Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein

Journal of Medicinal Chemistry

Volumn 46, Issue 17, 2003, Pages 3563-3564

  Vogtherr, Martin ^b   Grimme, Susanne ^b   Elshorst, Bettina ^b   Jacobs, Doris M ^b   Fiebig, Klaus ^b,d   Griesinger, Christian ^c   Zahn, Ralph ^a  

^a ETH ZURICH   (Switzerland)

^b GOETHE UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d Affinium Pharmaceuticals   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACEPROMAZINE; ACRIDINE DERIVATIVE; ANTIMALARIAL AGENT; CARBAMAZEPINE; CHLOROQUINE; CHLORPROMAZINE; GLYCINE; HALOPERIDOL; IMIPRAMINE; MEPACRINE; PHENAZINE; PHENOTHIAZINE DERIVATIVE; PRION PROTEIN; PROMAZINE; PROMETHAZINE; PROTEIN X; TYROSINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; BINDING SITES; CHLOROQUINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PHENOTHIAZINES; PRIONS; PROTEIN STRUCTURE, SECONDARY; QUINACRINE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0041731605     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034093h     Document Type: Article

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