The soyabean isoflavone genistein modulates endothelial cell behaviour

British Journal of Nutrition

Volumn 104, Issue 2, 2010, Pages 171-179

  Sandoval, Marisa J ^a   Cutini, Pablo H ^a,b   Rauschemberger, María Belén ^a,b   Massheimer, Virginia L ^a,b  

^a UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Apoptosis; Genistein; Monocyte adhesion; Phyto oestrogens; Proliferation

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CELL ADHESION MOLECULE; DNA; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FULVESTRANT; GENISTEIN; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL CELL CULTURE; AORTA; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIUM CELL; FEMALE; LEUKOCYTE ADHERENCE; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; ANIMAL; CELL ADHESION; CELL CULTURE; CELL MOTION; CHEMISTRY; CYTOLOGY; DRUG EFFECT; SOYBEAN; THORACIC AORTA; WISTAR RAT;

BACTERIA (MICROORGANISMS); RATTUS;

ANIMALS; AORTA, THORACIC; APOPTOSIS; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; GENISTEIN; RATS; RATS, WISTAR; SOYBEANS;

EID: 77955302115     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510000413     Document Type: Article

References (56)

1. De Caterina R (2000) Endothelial dysfunctions: common denominators in vascular disease. Curr Opin Lipidol 11, 9-23.
2. Ross R (1999) Atherosclerosis: an inflamatory disease. N Engl J Med 340, 115-126.
3. Gimbrone MA Jr (1995) Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis. Am J Cardiol 75, 67B-70B.
4. Rao RM, Yang L, García-Cardena G, et al. (2007) Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res 101, 234-247.
5. Mizia-Stec K (2006) Cytokines and adhesive molecules in detection of endothelial dysfunction. Pharmacol Rep 58, 21-32.
6. Choy JC, Granville DJ, Hunt DW, et al. (2001) Endothelial cell apoptosis: biochemical characteristics and potencial implications for atherosclerosis. J Mol Cell Cardiol 33, 1673-1690.
7. Burlacu A, Jinga V, Gafencu AV, et al. (2001) Severity of oxidative stress generates different mechanisms of endothelial cell death. Cell Tissue Res 306, 409-416.
8. 2\+ mobilization. Circ Res 81, 885-892.
9. Simoncini T, Maffei S, Basta G, et al. (2000) Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res 87, 19-25.
10. Colacurci N, Chiàntera A, Fornaro F, et al. (2005) Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause 12, 299-307.
11. Reinli K & Block G (1996) Phytoestrogen content of foods-a compedium of literature values. Nutr Cancer 26, 123-148.
12. Barnes S (1998) Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metab 12, 559-579.
13. Kuiper GG, Carlsson B, Grandien K, et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138, 863-870. (Pubitemid 27089735)
14. Akiyama T, Ishida J, Nakagawa S, et al. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262, 5592-5595.
15. 00-monophosphate-dependent mechanism. Endocrinology 145, 5532-5539.
16. Dixon R & Ferrerira D (2002) Genistein. Phytochemistry 60, 205-211.
17. Polini N, Rauschemberger MB, Mendiberri J, et al. (2007) Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 267, 55-62.
18. Cutini P, Sellés J & Massheimer V (2009) Cross-talk between rapid and long term effect of progesterone on endothelial cells. J Steroid Biochem Mol Biol 115, 36-43.
19. Yeh YC, Hwang GY, Liu IP, et al. (2002) Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Atherosclerosis 161, 95-103.
20. Bachetti T & Morbidelli L (2000) Endothelial cells in culture: a model for studying vascular functions. Pharmacol Res 42, 9-19.
21. Rauschemberger MB, Sellés J & Massheimer V (2008) The direct action of estrone on vascular tissue involves genomic and non-genomic actions. Life Sci 82, 115-123.
22. Lowry OH, Rosebrough NJ, Farr AL, et al. (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193, 265-277.
23. Kyaw M, Yoshizumi M, Tsuchiya K, et al. (2002) Antioxidants inhibit endothelin-1 (1-31)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1). Biochem Pharmacol 64, 1521-1531.
24. Peng Lv, Shelley Chireyath P, Yanjv X, et al. (2006) Effects of thalidomide on the expression of adhesion molecules in rat liver cirrhosis. Mediators Inflamm 2006, 1-10.
25. Callera GE, Montezano AC, Touyz RM, et al. (2004) ETA receptor mediates altered leukocyte-endothelial cell interaction and adhesion molecules expression in DOCA-salt rats. Hypertension 43, 872-879.
26. Ohtsuka M, Miyashita Y & Shirai K (2006) Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells. J Atheroscler Thromb 13, 256-262.
27. Rasband W Image J 1.43 c Version-Image Processing and Analysis in Java. National Institutes of Health. Bethesda; available at http://rsb.info.nih.gov/ ij/
28. Bøyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21, Suppl. 97, 77-89.
29. Pawlowski NA, Abraham EL, Pontier S, et al. (1985) Human monocyte-endothelial cell interaction in vitro. Proc Natl Acad Sci \USA 82, 8208-8212.
30. Gojova A & Barakat AI (2005) Vascular endothelial wound closure under shear stress: role of membrane fluidity and flow-sensitive ion channels. J Appl Physiol 98, 2355-2362.
31. Bürk RR (1973) A factor from a transformed cell line that affects cell migration. Proc Natl Acad Sci \USA 70, 368-372.
32. Pedram A, Razandi M, Aitkenhead M, et al. (2002) Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem 277, 50768-50775.
33. Izumi T, Piskula MK, Osawa S, et al. (2000) Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 130, 1695-1699.
34. Bhakta D, Higgins CD, Sevak L, et al. (2006) Phyto-oestrogen intake and plasma concentrations in South Asian and native British women resident in England. Br J Nutr 95, 1150-1158.
35. Koroma BM & de Juan E Jr (1994) Phosphotyrosine inhibition and control of vascular endothelial cell proliferation by genistein. Biochem Pharmacol 48, 809-818.
36. Fotsis T, Pepper M, Adlercreutz H, et al. (1993) Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci \USA 90, 2690-2694.
37. Xu SZ, Zhong W, Ghavideldarestani M, et al. (2009) Multiple mechanisms of soy isoflavones against oxidative stress-induced endothelium injury. Free Radic Biol Med 47, 167-175.
38. Moncada S (1997) Nitric oxide in the vaculature: physiology and pathophysiology. Ann N Y Acad Sci 811, 427-436.
39. Simoncini T, Varone G, Fornari L, et al. (2002) Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator. Endocrinology 143, 2052-2061. (Pubitemid 34521552)
40. Meyer MR, Haas E, Prossnitz ER, et al. (2009) Non-genomic regulation of vascular cell function and growth by estrogen. Mol Cell Endocrinol 308, 9-16.
41. Choi YS, Choi HJ, Min JK, et al. (2009) Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial NO production. Blood 114, 3117-3126.
42. Villalobo A (2007) Enhanced cell proliferation induced by nitric oxide. Dyn Cell Biol 1, 60-64.
43. Lamalice L, Le Boeuf F & Huot J (2007) Endothelial cell migration during angiogenesis. Circ Res 100, 782-794.
44. Jung U & Ley K (1999) Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol 162, 6755-6762.
45. Blann AD, Nadar SK & Lip GYH (2003) The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J 24, 2166-2179.
46. Barthel SR, Gavino JD, Descheny L, et al. (2007) Targeting selectins and selectin ligands in inflammation and cancer. Expert Opin Ther Targets 11, 1473-1491.
47. Collins T, Read M, Neish AS, et al. (1995) Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J 9, 899-909.
48. Simoncini T, Garibaldi S, Fu XD, et al. (2008) Effects of phytoestrogens derived from red clover on atherogenic adhesion molecules in human endothelial cells. Menopause 15, 542-550.
49. Piao M, Mori D, Satoh T, et al. (2006) Inhibition of endothelial cell proliferation, in vitro angiogenesis, and the down-regulation of cell adhesion-related genes by genistein. Combined with a cDNA microarray analysis. Endothelium 13, 249-266.
50. Armstead VE, Minchenko AG, Schuhl RA, et al. (1997) Regulation of P-selectin expression in human endothelial cells by nitric oxide. Am J Physiol Herat Circ Physiol 273, H740-H746.
51. Iafrati MD, Vitseva O, Tanriverdi K, et al. (2005) Compensatory mechanisms influence hemostasis in setting of eNOS deficiency. Am J Physiol Heart Circ Physiol 288, H1627-H1632.
52. Mukherjee TK, Nathan L, Dinh H, et al. (2003) 17-Epiestriol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression. J Biol Chem 278, 11746-11752.
53. Kockx MM & Herman AG (2000) Apoptosis in atherosclerosis: beneficial or detrimental? Cardiovasc Res 45, 736-746.
54. Dimmeler S, Haendeler J, Galle J, et al. (1997) Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis. Circulation 95, 1760-1763.
55. Dimmeler S, Rippmann V, Weiland U, et al. (1997) Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide. Circ Res 81, 970-976.
56. Vanhoutte PM (2009) Endothelial dysfunction: the first step toward coronary arteriosclerosis. Circ J 73, 595-601.