Genomic indicators in the blood predict drug-induced liver injury

Pharmacogenomics Journal

Volumn 10, Issue 4, 2010, Pages 267-277

  Huang, J ^a,g   Shi, W ^b   Zhang, J ^c   Chou, J W ^d,j   Paules, R S ^d   Gerrish, K ^d   Li, J ^d,k   Luo, J ^c   Wolfinger, R D ^e   Bao, W ^e   Chu, T M ^e   Nikolsky, Y ^b   Nikolskaya, T ^b,f   Dosymbekov, D ^f   Tsyganova, M O ^f   Shi, L ^g   Fan, X ^a,g   Corton, J C ^h   Chen, M ^g   Cheng, Y ^a   Tong, W ^g   Fang, H ⁱ   Bushel, P R ^d   more..

^a ZHEJIANG UNIVERSITY   (China)

^b GeneGo bioinformatics software Inc   (United States)

^c Systems Analytics   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e SAS INSTITUTE INC   (United States)

^f VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

^g NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^h U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

ⁱ CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^j WAKE FOREST SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF NORTH CAROLINA   (United States)

more..

Author keywords

acetaminophen; blood; cross tissue; liver injury; microarray gene expression; prediction

Indexed keywords

1,2 DICHLOROBENZENE; 1,4 DICHLOROBENZENE; ALANINE AMINOTRANSFERASE; ALLYL ALCOHOL; BIOLOGICAL MARKER; BROMOBENZENE; CALGRANULIN A; CALGRANULIN B; CARBON TETRACHLORIDE; CASPASE; CYSTEINE PROTEINASE INHIBITOR; DIACYLGLYCEROL ACYLTRANSFERASE 2; DIQUAT; GALACTOSAMINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GUANINE NUCLEOTIDE BINDING PROTEIN; HAPTOGLOBIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR TYPE II; MONOCROTALINE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTROPHIL COLLAGENASE; NITROSOMORPHOLINE; PARACETAMOL; PROTEIN BCL 2; SERINE PROTEINASE INHIBITOR; THIOACETAMIDE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; ANALGESIC AGENT; PROPANOL;

ACCURACY; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD ANALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG SAFETY; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION PROFILING; GENETIC DATABASE; HISTOPATHOLOGY; INFLAMMATION; K NEAREST NEIGHBOR; LIVER CELL DAMAGE; LIVER NECROSIS; LIVER PARENCHYMA; MALE; MICROARRAY ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUALITY CONTROL; RAT; SIGNAL TRANSDUCTION; SUPPORT VECTOR MACHINE; TOXIC HEPATITIS; ADVERSE DRUG REACTION; ALGORITHM; ARTIFICIAL INTELLIGENCE; BLOOD; CLUSTER ANALYSIS; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HUMAN; INTOXICATION; LIVER; LIVER FUNCTION TEST; PATHOLOGY; PREDICTIVE VALUE; TOXICITY;

ACETAMINOPHEN; ALGORITHMS; ANALGESICS, NON-NARCOTIC; ARTIFICIAL INTELLIGENCE; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE POISONING; CLUSTER ANALYSIS; DRUG-INDUCED LIVER INJURY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENE EXPRESSION; HUMANS; LIVER; LIVER FUNCTION TESTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROPANOLS; QUALITY CONTROL;

EID: 77955134859     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2010.33     Document Type: Article

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