jing, Xiang ^b   Wang, Yi Jun ^b   Wang, Feng Mei ^b   Jing, Li ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN THIRD CENTRAL HOSPITAL   (China)

Author keywords

C677T; Disease progression; Hepatitis B virus; Methylenetetrahydrofolate reductase; Polymorphism

Indexed keywords

METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ARTICLE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENOTYPE; HEPATITIS B; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 77955364613     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: 10.11569/wcjd.v18.i15.1555     Document Type: Article

References (28)

1. Rizzetto M, Ciancio A. Chronic HBV-related liver disease. Mol Aspects Med 2008; 29: 72-84
2. Shi YH, Shi CH. Molecular characteristics and stages of chronic hepatitis B virus infection. World J Gastroenterol 2009; 15: 3099-3105
3. Saffroy R, Pham P, Chiappini F, Gross-Goupil M, Castera L, Azoulay D, Barrier A, Samuel D, Debuire B, Lemoine A. The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis. Carcinogenesis 2004; 25: 1443-1448
4. Ventura P, Rosa MC, Abbati G, Marchini S, Grandone E, Vergura P, Tremosini S, Zeneroli ML. Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylene tetrahydrofolate reductase genetics. Liver Int 2005; 25: 49-56
5. Mu LN, Cao W, Zhang ZF, Cai L, Jiang QW, You NC, Goldstein BY, Wei GR, Chen CW, Lu QY, Zhou XF, Ding BG, Chang J, Yu SZ. Methylenet etrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. Cancer Causes Control 2007; 18: 665-675
6. Yuan JM, Lu SC, Van Den Berg D, Govindarajan S , Zhang ZQ, Mato JM, Yu MC. Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. Hepatology 2007; 46: 749-758
7. Bronowicki JP, Abdelmouttaleb I, Peyrin-Biroulet L, Venard V, Khiri H, Chabi N, Amouzou EK, Barraud H, Halfon P, Sanni A, Bigard MA, Le Faou A, Guéant JL. Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa. J Hepatol 2008; 48: 532-539
8. Fabris C, Toniutto P, Falleti E, Fontanini E, Cussigh A, Bitetto D, Fornasiere E, Fumolo E, Avellini C, Minisini R, Pirisi M. MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption. Alcohol Clin Exp Res 2009; 33: 102-107
9. D'Amico M, Pasta L, Sammarco P. MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis. J Thromb Thrombolysis 2009; 28: 70-73
10. Jin F, Qu LS, Shen XZ. Association between the methylenetetrahydrofolate reductase C677T polymorphism and hepatocellular carcinoma risk: a meta-analysis. Diagn Pathol 2009; 4: 39
11. Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost 1997; 78: 523-526
12. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 1997; 94: 3290-3295
13. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-113
14. Stern LL, Mason JB, Selhub J, Choi SW. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 2000; 9: 849-853
15. Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang JY, Gao CM, Götze T, Graziano F, Lacasaña-Navarro M, Lin D, López-Carrillo L, Qiao YL, Shen H, Stolzenberg-Solomon R, Takezaki T, Weng YR, Zhang FF, van Duijn CM, Boffetta P, Taioli E. Meta- and pooled analyses of the methyl enetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 2008; 167: 505-516
16. Sun L, Sun YH, Wang B, Cao HY, Yu C. Methy lenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis. Eur J Cancer Prev 2008; 17: 446-452
17. Kono S, Chen K. Genetic polymorphisms of methyl enetetrahydrofolate reductase and colorectal cancer and adenoma. Cancer Sci 2005; 96: 535-542
18. Pereira TV, Rudnicki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF. 5,10-Methylenetetrahy drofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006; 15: 1956-1963 (Pubitemid 44664274)
19. Mao R, Fan Y, Jin Y, Bai J, Fu S. Methylenetetrahy drofolate reductase gene polymorphisms and lung cancer: a meta-analysis. J Hum Genet 2008; 53: 340-348
20. Kwak SY, Kim UK, Cho HJ, Lee HK, Kim HJ, Kim NK, Hwang SG. Methylenetetrahydrofolat e reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population. Anticancer Res 2008; 28: 2807-2811
21. Machover D, Zittoun J, Saffroy R, Broët P, Giraudier S, Magnaldo T, Goldschmidt E, Debuire B, Orrico M, Tan Y, Mishal Z, Chevallier O, Tonetti C, Jouault H, Ulusakarya A, Tanguy ML, Metzger G, Hoffman RM. Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis. Cancer Res 2002; 62: 4685-4689
22. Lin J, Spitz MR, Wang Y, Schabath MB, Gorlov IP, Hernandez LM, Pillow PC, Grossman HB, Wu X. Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study. Carcinogenesis 2004; 25: 1639-1647
23. Schneider JA, Rees DC, Liu YT, Clegg JB. Worldwide distribution of a common methylenetet rahydrofolate reductase mutation. Am J Hum Genet 1998; 62: 1258-1260
24. Wilcken B, Bamforth F, Li Z, Zhu H, Ritvanen A, Renlund M, Stoll C, Alembik Y, Dott B, Czeizel AE, Gelman-Kohan Z, Scarano G, Bianca S, Ettore G, Tenconi R, Bellato S, Scala I, Mutchinick OM, López MA, de Walle H, Hofstra R, Joutchenko L, Kavteladze L, Bermejo E, Martínez-Frías ML, Gallagher M, Erickson JD, Vollset SE, Mastroiacovo P, Andria G, Botto LD. Geographical and ethnic variation of the 677C>T allele of 5,10 methylenete trahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet 2003; 40: 619-625
25. Wong FL, Wang MK, Boo NY, Hamidah NH, Ainoon BO. Rapid detection of the UGT1A1 single nucleotide polymorphism G211A using real-time PCR with Taqman minor groove binder probes. J Clin Lab Anal 2007; 21: 167-172
26. Dierkes J, Jeckel A, Ambrosch A, Westphal S, Luley C, Boeing H. Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer and Nutrition Potsdam study. Metabolism 2001; 50: 640-645
27. Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, McNulty H, Strain JJ, McPartlin J, Scott JM, Whitehead AS. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003; 101: 2483-2488
28. Adinolfi LE, Ingrosso D, Cesaro G, Cimmino A, D'Antò M, Capasso R, Zappia V, Ruggiero G. Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 2005; 41: 995-1003