Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro

Experimental Parasitology

Volumn 126, Issue 2, 2010, Pages 113-116

  Čtrnáctá, Vlasta ^a,b   Fritzler, Jason M ^c,d   Šurinová, Mária ^a   Hrdý, Ivan ^a   Zhu, Guan ^d   Stejskal, František ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

^c STEPHEN F AUSTIN STATE UNIVERSITY   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

(S) DHPA; Apicomplexa; Cryptosporidium parvum; D eritadenine; E.C. 3.3.1.1; Paromomycin; RT qPCR; S adenosylhomocysteine hydrolase

Indexed keywords

9 (2,3 DIHYDROXYPROPYL)ADENINE; ADENOSYLHOMOCYSTEINASE INHIBITOR; ERITADENINE; NITAZOXANIDE; PAROMOMYCIN; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ADENINE; ADENOSYLHOMOCYSTEINASE; CRYPTOSPORIDIUM PARVUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, PROTOZOAN;

APICOMPLEXA; CRYPTOSPORIDIUM PARVUM; PROTOZOA;

EID: 77955271448     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.04.007     Document Type: Article

References (30)

1. Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G., Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P., Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L., Anantharaman V., Aravind L., Kapur V. Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science 2004, 304:441-445.
2. Anderson V.R., Curran M.P. Nitazoxanide: a review of its use in the treatment of gastrointestinal infections. Drugs 2007, 67(13):1947-1967.
3. Bitonti A.J., Baumann R.J., Jarvi E.T., McCarthy J.R., McCann P.P. Antimalarial activity of a 4', 5'-unsaturated 5'-fluoroadenosine mechanism-based inhibitor of S-adenosyl-l-homocysteine hydrolase. Biochemical Pharmacology 1990, 40:601-606.
4. Cai X., Woods K.M., Upton S.J., Zhu G. Application of quantitative real-time reverse transcription-PCR in assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum in vitro. Antimicrobial Agents and Chemotherapy 2005, 49:4437-4442.
5. Chen X.M., Keithly J.S., Paya C.V., LaRusso N.F. Cryptosporidiosis. The New England Journal of Medicine 2002, 346:1723-1731.
6. Chiang P.K. Biological effects of inhibitors of S-adenosylhomocysteine hydrolase. Pharmacology and Therapeutics 1998, 77:115-134.
7. Chiang P.K., Gordon R.K., Tal J., Zeng G.C., Doctor B.P., Pardhasaradhi K., McCann P.P. S-adenosylmethionine and methylation. The FASEB Journal 1996, 10:471-480.
8. Ctrnacta V., Stejskal F., Keithly J.S., Hrdy I. Characterization of S-adenosylhomocysteine hydrolase from Cryptosporidium parvum. FEMS Microbiology Letters 2007, 273:87-95.
9. De Clercq E. The discovery of antiviral agents: ten different compounds, ten different stories. Medicinal Research Reviews 2008, 28:929-953.
10. De Clercq E., Bergstrom D.E., Holy A., Montgomery J.A. Broad-spectrum antiviral activity of adenosine analogues. Antiviral Research 1984, 4(3):119-133.
11. De Clercq E., Descamps J., De Somer P., Holy A. (S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity. Science 1978, 200:563-565.
12. Henderson D.M., Hanson S., Allen T., Wilson K., Coulter-Karis D.E., Greenberg M.L., Hershfield M.S., Ullman B. Cloning of the gene encoding Leishmania donovani S-adenosylhomocysteine hydrolase, a potential target for antiparasitic chemotherapy. Molecular and Biochemical Parasitology 1992, 53:169-183.
13. Holy A. Novel adenosine analogues with broad-spectrum biological activity: structure and mechanism of action. Nucleic Acids Symposium Series 1982, 199:202.
14. Holy A., Votruba I., De Clerq E. Synthesis and antiviral activity of stereoisomeric eritadenines. Collection of Czechoslovak Chemical Communications 1982, 47:1392-1407.
15. Holy A., Votruba I., De Clercq E. Structure activity studies on open chain analogues of nucleosides: inhibition of S-adenosyl-l-homocysteine hydrolase and antiviral activity I. Neutral open chain analogues. Collection of Czechoslovak Chemical Communications 1985, 50:245-261.
16. Huang Y., Komoto J., Takata Y., Powell D.R., Gomi T., Ogawa H., Fujioka M., Takusagawa F. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue d-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with d-eritadenine. The Journal of Biological Chemistry 2002, 277(9):7477-7482.
17. Lozada-Ramirez J.D., Martinez-Martinez I., Sanchez-Ferrer A., Garcia-Carmona F. A colorimetric assay for S-adenosylhomocysteine hydrolase. Journal of Biochemical and Biophysical Methods 2006, 67:131-140.
18. Nesterenko M.V., Upton S.J. A rapid microcentrifuge procedure for purification of Cryptosporidium sporozoites. Journal of Microbiological Methods 1996, 25:87-89.
19. Nozaki T., Ali V., Tokoro M. Sulfur-containing amino acid metabolism in parasitic protozoa. Advances in Parasitology 2005, 60:1-99.
20. Parker N.B., Yang X., Hanke J., Mason K.A., Schowen R.L., Borchardt R.T., Yin D.H. Trypanosoma cruzi: molecular cloning and characterization of the S-adenosylhomocysteine hydrolase. Experimental Parasitology 2003, 105:149-158.
21. Schanche J.S., Schanche T., Ueland P.M., Holy A., Votruba I. The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes. Molecular Pharmacology 1984, 26:553-558.
22. Singh V., Shi W., Almo S.C., Evans G.B., Furneaux R.H., Tyler P.C., Painter G.F., Lenz D.H., Mee S., Zheng R., Schramm V.L. Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. Biochemistry 2006, 45:12929-12941.
23. Tanaka N., Nakanishi M., Kusakabe Y., Shiraiwa K., Yabe S., Ito Y., Kitade Y., Nakamura K.T. Three-dimensional structure of S-adenosyl-l-homocysteine hydrolase from Plasmodium falciparum. Nucleic Acids Symposium Series (Oxford) 2004, 48:281-282.
24. Thompson R.C., Olson M.E., Zhu G., Enomoto S., Abrahamsen M.S., Hijjawi N.S. Cryptosporidium and cryptosporidiosis. Advances in Parasitology 2005, 59:77-158.
25. Tzipori S., Widmer G. A hundred-year retrospective on cryptosporidiosis. Trends in Parasitology 2008, 24:184-189.
26. Upton S.J., Tilley M., Brillhart D.B. Effects of select medium supplements on in vitro development of Cryptosporidium parvum in HCT-8 cells. Journal of Clinical Microbiology 1995, 33:371-375.
27. Votruba I., Holy A. Inhibition of S-adenosyl-l-homocysteine hydrolase by the aliphatic nucleoside analogue 9-(S)-(2,3-dihydroxypropyl) adenine. Collection of Czechoslovak Chemical Communications 1980, 45:3039-3044.
28. Votruba I., Holy A. Eritadenines - novel type of potent inhibitors of S-adenosyl-l-homocysteine hydrolase. Collection of Czechoslovak Chemical Communications 1982, 47:167-174.
29. Votruba I., Holy A., De Clercq E. Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines. Acta Virologica 1983, 27:273-276.
30. Xu P., Widmer G., Wang Y., Ozaki L.S., Alves J.M., Serrano M.G., Puiu D., Manque P., Akiyoshi D., Mackey A.J., Pearson W.R., Dear P.H., Bankier A.T., Peterson D.L., Abrahamsen M.S., Kapur V., Tzipori S., Buck G.A. The genome of Cryptosporidium hominis. Nature 2004, 431:1107-1112.