Molecular basis for the antiviral and anticancer activities of unnatural L-β-nucleosides

Expert Opinion on Investigational Drugs

Volumn 7, Issue 8, 1998, Pages 1285-1300

  Spadari, S ^a   Maga, G ^a   Verri, A ^a   Focher, F ^a  

^a CNR   (Italy)

Author keywords

Anticancer drugs; Antiviral drugs; Deoxycytidine kinase; DNA polymerase enantioselectivity; HBV; HCMV infections; HIV 1; HSV 1; L nucleosides; Thymidine kinase

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARBOVIR; DEOXYCYTIDINE KINASE; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DNA POLYMERASE; INDINAVIR; LAMIVUDINE; NUCLEOSIDE ANALOG; NUCLEOSIDE TRIPHOSPHATE; PHOSPHOTRANSFERASE; RNA DIRECTED DNA POLYMERASE; STAVUDINE; THYMIDINE KINASE; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; ZALCITABINE; ZIDOVUDINE; ZIDOVUDINE 5' TRIPHOSPHATE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; CYTOMEGALOVIRUS; DRUG DESIGN; DRUG TARGETING; ENANTIOMER; ENZYME INHIBITION; FOOD AND DRUG ADMINISTRATION; HEPATITIS B VIRUS; HERPES SIMPLEX VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; REVIEW; STRUCTURE ACTIVITY RELATION; UNITED STATES;

EID: 0031822118     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.7.8.1285     Document Type: Review

References (74)