Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa

Journal of Hepatology

Volumn 48, Issue 4, 2008, Pages 532-539

  Bronowicki, Jean Pierre ^a,b   Abdelmouttaleb, Idrissia ^a,b   Peyrin Biroulet, Laurent ^a,b   Venard, Véronique ^b   Khiri, Hacène ^c   Chabi, Nicodème ^d   Amouzou, Emile K ^e   Barraud, Hélène ^a,b   Halfon, Philippe ^c   Sanni, Ambaliou ^d   Bigard, Marc André ^a,b   Le Faou, Alain ^b   Guéant, Jean Louis ^a,b  

^a INSERM   (France)

^b UNIVERSITY HOSPITAL OF NANCY   (France)

^c Laboratoire Alphabio   (France)

^d Unité de Biologie Humaine   (Benin)

^e Laboratoire de biochimie et nutrition   (Togo)

Author keywords

Folate; Gene polymorphism; Hepatitis B virus; HLA DRB1; Homocysteine; Methionine synthase; Methylenetetrahydrofolate reductase; Vitamin B12

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HEPATITIS B SURFACE ANTIGEN; HOMOCYSTEINE; METHIONINE SYNTHASE; VIRUS DNA;

ADULT; AFRICA; ALLELE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA POLYMORPHISM; FEMALE; FOLIC ACID BLOOD LEVEL; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INCIDENCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; SCREENING; SEROLOGY; STATISTICAL ANALYSIS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADULT; ALLELES; BENIN; BIOLOGICAL MARKERS; DNA; DNA PROBES; DNA, VIRAL; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HLA-DR ANTIGENS; HOMOCYSTEINE; HUMANS; IMMUNOASSAY; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MORBIDITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; VITAMIN B 12;

EID: 40049099853     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.11.017     Document Type: Article

References (46)

1. Lee W.M. Hepatitis B virus infection. N Engl J Med 24 (1997) 1733-1745
2. Ayoola E.A. Viral hepatitis in Africa. In: Zuckerman A.J. (Ed). Viral hepatitis and liver diseases (1988), Liss, New York 161-169
3. Thursz M.R., Kwiatkowski D., Allsopp C.E.M., Greenwood B.M., Thomas H.C., and Hill A.V.S. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med 332 (1995) 1065-1069
4. Coursaget P., Yvonnet B., Chotard J., Vincelot P., Sarr M., Diouf C., et al. Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal). J Med Virol 22 (1987) 1-5
5. Lok A.S., Heathcote E.J., and Hoofnagle J.H. Management of hepatitis B: 2000-summary of a workshop. Gastroenterology 120 (2001) 1828-1853
6. Almarri A., and Batchelor J.R. HLA and hepatitis B infection. Lancet 344 (1994) 1194-1195
7. Höhler T., Gerken G., Notghi A., Lubjuhn R., Taheri H., Protzer U., et al. HLA-DRB1*1301 and *1302 protect against chronic hepatitis. J Hepatol 26 (1997) 503-507
8. Thio C.L., Carrington M., Marti D., O'Brien S.J., Vlahov D., Nelson K.E., et al. Class II HLA alleles and hepatitis B virus persistence in African Americans. J Infect Dis 179 (1999) 1004-1006
9. Ahn S.H., Park J.Y., Lee C.K., Lee C.K., Kang S.W., Chon C.Y., et al. Association between hepatitis B virus infection and HLA-DR type in Korea. Hepatology 31 (2000) 1371-1373
10. Höhler T., Kruger A., Gerken G., Schneider P.M., Meyer zum Büschenfelde K.H., and Rittner C. A tumour necrosis factor-alpha (TNF-α) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol 111 (1998) 579-582
11. Thomas H.C., Foster G.R., Sumiya M., McIntosh D., Jack D.L., Turner M.W., et al. Mutation of gene for mannose-binding protein associated with chronic hepatitis B viral infection. Lancet 348 (1996) 1417-1419
12. Höhler T., Wunschel M., Gerken G., Schneider P.M., Meyer zum Büschenfelde K.H., and Rittner C. No association between mannose-binding lectin alleles and susceptibility to chronic hepatitis B virus infection in German patients. Exp Clin Immunogenet 15 (1998) 130-133
13. Bellamy R., Ruwende C., Corrah T., Thursz M., Sumiya M., Summerfield J., et al. Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. Q J Med 91 (1998) 13-18
14. Bellamy R., Ruwende C., Corrah T., McAdam K.P., Thursz M., Whittle H.C., et al. Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J Infect Dis 179 (1999) 721-724
15. Thio C.L., Thomas D.L., and Carrington M. Chronic viral hepatitis and the human genome. Hepatology 31 (2000) 819-827
16. Jahner D., Stuhlmann H., Steward C.L., Harbers K., Löhler J., Simon I., et al. De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 298 (1982) 623-628
17. Ueland P.M., Hustad S., Schneede J., Refsum H., and Vollset S.E. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22 (2001) 195-201
18. Gueant-Rodriguez R.M., Gueant J.L., Debard R., Thirion S., Hong L.X., Bronowicki J.P., et al. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr 83 (2006) 701-707
19. Amouzou E.K., Chabi N.W., Adjalla C.E., Rodriguez-Guéant R.M., Feillet F., Villaume C., et al. High prevalence of hyperhomocysteinemia related to folate deficiency and the 677C→T mutation of the gene encoding methylenetetrahydrofolate reductase in coastal West Africa. Am J Clin Nutr 79 (2004) 619-624
20. Weisberg I., Tran P., Christensen B., Sibani S., and Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64 (1998) 169-172
21. Gueant-Rodriguez R.M., Juilliere Y., Candito M., Adjalla C.E., Gibelin P., Herbeth B., et al. Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb Haemost 3 (2005) 510-515
22. Grob P., Jilg W., Bornhak H., Gerken G., Gerlich W., Günther S., et al. Serological pattern "anti-HBc alone: report on a workshop. J Med Virol 62 (2000) 450-455
23. Dickson R.C., Everhart J.E., Lake J.R., Wei Y., Seaberg E.C., Wiesner R.H., et al. Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Gastroenterology 113 (1997) 1668-1674
24. Rosenblatt D.S., and Whitehead V.M. Cobalamin and folate deficiency: acquired and hereditary disorders in children. Semin Hematol 36 (1999) 19-34
25. Rajkovic A., Mahomed K., Rozen R., Malinow M.R., King I.B., and Williams M.A. Methylenetetrahydrofolate reductase 677 C→T polymorphism, plasma folate, vitamin B12 concentrations and risk of preeclampsia among black African women from Zimbabwe. Mol Genet Metab 69 (2000) 33-39
26. Botto L.D., and Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151 (2000) 862-877
27. Friso S., Choi S.W., Girelli D., Mason J.B., Dolnikowski G.G., Bagley P.J., et al. A common mutation in the 5,10-methylenetetra-hydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 99 (2002) 5606-5611
28. Robertson K.D., and Ambinder R.F. Methylation of the Epstein-Barr virus genome in normal lymphocytes. Blood 90 (1997) 4480-4484
29. Guidotti L.G., Rochford R., Chung J., Shapiro M., Purcell R., and Chisari F.V. Viral clearance without destruction of infected cells during acute HBV infection. Science 284 (1999) 825-829
30. Kakimi K., Guidotti L.G., Koezuka Y., and Chisari F.V. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med 192 (2000) 921-930
31. Chisari F.V., and Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 13 (1995) 29-60
32. Dhur A., Galan P., and Hercberg S. Folate status and the immune system. Prog Food Nutr Sci 15 (1991) 43-60
33. Gross R.L., Reid J.V.O., Newberne P.M., Burgess B., Marston R., and Hift W. Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. Am J Clin Nutr 28 (1975) 225-232
34. Blount B.C., Mack M.M., Wehr C.M., MacGregor J.T., Hiatt R.A., Wang G., et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA 94 (1997) 3290-3295
35. Dianov G.L., Timchenko T.V., Sinitsina O.I., Kuzminov A.V., Medvedev O.A., and Salganik R.I. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol Gen Genet 225 (1991) 448-452
36. Popescu N.C., DiPaolo J.A., and Amsbaugh S.C. Integration sites of human papillomavirus 18 DNA sequence on HeLa cell chromosomes. Cytogenet Cell Genet 44 (1987) 58-62
37. Brechot C., Hadchouel M., Scotto J., Fonck M., Potet F., Vyas G.N., et al. State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases. Proc Natl Acad Sci USA 78 (1981) 3906-3910
38. Yoffe B., Burns D.K., Bhatt H.S., and Combes B. Extrahepatic hepatitis B virus DNA sequences in patients with acute hepatitis B infection. Hepatology 12 (1990) 187-192
39. Gueant J.L., Chabi N., Gueant-Rodriguez R.M., Mutchinick O., Debard R., Payet C., et al. Environmental influence on the world-wide prevalence of a 776C > G variant in the transcobalamin gene (TCN2). J Med Genet 44 (2007) 363-367
40. Donaldson P.T., and Czaja A.J. Genetic effects on susceptibility, clinical expression, and treatment outcome of type 1 autoimmune hepatitis. Clin Liver Dis 6 (2002) 707-725
41. Mansur A.H., Williams G.A., Bishop D.T., Markham A.F., Lewis S., Britton J., et al. Evidence for a role of HLA DRB1 alleles in the control of IgE levels, strengthened by interacting TCR A/D marker alleles. Clin Exp Allergy 30 (2000) 1371-1378
42. Cavestro G.M., Frulloni L., Neri T.M., Seghini P., Nouvenne A., Zanetti A., et al. Association of HLA-DRB1*0401 allele with chronic pancreatitis. Pancreas 26 (2003) 388-391
43. Satsangi J., Welsh K.I., Bunce M., Julier C., Farrant J.M., Bell J.I., et al. Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet 347 (1996) 1212-1217
44. Andrade R.J., Lucena M.I., Alonso A., Garcia-Cortes M., Garcia-Ruiz E., Benitez R., et al. HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease. Hepatology 39 (2004) 1603-1612
45. Jiao J., and Wang J.B. Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-alpha and ribavirin in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int 4 (2005) 80-83
46. Chu R.H., Ma L.X., Wang G., and Shao L.H. Influence of HLA-DRB1 alleles and HBV genotypes on interferon-alpha therapy for chronic hepatitis B. World J Gastroenterol 11 (2005) 4753-4757