The antimicrobial peptide LL37 induces the migration of human pulp cells: A possible adjunct for regenerative endodontics

Journal of Endodontics

Volumn 36, Issue 6, 2010, Pages 1009-1013

  Kajiya, Mikihito ^a   Shiba, Hideki ^a   Komatsuzawa, Hitoshi ^b   Ouhara, Kazuhisa ^a   Fujita, Tsuyoshi ^a   Takeda, Katsuhiro ^a   Uchida, Yuushi ^a   Mizuno, Noriyoshi ^a   Kawaguchi, Hiroyuki ^a   Kurihara, Hidemi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Antimicrobial peptide; epidermal growth factor receptor; HBEGF; JNK; LL37; MAP kinase; migration; pulp cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3' O (4 BENZOYL)BENZOYLADENOSINE 5' TRIPHOSPHATE; 3'-O-(4-BENZOYL)BENZOYLADENOSINE 5'-TRIPHOSPHATE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ADENOSINE TRIPHOSPHATE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE; CELL SURFACE RECEPTOR; DRUG DERIVATIVE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FLAVONOID; HEPARIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; PROTEIN TYROSINE PHOSPHATASE; PURINERGIC P2 RECEPTOR; PURINERGIC P2X RECEPTOR; SIGNAL PEPTIDE; STRESS ACTIVATED PROTEIN KINASE; TYRPHOSTIN; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; HBEGF PROTEIN, HUMAN; PURINERGIC P2 RECEPTOR AGONIST; QUINAZOLINE DERIVATIVE;

ARTICLE; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENDODONTICS; HUMAN; METHODOLOGY; PHOSPHORYLATION; REGENERATIVE MEDICINE; TISSUE ENGINEERING; TOOTH PULP; AGONISTS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; PROCEDURES;

ADENOSINE TRIPHOSPHATE; ANTHRACENES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CATHELICIDINS; CELL MOVEMENT; CELLS, CULTURED; DENTAL PULP; ENDODONTICS; ENZYME INHIBITORS; FLAVONOIDS; HEPARIN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, PURINERGIC P2; REGENERATIVE MEDICINE; TISSUE ENGINEERING; TYRPHOSTINS; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; PURINERGIC P2 RECEPTOR AGONISTS; QUINAZOLINES; RECEPTORS, PURINERGIC P2X;

EID: 77955303841     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2010.02.028     Document Type: Article

References (35)

1. J.W. Larrick, M. Hirata, and R.F. Balint Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein Infect Immun 63 1995 1291 1297
2. R.I. Lehrer, and T. Ganz Antimicrobial peptides in mammalian and insect host defence Curr Opin Immunol 11 1999 23 27
3. M. Frohm Nilsson, B. Sandstedt, and O. Sorensen The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6 Infect Immun 67 1999 2561 2566
4. M. Zaiou, and R.L. Gallo Cathelicidins, essential gene-encoded mammalian antibiotics J Mol Med 80 2002 549 561
5. B. Ramanathan, E.G. Davis, and C.R. Ross Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity Microbes Infect 4 2002 361 372
6. R. Bals Epithelial antimicrobial peptides in host defense against infection Respir Res 1 2000 141 150
7. S. Tokumaru, K. Sayama, and Y. Shirakata Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37 J Immunol 175 2005 4662 4668
8. Y. De, Q. Chen, and A.P. Schmidt LL-37, the neutrophil granule-and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells J Exp Med 192 2000 1069 1074
9. K. Kandler, R. Shaykhiev, and P. Kleemann The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands Int Immunol 18 2006 1729 1736
10. R. Koczulla, G. von Degenfeld, and C. Kupatt An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 J Clin Invest 111 2003 1665 1672
11. C.L. Hahn, and F.R. Liewehr Relationships between caries bacteria, host responses, and clinical signs and symptoms of pulpitis J Endod 33 2007 213 219
12. M. Nakashima, and A. Akamine The application of tissue engineering to regeneration of pulp and dentin in endodontics J Endod 31 2005 711 718
13. E. Kawagishi, K. Nakakura-Ohshima, and S. Nomura Pulpal responses to cavity preparation in aged rat molars Cell Tissue Res 326 2006 111 122
14. A.J. Smith, N. Cassidy, and H. Perry Reactionary dentinogenesis Int J Dev Biol 39 1995 273 280
15. M. Trope Regenerative potential of dental pulp J Endod 34 7 Suppl 2008 S13 S17
16. L.J. McCawley, P. O'Brien, and L.G. Hudson Overexpression of the epidermal growth factor receptor contributes to enhanced ligand-mediated motility in keratinocyte cell lines Endocrinology 138 1997 121 127
17. G. Carpenter, and S. Cohen Epidermal growth factor J Biol Chem 265 1990 7709 7712
18. H. Daub, F.U. Weiss, and C. Wallasch Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors Nature 379 1996 557 560
19. S. Miyamoto, H. Teramoto, and J.S. Gutkind Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors J Cell Biol 135 6 Pt 1 1996 1633 1642
20. G.S. Tjabringa, J. Aarbiou, and D.K. Ninaber The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor J Immunol 171 2003 6690 6696
21. A. Elssner, M. Duncan, and M. Gavrilin A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release J Immunol 172 2004 4987 4994
22. R.K. Barr, and M.A. Bogoyevitch The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs) Int J Biochem Cell Biol 33 2001 1047 1063
23. Y.A. Abassi, and K. Vuori Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling EMBO J 21 2002 4571 4582
24. U. Huynh-Do, C. Vindis, and H. Liu Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis J Cell Sci 115 2002 3073 3081
25. T. Kawauchi, K. Chihama, and Y. Nabeshima The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration EMBO J 22 2003 4190 4201
26. D. Javelaud, J. Laboureau, and E. Gabison Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing J Biol Chem 278 2003 24624 24628
27. K. Midorikawa, K. Ouhara, and H. Komatsuzawa Staphylococcus aureus susceptibility to innate antimicrobial peptides, beta-defensins and CAP18, expressed by human keratinocytes Infect Immun 71 2003 3730 3739
28. J. Hu, and A.S. Verkman Increased migration and metastatic potential of tumor cells expressing aquaporin water channels FASEB J 20 2006 1892 1894
29. M. Kajiya, H. Shiba, and T. Fujita Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts J Biol Chem 283 2008 16259 16267
30. K. Ouhara, H. Komatsuzawa, and S. Yamada Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells J Antimicrob Chemother 55 2005 888-6
31. Y. Yasuda, M. Izumikawa, and K. Okamoto Dentin phosphophoryn promotes cellular migration of human dental pulp cells J Endod 34 2008 575 578
32. T. Saito, A.L. Arsenault, and M. Yamauchi Mineral induction by immobilized phosphoproteins Bone 21 1997 305 311
33. L. Chang, and M. Karin Mammalian MAP kinase signalling cascades Nature 410 2001 37 40
34. J. Bain, H. McLauchlan, and M. Elliott The specificities of protein kinase inhibitors: an update Biochem J 371 2003 199 204
35. J. Bain, L. Plater, and M. Elliott The selectivity of protein kinase inhibitors: a further update Biochem J 408 2007 297 315