A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system

Mechanisms of Development

Volumn 108, Issue 1-2, 2001, Pages 105-119

  Davis, Dorene L ^a   Edwards, Angela V ^a   Juraszek, Amy L ^b   Phelps, Aimee ^b   Wessels, Andy ^b   Burch, John B E ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cardiac conduction system; Cre recombinase; GATA 6; Heart development

Indexed keywords

TRANSCRIPTION FACTOR GATA 6;

ANIMAL CELL; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ATRIOVENTRICULAR NODE; BASE SEQUENCE; DNA; DNA-BINDING PROTEINS; ENDOCARDIUM; ENHANCER ELEMENTS (GENETICS); GATA6 TRANSCRIPTION FACTOR; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART CONDUCTION SYSTEM; INTEGRASES; LAC OPERON; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; TRANSCRIPTION FACTORS; TRETINOIN; VIRAL PROTEINS;

EID: 0034835134     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(01)00500-7     Document Type: Article

References (53)

1. Electrophysiological and ultrastructural study of the atrioventricular canal during the development of the chick embryo
2. Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage
3. Genomic circuits and the integrative biology of cardiac diseases
4. Chamber formation and morphogenesis in the developing mammalian heart
5. An Nkx-dependent enhancer regulates cGATA-6 gene expression during early stages of heart development
6. Persisting zones of slow impulse conduction in developing chicken hearts
7. Fashioning the vertebrate heart: Earliest embryonic decisions
8. Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system
9. Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers
10. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
11. The chicken GATA-6 locus contains multiple control regions that confer distinct patterns of heart region-specific expression in transgenic mouse embryos
12. Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development
13. The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis
14. Common role for each of the cGATA-4/5/6 genes in the regulation of cardiac morphogenesis
15. Cardiosensor mice and transcriptional subdomains of the vertebrate heart
16. Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice
17. The transcription factor GATA6 is essential for early extraembryonic development
18. Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis
19. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system
20. Characterization of a bone morphogenetic protein-responsive Smad-binding element
21. New findings concerning ventricular septation in the human heart. Implications for maldevelopment
22. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut
23. Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
24. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)
25. Modular regulation of cGATA-5 gene expression in the developing heart and gut
26. Mechanisms of segmentation, septation, and remodeling of the tubular heart: Endocardial cushion fate and cardiac looping
27. Early steps in vertebrate cardiogenesis
28. Abnormalities of the genitourinary tract in female mice lacking GATA5
29. Development of the conduction system of the vertebrate heart
30. Development of the cardiac conduction system
31. GATA-6: A zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm
32. Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP)
33. A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages
34. Molecular pathways controlling heart development
35. Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5
36. Visualization and functional characterization of the developing murine cardiac conduction system
37. Slug is an essential target of TGFbeta2 signaling in the developing chicken heart
38. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression
39. Invasion of mesenchyme into three-dimensional collagen gels: A regional and temporal analysis of interaction in embryonic heart tissue
40. A role for bone morphogenetic proteins in the induction of cardiac myogenesis
41. Building the heart piece by piece: Modularity of cis-elements regulating Nkx2-5 transcription
42. A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice
43. Generalized lacZ expression with the ROSA26 Cre reporter strain
44. A genetic blueprint for cardiac development
45. Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
46. Spatial distribution of 'tissue-specific' antigens in the developing human heart and skeletal muscle. III. An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system
47. The development of the atrioventricular junction in the human heart
48. Atrial development in the human heart: An immunohistochemical study with emphasis on the role of mesenchymal tissues
49. A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart
50. Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: Evidence for BMP2 induction of Tbx2
51. Diversification of cardiomyogenic cell lineages during early heart development