High Relative Biologic Effectiveness of Carbon Ion Radiation on Induction of Rat Mammary Carcinoma and its Lack of H-ras and Tp53 Mutations

International Journal of Radiation Oncology Biology Physics

Volumn 69, Issue 1, 2007, Pages 194-203

  Imaoka, Tatsuhiko ^a   Nishimura, Mayumi ^a   Kakinuma, Shizuko ^a   Hatano, Yukiko ^a   Ohmachi, Yasushi ^a   Yoshinaga, Shinji ^b   Kawano, Akihiro ^b,c   Maekawa, Akihiko ^c   Shimada, Yoshiya ^a  

^a Experimental Radiobiology for Children's Health Research Group   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION   (Japan)

Author keywords

Heavy ion radiotherapy; High linear energy transfer radiation; Rat mammary carcinogenesis; Relative biologic effectiveness; Tp53 and H ras mutations

Indexed keywords

ENERGY TRANSFER; MATHEMATICAL MODELS; MUTAGENESIS; RATS; TUMORS;

HEAVY-ION RADIOTHERAPY; HIGH LINEAR ENERGY TRANSFER RADIATION; RAT MAMMARY CARCINOGENESIS; RELATIVE BIOLOGIC EFFECTIVENESS;

RADIOTHERAPY;

CESIUM 137; ESTROGEN RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GAMMA RADIATION; GENE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; INCIDENCE; ION THERAPY; LUNG METASTASIS; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PROTECTION; RAT; RELATIVE BIOLOGIC EFFECTIVENESS; TP53 GENE;

ANIMALS; CARBON; CESIUM RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GENES, P53; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; HEAVY IONS; LINEAR ENERGY TRANSFER; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASM PROTEINS; NEOPLASMS, HORMONE-DEPENDENT; NEOPLASMS, RADIATION-INDUCED; POINT MUTATION; RADIATION PROTECTION; RATS; RATS, INBRED ACI; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, ESTROGEN; RELATIVE BIOLOGICAL EFFECTIVENESS; SPECIES SPECIFICITY;

EID: 34547828770     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.05.026     Document Type: Article

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