Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: A direct effect on the brain

Anesthesia and Analgesia

Volumn 106, Issue 5, 2008, Pages 1450-1455

  Nakamura, Taketo ^a   Oda, Yutaka ^a   Takahashi, Ryota ^a   Tanaka, Katsuaki ^a   Hase, Ichiro ^a   Asada, Akira ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE; PROPRANOLOL; ANTICONVULSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GAS ANALYSIS; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG RESEARCH; HEART RATE; HEMODYNAMICS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; TONIC CLONIC SEIZURE; WAKEFULNESS; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG INTERACTION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PROTEIN BINDING; SEIZURE; SPRAGUE DAWLEY RAT;

ADRENERGIC BETA-ANTAGONISTS; ANESTHETICS, LOCAL; ANIMALS; ANTICONVULSANTS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HEMODYNAMICS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; LIDOCAINE; MALE; PROPRANOLOL; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; WAKEFULNESS;

EID: 42449102641     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31816ba49d     Document Type: Article

References (19)

1. Tyrer P. Current status of beta-blocking drugs in the treatment of anxiety disorders. Drugs 1988;36:773-83
2. Elghozi JL, Bianchetti G, Morselli PL, Meyer P. Brain distribution of propranolol in the rat. Eur J Pharmacol 1979;55:319-22
3. Noyes R Jr. Beta-blocking drugs and anxiety. Psychosomatics 1982;23:155-70
4. Raju SS, Gopalakrishna HN, Venkatadri N. Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: individually and in combination. Pharmacol Res 1998;38:449-52
5. Louis WJ, Papanicolaou J, Summers RJ, Vajda FJ. Role of central beta-adrenoceptors in the control of pentylenetetrazol-induced convulsions in rats. Br J Pharmacol 1982;75:441-6
6. Fischer W. Anticonvulsant profile and mechanism of action of propranolol and its two enantiomers. Seizure 2002;11:285-302
7. Tella SR, Korupolu GR, Schindler CW, Goldberg SR. Pathophysiological and pharmacological mechanisms of acute cocaine toxicity in conscious rats. J Pharmacol Exp Ther 1992;262:936-46
8. Catravas JD, Waters IW. Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality. J Pharmacol Exp Ther 1981;217:350-6
9. Derlet RW, Albertson TE. Acute cocaine toxicity: antagonism by agents interacting with adrenoceptors. Pharmacol Biochem Behav 1990;36:225-31
10. Okura T, Saito M, Nakanishi M, Komiyama N, Fujii A, Yamada S, Kimura R. Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats. Br J Pharmacol 2003;140:211-7
11. Takahashi R, Oda Y, Tanaka K, Morishima HO, Inoue K, Asada A. Epinephrine increases the extracellular lidocaine concentration in the brain: a possible mechanism for increased central nervous system toxicity. Anesthesiology 2006;105:984-9
12. Funao T, Oda Y, Tanaka K, Asada A. The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats. Can J Anaesth 2003;50:805-11
13. Serlin MJ, Orme MLE, Baber NS, Sibeon RG, Laws E, Breckenridge A. Propranolol in the control of blood pressure: a doseresponse study. Clin Pharmacol Ther 1980;27:586-92
14. Abed WT. Alterations of lidocaine and pentylenetetrazol-induced convulsions by manipulation of brain monoamines. Pharmacol Toxicol 1994;75:162-5
15. Satoh T, Sawaki K, Kawaguchi M. Pharmacological analysis of local anaesthetic tolycaine-induced convulsions by modification of monoamines in rat brain. Pharmacol Toxicol 1996;79:305-11
16. Ferraro G, Sardo P, Sabatino M, Caravaglios G, La Grutta V. Anticonvulsant activity of the noradrenergic locus coeruleus system: role of beta mediation. Neurosci Lett 1994;169:93-6
17. Englesson S. The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. I. An experimental study in cats. Acta Anaesthesiol Scand 1974;18:79-87
18. Blumer J, Strong JM, Atkinson AJ Jr. The convulsant potency of lidocaine and its N-dealkylated metabolites. J Pharmacol Exp Ther 1973;186:31-6
19. Lalka D, Griffith RK, Cronenberger CL. The hepatic first-pass metabolism of problematic drugs. J Clin Pharmacol 1993;33:657-69