메뉴 건너뛰기




Volumn 174, Issue 2, 2010, Pages 206-215

DNA copy number aberrations and disruption of the p16ink4a/rb pathway in radiation-induced and spontaneous rat mammary carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; PROTEIN P19ARF; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; DNA; PRIMER DNA; RNA;

EID: 77955146598     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2006.1     Document Type: Article
Times cited : (16)

References (41)
  • 1
    • 0034063909 scopus 로고    scopus 로고
    • Radiation carcinogenesis
    • J. B. Little, Radiation carcinogenesis. Carcinogenesis 21, 397-404 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 397-404
    • Little, J.B.1
  • 3
    • 0141645600 scopus 로고    scopus 로고
    • Radiation-induced genomic instability and its implications for radiation carcinogenesis
    • L. Huang, A. R. Snyder and W. F. Morgan, Radiation-induced genomic instability and its implications for radiation carcinogenesis. Oncogene 22, 5848-5854 (2003).
    • (2003) Oncogene , vol.22 , pp. 5848-5854
    • Huang, L.1    Snyder, A.R.2    Morgan, W.F.3
  • 4
    • 0036204339 scopus 로고    scopus 로고
    • Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of hetero-zygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice
    • S. Kakinuma, M. Nishimura, S. Sasanuma, K. Mita, G. Suzuki, Y. Katsura, T. Sado and Y. Shimada, Spectrum of Znfn1a1 (Ikaros) inactivation and its association with loss of hetero-zygosity in radiogenic T-cell lymphomas in susceptible B6C3F1 mice. Radiat. Res. 157, 331-340 (2002).
    • (2002) Radiat. Res. , vol.157 , pp. 331-340
    • Kakinuma, S.1    Nishimura, M.2    Sasanuma, S.3    Mita, K.4    Suzuki, G.5    Katsura, Y.6    Sado, T.7    Shimada, Y.8
  • 7
    • 0033817818 scopus 로고    scopus 로고
    • Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas
    • Y. Shimada, M. Nishimura, S. Kakinuma, M. Okumoto, T. Shiroishi, K. H. Clifton and S. Wakana, Radiation-associated loss of heterozygosity at the Znfn1a1 (Ikaros) locus on chromosome 11 in murine thymic lymphomas. Radiat. Res. 154, 293-300 (2000).
    • (2000) Radiat. Res. , vol.154 , pp. 293-300
    • Shimada, Y.1    Nishimura, M.2    Kakinuma, S.3    Okumoto, M.4    Shiroishi, T.5    Clifton, K.H.6    Wakana, S.7
  • 8
    • 0033996842 scopus 로고    scopus 로고
    • P53 gene deletions in paraffin-preserved lymphoid tumors from irradiated mice
    • T. Paunesku, Y. Zhang, M. A. Gemmell and G. E. Woloschak, p53 gene deletions in paraffin-preserved lymphoid tumors from irradiated mice. Leuk. Res. 24, 511-517 (2000).
    • (2000) Leuk. Res. , vol.24 , pp. 511-517
    • Paunesku, T.1    Zhang, Y.2    Gemmell, M.A.3    Woloschak, G.E.4
  • 10
    • 43049096400 scopus 로고    scopus 로고
    • Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors: Associations with radiation exposure and histologic grade
    • S. Miura, M. Nakashima, M. Ito, H. Kondo, S. Meirmanov, T. Hayashi, M. Soda, T. Matsuo and I. Sekine, Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors: associations with radiation exposure and histologic grade. Cancer 112, 2143-2151 (2008).
    • (2008) Cancer , vol.112 , pp. 2143-2151
    • Miura, S.1    Nakashima, M.2    Ito, M.3    Kondo, H.4    Meirmanov, S.5    Hayashi, T.6    Soda, M.7    Matsuo, T.8    Sekine, I.9
  • 12
  • 14
    • 0029036480 scopus 로고
    • Hormones and mammary carcinogenesis in mice, rats, and humans: A unifying hypothesis
    • S. Nandi, R. C. Guzman and J. Yang, Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc. Natl. Acad. Sci. USA 92, 3650-3657 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3650-3657
    • Nandi, S.1    Guzman, R.C.2    Yang, J.3
  • 17
    • 33646831438 scopus 로고    scopus 로고
    • Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis
    • T. Imaoka, M. Nishimura, Y. Nishimura, S. Kakinuma and Y. Shimada, Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis. In Vivo 20, 353-358 (2006).
    • (2006) Vivo , vol.20 , pp. 353-358
    • Imaoka, T.1    Nishimura, M.2    Nishimura, Y.3    Kakinuma, S.4    Shimada, Y.5
  • 18
    • 17844401263 scopus 로고    scopus 로고
    • Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation
    • T. Imaoka, M. Nishimura, A. Teramoto, Y. Nishimura, M. Ootawara, H. Osada, S. Kakinuma, A. Maekawa and Y. Shimada, Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation. Int. J. Cancer 115, 187-193 (2005).
    • (2005) Int. J. Cancer , vol.115 , pp. 187-193
    • Imaoka, T.1    Nishimura, M.2    Teramoto, A.3    Nishimura, Y.4    Ootawara, M.5    Osada, H.6    Kakinuma, S.7    Maekawa, A.8    Shimada, Y.9
  • 19
    • 47749105289 scopus 로고    scopus 로고
    • Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas
    • Tokyo
    • T. Imaoka, S. Yamashita, M. Nishimura, S. Kakinuma, T. Ushijima and Y. Shimada, Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas. J. Radiat. Res. (Tokyo) 49, 349-360 (2008).
    • (2008) J. Radiat. Res. , vol.49 , pp. 349-360
    • Imaoka, T.1    Yamashita, S.2    Nishimura, M.3    Kakinuma, S.4    Ushijima, T.5    Shimada, Y.6
  • 20
    • 0029952874 scopus 로고    scopus 로고
    • Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesis
    • J. D. Haag, L. C. Hsu, M. A. Newton and M. N. Gould, Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesis. Mol. Carcinog. 17, 134-143 (1996).
    • (1996) Mol. Carcinog. , vol.17 , pp. 134-143
    • Haag, J.D.1    Hsu, L.C.2    Newton, M.A.3    Gould, M.N.4
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402-408 (2001).
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
    • J. G. Herman, J. Jen, A. Merlo and S. B. Baylin, Hypermethylation- associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res. 56, 722-727 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3    Baylin, S.B.4
  • 25
    • 0347357849 scopus 로고    scopus 로고
    • Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines
    • K. Honoki, T. Tsujiuchi, T. Mori, K. Yoshitani, M. Tsutsumi, Y. Takakura and Y. Mii, Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines. Mol. Carcinog. 39, 10-14 (2004).
    • (2004) Mol. Carcinog. , vol.39 , pp. 10-14
    • Honoki, K.1    Tsujiuchi, T.2    Mori, T.3    Yoshitani, K.4    Tsutsumi, M.5    Takakura, Y.6    Mii, Y.7
  • 26
    • 0034895071 scopus 로고    scopus 로고
    • Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype
    • K. Milde-Langosch, A. M. Bamberger, G. Rieck, B. Kelp and T. Loning, Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype. Breast Cancer Res. Treat. 67, 61-70 (2001).
    • (2001) Breast Cancer Res. Treat. , vol.67 , pp. 61-70
    • Milde-Langosch, K.1    Bamberger, A.M.2    Rieck, G.3    Kelp, B.4    Loning, T.5
  • 27
    • 0035042153 scopus 로고    scopus 로고
    • Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast
    • S. C. Wong, J. K. Chan, K. C. Lee and W. L. Hsiao, Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast. J. Pathol. 194, 35-42 (2001).
    • (2001) J. Pathol. , vol.194 , pp. 35-42
    • Wong, S.C.1    Chan, J.K.2    Lee, K.C.3    Hsiao, W.L.4
  • 28
    • 0032548965 scopus 로고    scopus 로고
    • Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and histopathological parameters
    • E. A. Dublin, N. K. Patel, C. E. Gillett, P. Smith, G. Peters and D. M. Barnes, Retinoblastoma and p16 proteins in mammary carcinoma: their relationship to cyclin D1 and histopathological parameters. Int. J. Cancer 79, 71-75 (1998).
    • (1998) Int. J. Cancer , vol.79 , pp. 71-75
    • Dublin, E.A.1    Patel, N.K.2    Gillett, C.E.3    Smith, P.4    Peters, G.5    Barnes, D.M.6
  • 30
    • 0037201530 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature
    • A. T. Christian, E. G. Snyderwine and J. D. Tucker, Comparative genomic hybridization analysis of PhIP-induced mammary carcinomas in rats reveals a cytogenetic signature. Mutat. Res. 506-507, 113-119 (2002).
    • (2002) Mutat. Res. , vol.506-507 , pp. 113-119
    • Christian, A.T.1    Snyderwine, E.G.2    Tucker, J.D.3
  • 31
    • 67449123331 scopus 로고    scopus 로고
    • Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization
    • T. Adamovic, D. McAllister, V. Guryev, X. Wang, J. W. Andrae, E. Cuppen, H. J. Jacob and S. L. Sugg, Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization. Cancer Res. 69, 5159-5167 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 5159-5167
    • Adamovic, T.1    McAllister, D.2    Guryev, V.3    Wang, X.4    Andrae, J.W.5    Cuppen, E.6    Jacob, H.J.7    Sugg, S.L.8
  • 32
    • 11144228109 scopus 로고    scopus 로고
    • Estrogen mediates Aurora-A overexpression, centro-some amplification, chromosomal instability, and breast cancer in female ACI rats
    • J. J. Li, S. J. Weroha, W. L. Lingle, D. Papa, J. L. Salisbury and S. A. Li, Estrogen mediates Aurora-A overexpression, centro-some amplification, chromosomal instability, and breast cancer in female ACI rats. Proc. Natl. Acad. Sci. USA 101, 18123-18128 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 18123-18128
    • Li, J.J.1    Weroha, S.J.2    Lingle, W.L.3    Papa, D.4    Salisbury, J.L.5    Li, S.A.6
  • 34
    • 0017588094 scopus 로고
    • Excees chromosome no, 4 in ethylnitrosourea-induced neurogenic tumor lines of the rat
    • W. Au, S. W. Soukup and T. I. Mandybur, Excess chromosome no.4 in ethylnitrosourea-induced neurogenic tumor lines of the rat. J. Natl. Cancer Inst. 59, 1709-1716 (1977).
    • (1977) J. Natl. Cancer Inst. , vol.59 , pp. 1709-1716
    • Au, W.1    Soukup, S.W.2    Mandybur, T.I.3
  • 35
    • 0343238142 scopus 로고    scopus 로고
    • Genomewide assessment of genetic alterations in DMBA-induced rat sarcomas: Cytogenetic CGH, and allelotype analyses reveal recurrent DNA copy number changes in rat chromosomes 1 2, 4, and 7
    • A. Walentinsson, A. Sjoling, K. Helou, K. Klinga-Levan and G. Levan, Genomewide assessment of genetic alterations in DMBA-induced rat sarcomas: cytogenetic, CGH, and allelotype analyses reveal recurrent DNA copy number changes in rat chromosomes 1, 2, 4, and 7. Genes Chromosomes Cancer 28, 184-195 (2000).
    • (2000) Genes Chromosomes Cancer , vol.28 , pp. 184-195
    • Walentinsson, A.1    Sjoling, A.2    Helou, K.3    Klinga-Levan, K.4    Levan, G.5
  • 38
    • 0028034775 scopus 로고
    • Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
    • Y. Li, M. A. Nichols, J. W. Shay and Y. Xiong, Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res. 54, 6078-6082 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 6078-6082
    • Li, Y.1    Nichols, M.A.2    Shay, J.W.3    Xiong, Y.4
  • 40
    • 34250379011 scopus 로고    scopus 로고
    • Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT
    • S. C. Brownhill, C. Taylor and S. A. Burchill, Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT. Br. J. Cancer 96, 1914-1923 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 1914-1923
    • Brownhill, S.C.1    Taylor, C.2    Burchill, S.A.3
  • 41
    • 17844382441 scopus 로고    scopus 로고
    • Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors
    • A. Kuijper, R. A. de Vos, J. H. Lagendijk, E. van der Wall and P. J. van Diest, Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Am. J. Clin. Pathol. 123, 690-698 (2005).
    • (2005) Am. J. Clin. Pathol. , vol.123 , pp. 690-698
    • Kuijper, A.1    De Vos, R.A.2    Lagendijk, J.H.3    Wall Der E.Van4    Van Diest, P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.