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Volumn 56, Issue 1, 2010, Pages 6-15

The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype

Author keywords

AV node; conduction system; development; gene expression; heart; sinus node

Indexed keywords

CONNEXIN 40; CONNEXIN 43; NATRIURETIC PEPTIDE RECEPTOR A; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TBX2; TRANSCRIPTION FACTOR TBX3; UNCLASSIFIED DRUG;

EID: 77955230192     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181e775d3     Document Type: Conference Paper
Times cited : (32)

References (66)
  • 1
    • 0033617416 scopus 로고    scopus 로고
    • Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node1
    • Ishii TM, Takano M, Xie LH, et al. Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node1. J Biol Chem. 1999;274:12835-12839.
    • (1999) J Biol Chem , vol.274 , pp. 12835-12839
    • Ishii, T.M.1    Takano, M.2    Xie, L.H.3
  • 2
    • 0034818628 scopus 로고    scopus 로고
    • Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues
    • Moosmang S, Stieber J, Zong X, et al. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem. 2001;268:1646-1652.
    • (2001) Eur J Biochem , vol.268 , pp. 1646-1652
    • Moosmang, S.1    Stieber, J.2    Zong, X.3
  • 3
    • 0344444741 scopus 로고    scopus 로고
    • Expression of the hyperpolarizationactivated cyclic nucleotide-gated cation channel HCN4 during mouse heart development
    • Garcia-Frigola C, Shi Y, Evans SM. Expression of the hyperpolarizationactivated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns. 2003;3:777-783.
    • (2003) Gene Expr Patterns , vol.3 , pp. 777-783
    • Garcia-Frigola, C.1    Shi, Y.2    Evans, S.M.3
  • 4
    • 41149085528 scopus 로고    scopus 로고
    • The missing link in the mystery of normal automaticity of cardiac pacemaker cells
    • Lakatta EG, Vinogradova TM, Maltsev VA. The missing link in the mystery of normal automaticity of cardiac pacemaker cells. Ann N Y Acad Sci. 2008;1123:41-57.
    • (2008) Ann N y Acad Sci , vol.1123 , pp. 41-57
    • Lakatta, E.G.1    Vinogradova, T.M.2    Maltsev, V.A.3
  • 5
    • 0028829253 scopus 로고
    • Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system
    • Delorme B, Dahl E, Jarry-Guichard T, et al. Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev Dyn. 1995;204:358-371.
    • (1995) Dev Dyn , vol.204 , pp. 358-371
    • Delorme, B.1    Dahl, E.2    Jarry-Guichard, T.3
  • 6
    • 0034283053 scopus 로고    scopus 로고
    • Role of gap junctions in cardiac conduction and development
    • Lo CW. Role of gap junctions in cardiac conduction and development. Circ Res. 2000;87:346-348.
    • (2000) Circ Res , vol.87 , pp. 346-348
    • Lo, C.W.1
  • 7
    • 2942612343 scopus 로고    scopus 로고
    • Architectural and functional asymmetry of the His-Purkinje system of the murine heart
    • Miquerol L, Meysen S, Mangoni M, et al. Architectural and functional asymmetry of the His-Purkinje system of the murine heart. Cardiovasc Res. 2004;63:77-86.
    • (2004) Cardiovasc Res , vol.63 , pp. 77-86
    • Miquerol, L.1    Meysen, S.2    Mangoni, M.3
  • 8
    • 70349667322 scopus 로고    scopus 로고
    • The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium
    • Remme CA, Verkerk AO, Hoogaars WM, et al. The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium. Basic Res Cardiol. 2009;104:511-522.
    • (2009) Basic Res Cardiol , vol.104 , pp. 511-522
    • Remme, C.A.1    Verkerk, A.O.2    Hoogaars, W.M.3
  • 9
    • 33845455495 scopus 로고    scopus 로고
    • Epicardium-derived cells are important for correct development of the Purkinje fibers in the avian heart
    • Eralp I, Lie-Venema H, Bax NAM, et al. Epicardium-derived cells are important for correct development of the Purkinje fibers in the avian heart. Anat Rec A Discov Mol Cell Evol Biol. 2006;288:1272-1280.
    • (2006) Anat Rec A Discov Mol Cell Evol Biol , vol.288 , pp. 1272-1280
    • Eralp, I.1    Lie-Venema, H.2    Nam, B.3
  • 10
    • 33847713360 scopus 로고    scopus 로고
    • Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles
    • Gurjarpadhye A, Hewett KW, Justus C, et al. Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles. Am J Physiol Heart Circ Physiol. 2007;292:H1291-H1300.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Gurjarpadhye, A.1    Hewett, K.W.2    Justus, C.3
  • 11
    • 33847348346 scopus 로고    scopus 로고
    • Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations
    • Hutson MR, Kirby ML. Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations. Semin Cell Dev Biol. 2007;18:101-110.
    • (2007) Semin Cell Dev Biol , vol.18 , pp. 101-110
    • Hutson, M.R.1    Kirby, M.L.2
  • 12
    • 1842584370 scopus 로고    scopus 로고
    • Embryonic conduction tissue: A spatial correlation with adult arrhythmogenic areas
    • Jongbloed MRM, Schalij MJ, Poelmann RE, et al. Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas. J Cardiovasc Electrophysiol. 2004;15:349-355.
    • (2004) J Cardiovasc Electrophysiol , vol.15 , pp. 349-355
    • Mrm, J.1    Schalij, M.J.2    Poelmann, R.E.3
  • 13
    • 0029024925 scopus 로고
    • Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system
    • Gourdie RG, Mima T, Thompson RP, et al. Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system. Development. 1995;121:1423-1431.
    • (1995) Development , vol.121 , pp. 1423-1431
    • Gourdie, R.G.1    Mima, T.2    Thompson, R.P.3
  • 14
    • 0033429649 scopus 로고    scopus 로고
    • Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage
    • Cheng G, Litchenberg WH, Cole GJ, et al. Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage. Development. 1999;126:5041-5049.
    • (1999) Development , vol.126 , pp. 5041-5049
    • Cheng, G.1    Litchenberg, W.H.2    Cole, G.J.3
  • 15
    • 77955227629 scopus 로고
    • The contraction of cardiac muscle
    • Sharpey-Schafer EA, ed. London Edinburgh: Pentland
    • GaskellWH. The contraction of cardiac muscle. In: Sharpey-SchaferEA, ed. Textbook of Physiology. London Edinburgh: Pentland; 1900: 169-227.
    • (1900) Textbook of Physiology , pp. 169-227
    • Gaskell, W.H.1
  • 16
    • 0002519492 scopus 로고
    • Developmental horizons in human embryos. Description of age groups XV, XVI, XVII, and XVIII, being the third issue of a survey of the Carnegie Collection
    • Carnegie Instn. Wash. Publ. 575
    • Streeter GL. Developmental horizons in human embryos. Description of age groups XV, XVI, XVII, and XVIII, being the third issue of a survey of the Carnegie Collection. Carnegie Instn. Wash. Publ. 575. Contrib Embryol. 1948:32:133-203.
    • (1948) Contrib Embryol , vol.32 , pp. 133-203
    • Streeter, G.L.1
  • 18
    • 0001554260 scopus 로고
    • Differentiation of the atrioventricular conducting system of the heart
    • de Haan RL. Differentiation of the atrioventricular conducting system of the heart. Circulation. 1961;24:458-470.
    • (1961) Circulation , vol.24 , pp. 458-470
    • De Haan, R.L.1
  • 19
    • 0017362253 scopus 로고
    • The development of the conduction system in the mouse embryo heart. I. The first embryonic A-V conduction pathway
    • Virágh Sz, Challice CE. The development of the conduction system in the mouse embryo heart. I. The first embryonic A-V conduction pathway. Dev Biol. 1977;56:382-396.
    • (1977) Dev Biol , vol.56 , pp. 382-396
    • Sz, V.1    Challice, C.E.2
  • 20
    • 0017329988 scopus 로고
    • The development of the conduction system in the mouse embryo heart. II. Histogenesis of the atrioventricular node and bundle
    • Virágh Sz, Challice CE. The development of the conduction system in the mouse embryo heart. II. Histogenesis of the atrioventricular node and bundle. Dev Biol. 1977;56:397-411.
    • (1977) Dev Biol , vol.56 , pp. 397-411
    • Sz, V.1    Challice, C.E.2
  • 21
    • 0019297799 scopus 로고
    • The development of the conduction system in the mouse embryo heart. III. The development of sinus muscle and sinoatrial node
    • Virágh Sz, Challice CE. The development of the conduction system in the mouse embryo heart. III. The development of sinus muscle and sinoatrial node. Dev Biol. 1980;80:28-45.
    • (1980) Dev Biol , vol.80 , pp. 28-45
    • Sz, V.1    Challice, C.E.2
  • 22
    • 0017068954 scopus 로고
    • Development of the human cardiac conduction system
    • Wenink ACG. Development of the human cardiac conduction system. J Anat. 1976;121:617-631.
    • (1976) J Anat , vol.121 , pp. 617-631
    • Acg, W.1
  • 23
    • 42249090522 scopus 로고    scopus 로고
    • Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis
    • Jongbloed MR, Mahtab EA, Blom NA, et al. Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis. ScientificWorldJournal. 2008;8:239-269.
    • (2008) Scientific World Journal , vol.8 , pp. 239-269
    • Jongbloed, M.R.1    Mahtab, E.A.2    Blom, N.A.3
  • 24
    • 0036709141 scopus 로고    scopus 로고
    • Induction and patterning of the cardiac conduction system
    • Pennisi DJ, Rentschler S, Gourdie RG, et al. Induction and patterning of the cardiac conduction system. Int J Dev Biol. 2002;46: 765-775.
    • (2002) Int J Dev Biol , vol.46 , pp. 765-775
    • Pennisi, D.J.1    Rentschler, S.2    Gourdie, R.G.3
  • 26
    • 0000333921 scopus 로고
    • Regional differences in DNA-synthetic activity in the preseptation myocardium of the chick
    • Clark EB, Takao A, eds. Mount Kisco, NY: Futura Publishing Co
    • Thompson RP, Lindroth JR, Wong YMM. Regional differences in DNA-synthetic activity in the preseptation myocardium of the chick. In: Clark EB, Takao A, eds. Developmental Cardiology: Morphogenesis and Function. Mount Kisco, NY: Futura Publishing Co; 1990: 219-234.
    • (1990) Developmental Cardiology: Morphogenesis and Function , pp. 219-234
    • Thompson, R.P.1    Lindroth, J.R.2    Ymm, W.3
  • 27
    • 0001447085 scopus 로고
    • Organization and function of early specialized myocardium
    • Clark EB, Markwald RR, Takao A, eds. Armonk, NY: Futura Publishing Co
    • Thompson RP, Kanai T, Germroth PG, et al. Organization and function of early specialized myocardium. In: Clark EB, Markwald RR, Takao A, eds. Developmental Mechanisms of Heart Disease. Armonk, NY: Futura Publishing Co; 1995:269-279.
    • (1995) Developmental Mechanisms of Heart Disease , pp. 269-279
    • Thompson, R.P.1    Kanai, T.2    Germroth, P.G.3
  • 28
    • 67649870457 scopus 로고    scopus 로고
    • The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle
    • Aanhaanen WT, Brons JF, Dominguez JN, et al. The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle. Circ Res. 2009;104:1267.
    • (2009) Circ Res , vol.104 , pp. 1267
    • Aanhaanen, W.T.1    Brons, J.F.2    Dominguez, J.N.3
  • 30
    • 0020054766 scopus 로고
    • The development of the conduction system in the mouse embryo heart. IV. Differentiation of the atrioventricular conduction system
    • Virágh Sz, Challice CE. The development of the conduction system in the mouse embryo heart. IV. Differentiation of the atrioventricular conduction system. Dev Biol. 1982;89:25-40.
    • (1982) Dev Biol , vol.89 , pp. 25-40
    • Sz, V.1    Challice, C.E.2
  • 31
    • 67949097457 scopus 로고    scopus 로고
    • Gene expression profiling of the forming atrioventricular node using a novel Tbx3-based node-specific transgenic reporter
    • Horsthuis T, Buermans HP, Brons JF, et al. Gene expression profiling of the forming atrioventricular node using a novel Tbx3-based node-specific transgenic reporter. Circ Res. 2009;105:61-69.
    • (2009) Circ Res , vol.105 , pp. 61-69
    • Horsthuis, T.1    Buermans, H.P.2    Brons, J.F.3
  • 32
    • 0038707943 scopus 로고    scopus 로고
    • Cardiac chamber formation: Development, genes and evolution
    • Moorman AFM, Christoffels VM. Cardiac chamber formation: development, genes and evolution. Physiol Rev. 2003;83:1223-1267.
    • (2003) Physiol Rev , vol.83 , pp. 1223-1267
    • Afm, M.1    Christoffels, V.M.2
  • 33
    • 33748357932 scopus 로고    scopus 로고
    • Regionalized sequence of myocardial cell growth and proliferation characterizes early chamber formation
    • Soufan AT, van den Berg G, Ruijter JM, et al. Regionalized sequence of myocardial cell growth and proliferation characterizes early chamber formation. Circ Res. 2006;99:545-552.
    • (2006) Circ Res , vol.99 , pp. 545-552
    • Soufan, A.T.1    Van Den Berg, G.2    Ruijter, J.M.3
  • 34
    • 0034662018 scopus 로고    scopus 로고
    • Chamber formation and morphogenesis in the developing mammalian heart
    • Christoffels VM, Habets PEMH, Franco D, et al. Chamber formation and morphogenesis in the developing mammalian heart. Dev Biol. 2000;223: 266-278.
    • (2000) Dev Biol , vol.223 , pp. 266-278
    • Christoffels, V.M.1    Pemh, H.2    Franco, D.3
  • 35
    • 0026633831 scopus 로고
    • Persisting zones of slow impulse conduction in developing chicken hearts
    • de Jong F, Opthof T, Wilde AA, et al. Persisting zones of slow impulse conduction in developing chicken hearts. Circ Res. 1992;71:240-250.
    • (1992) Circ Res , vol.71 , pp. 240-250
    • De Jong, F.1    Opthof, T.2    Wilde, A.A.3
  • 36
    • 34247857520 scopus 로고    scopus 로고
    • Characterization of sinoatrial node in four conduction system marker mice
    • Viswanathan S, Burch JB, Fishman GI, et al. Characterization of sinoatrial node in four conduction system marker mice. J Mol Cell Cardiol. 2007; 42:946-953.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 946-953
    • Viswanathan, S.1    Burch, J.B.2    Fishman, G.I.3
  • 37
    • 70349652537 scopus 로고    scopus 로고
    • Transcription profiling of HCN-channel isotypes throughout mouse cardiac development
    • Schweizer PA, Yampolsky P, Malik R, et al. Transcription profiling of HCN-channel isotypes throughout mouse cardiac development. Basic Res Cardiol. 2009;104:778-786.
    • (2009) Basic Res Cardiol , vol.104 , pp. 778-786
    • Schweizer, P.A.1    Yampolsky, P.2    Malik, R.3
  • 38
    • 2442513900 scopus 로고    scopus 로고
    • The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    • Hoogaars WMH, Tessari A, Moorman AFM, et al. The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc Res. 2004;62:489-499.
    • (2004) Cardiovasc Res , vol.62 , pp. 489-499
    • Wmh, H.1    Tessari, A.2    Afm, M.3
  • 39
    • 0034551683 scopus 로고    scopus 로고
    • Expression of chick Tbx-2 Tbx-3 and Tbx-5 genes during early heart development: Evidence for BMP2 induction of Tbx2
    • Yamada M, Revelli JP, Eichele G, et al. Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Dev Biol. 2000;228:95-105.
    • (2000) Dev Biol , vol.228 , pp. 95-105
    • Yamada, M.1    Revelli, J.P.2    Eichele, G.3
  • 40
    • 0037093383 scopus 로고    scopus 로고
    • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation
    • Habets PEMH, Moorman AFM, Clout DEW, et al. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 2002;16: 1234-1246.
    • (2002) Genes Dev , vol.16 , pp. 1234-1246
    • Pemh, H.1    Afm, M.2    Dew, C.3
  • 41
    • 1842561719 scopus 로고    scopus 로고
    • T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    • Christoffels VM, Hoogaars WMH, Tessari A, et al. T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev Dyn. 2004;229:763-770.
    • (2004) Dev Dyn , vol.229 , pp. 763-770
    • Christoffels, V.M.1    Wmh, H.2    Tessari, A.3
  • 42
    • 34247590280 scopus 로고    scopus 로고
    • Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
    • Hoogaars WM, Engel A, Brons JF, et al. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007;21:1098-1112.
    • (2007) Genes Dev , vol.21 , pp. 1098-1112
    • Hoogaars, W.M.1    Engel, A.2    Brons, J.F.3
  • 43
    • 44949102430 scopus 로고    scopus 로고
    • Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    • Bakker ML, Boukens BJ, Mommersteeg MTM, et al. Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res. 2008;102:1340-1349.
    • (2008) Circ Res , vol.102 , pp. 1340-1349
    • Bakker, M.L.1    Boukens, B.J.2    Mtm, M.3
  • 44
    • 0029791439 scopus 로고    scopus 로고
    • Atrioventricular junctional tissue. Discrepancy between histological and electrophysiological characteristics
    • McGuire MA, de Bakker JM, Vermeulen JT, et al. Atrioventricular junctional tissue. Discrepancy between histological and electrophysiological characteristics. Circulation. 1996;94:571-577.
    • (1996) Circulation , vol.94 , pp. 571-577
    • McGuire, M.A.1    De Bakker, J.M.2    Vermeulen, J.T.3
  • 45
    • 0031437203 scopus 로고    scopus 로고
    • Electrical activity in Koch's triangle
    • Janse MJ, McGuire MA, Loh P, et al. Electrical activity in Koch's triangle. Can J Cardiol. 1997;13:1065-1068.
    • (1997) Can J Cardiol , vol.13 , pp. 1065-1068
    • Janse, M.J.1    McGuire, M.A.2    Loh, P.3
  • 46
    • 33746167289 scopus 로고    scopus 로고
    • Successful catheter ablation of focal left atrial tachycardia originating from the mitral annulus aorta junction
    • Otomo K, Azegami K, Sasaki T, et al. Successful catheter ablation of focal left atrial tachycardia originating from the mitral annulus aorta junction. Int Heart J. 2006;47:461-468.
    • (2006) Int Heart J , vol.47 , pp. 461-468
    • Otomo, K.1    Azegami, K.2    Sasaki, T.3
  • 47
    • 20844462877 scopus 로고    scopus 로고
    • Left atrial tachycardia originating from the mitral annulus-aorta junction
    • Gonzalez MD, Contreras LJ, Jongbloed MR, et al. Left atrial tachycardia originating from the mitral annulus-aorta junction. Circulation. 2004;110: 3187-3192.
    • (2004) Circulation , vol.110 , pp. 3187-3192
    • Gonzalez, M.D.1    Contreras, L.J.2    Jongbloed, M.R.3
  • 48
    • 0037633249 scopus 로고    scopus 로고
    • Focal atrial tachycardia arising from the mitral annulus: Electrocardiographic and electrophysiologic characterization
    • Kistler PM, Sanders P, Hussin A, et al. Focal atrial tachycardia arising from the mitral annulus: electrocardiographic and electrophysiologic characterization. J Am Coll Cardiol. 2003;41:2212-2219.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2212-2219
    • Kistler, P.M.1    Sanders, P.2    Hussin, A.3
  • 49
    • 33644680809 scopus 로고    scopus 로고
    • Building the mammalian heart from two sources of myocardial cells
    • Buckingham M, Meilhac S, Zaffran S. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet. 2005;6:826-837.
    • (2005) Nat Rev Genet , vol.6 , pp. 826-837
    • Buckingham, M.1    Meilhac, S.2    Zaffran, S.3
  • 50
    • 59849120408 scopus 로고    scopus 로고
    • A caudal proliferating growth center contributes to both poles of the forming heart tube
    • van den Berg G, Abu-Issa R, de Boer BA, et al. A caudal proliferating growth center contributes to both poles of the forming heart tube. Circ Res. 2009;104:179-188.
    • (2009) Circ Res , vol.104 , pp. 179-188
    • Van Den Berg, G.1    Abu-Issa, R.2    De Boer, B.A.3
  • 52
    • 0034835134 scopus 로고    scopus 로고
    • A GATA-6 gene heart-regionspecific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system
    • Davis DL, Edwards AV, Juraszek AL, et al. A GATA-6 gene heart-regionspecific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system. Mech Dev. 2001;108: 105-119.
    • (2001) Mech Dev , vol.108 , pp. 105-119
    • Davis, D.L.1    Edwards, A.V.2    Juraszek, A.L.3
  • 53
    • 33746563019 scopus 로고    scopus 로고
    • Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18
    • Christoffels VM, Mommersteeg MTM, Trowe MO, et al. Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res. 2006;98:1555-1563.
    • (2006) Circ Res , vol.98 , pp. 1555-1563
    • Christoffels, V.M.1    Mtm, M.2    Trowe, M.O.3
  • 54
    • 61949215108 scopus 로고    scopus 로고
    • Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by tbx18 and tbx3
    • Wiese C, Grieskamp T, Airik R, et al. Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by tbx18 and tbx3. Circ Res. 2009;104:388-397.
    • (2009) Circ Res , vol.104 , pp. 388-397
    • Wiese, C.1    Grieskamp, T.2    Airik, R.3
  • 55
    • 77955138809 scopus 로고    scopus 로고
    • The sinus venosus progenitors separate and diversify from the first and second heart fields early in development
    • Mommersteeg MT, Dominguez JN, Wiese C, et al. The sinus venosus progenitors separate and diversify from the first and second heart fields early in development. Cardiovasc Res. 2010;87:92-101.
    • (2010) Cardiovasc Res , vol.87 , pp. 92-101
    • Mommersteeg, M.T.1    Dominguez, J.N.2    Wiese, C.3
  • 56
    • 42049095509 scopus 로고    scopus 로고
    • Distinct regulation of developmental and heart disease induced atrial natriuretic factor expression by two separate distal sequence
    • Horsthuis T, Houweling AC, Habets PEMH, et al. Distinct regulation of developmental and heart disease induced atrial natriuretic factor expression by two separate distal sequence. Circ Res. 2008;102:849-859.
    • (2008) Circ Res , vol.102 , pp. 849-859
    • Horsthuis, T.1    Houweling, A.C.2    Pemh, H.3
  • 57
    • 33847020703 scopus 로고    scopus 로고
    • Molecular pathway for the localized formation of the sinoatrial node
    • Mommersteeg MTM, Hoogaars WMH, Prall OWJ, et al. Molecular pathway for the localized formation of the sinoatrial node. Circ Res. 2007;100:354-362.
    • (2007) Circ Res , vol.100 , pp. 354-362
    • Mtm, M.1    Wmh, H.2    Owj, P.3
  • 58
    • 0027218911 scopus 로고
    • The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system
    • Gourdie RG, Severs NJ, Green CR, et al. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci. 1993;105:985-991.
    • (1993) J Cell Sci , vol.105 , pp. 985-991
    • Gourdie, R.G.1    Severs, N.J.2    Green, C.R.3
  • 59
    • 0033596919 scopus 로고    scopus 로고
    • Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation
    • Hagendorff A, Schumacher B, Kirchhoff S, et al. Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation. Circulation. 1999;99: 1508-1515.
    • (1999) Circulation , vol.99 , pp. 1508-1515
    • Hagendorff, A.1    Schumacher, B.2    Kirchhoff, S.3
  • 60
    • 0034634288 scopus 로고    scopus 로고
    • High-resolution optical mapping of the right bundle branch in connexin 40 knockout mice reveals slow conduction in the specialized conduction system
    • Tamaddon HS, Vaidya D, Simon AM, et al. High-resolution optical mapping of the right bundle branch in connexin 40 knockout mice reveals slow conduction in the specialized conduction system. Circ Res. 2000;87: 929-936.
    • (2000) Circ Res , vol.87 , pp. 929-936
    • Tamaddon, H.S.1    Vaidya, D.2    Simon, A.M.3
  • 61
    • 0032567957 scopus 로고    scopus 로고
    • Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin 40-deficient mice
    • Kirchhoff S, Nelles E, Hagendorff A, et al. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin 40-deficient mice. Curr Biol. 1998;8:299-302.
    • (1998) Curr Biol , vol.8 , pp. 299-302
    • Kirchhoff, S.1    Nelles, E.2    Hagendorff, A.3
  • 62
    • 33746881733 scopus 로고    scopus 로고
    • Atrioventricular ring reentry in embryonic mouse hearts
    • Valderrabano M, Chen F, Dave AS, et al. Atrioventricular ring reentry in embryonic mouse hearts. Circulation. 2006;114:543-549.
    • (2006) Circulation , vol.114 , pp. 543-549
    • Valderrabano, M.1    Chen, F.2    Dave, A.S.3
  • 63
    • 0036677402 scopus 로고    scopus 로고
    • Neuregulin-1 promotes formation of the murine cardiac conduction system
    • Rentschler S, Zander J, Meyers K, et al. Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A. 2002; 99:10464-10469.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10464-10469
    • Rentschler, S.1    Zander, J.2    Meyers, K.3
  • 64
    • 11144355678 scopus 로고    scopus 로고
    • Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
    • Jay PY, Harris BS, Maguire CT, et al. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004;113: 1130-1137.
    • (2004) J Clin Invest , vol.113 , pp. 1130-1137
    • Jay, P.Y.1    Harris, B.S.2    Maguire, C.T.3
  • 65
    • 34250754981 scopus 로고    scopus 로고
    • A molecular pathway including id2, tbx5, and nkx2-5 required for cardiac conduction system development
    • Moskowitz IP, Kim JB, Moore ML, et al. A molecular pathway including id2, tbx5, and nkx2-5 required for cardiac conduction system development. Cell. 2007;129:1365-1376.
    • (2007) Cell , vol.129 , pp. 1365-1376
    • Moskowitz, I.P.1    Kim, J.B.2    Moore, M.L.3
  • 66
    • 70349439264 scopus 로고    scopus 로고
    • Development of the cardiac conduction system: Why are some regions of the heart more arrhythmogenic than others?
    • Christoffels VM, Moorman AF. Development of the cardiac conduction system: why are some regions of the heart more arrhythmogenic than others? Circ Arrhythm Electrophysiol. 2009;2:195-207.
    • (2009) Circ Arrhythm Electrophysiol , vol.2 , pp. 195-207
    • Christoffels, V.M.1    Moorman, A.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.