The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): Implications for the development of dCK-activated acyclic guanine analogues

Journal of Medicinal Chemistry

Volumn 53, Issue 15, 2010, Pages 5792-5800

  Hazra, Saugata ^a   Konrad, Manfred ^b   Lavie, Arnon ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; DEOXYCYTIDINE KINASE; GUANINE DERIVATIVE; NUCLEOSIDE; THYMIDINE KINASE;

ARTICLE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HERPES SIMPLEX VIRUS 1;

ACYCLOVIR; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEOXYCYTIDINE KINASE; GUANINE; HERPESVIRIDAE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEOSIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; THYMIDINE KINASE; URIDINE DIPHOSPHATE;

EID: 77955343890     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1005379     Document Type: Article

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