Polymorphism of MTHFR C677T, serum vitamin levels and cognition in subjects with hyperhomocysteinemia in China

Nutritional Neuroscience

Volumn 13, Issue 4, 2010, Pages 175-182

  Cheng, Dao Mei ^a,b   Jiang, Yu Gang ^b   Huang, Cheng Yu ^a   Kong, Hai Yan ^a   Pang, Wei ^b   Yang, Hong Peng ^b  

^a SICHUAN UNIVERSITY   (China)

^b INSTITUTE OF HEALTH AND ENVIRONMENTAL MEDICINE   (China)

Author keywords

5,10 methylenetetrahydrofolate reductase; cognition; homocysteine; polymorphism; vitamin

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PYRIDOXINE; VITAMIN;

ADULT; AGED; ARTICLE; BASIC COGNITIVE APTITUDE TEST; CHINA; COGNITION; CONTROLLED STUDY; DEMENTIA; FEMALE; FOLIC ACID BLOOD LEVEL; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; VITAMIN BLOOD LEVEL; AGING; BLOOD; COGNITION DISORDERS; GENETICS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; COGNITION; COGNITION DISORDERS; FEMALE; FOLIC ACID; GENOTYPE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; VITAMIN B 12; VITAMIN B 6; VITAMINS;

EID: 77955193858     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/147683010X12611460764200     Document Type: Article

References (40)

1. Van Duijn CM, Hofman A. Risk factor for Alzheimer's disease: the EURODEM collaborative re-analysis of case-control studies. Neuroepidemiology 1992; 1: 106-113.
2. Morley KI, Montgomery GW. The genetics of cognitive processes: candidate genes in humans and animals. Behav Genet 2001; 6: 511-531.
3. Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992; 55: 131-138.
4. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999; 19: 217-246.
5. 12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998; 55: 1449-1455.
6. Seshadri S, Beiser A, Selhub J et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002; 346: 476-483. (Pubitemid 34441738)
7. Dufouil C, Alpérovitch A, Ducros V et al. Homocysteine, white matter hyperintensities, and cognition in healthy elderly people. Ann Neurol 2003; 53: 214-221.
8. Kado DM, Karlamangla AS, Huang MH et al. Homocysteine versus the vitamins folate, B6, B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 2005; 118: 161-167.
9. Prins ND, Heijer T, Hofman A et al. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 2002; 59: 1375-1380.
10. Lewerin C, Matousek M, Steen G et al. Significant correlations of plasma homocysteine and serum methymalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am J Clin Nutr 2005; 81: 1155-1162.
11. McMahon JA, Green TJ, Skeaff CM et al. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006; 354: 2764-2772.
12. Voutilainen S, Rissanen TH, Virtanen J et al. Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 2001; 103: 2674-2680. (Pubitemid 32538781)
13. Klerk M, Verhoef P, Clarke R et al. MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002; 288: 2023-2031. (Pubitemid 35204693)
14. Gussekloo J, Heijmans BT, Slagboom PE et al. Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85. J Neurol Neurosurg 1999; 67: 535-538. (Pubitemid 29438214)
15. Visscher PM, Tynan M, Whiteman MC et al. Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans. Neurosci Lett 2003; 347: 175-178.
16. Almeida, OP, Flicker L, Lautenschlager NT et al. Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiol Aging 2005; 26: 251-257.
17. Durga J, Boxtel MPJ, Schouten EG et al. Folate and the methylenetetrahydrofolate reductase 677.T mutation correlate with cognitive performance. Neurobiol Aging 2006; 2: 334-343.
18. Kong Haiyan, Jiang Yugang, Huang Chengyu et al. A survey on serum homocysteine levels and cognitive function of the middle-aged and elderly persons in Tianjin City. Wei Sheng Yan Jiu 2008; 6: 677-679.
19. Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-113.
20. De Bree A, Verschuren WM, Kromhout D, Luijtmans LAJ, Blom HJ. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 2002; 54: 599-618.
21. Herrmann W, Herrmann M, Obeid R. Hyperhomocysteinaemia: a critical review of old and new aspects. Curr Drug Metab 2007; 8: 17-31.
22. Malinow MR, Bostom AG, Krauss RM. Homocysteine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1999; 39: 178-189.
23. Salerno-Kennedy R, Cashman KD. The relationship between nutrient intake and cognitive performance in people at risk of dementia. Ir J Med Sci 2007; 176: 193-198.
24. Kruman II, Kumaravel TS, Lohani A et al. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 2002; 22: 1752-1762.
25. Tucker KL, Qiao N, Scott T et al. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr 2005; 82: 627-635.
26. Nurk E, Refsum H, Tell GS et al. Plasma total homocysteine and memory in the elderly: The Hordaland Homocysteine study. Ann Neurol 2005; 58: 847-857.
27. Ravaglia G, Forti P, Maioli F et al. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005; 82: 636-643.
28. Luchsinger JA, Tang MX, Shea S et al. Plasma homocysteine levels and risk of Alzheimer disease. Neurology 2004; 62: 1972-1976. (Pubitemid 38738206)
29. Ravaglia G, Forti P, Maioli F et al. Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects. J Nutr Health Aging 2000; 4: 218-222.
30. Ravaglia G, Forti P, Maioli F et al. Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment. Mech Ageing Dev 2000; 21: 251-261. (Pubitemid 32115418)
31. Manders M, Vasse E, Groot LC et al. Homocysteine and cognitive function in institutionalised elderly: a cross-sectional analysis. Eur J Nutr 2006; 45: 70-78.
32. The Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002; 288: 2015-2022.
33. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002; 325: 1202.
34. Selhub J, Jacques PF, Wilson PW et al. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270: 2693-2698.
35. Rasmussen LB, Ovesen L, Bulow I et al. Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. Am J Clin Nutr 2000; 72: 1156-1163.
36. Alvares VD, Andrade AC, Mocelin AJ et al. Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients. Nutrition 2007; 23: 242-247.
37. Mattay VS, Goldberg TE, Sambataro F, Weinberger DR. Neurobiology of cognitive aging: insights from imaging genetics. Biol Psychol 2008; 79: 9-22.
38. Refsum H, Ueland PM. Recent data are not in conflict with homocysteine as a cardiovascular risk factor. Curr Opin Lipidol 1998; 9: 533-539.
39. 12, and total homocysteine and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case-control study. Gerontology 2001; 6: 324-329.
40. Balasa VV, Gruppo RA, Gartside PS, Kalinyak KA. Correlation of the C677T MTHFR genotype with homocysteine levels in children with sickle cell disease. J Pediatr Hematol Oncol 1999; 21: 397-400.