Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24307-24312

  Whisstock, James C ^a   Silverman, Gary A ^b   Bird, Phillip I ^a   Bottomley, Stephen P ^a   Kaiserman, Dion ^a   Luke, Cliff J ^b   Pak, Stephen C ^b   Reichhart, Jean Marc ^c   Huntington, James A ^d  

^a Australian Government Australian Research Council   (Australia)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; DYES; POLYMERIZATION;

BIOPHYSICAL STUDIES; DOMAIN SWAPPING; HORMONE BINDING; INHIBITORY FUNCTION; META-STABLE STATE; MULTIMERS; REACTIVE CENTER LOOPS; SERPINOPATHIES; SERPINS; STRUCTURAL INSIGHTS; STRUCTURAL STUDIES; TRANSPORT FUNCTION;

TARGETS;

MONOMER; PEPTIDASE; POLYMER; SERINE PROTEINASE INHIBITOR; HORMONE; PEPTIDE HYDROLASE; PROTEIN BINDING; THROMBIN;

COMPLEX FORMATION; CONFORMATIONAL TRANSITION; HORMONE BINDING; MOLECULAR RECOGNITION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SHORT SURVEY; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HUMAN; KINETICS; PHYSIOLOGY; PROCEDURES; PROTEIN TERTIARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BIOPHYSICS; CATALYTIC DOMAIN; HORMONES; HUMANS; KINETICS; MODELS, BIOLOGICAL; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERPINS; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 77955291831     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R110.141408     Document Type: Short Survey

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