Loss of Either CD4+ or CD8+ T Cells Does Not Affect the Magnitude of Protective Immunity to an Intracellular Pathogen, Francisella tularensis Strain LVS

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 5042-5048

  Yee, Daphne ^a   Rhinehart Jones, Tonya R ^a   Elkins, Karen L ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD4 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; FRANCISELLA TULARENSIS; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NUDE MOUSE; PATHOGENICITY; T LYMPHOCYTE SUBPOPULATION; TULAREMIA;

ANIMALS; ANTIGENS, CD4; BETA 2-MICROGLOBULIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FRANCISELLA TULARENSIS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; TULAREMIA;

EID: 0030443350     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Tärnvik, A. 1989. Nature of protective immunity to Francisella tularensis. Rev. Infect. Dis. 11:440.
2. Fortier, A. H., M. V. Slayter, R. Ziemba, M. S. Meltzer, and C. A. Nacy. 1991. Live vaccine strain of Francisella tularensis: infection and immunity in mice. Infect. Immun. 59:2922.
3. Elkins, K. L., R. K. Winegar, C. A. Nacy, and A. H. Fortier. 1992. Introduction of Francisella tularensis at skin sites induces resistance to infection and generation of protective immunity. Microb. Pathog. 13:417.
4. Elkins, K. L., D. A. Leiby, R. K. Winegar, C. A. Nacy, and A. H. Fortier. 1992. Rapid generation of specific protective immunity to Francisella tularensis. Infect. Immun. 60:4571.
5. Elkins, K. L., T. Rhinehart-Jones, C. A. Nacy, R. K. Winegar, and A. H. Fortier. 1993. T-cell-independent resistance to infection and generation of immunity to Francisella tularensis. Infect. Immun. 61:823.
6. Tärnvik, A., M. Eriksson, G. Sandström, and A. Sjöstedt. 1992. Francisella tularensis: a model for studies of the immune response to intracellular bacteria in man. Immunology 76:349.
7. Rhinehart-Jones, T. R., A. H. Fortier, and K. L. Elkins. 1994. Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells. Infect. Immun. 62:3129.
8. Elkins, K. L., T. R. Rhinehart-Jones, S. J. Culkin, D. Yee, and R. K. Winegar. 1996. Minimal requirements for murine resistance to infection with Francisella tularensis strain LVS. Infect. Immun. 8:3288.
9. Leiby, D. A., A. H. Fortier, R. M. Crawford, R. D. Schreiber, and C. A. Nacy. 1992. In vivo modulation of the murine immune response to Francisella tularensis LVS by administration of anticytokine antibodies. Infect. Immun. 60:84.
10. Anthony, L. S. D., E. Ghadirian, F. P. Nestel, and P. A. L. Kongshavn. 1989. The requirement for gamma interferon in resistance of mice to experimental tularemia. Microb. Pathog. 7:421.
11. Sjöstedt, A., J. W. Conlan, and R. J. North. 1994. Neutrophils are critical for host defense against primary infection with the facultative intracellular bacterium Francisella tularensis in mice and participate in defense against reinfection. Infect. Immun. 62:2779.
12. Bandeira, A., S. Itohara, M. Bonneville, O. Burlen-Defranoux, T. Mota-Santos, A. Coutinho, and S. Tonegawa. 1991. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma/delta. Proc. Natl. Acad. Sci. USA 88:43.
13. + T-cell-dependent and -independent host defense mechanisms can operate to control and resolve primary and secondary Francisella tularensis LVS infection in mice. Infect. Immun. 62:5603.
14. Baker, C. N., D. G. Hollis, and C. Thornsberry. 1985. Anti-microbial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth. J. Clin. Microbiol. 22:212.
15. Skeen, M. J., and H. K. Ziegler. 1993. Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection. J. Exp. Med. 178:971.
16. Portnoy, D. A. 1992. Innate immunity to a facultative intracellular bacterial pathogen. Curr. Opin. Immunol. 4:20.
17. + T cells. J. Exp. Med. 176:581.
18. O'Brien, A. D., and E. S. Metcalf. 1982. Control of early Salmonella typhimurium growth in innately Salmonella-resistant mice does not require functional T cells. J. Immunol. 129:1349.
19. Nauciel, C., and F. Espinasse-Maes. 1992. Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection. Infect. Immun. 60:450.
20. Belosevic, M., D. S. Finbloom, P. H. Van der Meide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major. J. Immunol. 143:266.
21. Laskay, T., M. Röllinghoff, and W. Solbach. 1993. Natural killer cells participate in the early defense against Leishmania major infection in mice. Eur. J. Immunol. 23:2237.
22. Hunter, C. A., J. S. Abrams, M. H. Beaman, and J. S. Remington. 1993. Cytokine mRNA in the central nervous system of SCi.d. mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii. Infect. Immun. 61:4038.
23. Anthony, L. S. D., and P. A. L. Kongshavn. 1988. H-2 restriction in acquired cell-mediated immunity to infection with Francisella tularensis LVS. Infect. Immun. 56:452.
24. Surcel, H.-M., J. Ilonen, K. Poikonen, and E. Herva. 1989. Francisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production. Infect. Immun. 57:2906.
25. Bennink, J. R., and J. W. Yewdell. 1990. Recombinant vaccinia viruses as vectors for studying T lymphocyte specificity and function. Curr. Top. Microbiol. Immunol. 163:153.
26. Reimann, J., A. Rudolphi, and M. H. Claesson. 1991. Selective reconstitution of T lymphocyte subsets in acid mice. Immunol. Rev. 124:75.
27. - cells. J. Infect. Dis. 164:869.
28. Locksley, R. M., S. L. Reiner, F. Hatam, D. R. Littman, and N. Killeen. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261:1448.
29. + T cells. Nature 372:691.
30. + T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. USA 89:6070.
31. Yewdell, J. W., and J. R. Bennink. 1990. The binary logic of antigen processing and presentation to T cells. Cell 62:203.
32. Fortier, A. H., S. J. Green, T. Polsinelli, T. Rhinehart-Jones, R. M. Crawford, D. A. Leiby, K. L. Elkins, M. S. Meltzer, and C. A. Nacy. 1994. Life and death of an intracellular pathogen: Francisella tularensis and the macrophage. Immunol. Ser. 60:349.
33. Anthony, L. S. D., R. D. Burke, and F. E. Nano. 1991. Growth of Francisella spp. in rodent macrophages. Infect. Immun. 59:3291.
34. Ladel, C. H., I. E. A. Flesch, J. Arnoldi, and S. H. E. Kaufmann. 1994. Studies with MHC-deficient knock-out mice reveal impact of both MHC 1 - and MHC II-dependent T cell responses on Listeria monocytogenes infection. J. Immunol. 153:3116.
35. + cells in resistance to primary and secondary infection, delayed-type hypersensitivity and adoptive transfer of resistance. Immunology 71:107.
36. Harty, J. T., R. D. Schreiber, and M. J. Bevan. 1992. CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion. Proc. Natl. Acad. Sci. USA 89:11612.
37. Pfeifer, J. D., M. J. Wick, R. L. Roberts, K. Findlay, S. J. Normark, and C. V. Harding. 1993. Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361:359.
38. Mombaerts, P., J. Arnoldi, F. Russ, S. Tonegawa, and S. H. E. Kaufmann. 1993. Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 365:53.
39. Ladel, C. H., J. Hess, S. Daugelat, P. Mombaerts, S. Tonegawa, and S. H. E. Kaufmann. 1995. Contribution of α/β and γ/α T lymphocytes to immunity against Mycobacterium bovis bacillus Calmette-Guérin: studies with T cell receptor-deficient mutant mice. Eur. J. Immunol. 25:838.
40. Ladel, C. H., C. Blum, A. Dreher, K. Reifenberg, and S. H. E. Kaufmann. 1995. Protective role of γ/δ T cells and α/β T cells in tuberculosis. Eur. J Immunol. 25:2877.
41. Kaufmann, S. H. E. 1989. In vitro analysis of the cellular mechanisms involved in immunity to tuberculosis. Rev. Infect. Dis. 11:S448.
42. Czuprynski, C. J., J. F. Brown, K. M. Young, and A. J. Cooley. 1989. Administration of purified anti-L3T4 monoclonal antibody impairs the resistance of mice to Listeria monocytogenes infection. Infect. Immun. 57:100.
43. Ladel, C. H., S. Daugelat, and S. H. E. Kaufmann. 1995. Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance. Eur. J. Immunol. 25:377.
44. 2 microglobulin-deficient mice. Infect. Immun. 61:1113.
45. Flynn, J. L., M. M. Goldstein, K. J. Triebold, B. Koller, and B. R. Bloom. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA 89:12013.
46. Kaufmann, S. H. E. 1994. Bacterial and protozoal infections in genetically disrupted mice. Curr. Opin. Immunol. 6:518.