Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85

Journal of Neurology Neurosurgery and Psychiatry

Volumn 67, Issue 4, 1999, Pages 535-538

  Gussekloo, J ^a   Heijmans, B T ^b   Slagboom, P E ^b   Lagaay, A M ^a   Knook, D L ^a,b   Westendorp, R G J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

Cognitive impairment; Methylenetetrahydrofolate reductase gene

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

AGED; ARTICLE; BLOOD LEVEL; COGNITION; COGNITIVE DEFECT; DEMENTIA; ENVIRONMENTAL FACTOR; FEMALE; GENE MUTATION; GENETIC RISK; GENOTYPE; HEREDITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0032864487     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.67.4.535     Document Type: Article

References (25)

1. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;9:1042-50.
2. Riggs KM, Spiro III A, Tucker K, et al. Relations of vitamin B-12, Vitamin B-6, folate, and homocysteine to cognitive performance in the normative aging study. Am J Clin Nutr 1996;63:306-14.
3. Bell IR, Edman JS, Selhub J, et al. Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people. Acta Psychiatr Scand 1992;86:386-90.
4. Jensen E, Dehlin O, Erfurth EM, et al. Plasma homocysteine in 80-years olds: relationships to medical, psychological and social variables. Arch Gerontol Geriatr 1998;26:215-26.
5. McCaddon A, Davies G, Hudson P, et al. Total serum homocysteine in senile dementia of Alzheimer type. International Joural of Geriatric Psychiatry 1998;143:235-23.
6. Joosten E, Lesaffre E, Riezler R, et al. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 1997;52:M76-9.
7. Refsum H, Ueland OM, Nygard O, et al. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.
8. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
9. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations. Circulation 1996;93:7-9.
10. Deloughery TG, Evans A, Sadeghi A, et al. Common mutation in methylenetetra-hydrofolate reductase. Correlation with homocysteine metabolism and late onset vascular disease. Circulation 1996;94:3074-8.
11. Gudnason V, Stansbie D, Scott J, et al. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 1998;136:347-54.
12. Weverling-Rijnsburger AW, Blauw GJ, Lagaay AM, et al. Total cholesterol and risk of mortality in the oldest old. Lancet 1997;350:1119-23.
13. Heeren TJ, Lagaay AM, Hijmans W, et al. Prevalence of dementia in the oldest old of a Dutch community. J Am Geriatr Soc 1991;39:755-9.
14. Gussekloo J, Heeren TJ, Izaks GJ, et al. A community based study of the incidence of dementia in persons aged 85 years and over. J Neurol Neurosurg Psychiatry 1995;59:507-10.
15. Tysoe C, Galinsky D, Robinson D, et al. Analysis of α-1 antichymotrypsin, presenilin-1, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase loci as candidates for dementia. Am J Med Genet 1997;74:207-12.
16. Chapman J, Wang N, Treves TA, et al. ACE, MTHFR, factor V Leiden, and apoE polymorphisms in patients with vascular and Alzheimer's dementia. Stroke 1998;29:1401-4.
17. Selhub J, Dangelo A. Relationship between homocysteine and thrombotic disease. Am J Med Sci 1998;316:129-41.
18. Kostulas K, Crisby M, Huang WX, et al. A methylenetetrahydrofolate reductase gene polymorphism in ischemic stroke and in carotid artery stenosis. Eur J Clin Invest 1998; 28:285-9.
19. Markus HS, Ali N, Swaminathan R, et al. A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine and ischemic cerebrovascular disease. Stroke 1997;28:1739-43.
20. Heijmans BT, Gussekloo J, Kluft C, et al. The risk of mortality in men is associated with a common mutation in methylenetetrahydrofolate reductase gene (MTHFR). Eur J Hum Genet 1999 1999;7:197-204.
21. Bockxmeer FM van, Mamotte CDS, Vasikaran SD, et al. Methylenetetra-hydrofolate reductase gene and coronary artery disease. Circulation 1997;95:21-2.
22. Verhoef P, Kok FJ, Kluijtmans LAJ, et al. The 677C-T mutation in the methylenetetra-hydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease. Atherosclerosis 1997; 132:105-13.
23. Schwarp SM, Siscovick DS, Laminov MR, et al. Myocardial infarction in young women in relation to plasma homocyst(e)ine, folate and a common variant in the methylenetetra-hydrofolate reductase gene. Circulation 1997;96:412-17.
24. Kluijtmans LAJ, den Heijer M, Reitsma PH, et al. Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis. Thromb Haemost 1998;79:254-8.
25. Van der Put NMJ, Van der Heuvel LPWJ, SteegersTheunissen RPM, et al. Decreased methylenetetrahydrofolate reductase activity due to the 677C-T mutation in families with spina bifida offspring. J Mol Med 1996;74: 691-4.