Evidence that MEK1 positively promotes interhomologue double-strand break repair

Nucleic Acids Research

Volumn 38, Issue 13, 2010, Pages 4349-4360

  Terentyev, Yaroslav ^a   Johnson, Rebecca ^a,b   Neale, Matthew J ^a,c   Khisroon, Muhammad ^a,d   Bishop Bailey, Anna ^a   Goldman, Alastair S H ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d UNIVERSITY OF PESHAWAR   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE 1;

ARTICLE; CHROMATID; CHROMOSOME PAIRING; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; GENE CONVERSION; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE LOSS; GENETIC RECOMBINATION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; YEAST;

DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENE CONVERSION; MAP KINASE KINASE 1; MEIOSIS; MUTATION; PROTON-TRANSLOCATING ATPASES; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE PROTEINS; SPORES, FUNGAL;

EID: 77955258141     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq137     Document Type: Article

References (41)

1. Watanabe, Y. (2004) Modifying sister chromatid cohesion for meiosis. J. Cell. Sci., 117, 4017-4023. Nucleic Acids Research, 2010, Vol. 38, No. 13 4359
2. Cromie, G.A., Hyppa, R.W., Taylor, A.F., Zakharyevich, K., Hunter, N. and Smith, G.R. (2006) Single Holliday junctions are intermediates of meiotic recombination. Cell, 127, 1167-1178.
3. Schwacha, A. and Kleckner, N. (1997) Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway. Cell, 90, 1123-1135.
4. Schwacha, A. and Kleckner, N. (1994) Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis. Cell, 76, 51-63.
5. Bishop, D.K., Park, D., Xu, L. and Kleckner, N. (1992) DMC1:a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell, 69, 439-456.
6. Bishop, D.K., Nikolski, Y., Oshiro, J., Chon, J., Shinohara, M. and Chen, X. (1999) High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway. Genes Cells, 4, 425-444.
7. Busygina, V., Sehorn, M.G., Shi, I.Y., Tsubouchi, H., Roeder, G.S. and Sung, P. (2008) Hed1 regulates Rad51-mediated recombination via a novel mechanism. Genes Dev., 22, 786-795.
8. Tsubouchi, H. and Roeder, G.S. (2006) Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired. Genes Dev., 20, 1766-1775.
9. Tsubouchi, H. and Roeder, G.S. (2003) The importance of genetic recombination for fidelity of chromosome pairing in meiosis. Dev. Cell, 5, 915-925.
10. Bailis, J.M. and Roeder, G.S. (1998) Synaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein. Genes Dev., 12, 3551-3563.
11. Hollingsworth, N.M. and Ponte, L. (1997) Genetic interactions between HOP1, RED1 and MEK1 suggest that MEK1 regulates assembly of axial element components during meiosis in the yeast Saccharomyces cerevisiae. Genetics, 147, 33-42.
12. Nag, D.K., Scherthan, H., Rockmill, B., Bhargava, J. and Roeder, G.S. (1995) Heteroduplex DNA formation and homolog pairing in yeast meiotic mutants. Genetics, 141, 75-86.
13. Rockmill, B. and Roeder, G.S. (1991) A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev., 5, 2392-2404.
14. Xu, L., Weiner, B.M. and Kleckner, N. (1997) Meiotic cells monitor the status of the interhomolog recombination complex. Genes Dev., 11, 106-118.
15. Thompson, D.A. and Stahl, F.W. (1999) Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics, 153, 621-641.
16. Hollingsworth, N.M., Ponte, L. and Halsey, C. (1995) MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev., 9, 1728-1739.
17. Leem, S.H. and Ogawa, H. (1992) The MRE4 gene encodes a novel protein kinase homologue required for meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res., 20, 449-457.
18. Niu, H., Wan, L., Baumgartner, B., Schaefer, D., Loidl, J. and Hollingsworth, N.M. (2005) Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1. Mol. Biol. Cell, 16, 5804-5818.
19. Niu, H., Li, X., Job, E., Park, C., Moazed, D., Gygi, S.P. and Hollingsworth, N.M. (2007) Mek1 kinase is regulated to suppress double-strand break repair between sister chromatids during budding yeast meiosis. Mol. Cell. Biol., 27, 5456-5467.
20. Wan, L., de los Santos, T., Zhang, C., Shokat, K. and Hollingsworth, N.M. (2004) Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Mol. Biol. Cell, 15, 11-23.
21. Niu, H., Wan, L., Busygina, V., Kwon, Y., Allen, J.A., Li, X., Kunz, R.C., Kubota, K., Wang, B., Sung, P. et al. (2009) Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Mol. Cell, 36, 393-404.
22. Johnson, R., Borde, V., Neale, M.J., Bishop-Bailey, A., North, M., Harris, S., Nicolas, A. and Goldman, A.S.H. (2007) Excess single-stranded DNA inhibits meiotic double-strand break repair. PLoS Genet., 3, e223.
23. Neale, M.J., Ramachandran, M., Trelles-Sticken, E., Scherthan, H. and Goldman, A.S.H. (2002) Wild-type levels of Spo11-Induced DSBs are required for normal single-strand resection during meiosis. Mol. Cell, 9, 835-846.
24. Allers, T. and Lichten, M. (2000) A method for preparing genomic DNA that restrains branch migration of Holliday junctions. Nucleic Acids Res., 28, e6.
25. de los Santos, T. and Hollingsworth, N.M. (1999) Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast. J. Biol. Chem., 274, 1783-1790.
26. Egel, R. (2005) Fission yeast mating-type switching: programmed damage and repair. DNA Repair, 4, 525-536.
27. Haber, J.E. (1998) Mating-type gene switching in Saccharomyces cerevisiae. Annu. Rev. Genet., 32, 561-599.
28. Arbel, A., Zenvirth, D. and Simchen, G. (1999) Sister chromatid-based DNA repair is mediated by RAD54, not by DMC1 or TID1. EMBO J., 18, 2648-2658.
29. Heyer, W.D., Li, X., Rolfsmeier, M. and Zhang, X.P. (2006) Rad54: the Swiss Army knife of homologous recombination? Nucleic Acids Res., 34, 4115-4125.
30. Ivanov, E.L., Sugawara, N., Fishman-Lobell, J. and Haber, J.E. (1996) Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae. Genetics, 142, 693-704.
31. Allers, T. and Lichten, M. (2001) Differential timing and control of noncrossover and crossover recombination during meiosis. Cell, 106, 47-57.
32. Shinohara, A., Ogawa, H. and Ogawa, T. (1992) Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein. Cell, 69, 457-470.
33. Sheridan, S. and Bishop, D.K. (2006) Red-Hed regulation: recombinase Rad51, though capable of playing the leading role, may be relegated to supporting Dmc1 in budding yeast meiosis. Genes Dev., 20, 1685-1691.
34. Heyting, C. (1996) Synaptonemal complexes: structure and function. Curr. Opin. Cell. Biol., 8, 389-396.
35. Zickler, D. and Kleckner, N. (1998) The leptotene-zygotene transition of meiosis. Annu. Rev. Genet., 32, 619-697.
36. Klein, F., Mahr, P., Galova, M., Buonomo, S.B., Michaelis, C., Nairz, K. and Nasmyth, K. (1999) A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell, 98, 91-103.
37. Zierhut, C., Berlinger, M., Rupp, C., Shinohara, A. and Klein, F. (2004) Mnd1 is required for meiotic interhomolog repair. Curr. Biol., 14, 752-762.
38. Storlazzi, A., Xu, L., Schwacha, A. and Kleckner, N. (1996) Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc. Natl Acad. Sci. USA, 93, 9043-9048.
39. Smith, A.V. and Roeder, G.S. (1997) The yeast Red1 protein localizes to the cores of meiotic chromosomes. J. Cell. Biol., 136, 957-967.
40. Hollingsworth, N.M. and Byers, B. (1989) HOP1: a yeast meiotic pairing gene. Genetics, 121, 445-462.
41. Steele, D.F., Morris, M.E. and Jinks-Robertson, S. (1991) Allelic and ectopic interactions in recombination-defective yeast strains. Genetics, 127, 53-60.